Journal articles, Monographs, Proceedings, Chapters

 

Journal articles:

2015

Bonnema SJ, Stovgaard ES, Fast S, Broedbaek K, Andersen JT, Weimann A, Grupe P, Hegedüs L, Poulsen HE. Systemic oxidative stress to nucleic acids is unaltered following radioiodine therapy of patients with benign nodular goiter.Eur Thyroid J. 2015 Mar;4(1):20-5. doi: 10.1159/000371883. Epub 2015 Feb 11. PMID: 25960958

Thomseth V, Cejvanovic V, Jimenez-Solem E, Petersen KM, Poulsen HE, Andersen JT. Exposure to topical chloramphenicol during pregnancy and the risk of congenital malformations: a Danish nationwide cohort study.Acta Ophthalmol. 2015 Apr 28. doi: 10.1111/aos.12737. PMID: 25923453 [Epub ahead of print]

Klaus Munkholm, Henrik Enghusen Poulsen, Lars Vedel Kessing, Maj Vinberg, Elevated levels of urinary markers of oxidatively generated DNA and RNA damage in bipolar disorder. Bipolar disorders 2015, vol. 17, nummer 3, 2015, s. 257-68.  

Anders Jorgensen, Ulla Knorr, Mia Greisen Soendergaard, Jens Lykkesfeldt, Anders Fink-Jensen, Henrik Enghusen Poulsen, Martin Balslev Jorgensen, Niels Vidiendal Olsen, Jonatan Myrup Staalsø, Asymmetric dimethylarginine in somatically healthy schizophrenia patients treated with atypical antipsychotics: a case-control study. BMC psychiatry 2015, vol. 15, 2015, s. 67   DOI 10.1186/s12888-015-0455-4

Gidén K, Andersen JT, Torp-Pedersen AL, Enghusen Poulsen H, Torp-Pedersen C, Jimenez-Solem E. Use of thyroid hormones in relation to pregnancy: a Danish nationwide cohort study. Acta Obstet Gynecol Scand. 2015 Mar 3. doi: 10.1111/aogs.12621. [Epub ahead of print]

Gjesing A, Gislason GH, Christensen SB, Jørgensen ME, Mérie C, Norgaard ML, Poulsen HE, Gustafsson F, Køber L, Torp-Pedersen C, Andersson C. Use of quinine and mortality-risk in patients with heart failure-a Danish nationwide observational study.Pharmacoepidemiol Drug Saf. 2015 Feb 4. doi: 10.1002/pds.3746. [Epub ahead of print] PMID: 25656791 [

Broedbaek K, Siersma V, Henriksen T, Weimann A, Petersen M, Andersen JT, Jimenez-Solem E, Hansen LJ, Henriksen JE, Bonnema SJ, de Fine Olivarius N, Friis S, Poulsen HE. Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes. Redox Biol. 2015;4:34-9. doi: 10.1016/j.redox.2014.11.010. Epub 2014 Dec 2. PMID: 25498965

Skov M, Pressler T, Lykkesfeldt J, Poulsen HE, Jensen PØ, Johansen HK, Qvist T, Kræmer D, Høiby N, Ciofu O. he effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection -- a pilot study. J Cyst Fibros. 2015 Mar;14(2):211-8. doi: 10.1016/j.jcf.2014.09.015. Epub 2014 Oct 23. PMID: 25458464

Nielsen TK, Højgaard M, Andersen JT, Poulsen HE, Lykkesfeldt J, Mikines KJ. Elimination of ascorbic Acid after high-dose infusion in prostate cancer patients: a pharmacokinetic evaluation. Basic Clin Pharmacol Toxicol. 2015 Apr;116(4):343-8. doi: 10.1111/bcpt.12323. Epub 2014 Oct 7.PMID: 25220574

2014

Skov, M., Pressler, T., Lykkesfeldt, J., Poulsen, H. E., Jensen, P. O., Johansen, H. K., Qvist, T., Kraemer, D., Hoiby, N., Ciofu, O. The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection - A pilot study. J Cyst Fibros 2014 Oct 23

Andersen JT, Andersen NL, Horwitz H, Poulsen HE, Jimenez-Solem E. Exposure to selective serotonin reuptake inhibitors in early pregnancy and the risk of miscarriage. Obstet Gynecol 2014 Oct;124(4):655-61.

Bolling R, Scheller NM, Kober L, Poulsen HE, Gislason GH, Torp-Pedersen C. Comparison of the clinical outcome of different beta-blockers in heart failure patients: a retrospective nationwide cohort study. Eur J Heart Fail 2014 Jun;16(6):678-84.

Cejvanovic V, Jimenez-Solem E, Poulsen H, Andersen J. NSAID use during pregnancy: maternal characteristics and prescription patterns. A nationwide cohort study. Scand J Rheumatol 2014;43(5):424-6.

Rosmarin D1, Palles C, Church D, Domingo E, Jones A, Johnstone E, Wang H, Love S, Julier P, Scudder C, Nicholson G, Gonzalez-Neira A, Martin M, Sargent D, Green E, McLeod H, Zanger UM, Schwab M, Braun M, Seymour M, Thompson L, Lacas B, Boige V, Ribelles N, Afzal S, Enghusen H, Jensen SA, Etienne-Grimaldi MC, Milano G, Wadelius M, Glimelius B, Garmo H, Gusella M, Lecomte T, Laurent-Puig P, Martinez-Balibrea E, Sharma R, Garcia-Foncillas J, Kleibl Z, Morel A, Pignon JP, Midgley R, Kerr D, Tomlinson I. Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.  J Clin Oncol. 2014 Apr 1;32(10):1031-9. doi: 10.1200/JCO.2013.51.1857. Epub 2014 Mar 3.

Grew IS, Cejvanovic V, Broedbaek K, Henriksen T, Petersen M, Andersen JT, et al. Diurnal variation of urinary markers of nucleic acid oxidation. Scand J Clin Lab Invest 2014 Jun;74(4):336-43.

Munkholm K, Poulsen HE, Kessing LV, Vinberg M. Elevated levels of urinary markers of oxidatively generated DNA and RNA damage in bipolar disorder. Bipolar Disord 2014 Aug 13.

Poulsen HE, Nadal LL, Broedbaek K, Nielsen PE, Weimann A. Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid. Biochim Biophys Acta 2014 Feb;1840(2):801-8.

Weeke P., Jensen A., Folke F., Gislason G. H., Olesen J. B., Fosbol E. L., Wissenberg M., Lippert F. K., Christensen E. F., Nielsen S. L., Holm E., Kanters J. K., Poulsen H. E., Kober L., Torp-Pedersen C. Antipsychotics and associated risk of out-of-hospital cardiac arrest. Clin Pharmacol Ther 2014 Oct;96(4):490-7..

 Bjarke Askaa, Espen Jimenez-Solem, Henrik Enghusen Poulsen, Jon Traerup Andersen, Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during Pregnancy Obstetrics and Gynecology International, vol. 2014, Article ID 945621, 5 pages, 2014. doi:10.1155/2014/945621.

 

2013

Andersen J. T., Petersen M., Jimenez-Solem E., Rasmussen J. N., Andersen N. L., Afzal S., Broedbaek K., Hjelvang B. R., Kober L., Torp-Pedersen C., Poulsen H. E. Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study. Obstet Gynecol Int 2013;2013:364526.

Andersen J. T., Petersen M., Jimenez-Solem E., Broedbaek K., Andersen N. L., Torp-Pedersen C., Keiding N., Poulsen H. E. Clarithromycin in early pregnancy and the risk of miscarriage and malformation: a register based nationwide cohort study. PLoS One 2013;8(1):e53327.

Andersen J. T., Petersen M., Jimenez-Solem E., Broedbaek K., Andersen E. W., Andersen N. L., Afzal S., Torp-Pedersen C., Keiding N., Poulsen H. E. Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study. Epidemiol Infect 2013 Aug;141(8):1749-55.

Barregard L., Moller P., Henriksen T., Mistry V., Koppen G., Rossner P., Jr., Sram R. J., Weimann A., Poulsen H. E., Nataf R., Andreoli R., Manini P., Marczylo T., Lam P., Evans M. D., Kasai H., Kawai K., Li Y. S., Sakai K., Singh R., Teichert F., Farmer P. B., Rozalski R., Gackowski D., Siomek A., Saez G. T., Cerda C., Broberg K., Lindh C., Hossain M. B., Haghdoost S., Hu C. W., Chao M. R., Wu K. Y., Orhan H., Senduran N., Smith R. J., Santella R. M., Su Y., Cortez C., Yeh S., Olinski R., Loft S., Cooke M. S. Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine. Antioxid Redox Signal 2013 Jun 20;18(18):2377-91.

Broedbaek K., Siersma V., Henriksen T., Weimann A., Petersen M., Andersen J. T., Jimenez-Solem E., Hansen L. J., Henriksen J. E., Bonnema S. J., de Fine Olivarius N., Poulsen H. E. Association between urinary markers of nucleic acid oxidation and mortality in type 2 diabetes: a population-based cohort study. Diabetes Care 2013 Mar;36(3):669-76.

Broedbaek K, Kasper; Andersen, Jon T.; Jimenez-Solem, Espen; Petersen, Morten; Lajer, Maria; Henriksen, Trine; Weimann, Allan; Parving, Hans-Henrik; Rossing, Peter; Poulsen, Henrik. RNA oxidation and albuminuria in type 1 diabetes patients. Cardiovascular  Endocrinology: December 2013 - Volume 2 - Issue 4 - p 103-105

Jimenez-Solem E., Andersen J. T., Petersen M., Broedbaek K., Lander A. R., Afzal S., Torp-Pedersen C., Poulsen H. E. SSRI use during pregnancy and risk of stillbirth and neonatal mortality. Am J Psychiatry 2013 Mar;170(3):299-304.

Jimenez-Solem E., Andersen J. T., Petersen M., Broedbaek K., Andersen N. L., Torp-Pedersen C., Poulsen H. E. Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study. PLoS One 2013;8(4):e63034.

Jorgensen A., Broedbaek K., Fink-Jensen A., Knorr U., Greisen Soendergaard M., Henriksen T., Weimann A., Jepsen P., Lykkesfeldt J., Poulsen H. E., Balslev Jorgensen M. Increased systemic oxidatively generated DNA and RNA damage in schizophrenia. Psychiatry Res 2013 Oct 30;209(3):417-23.

Jorgensen A., Maigaard K., Wortwein G., Hageman I., Henriksen T., Weimann A., Moller P., Loft S., Hau J., Poulsen H. E., Jorgensen M. B. Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage. Prog Neuropsychopharmacol Biol Psychiatry 2013 Jan 10;40:30-7.

Jorgensen A., Krogh J., Miskowiak K., Bolwig T. G., Kessing L. V., Fink-Jensen A., Nordentoft M., Henriksen T., Weimann A., Poulsen H. E., Jorgensen M. B. Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy. J Affect Disord 2013 Jul;149(1-3):355-62.

Kalliokoski O., Jacobsen K. R., Darusman H. S., Henriksen T., Weimann A., Poulsen H. E., Hau J., Abelson K. S. Mice do not habituate to metabolism cage housing--a three week study of male BALB/c mice. PLoS One 2013;8(3):e58460.

Klarskov P., Andersen J. T., Jimenez-Solem E., Torp-Pedersen C., Poulsen H. E. Short-acting sulfonamides near term and neonatal jaundice. Obstet Gynecol 2013 Jul;122(1):105-10.

Loft S., Olsen A., Moller P., Poulsen H. E., Tjonneland A. Association between 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and risk of postmenopausal breast cancer: nested case-control study. Cancer Epidemiol Biomarkers Prev 2013 Jul;22(7):1289-96.

Mullner E., Brath H., Pleifer S., Schiermayr C., Baierl A., Wallner M., Fastian T., Millner Y., Paller K., Henriksen T., Poulsen H. E., Forster E., Wagner K. H. Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes. Mol Nutr Food Res 2013 Feb;57(2):328-38.

Wallner M., Antl N., Rittmannsberger B., Schreidl S., Najafi K., Mullner E., Molzer C., Ferk F., Knasmuller S., Marculescu R., Doberer D., Poulsen H. E., Vitek L., Bulmer A. C., Wagner K. H. Anti-genotoxic potential of bilirubin in vivo: damage to DNA in hyperbilirubinemic human and animal models. Cancer Prev Res (Phila) 2013 Oct;6(10):1056-63.

 

2012

Afzal S., Jensen S. A., Sorensen J. B., Henriksen T., Weimann A., Poulsen H. E. Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin. Cancer Chemother Pharmacol 2012 Feb;69(2):301-7.

Egefjord L., Gejl M., Moller A., Braendgaard H., Gottrup H., Antropova O., Moller N., Poulsen H. E., Gjedde A., Brock B., Rungby J. Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer s disease - protocol for a controlled, randomized double-blinded trial. Dan Med J 2012 Oct;59(10):A4519.

Jimenez-Solem E., Andersen J. T., Petersen M., Broedbaek K., Jensen J. K., Afzal S., Gislason G. H., Torp-Pedersen C., Poulsen H. E. Exposure to selective serotonin reuptake inhibitors and the risk of congenital malformations: a nationwide cohort study. BMJ Open 2012;2(3).

Jorgensen A., Jorgensen M. B., Poulsen H. E. [Stress and aging]. Ugeskr Laeger 2012 Jan 23;174(4):201-4.

Meidahl Petersen K., Jimenez-Solem E., Andersen J. T., Petersen M., Brodbaek K., Kober L., Torp-Pedersen C., Poulsen H. E. beta-Blocker treatment during pregnancy and adverse pregnancy outcomes: a nationwide population-based cohort study. BMJ Open 2012;2(4).

Petersen M., Andersen J. T., Jimenez-Solem E., Broedbaek K., Hjelvang B. R., Henriksen T., Frandsen E., Forman J. L., Torp-Pedersen C., Kober L., Poulsen H. E. Effect of the Arg389Gly beta(1)-adrenoceptor polymorphism on plasma renin activity and heart rate, and the genotype-dependent response to metoprolol treatment. Clin Exp Pharmacol Physiol 2012 Sep;39(9):779-85.

Petersen M., Andersen J. T., Jimenez-Solem E., Broedbaek K., Afzal S., Nyegaard M., Borglum A. D., Stender S., Torp-Pedersen C., Kober L., Poulsen H. E. Effect of specific ADRB1/ADRB2/AGT genotype combinations on the association between survival and carvedilol treatment in chronic heart failure: a substudy of the ECHOS trial. Pharmacogenet Genomics 2012 Oct;22(10):709-15.

Poulsen H. E., Specht E., Broedbaek K., Henriksen T., Ellervik C., Mandrup-Poulsen T., Tonnesen M., Nielsen P. E., Andersen H. U., Weimann A. RNA modifications by oxidation: a novel disease mechanism? Free Radic Biol Med 2012 Apr 15;52(8):1353-61.

Sarac S. B., Rasmussen C. H., Afzal S., Thirstrup S., Jensen S. A., Colding-Jorgensen M., Poulsen H. E., Mosekilde E. Data-driven assessment of the association of polymorphisms in 5-Fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer. Basic Clin Pharmacol Toxicol 2012 Sep;111(3):189-97.

Torp-Pedersen A., Jimenez-Solem E., Andersen J. T., Broedbaek K., Torp-Pedersen C., Poulsen H. E. Exposure to mebendazole and pyrvinium during pregnancy: a Danish nationwide cohort study. Infect Dis Obstet Gynecol 2012;2012:769851.

Tveden-Nyborg P., Hasselholt S., Miyashita N., Moos T., Poulsen H. E., Lykkesfeldt J. Chronic vitamin C deficiency does not accelerate oxidative stress in ageing brains of guinea pigs. Basic Clin Pharmacol Toxicol 2012 Jun;110(6):524-9.

Weeke P., Folke F., Gislason G. H., Lippert F. K., Olesen J. B., Andersson C., Wissenberg M., Poulsen H. E., Nielsen S. L., Kober L., Torp-Pedersen C. Hospital admissions and pharmacotherapy before out-of-hospital cardiac arrest according to age. Resuscitation 2012 May;83(5):584-90.

Weeke P., Jensen A., Folke F., Gislason G. H., Olesen J. B., Andersson C., Fosbol E. L., Larsen J. K., Lippert F. K., Nielsen S. L., Gerds T., Andersen P. K., Kanters J. K., Poulsen H. E., Pehrson S., Kober L., Torp-Pedersen C. Antidepressant use and risk of out-of-hospital cardiac arrest: a nationwide case-time-control study. Clin Pharmacol Ther 2012 Jul;92(1):72-9.

Weimann A., Broedbaek K., Henriksen T., Stovgaard E. S., Poulsen H. E. Assays for urinary biomarkers of oxidatively damaged nucleic acids. Free Radic Res 2012 Apr;46(4):531-40.

 

2011

Afzal S., Gusella M., Vainer B., Vogel U. B., Andersen J. T., Broedbaek K., Petersen M., Jimenez-Solem E., Bertolaso L., Barile C., Padrini R., Pasini F., Jensen S. A., Poulsen H. E. Combinations of polymorphisms in genes involved in the 5-Fluorouracil metabolism pathway are associated with gastrointestinal toxicity in chemotherapy-treated colorectal cancer patients. Clin Cancer Res 2011 Jun 1;17(11):3822-9.

Afzal S., Gusella M., Jensen S. A., Vainer B., Vogel U., Andersen J. T., Brodbaek K., Petersen M., Jimenez-Solem E., Adleff V., Budai B., Hitre E., Lang I., Orosz E., Bertolaso L., Barile C., Padrini R., Kralovanszky J., Pasini F., Poulsen H. E. The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer. Pharmacogenomics 2011 Sep;12(9):1257-67.

Broedbaek K., Henriksen T., Weimann A., Petersen M., Andersen J. T., Afzal S., Jimenez-Solem E., Persson F., Parving H. H., Rossing P., Poulsen H. E. Long-term effects of Irbesartan treatment and smoking on nucleic acid oxidation in patients with type 2 diabetes and microalbuminuria: an Irbesartan in patients with type 2 diabetes and Microalbuminuria (IRMA 2) substudy. Diabetes Care 2011 May;34(5):1192-8.

Broedbaek K., Ribel-Madsen R., Henriksen T., Weimann A., Petersen M., Andersen J. T., Afzal S., Hjelvang B., Roberts L. J., Vaag A., Poulsen P., Poulsen H. E. Genetic and environmental influences on oxidative damage assessed in elderly Danish twins. Free Radic Biol Med 2011 Jun 1;50(11):1488-91.

Broedbaek K., Weimann A., Stovgaard E. S., Poulsen H. E. Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker in type 2 diabetes. Free Radic Biol Med 2011 Oct 15;51(8):1473-9.

Broedbaek K., Siersma V., Henriksen T., Weimann A., Petersen M., Andersen J. T., Jimenez-Solem E., Stovgaard E. S., Hansen L. J., Henriksen J. E., Bonnema S. J., Olivarius Nde F., Poulsen H. E. Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients. Diabetes Care 2011 Dec;34(12):2594-6.

Broedbaek K., Siersma V., Andersen J. T., Petersen M., Afzal S., Hjelvang B., Weimann A., Semba R. D., Ferrucci L., Poulsen H. E. The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly. Free Radic Res 2011 Apr;45(4):409-16.

Castaner O., Fito M., Lopez-Sabater M. C., Poulsen H. E., Nyyssonen K., Schroder H., Salonen J. T., Torre-Carbot K., Zunft H. F., De la Torre R., Baumler H., Gaddi A. V., Saez G. T., Tomas M., Covas M. I. The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial. Clin Nutr 2011 Aug;30(4):490-3.

Gorovic N., Afzal S., Tjonneland A., Overvad K., Vogel U., Albrechtsen C., Poulsen H. E. Genetic variation in the hTAS2R38 taste receptor and brassica vegetable intake. Scand J Clin Lab Invest 2011 Jul;71(4):274-9.

Joergensen A., Broedbaek K., Weimann A., Semba R. D., Ferrucci L., Joergensen M. B., Poulsen H. E. Association between urinary excretion of cortisol and markers of oxidatively damaged DNA and RNA in humans. PLoS One 2011;6(6):e20795.

Petersen M., Andersen J. T., Hjelvang B. R., Broedbaek K., Afzal S., Nyegaard M., Borglum A. D., Stender S., Kober L., Torp-Pedersen C., Poulsen H. E. Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients. Br J Clin Pharmacol 2011 Apr;71(4):556-65.

 

2010

Nurmi T, Mursu J, Penalvo JL, Poulsen HE, Voutilainen S. Dietary intake and urinary excretion of lignans in Finnish men. Br J Nutr 2010 Mar;103(5):677-85.

Lykkesfeldt J, Poulsen HE. Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials. Br J Nutr. 2010 May;103(9):1251-9. Epub 2009 Dec 15. Review..

Lopez-Miranda J, Perez-Jimenez F, Ros E, De CR, Badimon L, Covas MI, et al. Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008. Nutr Metab Cardiovasc Dis 2010 Mar 19.

Olesen JB, Hansen PR, Erdal J, Abildstrom SZ, Weeke P, Fosbol EL, et al. Antiepileptic drugs and risk of suicide: a nationwide study. Pharmacoepidemiol Drug Saf 2010 Mar 16.

Glintborg B, Andersen SK, Poulsen HE. Prescription data improve the medication history in primary care. Qual Saf Health Care 2010 Mar 1.

Sorensen R, Abildstrom SZ, Weeke P, Fosbol EL, Folke F, Hansen ML, et al. Duration of clopidogrel treatment and risk of mortality and recurrent myocardial infarction among 11 680 patients with myocardial infarction treated with percutaneous coronary intervention: a cohort study. BMC Cardiovasc Disord 2010;10:6.

de lT-C, Chavez-Servin JL, Jauregui O, Castellote AI, Lamuela-Raventos RM, Nurmi T, et al. Elevated circulating LDL phenol levels in men who consumed virgin rather than refined olive oil are associated with less oxidation of plasma LDL. J Nutr 2010 Mar;140(3):501-8.

Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress.
European Standards Committee on Urinary (DNA) Lesion Analysis, Evans MD, Olinski R, Loft S, Cooke MS. Collaborators (40) Rossner P Jr, Sram R, Henriksen T, Poulsen HE, Weimann A, Barbieri A, Sabatini L, Violante F, Kino S, Ochi T, Tairin K, Takeuchi M, Kasai H, Meerman JH, Gackowski D, Rozalski R, Siomek A, Halliwell B, Jenner AM, Wang H, Cerda C, Saez G, Haghdoost S, Svoboda P, Hu CW, Chao MR, Peng KY, Shih WC, Wu KY, Orhan H, Istanbullu NS, Mistry V, Farmer PB, Sandhu J, Singh R, Cortez C, Su Y, Santella RM, Lambert P, Smith R.  2010 Apr;24(4):1249-60. doi: 10.1096/fj.09-147124. Epub 2009 Dec 4.

Cadet J, Poulsen H.  Measurement of oxidatively generated base damage in cellular DNA and urine. Free Radic Biol Med. 2010 Jun 1;48(11):1457-9. Epub 2010 Mar 12.

Fosbøl EL, Folke F, Jacobsen S, Rasmussen JN, Sørensen R, Schramm TK, Andersen SS, Rasmussen S, Poulsen HE, Køber L, Torp-Pedersen C, Gislason GH. Cause-Specific Cardiovascular Risk Associated With Nonsteroidal Antiinflammatory Drugs Among Healthy Individuals. Circ Cardiovasc Qual Outcomes. 2010 Jun 8. [Epub ahead of print]

Weeke P, Folke F, Gislason GH, Lippert FK, Olesen JB, Andersson C, et al. Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest: a nationwide study. Resuscitation 2010 Dec;81(12):1657-63

Morten L. Hansen, MD, PhD; Rikke Sørensen, MD; Mette T. Clausen, MSc Pharm; Marie Louise Fog-Petersen, MSc Pharm; Jakob Raunsø, MD; Niels Gadsbøll, MD, DMSc; Gunnar H. Gislason, MD, PhD; Fredrik Folke, MD; Søren S. Andersen, MD; Tina K. Schramm, MD; Steen Z. Abildstrøm, MD, PhD; Henrik E. Poulsen, MD, DMSc; Lars Køber, MD, DMSc; Christian Torp-Pedersen, MD, DMSc. Risk of Bleeding With Single, Dual, or Triple Therapy With Warfarin, Aspirin, and Clopidogrel in Patients With Atrial Fibrillation ARCH INTERN MED/VOL 170 (NO. 16), SEP 13, 2010

Lykkesfeldt J, Poulsen HE.Reply to Hemilä by Lykkesfeldt and Poulsen. PMID: 20854702 [PubMed - as supplied by publisher]Br J Nutr. 2010 Sep 21:1.

Berendt L, Håkansson C, Bach KF, Andreasen PB, Petersen LG, Andersen E, Poulsen HE, Dalhoff K. Methodological characteristics of academic clinical drug trials--a retrospective cohort study of applications to the Danish Medicines Agency 1993-2005.Br J Clin Pharmacol. 2010 Nov;70(5):729-35

Helena Dominguez1*, Tina Kenn Schramm2, Gunnar Hilmar Gislason3, Mette Lykke Norgaard3, Jakob Raunsø3, Steen Zabell Abildstrøm4,5, Lars Kober2, Henrik Enghusen Poulsen5,6,7 and Christian Tobias Torp-Pedersen3,7 National background is associated with disparities in initiation and persistence to statin treatment in subjects with diabetes in Denmark. Frontiers in Pharmacology, Pharmacotherapy of Cardiovascular Disorders December 2010 | Volume 1 | Article 142 doi: 10.3389/fphar.2010.00142

 

2009

 Poulsen HE, Andersen JT, Keiding N, Schramm TK, Sørensen R, Gislasson G, Fosbøl EL, Torp-Pedersen C. Why epidemiological and clinical intervention studies often give different or diverging results? IUBMB Life, 61(4): 391–393, April 2009

 Fosbøl E, Gislason G, Jacobsen S, Folke F, Hansen M, Schramm T, Sørensen R, Rasmussen J, Andersen S, Abildstrom S, Trærup J, Poulsen H, Rasmussen S, Køber L, Torp-Pedersen C. Risk of Myocardial Infarction and Death Associated With the Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Among Healthy Individuals: A Nationwide Cohort Study. Clin Pharmacol Ther. (2009); 85, 2, 190–197

Christine Dalgård , Flemming Nielsen, Jason D. Morrow, Henrik Enghusen-Poulsen, Torbjörn Jonung, Mogens Hørder and Moniek P. M. de Maat. Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease  Br J Nutr. 2009 Feb;101(2):263-9.

Gunnar H. Gislason, MD, PhD; Jeppe N. Rasmussen, MD, PhD; Steen Z. Abildstrom, MD, PhD; Tina K. Schramm, MD;Morten L. Hansen, MD; Emil L. Fosbøl, MB; Rikke Sørensen, MD; Fredrik Folke, MD; Pernille Buch, MD, PhD; Niels Gadsbøll, MD, DMSc; Søren Rasmussen, MSc, PhD; Henrik E. Poulsen, MD, DMSc; Lars Køber, MD, DMSc;
Mette Madsen, MSc; Christian Torp-Pedersen, MD, DMSc. Increased Mortality and Cardiovascular Morbidity Associated With Use of Nonsteroidal Anti-inflammatory Drugs in Chronic Heart Failure. Arch Intern Med. 2009 Jan 26;169(2):141-9. 

Hansen ML, Gadsbøll N, Rasmussen S, Gislason GH, Folke F, Andersen SS, Schramm TK, Sørensen R, Fosbøl EL, Abildstrøm SZ, Madsen M, Poulsen HE, Køber L, Torp-Pedersen C.Clinical consequences of hospital variation in use of oral anticoagulant therapy after first-time admission for atrial fibrillation. Journal of Internal Medicine 265; 335–344

L. F. Mandsberg, O. Ciofu, N. Kirkby, L. E. Christiansen, H. E. Poulsen and N. Høiby. Antibiotic Resistance in Pseudomonas aeruginosa Strains with
Increased Mutation Frequency due to Inactivation of the DNA Oxidative Repair System. Antimicrobial Agents and Chemotherapy, June 2009, 2483–91

 Afzal S, Jensen SA, Vainer B, Vogel U, Matsen JP, Sorensen JB, et al. MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer. Ann Oncol 2009 Oct;20(10):1660-6

Trine Henriksen, Peter R. Hillestrøm, Henrik E. Poulsen, Allan Weimann. Automated method for the direct analysis of 8-oxo-guanosine and 8-oxo-2′-deoxyguanosine in human urine using ultraperformance liquid chromatography and tandem mass spectrometry. Free Radical Biology & Medicine 47 (2009) 629–635

Broedbaek K, Poulsen HE, Weimann A, Kom GD, Schwedhelm E, Nielsen P, et al. Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis. Free Radic Biol Med 2009 Oct 15;47(8):1230-3.

Davanipour Z, Poulsen HE, Weimann A, Sobel E. Endogenous melatonin and oxidatively damaged guanine in DNA. BMC Endocr Disord 2009;9:22(

Poulsen HE. Report from the President of SFRR-Europe. Free Radical Research, December 2009; 43(12): 1254–1255

Fosbol EL, Gislason GH, Poulsen HE, Hansen ML, Folke F, Schramm TK, et al. Prognosis in heart failure and the value of {beta}-blockers are altered by the use of antidepressants and depend on the type of antidepressants used. Circ Heart Fail 2009 Nov;2(6):582-90.

Dominguez H, Schramm TK, Norgaard ML, Abildstrom SZ, Kober L, Jorgensen C, et al. Initiation and persistence to statin treatment in patients with diabetes receiving glucose-lowering medications. Open Cardiovasc Med J 2009;3:152-9

 

2008

Glintborg B, Poulsen HE, Dalhoff KP.The use of nationwide on-line prescription records improves the drug history in hospitalized patients. Br J Clin Pharmacol. 2008 Feb;65(2):265-9;

Hansen M, Baunsgaard D, Autrup H, Vogel UB, Møller P, Lindecrona R, Wallin H, Poulsen HE, Loft S, Dragsted LO.Sucrose, glucose and fructose have similar genotoxicity in the rat colon and affect the metabolome.Food Chem Toxicol.Volume 46,  2008;46:752-60  

Berendt L, Håkansson C, Bach KF, Dalhoff K, Andreasen PB, Petersen LG, Andersen E, Poulsen HE. Effect of European Clinical Trials Directive on academic drug trials in Denmark: retrospective study of applications to the Danish Medicines Agency 1993-2006. BMJ 2008;336;33-35

Morten Lock Hansen, Niels Gadsbøll, Gunnar H. Gislason, Steen Z. Abildstrom, Tina K. Schramm, Fredrik Folke, Jens Friberg, Rikke Sørensen, Søren Rasmussen, Henrik E. Poulsen, Lars Køber, Mette Madsen, and Christian Torp-Pedersen. Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers.Europace. 2008 Apr;10(4):395-402

Serena Guarnieri, Steffen Loft, Patrizia Riso, Marisa Porrini, Lotte Risom, Henrik E. Poulsen, Lars O. Dragsted and Peter Møller. DNA repair phenotype and dietary antioxidant supplementation British Journal of Nutrition (2008), 99, 1018–1024

Marcus S. Cooke, Ryszard Olinski, and Steffen Loft members of the European Standards Committee on Urinary (DNA) Lesion Analysis (ESCULA) ESCULA members include Mark D. Evans, Rajinder Singh, Vilas Mistry, Peter B. Farmer (University of Leicester, United Kingdom); Rafal Rozalski, Daniel Gackowski, Marek Foksinski, Agnieszka Siomek (Nicolaus Copernicus University, Poland); Peter Møller, Pernille Danielsen, Elvira Vaklavik, Lykke Forchhammer (University of Copenhagen, Denmark); Jean Cadet, Jean-luc Ravanat (CEA/Grenoble, France); Jagadeesan Nair, Urmila Nair (DKFZ, Germany); Henrik E. Poulsen, Allan Weimann, Peter R. Hillestrom (Rigshospitalet, Denmark). Measurement and Meaning of Oxidatively Modified DNA Lesions in Urine. Cancer Epidemiol Biomarkers Prev 2008;17(1).

Cand.pharm Louise Berendt, cand.pharm. Cecilia Håkansson, cand.pharm. Karin Friis Bach, overlæge Kim Dalhoff, overlæge Per Buch Andreasen, cand.pharm. Lene Grejs Petersen, kontorchef Elin Andersen & professor Henrik Enghusen Poulsen. Effekten af GCP- direktivet på forskerinitierede kliniske lægemiddelforsøg – sekundærpublikation. Ugeskr Laeger. 2008;170:2437-9

Glintborg B, Olsen L, Poulsen H, Linnet K, Dalhoff K.Clin Toxicol (Phila). Reliability of self-reported use of amphetamine, barbiturates, benzodiazepines, cannabinoids, cocaine, methadone, and opiates among acutely hospitalized elderly medical patients. 2008 Mar;46(3):239-42.

Arrigo F.G. Cicero, MD, PhD, Simona Nascetti, MD, PhD, Maria C. López-Sabater, MD, Roberto Elosua, MD, Jukka T. Salonen, MD, PhD, Kristiina Nyyssönen, MD, Henrik E. Poulsen, MD, PhD, Hans-Joachim F. Zunft, MD, PhD, Holger Kiesewetter, MD, Karina de la Torre, MD, Marıa-Isabel Covas, BD, PhD, Jari Kaikkonen, Jaakko Mursu, Corina Koenbick, MD, Hans Bäumler, MD, PhD, and Antonio V. Gaddi, MD, PhD, for the EUROLIVE Study Group. Changes in LDL fatty acid composition as a response to olive oil treatment are inversely related to lipid oxidative damage: The EUROLIVE Study. Journal of the American College of Nutrition, 2008;27:314–20

Gottipati KR, Poulsen H, Starcher B. Passive cigarette smoke exposure inhibits ultraviolet light B-induced skin tumors in SKH-1 hairless mice by blocking the nuclear factor kappa B signalling pathway.Exp Dermatol. 2008 Sep;17(9):780-7.

 

2007

Machowetz A, Poulsen HE, Gruendel S, Weimann A, Fito M, Marrugat J, de la Torre R, Salonen JT, Nyyssonen K, Mursu J, Nascetti S, Gaddi A, Kiesewetter H, Baumler H, Selmi H, Kaikkonen J, Zunft HJ, Covas MI, Koebnick C. Effect of olive oils on biomarkers of oxidative DNA stress in Northern and Southern Europeans The FASEB Journal • Research Communication. The FASEB Journal. 2007;21:45-52.

Bondia-Pons I, Schroder H, Covas MI, Castellote AI, Kaikkonen J, Poulsen HE, Gaddi AV, Machowetz A, Kiesewetter H, Lopez-Sabater MC.Moderate Consumption of Olive Oil by Healthy European Men Reduces Systolic Blood Pressure in Non-Mediterranean Participants.
J Nutr. 2007 Jan;137(1):84-87.

Tuomainen TP, Loft S, Nyyssonen K, Punnonen K, Salonen JT, Poulsen HE. Body iron is a contributor to oxidative damage of DNA. Free Radic. Res. 2007 Mar;41(3):324-8.

Bader N, Bosy-Westphal A, Koch A, Rimbach G, Weimann A, Poulsen HE, Muller MJ Effect of hyperbaric oxygen and vitamin C and E supplementation on biomarkers of oxidative stress in healthy men.  Br J Nutr.  2007 Oct;98(4):826-33 261) Gravholt CH, Poulsen HE, Ott P, Christiansen JS, Vilstrup H. Quantitative liver functions in Turner syndrome with and without hormone replacement therapy. Eur J Endocrinol. 2007 Jun;156(6):679-86.

Glintborg B, Hillestrom PR, Olsen LH, Dalhoff KP, Poulsen HE. Are patients reliable when self-reporting medication use? Validation of structured drug interviews and home visits by drug analysis and prescription data in acutely hospitalized patients. J Clin Pharmacol. 2007 Nov;47(11):1440-9.

Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain. Lykkesfeldt J, Trueba GP, Poulsen HE, Christen S. Br J Nutr. 2007 Dec;98(6):1116-9.

 

2006

Hillestrom PR, Weimann A, Poulsen HE.Quantification of Urinary Etheno-DNA Adducts by Column-Switching LC/APCI-MS/MS. J Am Soc Mass

Hillestrom PR, Weimann A, Jensen, CB, Storgaard H, Vaag AA, Poulsen HE.  Consequences of low birthweight on urinary excretion of DNA markers of oxidative stress in young men. Scand J Clin Lab Invest 2006; 66: 363–70.

Hillestrom PR, Covas MI, Poulsen HE. Effect of dietary virgin olive oil on urinary excretion of etheno-DNA adducts. Free Radic Biol Med. 2006 Oct 1;41(7):1133-8. Epub 2006 Jul 4.

Covas MI, Nyyssonen K, Poulsen HE, Kaikkonen J, Zunft HJ, Kiesewetter H, Gaddi A, de la Torre R, Mursu J, Baumler H, Nascetti S, Salonen JT, Fito M, Virtanen J, Marrugat J, EUROLIVE Study Group. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med. 2006 Sep 5;145(5):333-41.

Glintborg B, Weimann A, Kensler TW, Poulsen HE. Oltipraz chemoprevention trial in Qidong, People's Republic of China: Unaltered oxidative biomarkers. Free Radic Biol Med. 2006 Sep 15;41(6):1010-4.

 

 

2005

Riis B, Poulsen HE, Repair and Removal Systems DNA Repair: Mechanisms and Measurements In:The Handbook of Environmental Chemistry Vol. 2, Part O. eds. Springer-Verlag Berlin Heidelberg 2005: 151–75

Weimann A, Sabroe M, Poulsen HE Measurement of caffeine and five of the major metabolites in urine by high-performance liquid chromatography/tandem mass Spectrom. 2005;40:307-16

Hillestrøm PR, Nyssönen K, Tuomainen T-P, Pukkala E, Salonen JT, Poulsen HE Urinary excretion of of edA is not predictive of cancer development: A prospective nested case control study. Free Rad Research, 2005;39:51-3

Ciofu O, Riis B, Pressler T, Poulsen HE, Hoiby N Occurrence of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Patients Is Associated with the Oxidative Stress Caused by Chronic Lung Inflammation. Antimicrob. Agents Chemother. 2005;49:2276-2282

Laska MJ, Nexo BA, Vistisen K, Poulsen HE, Loft S, Vogel U Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer. Cancer Lett. 2005;225:245-51

Dalhoff KP, Poulsen HE.[Toxicology and pharmacogenetics] Ugeskr Laeger. 2005;167:2170-2. Danish.

Poulsen HE. Oxidative DNA modifications. Exp Toxicol Pathol. 2005 Jul;57 Suppl 1:161-9. Review.  

Gronbaek K, Sonne J, Ring-Larsen H, Poulsen HE, Friis H, Bygum Krarup H. Viral load is a negative predictor of antioxidant levels in hepatitis C patients .Scand J Infect Dis. 2005;37:686-9

Dalhoff K, Jensen KB, Poulsen HE. Cancer and molecular biomarkers of phase 2. In: John Abelson, USA, ed. Methods Enzymol. 400 ed. New York: Elsevier; 2005:618-27

 

2004

Hoberg AM, Otteneder M, Marnett LJ, Poulsen HE. Measurement of the malondialdehyde-2'-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.J Mass Spectrom. (2004); 39(1):38-42.

Collins AR, Cadet J, Möller L, Poulsen HE, Vina J. Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells? Archives of Biochemistry and Biophysics 423 (2004) 57-65

Poulsen HE, Moller P, Lykkesfeldt J, Weimann A, Loft S. Vitamin C and oxidative damage to DNA. In: Vitamin C, edited by Han Asard, James M. May and Nicholas Smirnoff, BIOS Scientific Publishers Ltd, Oxford 2004:189-202 

Vistisen K, Loft S, Olsen JH, Vallentin S, Ottesen S, Hirsch FR, Poulsen HE. Low CYP1A2 activity associated with testicular cancer. Carcinogenesis. 2004 Jun;25(6):923-929

Hillestrom PR, Hoberg AM, Weimann A, Poulsen HE. Quantification of 1,N6-etheno-2'-deoxyadenosine in human urine by column-switching LC/APCI-MS/MS. Free Radic Biol Med. 2004 Jun 1;36(11):1383-92

Weimann A, Riis B, Poulsen HE. Oligonucleotides in human urine do not contain 8-oxo-7,8-dihydrodeoxyguanosine. Free Radic Biol Med. 2004 1;36(11):1378-82

de Waard H de Wit J, Andresson J-O, van Oostrom CTM, Riis B, Weimann A, Poulsen HE, van Steeg H, Hoeijmakers JHJ, van der Horst GTJ. Different Effects of CSA and CSB Deficiency on Sensitivity to Oxidative DNA Damage Molecular and Cellular Biology, (2004);24:7941-8

Møller, P,Viscovich M, Lykkesfeldt J, Loft S, Jensen A, Poulsen HE. Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers. European Journal of Nutrition 2004 Jan;1-8

Lykkesfeldt J, Viscovich M, Poulsen HE. Plasma malondialdehyde is induced by smoking: a study with balanced antioxidant profiles. Br J Nutr. 2004;92(2):203-6.

Viscovich M, Lykkesfeldt L, Poulsen HE. Vitamin C pharmacokinetics of plain and slow release formulations in smokers Clinical Nutrition (2004) 23,1043-50 

Hansen M, Hald MT, Autrup H, Vogel U, Bornholdt J, Moller P, Molck AM, Lindecrona R, Poulsen HE, Wallin H, Loft S, Dragsted LO. Sucrose and IQ induced mutations in rat colon by independent mechanism.Mutat Res. 2004 Oct 4;554(1-2):279-86

ESCODD (European Standards Committee on Oxidative DNA Damage). Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study. The FASEB Journal express article10.1096/fj.04-1767fje. Published online November 8

Poulsen HE. Alkoholelimination i alkopops. Ugeskr Laeger. 2004;166:4449.

Poulsen HE, Dalhoff KP. Mangelfuld registrering af lægemiddelforgiftninger og – bivirkninger i Danmark. Ugeskr Laeger. 2004;166:4451

 

2003

Salonen RM, Nyyssonen K, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Rissanen TH et al. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression - The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study. Circulation 2003; 107(7):947-953.

Collins A, Gedik C, Vaughan N, Wood S, White A, Dubois J et al. Measurement of DNA oxidation in human cells by chromatographic and enzymic methods. Free Radical Biology and Medicine 2003; 34(8):1089-1099. 

Bruunsgaard H, Poulsen HE, Pedersen BK, Nyyssonen K, Kaikkonen J, Salonen JT. Long-term combined supplementations with alpha-tocopherol and vitamin C have no detectable anti-inflammatory effects in healthy men.Journal of Nutrition 2003;133:1170-1173

Lykkesfeldt J, Bolbjerg ML, Poulsen HE. Effect of smoking on erythorbic acid pharmacokinetics. British Journal of Nutrition 2003; 89:667-671

Osterberg O, Kiehr B, Erichsen L, Poulsen HE, Ingwersen SH. Pharmocokinetics and allometric scaling of levormeloxifene, a selective oestrogen receptor modulator. Biopharm Drug Dispos. 2003;24:121-129.

Verhagen H, Aruoma OI, van Delft JH, Dragsted LO, Ferguson LR, Knasmuller S, Pool-Zobel BL, Poulsen HE, Williamson G, Yannai S. The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo. Food Chem Toxicol 2003;41(5):603-10

Vogel U, Danesvar B, Autrup H, Risom L, Weimann A, Poulsen HE, Moller P, Loft S, Wallin H, Dragsted LO. Effect of increased intake of dietary animal fat and fat energy on oxidative damage, mutation frequency, DNA adduct level and DNA repair in rat colon and liver. Free Radic Res. 2003;37(9):947-56. 

Møller P, Daneshvar B, Loft S, Wallin H, Poulsen HE, Autrup H, Ravn-Haren G, Dragsted LO. Oxidative DNA damage in vitamin C-supplemented guinea pigs after intrtracheal instillation of diesel exhaust particles. Toxicology and Applied Pharmacology 2003;189:39-44.

Møller P, Hansen M, Autrup H, Bornholt J, Vogel  U, Mølck A-M, Wallin H , Dragsted LO, Risom L,  Poulsen HE, Loft S. Dietary low-dose sucrose modulation of IQ-induced genotoxicity in the colon and liver of Big Blue™ rats Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2003; 527:91-97

Dybdahl M, Risom L, Moller P, Autrup H, Wallin H, Vogel U, Bornholdt J, Daneshvar B, Dragsted L, Weimann A, Poulsen HE, Loft S. DNA adduct formation and oxidative stress in colon and liver of Big Blue(R) rats after dietary exposure to diesel particles.Carcinogenesis. 2003 Nov;24(11):1759-66

Loft S, Kold-Jensen T, Hjollund NH, Giwercman A, Gyllemborg J, Ernst E, Olsen J, Scheike T, Poulsen HE, Bonde JP. Oxidative DNA damage in human sperm influences time to pregnancy.Hum Reprod. 2003;18(6):1265-72.

Poulsen HE, Gronlykke TB [Does the public sector have an independent research role in the development of drugs?]
Ugeskr Laeger. 2003 Apr 14;165(16):1674-6. Danish.   

Risom L, Moller P, Hansen M, Autrup H, Bornholdt J, Vogel U, Wallin H, Poulsen HE, Dragsted LO, Loft S. Dietary elevated sucrose modulation of diesel-induced genotoxicity in the colon and liver of Big Blue rats. Arch Toxicol 2003;77:651-6

Lykkesfeldt J, Viscovich M, Poulsen H. Ascorbic acid recycling in human erythrocytes is induced by smoking in vivo. FRBM 2003;35:1439-47.

Kramer I, Dalhoff K, Clemmensen JO, Loft S, Poulsen HE, Comparison of chlorzoxazone one-sample methods to estimate CYP2E1 activity in humans. Eur J Clin Pharm 2003; 59:775-8

Osterberg O, Erichsen L, Ingwersen SH, Plum A, Poulsen HE, Vicini P.Pharmacokinetic and pharmacodynamic properties of insulin aspart and human insulin. J Pharmacokinet Pharmacodyn. 2003 Jun;30(3):221-35.

Loft, S., Møller, P., Vogel, U., Risom. L., Sørensen, M., Riis, B., Poulsen, H.E., Dybdahl, M., and Wallin, H. (2003) Oxidative Stress by Environmental Agents, Journal of University of Occupational and Environmental Health 2003;25(suppl.1):47-59

 

2002

Weimann, A, Belling D, Poulsen HE. Quantification of 8-oxoGuanine and Guanine as the Nucleobase, Nucleoside and Deoxynucleoside forms in Human Urine by High Preformance Liquid Chromatography - Electrospray Tandem Mass Spectrometry. Nucleic Acids Research 2002; 30 no.2 e 7  

Kaikkonen, J, Porkkala-Sarataho, E, Morrow JD, Jackson Roberts II, L, Nyyssönen, K, Salonen, R, Tuomainen, TP, Ristonmaa, U, Poulsen, HE, Salonen JT. Supplementation with Vitamin E but not with Vitamin C Lowers Lipid Peroxidation In Vivo in Mildly Hypercholesterolemic Men. Free Radical Researchs, 2002; 35:967-978

Schmidt,L.E., Dalhoff,K. Poulsen,H.E. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity, Hepatology, 2002, 35:876-882

ESCODD. Inter-laboratory Validation of Procedures for Measuring 8-oxo7,8-dihydrogunanine/8-oxo-7,8-dihydro-2´-deoxyguanosine in DNA. Free Radical Research, 2002; 36 (3):239-245 

Riis, Bente and ESCODD. Comparison of Results from Different Laboratories in Measuring 8-oxo-2´-deoxyguanosine in Synthetic Oligonucleotides. Free Radical Research, 2002; 36 (3): 649-659. 

B, Risom L, Loft S, Poulsen H.E. Increased rOGG1 expression in regenerating rat liver tissue without a corresponding increase in incision activity. DNA Repair, 2002; (1): 419-424

Møller P, Wallin H, Vogel U, Autrup H,Risom l, Hald M.T., Daneshvar B, Dragsted L.O., Poulsen H.E., Loft S. Mutagenicity of 2-amino-3methylimidazo [4,5f] quinoline in colon and liver of Big Blue rats: role of DNA adducts, strand breaks, DNA repair and oxidative stress. Carcinogenesis, 2002; 23(8): 1379-1385. 

Dragsted L.O., Daneshvar B, Vogel U, Autrup H.N., Wallin H, Risom L, Møller P, Mølck A.M., Hansen M, Poulsen H.E., Loft s. A sucrose-rich Diet Induces Mutation in the Rat Colon. Cancer Research, 2002; 62: 4339-4345. 

Escodd (European Standards Comittee on Oxidative DNA Damage). Comparative analysis of baseline 8-oxo-7,8-dihydroguanine in mammalian cell DNA, by different methods in different laboratories: an approach to consensus. Carcinogenesis, 2002;23(12): 2129-2133.
 

Riis B, Risom L, Loft S, Poulsen HE. OGG1 m RNA expression and incision activity in rats are higher in foetal tissue than in adult liver tissue while 8-oxo-2'-deoxyguanosine levels are unchanged. DNA Repair 2002;1:709-17.

Clinical pharmacology 2001--important events. The Danish Society of Clinical Pharmacology]
Ugeskr Laeger. 2002 Mar 18;164(12):1652.

 

2001

Dalhoff K, Laursen H, Bangert K, Poulsen HE, Anderson ME, Grunnet N et al. Autoprotection in acetaminophen intoxication in rats: the role of liver regeneration. Pharmacol Toxicol 2001; 88(3):135-141.

Weimann A, Belling D, Poulsen HE. Measurement of 8-oxo-2-deoxyguanosine and 8-oxo-2-deoxyadenosine in DNA and Human Urine by High Performance Liquid Chromatography-Electrospray Tandem Mass Spectrometry. Free Rad Biol Med 2001; 30:757-764.

Schmidt LE, Rasmussen A, Norrelykke MR, Poulsen HE, Hansen BA. The effect of selective bowel decontamination on the pharmacokinetics of mycophenolate mofetil in liver transplant recipients. Liver Transpl 2001; 7(8):739-742.

Sorensen M, Jensen BR, Poulsen HE, Deng X, Tygstrup N, Dalhoff K et al. Effects of a Brussels sprouts extract on oxidative DNA damage and metabolising enzymes in rat liver. Food Chem Toxicol 2001; 39(6):533-540.

Nielsen HB, Kharazmi A, Bolbjerg ML, Poulsen HE, Pedersen BK, Secher NH. N-acetylcysteine attenuates oxidative burst by neutrophils in response to ergometer rowing with no effect on pulmonary gas exchange. Int J Sports Med 2001; 22 (4):256-260.

Laursen JB, Boesgaard S, Trautner S, Rubin I, Poulsen HE, Aldershvile J.  Endothelium-dependent vasorelaxation is inhibited by in vivo depletion of vascular  thiol levels:role of endothelial nitric oxide synthase. Free Rad Res 2001; 35:387-394.

P, Poulsen HE, Parving HH, Pedersen O. Double-blind, randomised study of the effect of combined treatment with vitamin C and E on albuminuria in Type 2 diabetic patients. Diabetic Medicine 2001; 18 :756-760.

Hoberg, AM, Poulsen HE. Analysis of a promutagenic exocyclic DNA adduct in human urine by HPLC APCI tandem mass spectrometry. Advances in Mass Spectrometry, 2001; 15:597-598.

 

2000

ESCODD (European Standards Committee on Oxidative DNA Damage) Comparison of different Methods of Measuring 8-oxoguanine as a Marker of Oxidative DNA Damage.Free Rad. Res 2000; 32:333-341

Loft S, Poulsen HE. Antioxidant Intervention Studies Related to DNA Damage, DNA Repair and Gene Expression. Free Rad Res 2000; 33:S67-83

Dalhoff KP, Poulsen HE. Talidomid fiasko eller succes. Ugeskr Laeger 2000; 162(1):52-53.

Porkkala-Sarataho E, Salonen JT, Nyyssonen K, Kaikkonen J, Salonen R, Ristonmaa U et al. Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2'-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men. Arterioscler Thromb Vasc Biol 2000; 20(9):2087-2093.

Poulsen HE, Jensen BR, Weimann A, Jensen SA, Sørensen M, Loft S. Antioxidants, DNA damage and gene expression. Free Rad Res 2000; 33:S33-39

Salonen JT, Nyyssonen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E et al. Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Intern Med 2000; 248(5):377-386.

Jingsheng Tuo, Li Liu, Henrik E. Poulsen, Allan Weimann, Ove Svendsen and Steffen Loft. Importance of guanine nitration and hydroxylation in DNA in vitro and in vivo. Free Radical Biology & Medicine 2000;29:147-155

Voutilainen S, Lakka TA, Hamelahti P, Lehtimaki T, Poulsen HE, Salonen JT. Plasma total homocysteine concentration and the risk of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Studytpdel. J Intern Med 2000; 248(3):217-222.

Wellejus A, Poulsen HE, Loft S. Iron-induced oxidative DNA damage in rat sperm cells in vivo and in vitro. Free Radic Res 2000; 32(1):75-83.

Wellejus A, Poulsen HE, Loft S. Iron-induced oxidative DNA damage in rat sperm cells in vivo and in vitro. Free Radic Res 2000; 32(1):75-83.

Zhu C, Poulsen HE, Loft S. Inhibition of oxidative DNA damage in vitro by extracts of brussels sprouts [In Process Citation]. Free Radic Res 2000; 33(2):187-196.

1999

(166) Jensen SA, Jensen BR, Weiman A, Li L, Poulsen HE. [Oxidative stress and aging]. Ugeskr Laeger 1999; 162(17):2431-2435.

(167) Loft S, Poulsen HE, Vistisen K, Knudsen LE. Increased urinary excretion of 8-oxo-2'-deoxyguanosine, a biomaker of oxidative DNA damage, in urban bus drivers. Mutat Res 1999; 441:11-19.

(168) Loft S, Poulsen HE. Measurement of oxidative damage to DNA: interpretation of nuclear levels and urinary excretion of repair products in DNA damage and Repair: Oxygen Radical effects, cellular protection and biological consequeences. In: Karakaya A, Dizdaroglu M, editors. Oxygen Radical Effects, Cellular Protection and Biological Consequences. New York: Plenum Press, 1999: 267-281.

(169) Loft S, Poulsen HE. Markers of oxidative damage to DNA: antioxidants and molecular damage. Methods Enzymol 1999; 300:166-184.

(170) Poulsen HE, Loft S. Motion og velvære. Miljømedicin. 1999: 364-367.

(171) Poulsen HE, Loft S, Strandgaard S, Vilstrup H. Rationel farmakoterapi. In: Lorenzen I, Bendixen G, Hansen NE, editors. Medicinsk Kompendium. Copenhagen: Nyt Nordisk forlag Arnold Busck A/S, 1999: 2942-2954.

(173) Salonen J, Nyyssonen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E et al. The Effect of Vitamin E and Vitamin C on Carotid Atherosclerotic Progression: The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study. Circulation 1999; Suppl. 100:I-238.

(174) Tuo J, Loft S, Poulsen HE. Enhanced benzene-induced DNA damage in PMA-stimulated cells in vitro and in LPS-treated animals. Free Rad Biol Med 1999; 26:801-808.

(175) Tuo J, Deng X, Loft S, Poulsen HE. Dexamethasone ameliorates oxidative DNA damage induced by benzene and LPS in mouse bone marrow. Free Rad Res 1999; 30:29-36.

 

1998

(150) Deng XS, Tuo J, Poulsen HE, Loft S. Prevention of oxidative DNA damage in rats by brussels sprouts. Free Rad Res 1998; 28(3):323-333. 

(151) Haderslev KV, Sonne J, Poulsen HE, Loft S. Paracetamol metabolism in patients with ulcerative colitis. British Journal of Clinical Pharmacology 1998; 46:513-516. 

(152) Loft S, Poulsen HE. Markers of oxidative damage to DNA: Antioxidants and molecular damage. Methods Enzymol 1998; 300:166-184.

(154) Loft S, Deng XS, Tuo J, Wellejus A, Sorensen M, Poulsen HE. Experimental study of oxidative DNA damage. Free Rad Res 1998; 29:525-539.

(155) Loft S, Thorling EB, Poulsen HE. High fat diet induced oxidative DNA damage estimated by 8-oxo-7,8-dehydro-2'-deoxyguanosine excretion in rats. Free Rad Res 1998; 29:595-600.

(156) Loft S, Poulsen HE. Estimation of oxidative DNA damage in man from urinary excretion of repair products. Acta Biochim Pol 1998; 45:133-144.

(157) Porkkala SE, Nyyssonen MK, Kaikkonen JE, Poulsen HE, Hayn EM, Salonen RM et al. A randomized, single-blind, placebo-controlled trial of the effects of 200 mg alpha -tocopherol on the oxidation resistance of atherogenic lipoproteins. Am J Clin Nutr 1998; 68/5(1034-1041):-1041.

(158) Poulsen HE, Loft S. Interpretation of oxidative DNA modification: Relation between tissue levels, excretion of urinary repair products and sigle cell gel electrophoresis (comet assay). In: Aruoma OI, Halliwell B, editors. DNA & free radicals: Techniques, mechanisms and applications. London: OICA International, 1998: 261-270.

(159) Poulsen HE. [Medication errors--the top of an iceberg? (editorial)]. Ugeskr Laeger 1998; 160(27):4041.

(160) Poulsen HE, Weimann A, Salonen JT, Nyyssonen K, Loft S, Cadet J et al. Does vitamin C have a pro-oxidant effect? [letter]. Nature 1998; 395(6699):231-232.

(161) Poulsen HE, Loft S, Prieme H, Vistisen K, Lykkesfeldt J, Nyyssonen K et al. Oxidative DNA damage in Vivo: Relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion. Free Rad Res 1998; 29:565-571.

(162) Poulsen HE, Prieme H, Loft S. Role of oxidative DNA damage in cancer initiation and promotion. European Journal of Cancer Prevention 1998; 7(1):9-16.

(163) Prieme H, Nyyssonen K, Gronbaek K, Klarlund M, Loft S, Tonnesen P et al. Randomized controlled smoking cessation study: transient increase in plasma high density lipoprotein but no change in lipoprotein oxidation resistance. Scand J Clin Lab Invest 1998; 58(1):11-18.

(164) Prieme H, Loft S, Klarlund M, Gronbaek K, Tonnesen P, Poulsen HE. Effect of smoking cessation on oxidative DNA modification estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion. Carcinogenesis 1998; 19(2):347-351.

(165) Tuo J, Wolff SP, Loft S, Poulsen HE. Formation of nitrated and hydroxylated aromatic compounds from benzene and peroxynitrite, a possible mechanism of benzene genotoxicity. Free Rad Res 1998; 28(4):369-375.

 

1997

(139) Cadenas S, Barja G, Poulsen HE, Loft S. Oxidative DNA damage estimated by oxo8dG in the liver of guinea-pigs supplemented with graded dietary doses of ascorbic acid and alpha-tocopherol. Carcinogenesis 1997; 18(12):2373-2377.

(140) Deng XS, Tuo J, Poulsen HE, Loft S. 2-Nitropropane-induced DNA damage in rat bone marrow. Mutat Res 1997; 391(3):165-169.

(141) Kaikkonen J, Nyyssonen K, Porkkala SE, Poulsen HE, Metsa KT, Hayn M et al. Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Rad Biol Med 1997; 22(7):1195-1202.

(142) Kaikkonen J, Nyyssonen K, Porkkala-Sarataho E, Poulsen HE, Metsa-Ketela T, Hayn M et al. Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Rad Biol Med 1997; 22(7):1195-1202.

(143) Klarlund M, Prieme H, Loft S, Poulsen HE. Smoking cessation does not change urinary albumin excretion in normal subjects. Scand J Clin Lab Invest 1997;

(144) Lykkesfeldt J, Loft S, Nielsen JB, Poulsen HE. Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking. Am J Clin Nutr 1997;

(145) Nyyssonen K, Poulsen HE, Hayn M, Agerbo P, Porkkala-Sarataho E, Kaikkonen J et al. Effect of supplementation of smoking men with plain or slow release ascorbic acid on lipoprotein oxidation. European Journal of Clinical

(146) Poulsen HE. [Adverse effects of drugs--25 years later (editorial)]. Ugeskr Laeger 1997; 159(33):4964.

(147) Poulsen HE, Loft S, Prieme H, Salonen JT. Antioxidants. In: Haunsø S, editor. Coronary microcirculation during ischaemia and reperfusion. Copenhagen: Munksgaard, 1997: 455-461.

(148) Prieme H, Loft S, Nyyssonen K, Salonen JT, Poulsen HE. No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion in smokers. Am J Clin

(149) Vistisen K, Prieme H, Okkels H, Vallentin S, Loft S, Olsen JH et al. Genotype and phenotype of glutathione S-transferase mu in testicular cancer patients.  1997 Feb;7(1):21-5.

 

1996

(126) Clemmensen JO, Ott P, Dalhoff KP, Astrup LB, Tage-Jensen U, Poulsen HE. Rekommandation for behandling af paracetamolforgiftning. Ugeskr Laeger 1996; 158:6892-6895.

(127) Jensen KG, Poulsen HE, Doehmer J, Loft S. Paracetamol-induced spindle disturbances in V79 cells with and without expression of human CYP1A2. Pharmacology and Toxicology 1996; 78(4):224-228.

(128) Jeppesen U, Loft S, Poulsen HE, Brosen K. A fluvoxamine-caffeine interaction study. Pharmacogenetics 1996; 6(3):213-222.

(129) Jeppesen U, Gram LF, Vistisen K, Loft S, Poulsen HE, Brosen K. Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. European Journal of Clinical Pharmacology 1996; 51(1):73-78.

(130) Laursen JB, Boesgaard S, Poulsen HE, Aldershvile J. Nitrate tolerance impairs nitric oxide-mediated vasodilation in vivo. Cardiovasc Res 1996; 31(5):814-819. 

(131) Loft S, Poulsen HE. Cancer risk and oxidative DNA damage in man.  J Mol Med 1996; 74(6):297-312.

(132) Loft S, Jensen KG, Ringby L, Poulsen HE, Doehmer J. Kinetic studies in engineered V79 cells in comparison with primary hepatocytes and human liver microsomes. Experimental and Toxicologic Pathology 1996; 48:249-256.

(133) Lykkesfeldt J, Prieme H, Loft S, Poulsen HE. Effect of smoking cessation on plasma ascorbic acid concentration. British Medical Journal 1996; 313(7049):91.

(134) Poulsen HE, Loft S, Vistisen K. Extreme exercise and oxidative DNA modification. J Sports Sci 1996; 14(4):343-346. 

(135) Poulsen HE. [Markers of vitamin deficiencies (editorial)]. [Danish]. Ugeskr Laeger 1996; 158(27):3906.

(136) Prieme H, Loft S, Cutler RG, Poulsen HE. Measurement of oxidative DNA injury in humans: evaluation of a commercially available ELISA assay. In: Kumpulainen JT, editor. Natural antioxidants and food quality in atherosclerosis and cancer prevention. The royal society of chemistry 1996, 1996: 78-82.

(137) Tuo J, Loft S, Thomsen MS, Poulsen HE. Ex vivo time-dependent cell DNA-degradation shown by single cell gel electrophoresis. Pharmacology and Toxicology 1996; 78(1):55-57.

(138) Tuo J, Loft S, Thomsen MS, Poulsen HE. Benzene-induced genotoxicity in mice in vivo detected by the alkaline comet assay: reduction by CYP2E1 inhibition. Mutat Res 1996; 368(3-4):213-219.

 

1995

(113) Fischer-Nielsen A, Corcoran GB, Poulsen HE, Kamendulis LM, Loft S. Menadione-induced DNA fragmentation without 8-oxo-2'-deoxyguanosine formation in isolated. Biochem Pharmacol. 1995 May 17;49(10):1469-74

(114) Jensen KG, Poulsen HE, Doehmer J, Loft S. Kinetics and inhibition by fluvoxamine of phenacetin O-deethylation in V79 cells expressing human CYP1A2. Pharmacology and Toxicology 1995; 76(4):286-288.

(115) Loft S, Velthuis-te WE, Van den Berg H, Poulsen HE. Energy restriction and oxidative DNA damage in humans. Cancer Epidemiol Biomarkers Prev 1995; 4(5):515-519.

(116) Loft S, Larsen PN, Rasmussen A, Fischer-Nielsen A, Bondesen S, Kirkegaard P et al. Oxidative DNA damage after transplantation of the liver and small intestine in pigs. Transplantation 1995; 59:16-20.

(117) Lykkesfeldt J, Loft S, Poulsen HE. Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection--are they reliable biomarkers of oxidative stress? Anal Biochem 1995; 229(2):329-335.

 

(119) Nielsen HB, Hanel B, Loft S, Poulsen HE, Pedersen BK, Diamant M et al. Restricted pulmonary diffusion capacity after exercise is not an ARDS-like injury. J Sports Sci 1995; 13(2):109-113.

(120) Poulsen HE, Loft S. Early biochemical markers of effects: enzyme induction, oncogene activation and markers of oxidative damage. Toxicology 1995; 101(1-2):55-64.

(121) Rasmussen BB, Maenpaa J, Pelkonen O, Loft S, Poulsen HE, Lykkesfeldt J et al. Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine. Br J Clin Pharmacol 1995; 39(2):151-159.

(122) Thomsen MS, Loft S, Roberts DW, Poulsen HE. Cytochrome P4502E1 inhibition by propylene glycol prevents acetaminophen (paracetamol) hepatotoxicity in mice without cytochrome P4501A2 inhibition. Pharmacology and Toxicology 1995; 76(6):395-399.

(123) van Poppel G, Poulsen HE, Loft S, Verhagen H. No influence of beta carotene on oxidative DNA damage in male smokers. J Nat Can Inst 1995; 87:310-311.

(124) Velthuis-te WE, van Leeuwen RE, Hendriks HF, Verhagen H, Loft S, Poulsen HE et al. Short-term moderate energy restriction does not affect indicators of oxidative stress and genotoxicity in humans. Journal of Nutrition 1995; 125(10):2631-2639.

(125) Verhagen H, Poulsen HE, Loft S, van Poppel G, Willems MI, van Bladeren PJ. Reduction of oxidative DNA-damage in humans by brussels sprouts. Carcinogenesis 1995; 16(4):969-970.

 

1994

(105) Boesgaard S, Iversen HK, Wroblewski H, Poulsen HE, Frandsen H, Kastrup J et al. Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine. J Am Coll Cardiol 1994; 23(1):163-169.

(106) Boesgaard S, Aldershvile J, Poulsen HE, Loft S, Anderson ME, Meister A. Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels. Circ Res 1994; 74(1):115-120.

(107) Kjoller-Hansen L, Boesgaard S, Laursen JB, Poulsen HE, Aldershvile J. [Nitroglycerin preparations. Effect and tolerance]. [Review] [38 refs] [Danish]. Ugeskr Laeger 1994; 156(24):3621-3625.

(108) Laursen JB, Boesgaard S, Poulsen HE, Aldershvile J. Endotelderiveret relakserende faktor/nitrogenoxid. Ugeskr Laeger 1994; 156:5661-5666.

(109) Loft S, Astrup A, Buemann B, Poulsen HE. Oxidative DNA damage correlates with oxygen consumption in humans. Faseb J 1994; 8(8):534-537.

(110) Lykkesfeldt J, Loft S, Poulsen HE. Simultaneous determination of urinary free cortisol and 6 beta-hydroxycortisol by high-performance liquid chromatography to measure human CYP3A activity. J Chromatogr B Biomed Appl 1994; 660(1):23-29.

(111) Poulsen HE, Loft S. The impact of genetic polymorphisms in risk assessment of drugs. [Review] [73 refs]. Arch Toxicol Suppl 1994; 16:211-222.

(112) Sandstrøm B, Astrup A, Dyerberg J, Hølmer G, Poulsen HE, Stender S et al. Den sundhedsmæssige betydning af antioxidanter i levnedsmidler og som kosttilskud. Ugeskr Laeger 1994; 156:7675-7679.

 

1993

(87) Boesgaard S, Poulsen HE, Aldershvile J, Loft S, Anderson ME, Meister A. Acute effects of nitroglycerin depend on both plasma and intracellular sulfhydryl compound levels in vivo. Effect of agents with different sulfhydryl-modulating properties. Circulation 1993; 87(2):547-553.

(88) Boesgaard S, Aldershvile J, Poulsen HE, Christensen S, Dige-Petersen H, Giese J. N-acetylcysteine inhibits angiotensin converting enzyme in vivo. J Pharmacol Exp Ther 1993; 265(3):1239-1244.

(89) Brosen K, Skjelbo E, Rasmussen BB, Poulsen HE, Loft S. Fluvoxamine is a potent inhibitor of cytochrome P4501A2. Biochem Pharmacol 1993; 45(6):1211-1214.

(90) Dalhoff K, Poulsen HE. Inhibition of acetaminophen oxidation by cimetidine and the effects on glutathione and activated sulphate synthesis rates. Pharmacology and Toxicolgy.1993, 73, 215-8

(91) Dalhoff K, Poulsen HE. Simultaneous measurements of glutathione and activated sulphate (PAPS) synthesis rates and the effects of selective inhibition of glutathione conjugation or sulphation of acetaminophen. Biochem Pharmacol 1993; 46(3):383-388.

(92) Dalhoff K, Poulsen HE. Synthesis rates of glutathione and activated sulphate (PAPS) and response to cysteine and acetaminophen administration in glutathione-depleted  rat hepatocytes. Biochem Pharmacol 1993; 46(7):1295-1297.

(93) Ding JW, Andersson R, Soltesz V, Willen R, Loft S, Poulsen HE et al. The effect of biliary decompression on bacterial translocation in jaundiced rats. Hpb Surg 1993; 7(2):99-110.

(94) Jeding IB, Loft S, Poulsen HE. Non-induction of extrahepatic antipyrine and metronidazole metabolism evaluated from partially hepatectomized rats. Xenobiotica 1993; 23(4):411-418.

(95) Jensen KG, Onfelt A, Poulsen HE, Doehmer J, Loft S. Effects of benzo[a]pyrene and (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene on mitosis in Chinese hamster V79 cells with stable expression of rat cytochrome P4501A1 or 1A2. Carcinogenesis 1993; 14(10):2115-2118.

(96) Jensen KG, Loft S, Doehmer J, Poulsen HE. Metabolism of phenacetin in V79 Chinese hamster cell cultures expressing rat liver cytochrome P4501A2 compared to isolated rat hepatocytes. Biochem Pharmacol 1993; 45(5):1171-1173.

(97) Kjoller-Hansen L, Boesgaard S, Laursen JB, Aldershvile J, Poulsen HE. [Importance of thiols (SH group) in the cardiovascular system]. [Review] [37 refs] [Danish]. Ugeskr Laeger 1993; 155(45):3642-3645.

(98) Loft S, Fischer-Nielsen A, Jeding IB, Vistisen K, Poulsen HE. 8-Hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage. J Toxicol Environ Health 1993; 40(2-3):391-404.

(99) Poulsen HE, Vilstrup H, Almdal T, Dalhoff K. No net splanchnic release of glutathione in man during N-acetylcysteine infusion. Scand J Gastroenterol 1993; 28(5):408-412. 

(100) Poulsen HE, Roberts DW, Hinson JA. Covalent binding of acetaminophen estimated from protein adducts. In: Jeffery EH, editor. Human Drug Metabolism. From molecular biology to man. Boca Raton, Ann Arbor, London, Tokyo: CRC Press,

(101) Poulsen HE, Loft S, Wassermann K. Cancer risk related to genetic polymorphisms in carcinogen metabolism and DNA repair. [Review] [93 refs]. Pharmacology and Toxicology 1993; 72:Suppl-103.

(102) Ranek L, Dalhoff K, Poulsen HE, Brøsen K, Flacks H, Loft S. Drug metabolism in subjects with previous halothane hepatitis. Scand J Gastroenterol 1993; 28:677-680.

(103) Ranek L, Dalhoff K, Poulsen HE, Brosen K, Flachs H, Loft S et al. Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis. Scand J Gastroenterol 1993; 28(8):677-680.

(104) Sherson DL, Sigsgaard TI, Overgaard E, Loft SH, Poulsen HE, Jongeneelen FC. [Risk of lung cancer among foundry workers]. [Danish]. Ugeskr Laeger 1993; 155(9):620-623.

 

1992

(78) Boesgaard S, Aldershvile J, Poulsen HE. Preventive administration of intravenous N-acetylcysteine and development of tolerance to isosorbide dinitrate in patients with angina pectoris. Circulation 1992;  85(1):143-149.

(79) Dalhoff K, Ranek L, Mantoni M, Poulsen HE. Glutathione treatment of hepatocellular carcinoma. Liver 1992; 12(5):341-343.

(80) Dalhoff K, Poulsen HE. Effects of cysteine and acetaminophen on the syntheses of glutathione and adenosine 3'-phosphate 5'-phosphosulfate in isolated rat hepatocytes. Biochem Pharmacol 1992; 44(3):447-454.

(81) Fischer-Nielsen A, Poulsen HE, Loft S. 8-Hydroxydeoxyguanosine in vitro: effects of glutathione, ascorbate, and 5-aminosalicylic acid. Free Rad Biol Med 1992;  13(2):121-126.

(82) Loft S, Vistisen K, Ewertz M, Tjonneland A, Overvad K, Poulsen HE. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis 1992;13(12):2241-2247.

(83) Loft S, Otte J, Poulsen HE, Sorensen H. Influence of intact and myrosinase-treated indolyl glucosinolates on the metabolism in vivo of metronidazole and antipyrine in the rat. Food Chem Toxicol 1992; 30(11):927-935.

(84) Poulsen HE, Loft S, Andersen M, Andersen JR. Disulfiram therapy - adverse drug reactions and interactions. Acta Scand Psych 1992; 86:59-66.

(85) Sherson D, Sigsgaard T, Overgaard E, Loft S, Poulsen HE, Jongeneelen FJ. Interaction of smoking, uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers. Br J Ind Med 1992; 49(3):197-202.

(86) Vistisen K, Poulsen HE, Loft S. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis 1992; 13(9):1561-1568.

 

1991

(68) Andersson R, Poulsen HE, Ahren B. Effect of bile on liver function tests in experimental E. coli peritonitis in the rat. Hepatogastroenterology 1991; 38(5):388-390.

(69) Boesgaard S, Petersen JS, Aldershvile J, Poulsen HE, Flachs H. Nitrate tolerance: effect of thiol supplementation during prolonged nitroglycerin infusion in an an in vivo rat model. J Pharmacol Exp Ther 1991; 258(3):851-856.

(70) Dalhoff K, Hansen PB, Ott P, Loft S, Poulsen HE. Acute ethanol administration reduces the antidote effect of N-acetylcysteine after acetaminophen overdose in mice. Hum Exp Toxicol 1991; 10(6):431-433.

(71) Fischer-Nielsen A, Poulsen HE, Hansen BA, Hage E, Keiding S. CCl4 cirrhosis in rats: irreversible histological changes and differentiated functional impairment. J Hepatol 1991; 12(1):110-117.

(72) Loft S, Nielsen AJ, Borg BE, Poulsen HE. Metronidazole and antipyrine metabolism in the rat: clearance determination from one saliva sample. Xenobiotica 1991; 21(1):33-46.

(73) Loft S, Otton SV, Lennard MS, Tucker GT, Poulsen HE. Characterization of metronidazole metabolism by human liver microsomes. Biochem Pharmacol 1991; 41(8):1127-1134.

(74) Poulsen HE, Ranek L, Jorgensen L. The influence of disulfiram on acetaminophen metabolism in man. Xenobiotica 1991; 21(2):243-249.

(75) Roberts DW, Benson RW, Pumford, NR, Potter DW, Poulsen HE et al. Sensitive immunochemical assays for monitoring acetaminophen toxicity in humans. In: Vanderlaan M, editor. Immunoassays for trace chemical analysis. Washington DC:

(76) Sjovall S, Ahren B, Hansson P, Loft S, Poulsen HE, Bengmark S. Metabolic responses to intermittent  hepatic dearterialization in the rat. J Hepatol 1991; 13(1):33-37.

(77) Vistisen K, Loft S, Poulsen HE. Cytochrome P450 IA2 activity in man measured by caffeine metabolism: effect of smoking, broccoli and exercise. Adv Exp Med Biol 1991; 283:407-411.

 

1990

(60) Hinson JA, Roberts DW, Benson RW, Dalhoff K, Loft S, Poulsen HE. Mechanism of paracetamol toxicity. Lancet 1990; 335(8691):732.

(61) Loft S, Poulsen HE. Prediction of xenobiotic metabolism by non-invasive methods. [Review] [104 refs]. Pharmacology and Toxicology 1990; 67(2):101-108.

(62) Loft S, Poulsen HE. Metabolism of metronidazole and antipyrine in hepatocytes isolated from mouse and rat. Xenobiotica 1990; 20(2):185-191.

(63) Loft S, Egsmose C, Sonne J, Poulsen HE, Dossing M, Andreasen PB. Metronidazole elimination is preserved in the elderly. Hum Exp Toxicol 1990; 9(3):155-159.

(64) Ott P, Hansen PB, Dalhoff KP, Loft SH, Poulsen HE. [Consumption of, overdose and fatal poisoning with analgesics in Denmark 1979-1986]. Ugeskr Laeger 1990; 152(4):250-252.

(65) Ott P, Dalhoff KP, Poulsen HE. [Analgesic-induced.mortality (letter)]. Ugeskr Laeger 1990;152(39):2867-2868.

(66) Ott P, Dalhoff K, Hansen PB, Loft S, Poulsen HE. Consumption, overdose and death from analgesics during a period of over-the-counter availability of paracetamol in  in Denmark. J Intern Med 1990; 227(6):423-428

(67) Sonne J, Boesgaard S, Poulsen HE, Loft S, Hansen JM, Dossing M et al. Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism. Br J Clin Pharmacol 1990; 30(5):737-742.

1989

(55) Fischer-Nielsen A, Poulsen HE, Hansen BA, Tygstrup N, Keiding S. Age dependence of rat liver function measurements. J Hepatol 1989; 9(2):190-197.

(56) Loft S, Poulsen HE. Metabolism of metronidazole and antipyrine in isolated rat hepatocytes. Influence of sex and enzyme induction and inhibition. Biochem Pharmacol 1989; 38(7):1125-1136.

(57) Perrild H, Kayser L, Poulsen HE, Skovsted L, Jorgensen B, Hansen JM. Differential effect of continuous administration of beta-adrenoceptor antagonists on antipyrine and phenytoin clearance. Br J Clin Pharmacol 1989;28(5):551-554.

(58) Poulsen HE, Hansen BA, Egeberg JC. Neutral red changes arginine-induced glucagon and insulin response in the rat. Pharmacology and Toxicology 1989; 65(1):65-68.

(59) Tvede KG, Loft S, Poulsen HE, Schou JS. Methyl parathion toxicity in rats is changed by pretreatment with the pesticides chlordecone, mirex and linuron.Arch Toxicol Suppl 1989; 13:446-447.

 

1988

(45) Jorgensen L, Thomsen P, Poulsen HE. Disulfiram prevents acetaminophen hepatotoxicity in rats. Pharmacology and Toxicology 1988; 62(5):267-271.  

(46) Knudsen GM, Poulsen HE, Paulson OB. Blood-brain barrier permeability in galactosamine-induced hepatic encephalopathy. No evidence for increased GABA-transport. J  Hepatol 1988; 6(2):187-192.

(47) Knudsen GM, Poulsen HE. Unchanged blood-brain barrier permability to GABA in experimental hepatic encephalopathy. In: Soeter PB, Wilson JHP, Maijer AJ, Holm E, editors. Advances in ammonia metabolism and hepatic encephalopathy. Elsevier Science Publishers B.V., 1988: 309-313.  

(48) Loft S, Poulsen HE, Sonne J, Dossing M. Metronidazole clearance: a one-sample method and  influencing factors. Clin Pharmacol Ther 1988; 43(4):420-428.

(49) Loft S, Dossing M, Sonne J, Dalhof K, Bjerrum K, Poulsen HE. Lack of effect of cimetidine on the pharmacokinetics and metabolism of a single oral dose of metronidazole. European Journal of Clinical Pharmacology 1988; ; 35(1):65-68.

(50) Loft S, Dossing M, Poulsen HE. Influence of age and consumption of tobacco, alcohol and caffeine on on antipyrine clearance. Hum Toxicol 1988; 7(3):277-280.

(51) Poulsen HE, Thomsen P. Long-term administration of toxic doses of paracetamol (acetaminophen) to rats. Liver 1988; 8(3):151-156.

(52) Poulsen HE, Loft S. Antipyrine as a model drug to study hepatic drug-metabolizing capacity. J Hepatol 1988; 6(3):374-382.

(53) Sonne J, Poulsen HE, Loft S, Dossing M, Vollmer-Larsen A, Simonsen K et al. Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism. European Journal of Clinical Pharmacology 1988; 35(1):109-111.

(54) Vilstrup H, Hansen BA, Almdal T, PetersenKF, Siggaard I, Poulsen HE. The capacity of urea synthesis in rats: regulation and physiological importance. In: Soeters PB, editor. Advances in ammonia metabolism and hepatic encephalopathy. Elsevier Science Publisheres B.V., 1988: 79-85

 

1987

Adelhøj B, Petring OU, Frosig F, Jensen BN, Ibsen M, Poulsen HE. The effect of spinal analgesia and surgery on peroperative drug absorption and gastric emptying in man.Acta Anaesth Scand 1987; 31(2):165-167.

Dalhoff K, Poulsen HE, Garred P, Placchi M, Gammans RE, Mayol RF et al. Buspirone pharmacokinetics in patients with cirrhosis. Br J Clin Pharmacol 1987; 24(4):547-550.

Loft S, Sonne J, Poulsen HE, Petersen KT, Jorgensen BG, Dossing M. Inhibition and induction of metronidazole and antipyrine metabolism. European Journal of Clinical Pharmacology 1987; 32(1):35-41.

Petersen KF, Hansen BA, Poulsen HE. Hepatic regeneration following glucagon treatment. Horm Metab Res 1987; 19(6):239-241.

Petring OU, Adelhøj B, Ibsen M, Poulsen HE. Effect of chlorpromazine on drug absorption and gastric emptying in man. Can J Anaesth 1987; 34(6):563-565.

Poulsen HE, Loft S. Quantitation of liver function: Antipyrine, an update. In: Okolicsanyi L, editor. Assessment and management of hepatobiliary disease. Berlin Heidelberg: Springer-Verlag, 1987: 189-195.  

Poulsen HE, Jorgensen L, Thomsen P. Prevention of acetaminophen hepatotoxicity by disulfiram. Pharmacol Ther 1987; 33(1):83.

Sonne J, Dossing M, Poulsen HE, Pilsgaard H, Rasmussen B, Loft S. Effect of concomitant administration of cimetidine and phenobarbital on antipyrine elimination and metabolite formation. Int J Clin Pharmacol Ther Toxicol 1987; 25(4):194-196.  

Tygstrup N, Poulsen HE. Post-marketing surveillance of hepatotoxicity. Milan, Italy: Wichtig Editore, 1987.

 

1986

Hansen BA, Poulsen HE. The capacity of urea-N synthesis as a quantitative measure of the liver mass in rats. J Hepatol 1986; 2(3):468-474.

Hansen BA, Poulsen HE. Changes in the hepatic capacity of urea-N synthesis, galactose elimination and antipyrine clearance following 70% hepatectomy in the rat. Scand J Clin Lab Invest 1986; 46:233-237.

Hansen BA, Poulsen HE. Starvation induced changes in quantitative measures of liver function in the rat. Clin Nutrit 1986; 5:213-216.

Loft S, Dossing M, Poulsen HE, Sonne J, Olesen KL, Simonsen K et al. Influence of dose and route of administration on disposition of metronidazole and its major metabolites. European Journal of Clinical Pharmacology 1986; 30(4):467-473.

Loft S, Sonne J, Pilsgaard H, Dossing M, Poulsen HE, Ciraulo DA et al. Inhibition of antipyrine elimination by disulfiram and cimetidine: the effect of concomitant administration Pharmacokinetic interaction of disulfiram and antidepressants. British Journal of Clinical Pharmacology 1986; 21:75-77.

Petring OU, Adelhøj B, Ibsen M, Poulsen HE. The relationship between gastric emptying of semisolids and paracetamol absorption. Br J Clin Pharmacol 1986; 22(6):659-662.

Sonne J, Poulsen HE, Andreasen PB. Single dose oxazepam has no effect on acetaminophen clearance or metabolism. European Journal of Clinical Pharmacology 1986 ; 30(1):127-129.

 

1985

(17) Adelhøj B, Petring OU, Brynnum J, Ibsen M, Poulsen HE. Effect of diazepam on drug absorption and gastric emptying in man. Br J Anaesth 1985; 57(11):1107-1109.

(18) Adelhøj B, Petring OU, Ibsen M, Brynnum J, Poulsen HE. Buprenorphine delays drug absorption and gastric emptying in man. Acta Anaesth Scand 1985; 29(6):599-601.

(19) Adelhøj B, Petring OU, Ibsen M, Brynnum J, Poulsen HE. Tardiv respirationsdepression efter intravenøs buprenorfin. Ugeskr Laeger 1985; 147:1343.

(20) Petring OU, Adelhøj B, Ibsen M, Brynnum J, Poulsen HE. Abstaining from cigarette smoking has no major effect on gastric emptying in habitual smokers. Br J Anaesth 1985; 57(11):1104-1106

(21) Poulsen HE. One sample antipyrine clearance after 90% partial hepatectomy in the rat. Liver 1985; 5(4):200-204.

(22) Poulsen HE, Lerche A, Skovgaard LT. Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose. Biochem Pharmacol 1985;34(20):3729-3733.

(23) Poulsen HE, Pilsgaard H. Antipyrine metabolism during hepatic regeneration in the rat. Liver 1985; 5(4):196-199.

(24) Poulsen HE, Lerche A, Pedersen NT. Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. Pharmacology 1985; 30(2):100-108.

(25) Poulsen HE, Gaub J, Iversen J. Changes in quantitative measures of hepatic function after 90% hepatectomy in rats. European Journal of Clinical Investigation1985; 15(5):285-289.

(26) Poulsen HE, Lerche A, Pedersen NT. Potentiated hepatotoxicity from concurrent administration of acetaminophen and allyl alcohol to rats. Biochem Pharmacol 1985;34(6):727-731.

(27) Tvedegaard E, Poulsen HE, Vilstrup H, Thomsen HK. Functional status of the liver during chronic renal failure: an experimental study in the rabbit. Liver 1985; 5(4):183-188.

 

1984

(12) Pilsgaard H, Poulsen HE. A one-sample method for antipyrine clearance determination in rats. Pharmacology 1984; 29(2):110-116.

(13) Poulsen HE, Vilstrup H, Keiding S. Galactose elimination kinetics in perfused rat liver after two thirds hepatectomy. Scand J Clin Lab Invest 1984; 44(2):155-158.

(14) Poulsen HE, Korsholm B. Quantitative liver functions after administration of allyl alcohol to rats. Acta Pharmacol Toxicol 1984; 54(2):120-123.

(15) Poulsen HE, Ranek L. Paracetamolforgiftning. Ugeskr Laeger 1984; 146:4030-4033.

(16) Tvedegaard E, Poulsen HE, Vilstrup H, Thomsen HK. Liver function during chronic renal failure  in rabbits. Experientia 1984; 40(11):1255-1256.

 

1983

(9) Dossing M, Volund A, Poulsen HE. Optimal sampling times for minimum variance of clearance determination. Br J Clin Pharmacol 1983; 15(2):231-235.

(10) Dossing M, Pilsgaard H, Rasmussen B, Poulsen HE. Time course of phenobarbital and cimetidine mediated changes in hepatic drug metabolism. European Journal of Clinical Pharmacology 1983; 25(2):215-222.

(11) Poulsen HE. A pocket calculator program to sort data. Comput Biol Med 1983; 13(4):299-301.

 

1982

(8) Dossing M, Poulsen HE, Andreasen PB, Tygstrup N. A simple method for determination of antipyrine clearance. Clin Pharmacol Ther 1982; 32(3):392-396.

 

1981

(4) Poulsen HE, Ranek L, Andreasen PB. The hepatic glutathione content in liver diseases. Scand J Clin LabInvest 1981; 41(6):573-576

(5) Poulsen HE, Petersen P, Vilstrup H. Quantitative liver function and morphology after paracetamol administration to rats. European Journal of Clinical Investigation 1981; 11(3):161-164.

(6) Sonne J, Poulsen HE, Dossing M, Larsen NE, Andreasen PB. Cimetidine clearance and bioavailability in hepatic cirrhosis. Clin Pharmacol Ther 1981; 29(2):191-197.

(7) Yildirim SI, Poulsen HE. Quantitative liver functions after 70% hepatectomy. European Journal of Clinical Investigation 1981; 11(6):469-472.

 

1980

(3) Milandri M, Poulsen HE, Ranek L, Andreasen PB. Effect of long-term disulfiram administration on rat liver. Pharmacology 1980; 21(1):76-80.

 

1977

(2) Poulsen HE, Bengmark S, Borgeson S, Flodgren P, Kallum B. Staging laparotomy with splenectomy in Hodkin's disease. Acta Chir Scand 1977; 143:347-357.

 

1976

Poulsen HE, Ranek L. [Duodenal ulcer as a cause of splenic vein thrombosis and esophageal varices]. Ugeskr Laeger 1976 Jul 5;138(28):1712-3..

 

Monographs

 Poulsen HE. Kvantitering af leverfunktionen ved eksperimentel akut toksisk leverskade sammenlignet med forholdene efter partiel og subtotal hepatectomi. Disputats. Copenhagen: University of Copenhagen, 1986

 

 

Proceedings

 Lykkesfeldt J, Loft S, Poulsen HE. Individuel kræftrisiko - biomarkører kan måske give os svaret. Naturens Verden 1995; 78:32-40.

Poulsen HE, Weimann A, Loft S. Methods to detect DNA damage by free radicals: relation to exercise. Proc Nutr Soc 1999 Nov;58(4):1007-14.

 

 

Book Chapters

2012

Poulsen HE: Klinisk farmakologi og farmakoterapi. In: Basisbog i Diagnostiske Fag. Eds. Thomsen HS et al. Munksgaard Forlag. Kapitel 7 (2012) 251-268

2006

Henrik E. Poulsen, Allan Weimann and Berry B. Halliwell: Cigarette Smoke and Oxidative DNA Modification in Cigarette Smoke and Oxidative Stress. Ed. Berry B. Halliwell and Henrik E. Poulsen. Springer-Verlag Berlin Heidelberg Chapter 16 (2006) 387-402.

2005

Dalhoff K, Jensen KB, Poulsen HE. Cancer and molecular biomarkers of phase 2. In: John Abelson, USA, ed. Methods Enzymol. 400 ed. New York: Elsevier; 2005:618-27

2003

Poulsen HE, Loft S, Jensen BR, Sørensen, M, Hoberg A-M, Weimann A. HPLC-ECD, LC-MS/MS (Urinary Biomarkers):  In: Oxidative Stress and Aging. Advances in Basic Science, Diagnostics, and Intervention, eds. Cutler RG, Rodriguez H. Singapore: World Scientific Publishing Co. Pte. Ltd; 2003:233-56(225)

Poulsen HE. Proper design of human intervention studies, power calculations. In:Free radicals, nitric oxide, and inflammation: Molecular, biochemical, and clinical aspects, eds. Tomasi A et al. Ohmsha: IOS Press; 2003:252-3.

Poulsen HE. Estimation of oxidative and lipids peroxidation DNA adduct in urine and DNA. Free radicals, nitric oxide, and inflammation: Methodological aspects and application in Molecular epidemiology.In: Molecular, biochemical, and clinical aspects, eds. Tomasi A, et al. Ohmsha: IOS Press; 2003:34-38

2002

Griffiths HR, Møller L, Bartosz G, Bast A, Bertoni-Freddari C, Collins A, Cooke M, Coolen S,  Haenen  G, Hpberg AM, Loft S, Lunec J, Olinski R, Parry J, Pompella A, Poulsen HE, Verhagen H, Astley SB. Chap 3; Biomarkers. In Molecular Aspects of Medicine 23 2002; 101-208.

2000

Poulsen HE, Loft S, Weimann A. Urinary measurement of 8-oxodG (8-oxo-2'-deoxyguanosine). In: Lunec J, Griffiths HR, editors. Measuring in vivo Oxidative Damage: A practical Approach. London: John Wiley and Sons (Ltd.), 2000: 69-80

1999

Loft S, Poulsen HE. Measurement of oxidative damage to DNA: interpretation of nuclear levels and urinary excretion of repair products in DNA damage and Repair: Oxygen Radical effects, cellular protection and biological consequeences. In: Karakaya A, Dizdaroglu M, editors. Oxygen Radical Effects, Cellular Protection and Biological Consequences. New York: Plenum Press, 1999: 267-281.

Poulsen HE, Loft S. Motion og velvære. Miljømedicin. 1999: 364-367.

Poulsen HE, Loft S, Strandgaard S, Vilstrup H. Rationel farmakoterapi. In: Lorenzen I, Bendixen G, Hansen NE, editors. Medicinsk Kompendium. Copenhagen: Nyt Nordisk forlag Arnold Busck A/S, 1999: 2942-2954.

1998

Poulsen HE, Loft S. Interpretation of oxidative DNA modification: Relation between tissue levels, excretion of urinary repair products and sigle cell gel electrophoresis (comet assay). In: Aruoma OI, Halliwell B, editors. DNA & free radicals: Techniques, mechanisms and applications. London: OICA International, 1998: 261-270. 

1997

Poulsen HE, Loft S, Prieme H, Salonen JT. Antioxidants. In: Haunsø S, editor. Coronary microcirculation during ischaemia and reperfusion. Copenhagen: Munksgaard, 1997: 455-461

1996

Prieme H, Loft S, Cutler RG, Poulsen HE. Measurement of oxidative DNA injury in humans: evaluation of a commercially available ELISA assay. In: Kumpulainen JT, editor. Natural antioxidants and food quality in atherosclerosis and cancer prevention. The royal society of chemistry 1996, 1996: 78-82.

1989

Roberts DW, Benson RW, Pumford, NR, Potter DW, Poulsen HE et al. Sensitive immunochemical assays for monitoring acetaminophen toxicity in humans. In: Vanderlaan M, editor. Immunoassays for trace chemical analysis. Washington DC:  1989:44-50

1988

Knudsen GM, Poulsen HE. Unchanged blood-brain barrier permability to GABA in experimental hepatic encephalopathy. In: Soeter PB, Wilson JHP, Maijer AJ, Holm E, editors. Advances in ammonia metabolism and hepatic encephalopathy. Elsevier Science Publishers B.V., 1988: 309-313

Vilstrup H, Hansen BA, Almdal T, PetersenKF, Siggaard I, Poulsen HE. The capacity of urea synthesis in rats: regulation and physiological importance. In: Soeters PB, editor. Advances in ammonia metabolism and hepatic encephalopathy. Elsevier Science Publisheres B.V., 1988: 79-85

1987

Poulsen HE, Loft S. Quantitation of liver function: Antipyrine, an update. In: Okolicsanyi L, editor. Assessment and management of hepatobiliary disease. Berlin Heidelberg: Springer-Verlag, 1987: 189-195. 

Tygstrup N, Poulsen HE. Post-marketing surveillance of hepatotoxicity. Milan, Italy: Wichtig Editore, 1987.

 

Other Publications

1990

Poulsen HE, Juul P. Note on the statistical evaluation of a randomized, cross-over bioavailability study. Danish National Board of Health, 1990 PDF (289K) 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Scientific publications

1976

(

2005

(242) Riis B, Poulsen HE, Repair and Removal Systems DNA Repair: Mechanisms and Measurements In:The Handbook of Environmental Chemistry Vol. 2, Part O. eds. Springer-Verlag Berlin Heidelberg 2005: 151–75

(243) Weimann A, Sabroe M, Poulsen HE Measurement of caffeine and five of the major metabolites in urine by high-performance liquid chromatography/tandem mass Spectrom. 2005;40:307-16

(244) Hillestrøm PR, Nyssönen K, Tuomainen T-P, Pukkala E, Salonen JT, Poulsen HE Urinary excretion of of edA is not predictive of cancer development: A prospective nested case control study. Free Rad Research, 2005;39:51-3

(245) Ciofu O, Riis B, Pressler T, Poulsen HE, Hoiby N Occurrence of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Patients Is Associated with the Oxidative Stress Caused by Chronic Lung Inflammation. Antimicrob. Agents Chemother. 2005;49:2276-2282

(246) Laska MJ, Nexo BA, Vistisen K, Poulsen HE, Loft S, Vogel U Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer. Cancer Lett. 2005;225:245-51

(247) Dalhoff KP, Poulsen HE.[Toxicology and pharmacogenetics] Ugeskr Laeger. 2005;167:2170-2. Danish.

(248) Poulsen HE. Oxidative DNA modifications. Exp Toxicol Pathol. 2005 Jul;57 Suppl 1:161-9. Review.  

(249) Gronbaek K, Sonne J, Ring-Larsen H, Poulsen HE, Friis H, Bygum Krarup H. Viral load is a negative predictor of antioxidant levels in hepatitis C patients .Scand J Infect Dis. 2005;37:686-9

 

2006

(251) Hillestrom PR, Weimann A, Poulsen HE.Quantification of Urinary Etheno-DNA Adducts by Column-Switching LC/APCI-MS/MS. J Am Soc Mass

(252) Hillestrom PR, Weimann A, Jensen, CB, Storgaard H, Vaag AA, Poulsen HE.  Consequences of low birthweight on urinary excretion of DNA markers of oxidative stress in young men. Scand J Clin Lab Invest 2006; 66: 363–70.

(253) Hillestrom PR, Covas MI, Poulsen HE. Effect of dietary virgin olive oil on urinary excretion of etheno-DNA adducts. Free Radic Biol Med. 2006 Oct 1;41(7):1133-8. Epub 2006 Jul 4.

(254) Covas MI, Nyyssonen K, Poulsen HE, Kaikkonen J, Zunft HJ, Kiesewetter H, Gaddi A, de la Torre R, Mursu J, Baumler H, Nascetti S, Salonen JT, Fito M, Virtanen J, Marrugat J, EUROLIVE Study Group. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med. 2006 Sep 5;145(5):333-41.

(255) Glintborg B, Weimann A, Kensler TW, Poulsen HE. Oltipraz chemoprevention trial in Qidong, People's Republic of China: Unaltered oxidative biomarkers. Free Radic Biol Med. 2006 Sep 15;41(6):1010-4.

(256) Henrik E. Poulsen, Allan Weimann and Berry B. Halliwell: Cigarette Smoke and Oxidative DNA Modification in Cigarette Smoke and Oxidative Stress. Ed. Berry B. Halliwell and Henrik E. Poulsen. Springer-Verlag Berlin Heidelberg Chapter 16 (2006) 387-402.

2007

(257) Machowetz A, Poulsen HE, Gruendel S, Weimann A, Fito M, Marrugat J, de la Torre R, Salonen JT, Nyyssonen K, Mursu J, Nascetti S, Gaddi A, Kiesewetter H, Baumler H, Selmi H, Kaikkonen J, Zunft HJ, Covas MI, Koebnick C. Effect of olive oils on biomarkers of oxidative DNA stress in Northern and Southern Europeans The FASEB Journal • Research Communication. The FASEB Journal. 2007;21:45-52.

(258) Bondia-Pons I, Schroder H, Covas MI, Castellote AI, Kaikkonen J, Poulsen HE, Gaddi AV, Machowetz A, Kiesewetter H, Lopez-Sabater MC.Moderate Consumption of Olive Oil by Healthy European Men Reduces Systolic Blood Pressure in Non-Mediterranean Participants.
J Nutr. 2007 Jan;137(1):84-87.

(259) Tuomainen TP, Loft S, Nyyssonen K, Punnonen K, Salonen JT, Poulsen HE. Body iron is a contributor to oxidative damage of DNA. Free Radic. Res. 2007 Mar;41(3):324-8.

(260) Bader N, Bosy-Westphal A, Koch A, Rimbach G, Weimann A, Poulsen HE, Muller MJ Effect of hyperbaric oxygen and vitamin C and E supplementation on biomarkers of oxidative stress in healthy men.  Br J Nutr.  2007 Oct;98(4):826-33

(261) Gravholt CH, Poulsen HE, Ott P, Christiansen JS, Vilstrup H. Quantitative liver functions in Turner syndrome with and without hormone replacement therapy. Eur J Endocrinol. 2007 Jun;156(6):679-86.

(262) Glintborg B, Hillestrom PR, Olsen LH, Dalhoff KP, Poulsen HE. Are patients reliable when self-reporting medication use? Validation of structured drug interviews and home visits by drug analysis and prescription data in acutely hospitalized patients. J Clin Pharmacol. 2007 Nov;47(11):1440-9.

(263) Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain. Lykkesfeldt J, Trueba GP, Poulsen HE, Christen S. Br J Nutr. 2007 Dec;98(6):1116-9.

2008

(264) Glintborg B, Poulsen HE, Dalhoff KP.The use of nationwide on-line prescription records improves the drug history in hospitalized patients. Br J Clin Pharmacol. 2008 Feb;65(2):265-9;

(265) Hansen M, Baunsgaard D, Autrup H, Vogel UB, Møller P, Lindecrona R, Wallin H, Poulsen HE, Loft S, Dragsted LO.Sucrose, glucose and fructose have similar genotoxicity in the rat colon and affect the metabolome.Food Chem Toxicol.Volume 46,  2008;46:752-60  

(266) Berendt L, Håkansson C, Bach KF, Dalhoff K, Andreasen PB, Petersen LG, Andersen E, Poulsen HE. Effect of European Clinical Trials Directive on academic drug trials in Denmark: retrospective study of applications to the Danish Medicines Agency 1993-2006. BMJ 2008;336;33-35

(267) Morten Lock Hansen, Niels Gadsbøll, Gunnar H. Gislason, Steen Z. Abildstrom, Tina K. Schramm, Fredrik Folke, Jens Friberg, Rikke Sørensen, Søren Rasmussen, Henrik E. Poulsen, Lars Køber, Mette Madsen, and Christian Torp-Pedersen. Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers.Europace. 2008 Apr;10(4):395-402

(268) Serena Guarnieri, Steffen Loft, Patrizia Riso, Marisa Porrini, Lotte Risom, Henrik E. Poulsen, Lars O. Dragsted and Peter Møller. DNA repair phenotype and dietary antioxidant supplementation British Journal of Nutrition (2008), 99, 1018–1024

(269) Marcus S. Cooke, Ryszard Olinski, and Steffen Loft members of the European Standards Committee on Urinary (DNA) Lesion Analysis (ESCULA) ESCULA members include Mark D. Evans, Rajinder Singh, Vilas Mistry, Peter B. Farmer (University of Leicester, United Kingdom); Rafal Rozalski, Daniel Gackowski, Marek Foksinski, Agnieszka Siomek (Nicolaus Copernicus University, Poland); Peter Møller, Pernille Danielsen, Elvira Vaklavik, Lykke Forchhammer (University of Copenhagen, Denmark); Jean Cadet, Jean-luc Ravanat (CEA/Grenoble, France); Jagadeesan Nair, Urmila Nair (DKFZ, Germany); Henrik E. Poulsen, Allan Weimann, Peter R. Hillestrom (Rigshospitalet, Denmark). Measurement and Meaning of Oxidatively Modified DNA Lesions in Urine. Cancer Epidemiol Biomarkers Prev 2008;17(1).

(270) Cand.pharm Louise Berendt, cand.pharm. Cecilia Håkansson, cand.pharm. Karin Friis Bach, overlæge Kim Dalhoff, overlæge Per Buch Andreasen, cand.pharm. Lene Grejs Petersen, kontorchef Elin Andersen & professor Henrik Enghusen Poulsen. Effekten af GCP- direktivet på forskerinitierede kliniske lægemiddelforsøg – sekundærpublikation. Ugeskr Laeger. 2008;170:2437-9

(271) Glintborg B, Olsen L, Poulsen H, Linnet K, Dalhoff K.Clin Toxicol (Phila). Reliability of self-reported use of amphetamine, barbiturates, benzodiazepines, cannabinoids, cocaine, methadone, and opiates among acutely hospitalized elderly medical patients. 2008 Mar;46(3):239-42.

(272) Arrigo F.G. Cicero, MD, PhD, Simona Nascetti, MD, PhD, Maria C. López-Sabater, MD, Roberto Elosua, MD, Jukka T. Salonen, MD, PhD, Kristiina Nyyssönen, MD, Henrik E. Poulsen, MD, PhD, Hans-Joachim F. Zunft, MD, PhD, Holger Kiesewetter, MD, Karina de la Torre, MD, Marıa-Isabel Covas, BD, PhD, Jari Kaikkonen, Jaakko Mursu, Corina Koenbick, MD, Hans Bäumler, MD, PhD, and Antonio V. Gaddi, MD, PhD, for the EUROLIVE Study Group. Changes in LDL fatty acid composition as a response to olive oil treatment are inversely related to lipid oxidative damage: The EUROLIVE Study. Journal of the American College of Nutrition, 2008;27:314–20

(273) Gottipati KR, Poulsen H, Starcher B. Passive cigarette smoke exposure inhibits ultraviolet light B-induced skin tumors in SKH-1 hairless mice by blocking the nuclear factor kappa B signalling pathway.Exp Dermatol. 2008 Sep;17(9):780-7.

 

2009

(274) Poulsen HE, Andersen JT, Keiding N, Schramm TK, Sørensen R, Gislasson G, Fosbøl EL, Torp-Pedersen C. Why epidemiological and clinical intervention studies often give different or diverging results? IUBMB Life, 61(4): 391–393, April 2009

 (275) Fosbøl E, Gislason G, Jacobsen S, Folke F, Hansen M, Schramm T, Sørensen R, Rasmussen J, Andersen S, Abildstrom S, Trærup J, Poulsen H, Rasmussen S, Køber L, Torp-Pedersen C. Risk of Myocardial Infarction and Death Associated With the Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Among Healthy Individuals: A Nationwide Cohort Study. Clin Pharmacol Ther. (2009); 85, 2, 190–197

(276) Christine Dalgård , Flemming Nielsen, Jason D. Morrow, Henrik Enghusen-Poulsen, Torbjörn Jonung, Mogens Hørder and Moniek P. M. de Maat. Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease  Br J Nutr. 2009 Feb;101(2):263-9.

(277) Gunnar H. Gislason, MD, PhD; Jeppe N. Rasmussen, MD, PhD; Steen Z. Abildstrom, MD, PhD; Tina K. Schramm, MD;Morten L. Hansen, MD; Emil L. Fosbøl, MB; Rikke Sørensen, MD; Fredrik Folke, MD; Pernille Buch, MD, PhD; Niels Gadsbøll, MD, DMSc; Søren Rasmussen, MSc, PhD; Henrik E. Poulsen, MD, DMSc; Lars Køber, MD, DMSc;
Mette Madsen, MSc; Christian Torp-Pedersen, MD, DMSc.
Increased Mortality and Cardiovascular Morbidity Associated With Use of Nonsteroidal Anti-inflammatory Drugs in Chronic Heart Failure. Arch Intern Med. 2009 Jan 26;169(2):141-9. 

(278) Hansen ML, Gadsbøll N, Rasmussen S, Gislason GH, Folke F, Andersen SS, Schramm TK, Sørensen R, Fosbøl EL, Abildstrøm SZ, Madsen M, Poulsen HE, Køber L, Torp-Pedersen C.Clinical consequences of hospital variation in use of oral anticoagulant therapy after first-time admission for atrial fibrillation. Journal of Internal Medicine 265; 335–344

(279) L. F. Mandsberg, O. Ciofu, N. Kirkby, L. E. Christiansen, H. E. Poulsen and N. Høiby. Antibiotic Resistance in Pseudomonas aeruginosa Strains with
Increased Mutation Frequency due to Inactivation of the DNA Oxidative Repair System. Antimicrobial Agents and Chemotherapy, June 2009, 2483–91

(280) Afzal S, Jensen SA, Vainer B, Vogel U, Matsen JP, Sorensen JB, et al. MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer. Ann Oncol 2009 Oct;20(10):1660-6

(281) Trine Henriksen, Peter R. Hillestrøm, Henrik E. Poulsen, Allan Weimann. Automated method for the direct analysis of 8-oxo-guanosine and 8-oxo-2′-deoxyguanosine in human urine using ultraperformance liquid chromatography and tandem mass spectrometry. Free Radical Biology & Medicine 47 (2009) 629–635

(282) Broedbaek K, Poulsen HE, Weimann A, Kom GD, Schwedhelm E, Nielsen P, et al. Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis. Free Radic Biol Med 2009 Oct 15;47(8):1230-3.

(283) Davanipour Z, Poulsen HE, Weimann A, Sobel E. Endogenous melatonin and oxidatively damaged guanine in DNA. BMC Endocr Disord 2009;9:22(

(284) Poulsen HE. Report from the President of SFRR-Europe. Free Radical Research, December 2009; 43(12): 1254–1255

(285) Fosbol EL, Gislason GH, Poulsen HE, Hansen ML, Folke F, Schramm TK, et al. Prognosis in heart failure and the value of {beta}-blockers are altered by the use of antidepressants and depend on the type of antidepressants used. Circ Heart Fail 2009 Nov;2(6):582-90.

(286) Dominguez H, Schramm TK, Norgaard ML, Abildstrom SZ, Kober L, Jorgensen C, et al. Initiation and persistence to statin treatment in patients with diabetes receiving glucose-lowering medications. Open Cardiovasc Med J 2009;3:152-9

 

2010

(287) Nurmi T, Mursu J, Penalvo JL, Poulsen HE, Voutilainen S. Dietary intake and urinary excretion of lignans in Finnish men. Br J Nutr 2010 Mar;103(5):677-85.

(288) Lykkesfeldt J, Poulsen HE. Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials. Br J Nutr. 2010 May;103(9):1251-9. Epub 2009 Dec 15. Review..

(289)   Lopez-Miranda J, Perez-Jimenez F, Ros E, De CR, Badimon L, Covas MI, et al. Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008. Nutr Metab Cardiovasc Dis 2010 Mar 19.

(290)   Olesen JB, Hansen PR, Erdal J, Abildstrom SZ, Weeke P, Fosbol EL, et al. Antiepileptic drugs and risk of suicide: a nationwide study. Pharmacoepidemiol Drug Saf 2010 Mar 16.

(291) Glintborg B, Andersen SK, Poulsen HE. Prescription data improve the medication history in primary care. Qual Saf Health Care 2010 Mar 1.

(292)  Sorensen R, Abildstrom SZ, Weeke P, Fosbol EL, Folke F, Hansen ML, et al. Duration of clopidogrel treatment and risk of mortality and recurrent myocardial infarction among 11 680 patients with myocardial infarction treated with percutaneous coronary intervention: a cohort study. BMC Cardiovasc Disord 2010;10:6.

(293) de lT-C, Chavez-Servin JL, Jauregui O, Castellote AI, Lamuela-Raventos RM, Nurmi T, et al. Elevated circulating LDL phenol levels in men who consumed virgin rather than refined olive oil are associated with less oxidation of plasma LDL. J Nutr 2010 Mar;140(3):501-8.

(294) Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress.
European Standards Committee on Urinary (DNA) Lesion Analysis, Evans MD, Olinski R, Loft S, Cooke MS. Collaborators (40) Rossner P Jr, Sram R, Henriksen T, Poulsen HE, Weimann A, Barbieri A, Sabatini L, Violante F, Kino S, Ochi T, Tairin K, Takeuchi M, Kasai H, Meerman JH, Gackowski D, Rozalski R, Siomek A, Halliwell B, Jenner AM, Wang H, Cerda C, Saez G, Haghdoost S, Svoboda P, Hu CW, Chao MR, Peng KY, Shih WC, Wu KY, Orhan H, Istanbullu NS, Mistry V, Farmer PB, Sandhu J, Singh R, Cortez C, Su Y, Santella RM, Lambert P, Smith R.  2010 Apr;24(4):1249-60. doi: 10.1096/fj.09-147124. Epub 2009 Dec 4.

(295) Cadet J, Poulsen H.  Measurement of oxidatively generated base damage in cellular DNA and urine. Free Radic Biol Med. 2010 Jun 1;48(11):1457-9. Epub 2010 Mar 12.

(296) Fosbøl EL, Folke F, Jacobsen S, Rasmussen JN, Sørensen R, Schramm TK, Andersen SS, Rasmussen S, Poulsen HE, Køber L, Torp-Pedersen C, Gislason GH. Cause-Specific Cardiovascular Risk Associated With Nonsteroidal Antiinflammatory Drugs Among Healthy Individuals. Circ Cardiovasc Qual Outcomes. 2010 Jun 8. [Epub ahead of print]

(297) Weeke P, Folke F, Gislason GH, Lippert FK, Olesen JB, Andersson C, et al. Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest: a nationwide study. Resuscitation 2010 Dec;81(12):1657-63

(298) Morten L. Hansen, MD, PhD; Rikke Sørensen, MD; Mette T. Clausen, MSc Pharm; Marie Louise Fog-Petersen, MSc Pharm; Jakob Raunsø, MD; Niels Gadsbøll, MD, DMSc; Gunnar H. Gislason, MD, PhD; Fredrik Folke, MD; Søren S. Andersen, MD; Tina K. Schramm, MD; Steen Z. Abildstrøm, MD, PhD; Henrik E. Poulsen, MD, DMSc; Lars Køber, MD, DMSc; Christian Torp-Pedersen, MD, DMSc. Risk of Bleeding With Single, Dual, or Triple Therapy With Warfarin, Aspirin, and Clopidogrel in Patients With Atrial Fibrillation ARCH INTERN MED/VOL 170 (NO. 16), SEP 13, 2010

(299) Lykkesfeldt J, Poulsen HE.Reply to Hemilä by Lykkesfeldt and Poulsen. PMID: 20854702 [PubMed - as supplied by publisher]Br J Nutr. 2010 Sep 21:1.

(300) Berendt L, Håkansson C, Bach KF, Andreasen PB, Petersen LG, Andersen E, Poulsen HE, Dalhoff K. Methodological characteristics of academic clinical drug trials--a retrospective cohort study of applications to the Danish Medicines Agency 1993-2005.Br J Clin Pharmacol. 2010 Nov;70(5):729-35

(301) Helena Dominguez1*, Tina Kenn Schramm2, Gunnar Hilmar Gislason3, Mette Lykke Norgaard3, Jakob Raunsø3, Steen Zabell Abildstrøm4,5, Lars Kober2, Henrik Enghusen Poulsen5,6,7 and Christian Tobias Torp-Pedersen3,7 National background is associated with disparities in initiation and persistence to statin treatment in subjects with diabetes in Denmark. Frontiers in Pharmacology, Pharmacotherapy of Cardiovascular Disorders December 2010 | Volume 1 | Article 142 doi: 10.3389/fphar.2010.00142

2011

(302) Broedbaek K, Siersma V, Andersen JT, Petersen M, Afzal S, Hjelvang B, Weimann A, Semba RD, Ferrucci L, Poulsen HE. The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly.Free Radic Res. 2011 Jan 28. [Epub ahead of print]

(303) NELA GOROVIC  SHOAIB AFZAL , ANNE TJØNNELAND KIM OVERVAD ULLA VOGEL CHRISTINA ALBRECHTSEN HENRIK E. POULSEN Genetic variation in the hTAS2R38 taste receptor and brassica vegetable intake Scandinavian Journal of Clinical & Laboratory Investigation, 2011; 71: (4):274-9. Epub 2011 Feb 21.

(304) Castañer O, Fitó M, López-Sabater MC, Poulsen HE, Nyyssönen K, Schröder H, Salonen JT, De la Torre-Carbot K, Zunft HF, De la Torre R, Bäumler H, Gaddi AV, Saez GT, Tomás M, Covas MI; for the EUROLIVE Study Group. The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial.Clin Nutr. 2011 Mar 2. [Epub ahead of print] PMID:21376434 

(305)  Broedbaek K, Ribel-Madsen R, Henriksen T, Weimann A, Petersen M, Andersen JT, Afzal S, Hjelvang B, Roberts LJ 2nd, Vaag A, Poulsen P, Poulsen HE.
Genetic and environmental influences on oxidative damage assessed in elderly Danish twins. Free Radic Biol Med. 2011 Feb 23. [Epub ahead of print]
PMID: 21354303

(306) Petersen M, Andersen JT, Hjelvang BR, Broedbaek K, Afzal S, Nyegaard M, Børglum AD, Stender S, Køber L, Torp-Pedersen C, Poulsen HE. Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients.Br J Clin Pharmacol. 2011 Apr;71(4):556-565. doi: 10.1111/j.1365-2125.2010.03868.

(307) Broedbaek K, Henriksen T, Weimann A, Petersen M, Andersen JT, Afzal S, et al. Long-Term Effects of Irbesartan Treatment and Smoking on Nucleic Acid Oxidation in Patients With Type 2 Diabetes and Microalbuminuria: An Irbesartan Microalbuminuria Type 2 Diabetes in Hypertensive Patients (IRMA) 2 substudy. Diabetes Care 2011 Mar 31.

(308) Shoaib Afzal, Milena Gusella, Ben Vainer, Ulla B. Vogel, Jon T. Andersen, Kasper Broedbaek, Morten Petersen, Espen Jimenez-Solem, Laura Bertolaso, Carmen Barile, Roberto Padrini, Felice Pasini, Søren A. Jensen, and Henrik E. Poulsen. Combinations of Polymorphisms in Genes Involved in the 5-Fluorouracil Metabolism Pathway Are Associated with Gastrointestinal Toxicity in Chemotherapy-Treated Colorectal Cancer Patients. Clin Cancer Res; 17(11) June 1, 2011 -   Published Online First on April 6, 2011; DOI:10.1158/1078-0432.CCR-11-0304

(309) Joergensen A, Broedbaek K, Weimann A, Semba RD, Ferrucci L, Joergensen MB, Poulsen HE. Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans. PLoS One. 2011;6(6):e20795. Epub 2011 Jun 7

(310) Afzal S, Gusella M, Jensen SA, Vainer B, Vogel U, Andersen JT, Brødbæk K, Petersen M, Jimenez-Solem E, Adleff V, Budai B, Hitre E, Láng I, Orosz E, Bertolaso L, Barile C, Padrini R, Kralovánszky J, Pasini F, Poulsen HE. The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer.Pharmacogenomics. 2011 Sep;12(9):1257-1267. PMID: 21919605

(311) Broedbaek K, Weimann A, Specht E, Poulsen HE. Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker in type 2 diabetes. Free Radic Biol Med. 2011 Jul 19. [Epub ahead of print] PMID:21820047

(312) KASPER BROEDBAEK, MD, VOLKERT SIERSMA, PHD,  TRINE HENRIKSEN, PHD,  ALLAN WEIMANN, PHD,   MORTEN PETERSEN, MD,  JON T. ANDERSEN, MD,  ESPEN JIMENEZ-SOLEM, MD,  ELISABETH S. STOVGAARD, MD,  LARS J. HANSEN, PHD,  JAN ERIK HENRIKSEN, PHD, STEEN J. BONNEMA, PHD  NIELS DE FINE OLIVARIUS, MD, HENRIK E. POULSEN, DMSC,  Urinary Markers of Nucleic Acid Oxidation and Long-Term Mortality of Newly Diagnosed Type 2  Diabetic Patients. Diabetes Care 34:2594–2596, 2011 

 

2012

(313) Pernille Tveden-Nyborg, Stine Hasselholt, Namiyo Miyashita,  Torben Moos, Henrik E. Poulsen,  Jens Lykkesfeldt. Chronic Vitamin C Deficiency does not Accelerate Oxidative Stress in Ageing Brains of Guinea Pigs Basic Clin Pharmacol Toxicol. 2012 Jun;110(6):524-9. doi: 10.1111/j.1742-7843.2011.00852.x. Epub 2012 Jan 20.PMID: 22212866 

(314) Weimann A, Broedbaek K, Henriksen T, Stovgaard ES, Poulsen HE. Assays for urinary biomarkers of oxidatively damaged nucleic acids. Free Radic Res 2012 Apr;46(4):531-40.

(315) Jørgensen A, Jørgensen MB, Poulsen HE.[Stress and aging.] Ugeskr Laeger. 2012 Jan 23;174(4):201-204. Danish. PMID: 22277362

(316) Henrik E. Poulsen, Elisabeth Specht, Kasper Broedbaek,Trine Henriksen, Christina Ellervik, Thomas Mandrup-Poulsen, Morten Tonnesen, Peter E. Nielsen, Henrik U. Andersen, Allan Weimann, RNA modifications by oxidation: A novel disease mechanism?, Free Radical Biology and Medicine (2012), doi:10.1016/j.freeradbiomed.2012.01.009

(317) Sarac SB, Rasmussen CH, Afzal S, Thirstrup S, Jensen SA, Colding-Jørgensen M, Poulsen HE, Mosekilde E.Data-Driven Assessment of the Association of Polymorphisms in 5-Fluorouracil Metabolism Genes with Outcome in Adjuvant Treatment of Colorectal Cancer. Basic Clin Pharmacol Toxicol. 2012 Mar 26. doi: 10.1111/j.1742-7843.2012.00885.x. [Epub ahead of print]

(318) Weeke P, Folke F, Gislason GH, Lippert FK, Olesen JB, Andersson C, Wissenberg M, Poulsen HE, Nielsen SL, Køber L, Torp-Pedersen C.Hospital admissions and pharmacotherapy before out-of-hospital cardiac arrest according to age. Resuscitation. 2012 May;83(5):584-90. Epub 2011 Nov 6.]

(319) Weeke P, Jensen A, Folke F, Gislason GH, Olesen JB, Andersson C, Fosbøl EL, Larsen JK, Lippert FK, Nielsen SL, Gerds T, Andersen PK, Kanters JK, Poulsen HE, Pehrson S, Køber L, Torp-Pedersen C. Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Case-Time-Control Study. Clin Pharmacol Ther. 2012 May 16. doi: 10.1038/clpt.2011.368. [Epub ahead of print]

(320) Afzal S, Jensen SA, Sørensen JB, Henriksen T, Weimann A, Poulsen HE Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin. Cancer Chemother Pharmacol. 2012 Feb;69(2):301-7. Epub 2011 Jun 28.PMID: 21710244 

(321)

(322) Petersen M, Andersen JT, Jimenez-Solem E, Broedbaek K, Hjelvang BR, Henriksen T, Frandsen E, Forman JL, Torp-Pedersen C, Køber L, Poulsen HE. The Effect of the Arg389Gly Beta-1 Adrenoceptor Polymorphism on Plasma Renin Activity and Heart Rate and the Genotype-Dependent Response to Metoprolol Treatment. Clin Exp Pharmacol Physiol. 2012 Jun 16. doi: 10.1111/j.1440-1681.2012.05736.x. [Epub ahead of print]

(323) Meidahl PK, Jimenez-Solem E, Andersen JT, Petersen M, Brodbaek K, Kober L, et al. beta-Blocker treatment during pregnancy and adverse pregnancy outcomes: a nationwide population-based cohort study. BMJ Open 2012;2(4).

(324) Petersen M, Andersen JT, Jimenez-Solem E, Broedbaek K, Afzal S, Nyegaard M, Børglum AD, Stender S, Torp-Pedersen C, Køber L, Poulsen HE.Effect of specific ADRB1/ADRB2/AGT genotype combinations on the association between survival and carvedilol treatment in chronic heart failure: a substudy of the ECHOS trial.Pharmacogenet Genomics. 2012 Jul 2. [Epub ahead of print]

(325)  A. Torp-PedersenE. Jimenez-Solem,J. T. AndersenK. BroedbaekC. Torp-Pedersen, and H. E. Poulsen "Exposure to Mebendazole and Pyrvinium during Pregnancy: A Danish Nationwide Cohort Study," Infectious Diseases in Obstetrics and Gynecology, vol. 2012, Article ID 769851, 6 pages, 2012. doi:10.1155/2012/769851.

(326) Torp-Pedersen A, Jimenez-Solem E, Andersen JT, Broedbaek K, Torp-Pedersen C, Poulsen HE. Exposure to Mebendazole and Pyrvinium during Pregnancy: A Danish Nationwide Cohort Study. Infect Dis Obstet Gynecol 2012;2012:769851..

(327) Egefjord L, Gejl M, Moller A, Braendgaard H, Gottrup H, Antropova O, et al. Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer s disease - protocol for a controlled, randomized double-blinded trial. Dan Med J 2012 Oct;59(10):A4519.

Henrik Enghusen Poulsen: Klinisk farmakologi og farmakoterapi. In: Basisbog i Diagnostiske Fag. Eds. Thomsen HS et al. Munksgaard Forlag. Kapitel 7 (2012) 251-268

2012

(313) Pernille Tveden-Nyborg, Stine Hasselholt, Namiyo Miyashita,  Torben Moos, Henrik E. Poulsen,  Jens Lykkesfeldt. Chronic Vitamin C Deficiency does not Accelerate Oxidative Stress in Ageing Brains of Guinea Pigs Basic Clin Pharmacol Toxicol. 2012 Jun;110(6):524-9. doi: 10.1111/j.1742-7843.2011.00852.x. Epub 2012 Jan 20.PMID: 22212866 

(314) Weimann A, Broedbaek K, Henriksen T, Stovgaard ES, Poulsen HE. Assays for urinary biomarkers of oxidatively damaged nucleic acids. Free Radic Res 2012 Apr;46(4):531-40.

(315) Jørgensen A, Jørgensen MB, Poulsen HE.[Stress and aging.] Ugeskr Laeger. 2012 Jan 23;174(4):201-204. Danish. PMID: 22277362

(316) Henrik E. Poulsen, Elisabeth Specht, Kasper Broedbaek,Trine Henriksen, Christina Ellervik, Thomas Mandrup-Poulsen, Morten Tonnesen, Peter E. Nielsen, Henrik U. Andersen, Allan Weimann, RNA modifications by oxidation: A novel disease mechanism?, Free Radical Biology and Medicine (2012), doi:10.1016/j.freeradbiomed.2012.01.009

(317) Sarac SB, Rasmussen CH, Afzal S, Thirstrup S, Jensen SA, Colding-Jørgensen M, Poulsen HE, Mosekilde E.Data-Driven Assessment of the Association of Polymorphisms in 5-Fluorouracil Metabolism Genes with Outcome in Adjuvant Treatment of Colorectal Cancer. Basic Clin Pharmacol Toxicol. 2012 Mar 26. doi: 10.1111/j.1742-7843.2012.00885.x. [Epub ahead of print]

(318) Weeke P, Folke F, Gislason GH, Lippert FK, Olesen JB, Andersson C, Wissenberg M, Poulsen HE, Nielsen SL, Køber L, Torp-Pedersen C.Hospital admissions and pharmacotherapy before out-of-hospital cardiac arrest according to age. Resuscitation. 2012 May;83(5):584-90. Epub 2011 Nov 6.]

(319) Weeke P, Jensen A, Folke F, Gislason GH, Olesen JB, Andersson C, Fosbøl EL, Larsen JK, Lippert FK, Nielsen SL, Gerds T, Andersen PK, Kanters JK, Poulsen HE, Pehrson S, Køber L, Torp-Pedersen C. Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Case-Time-Control Study. Clin Pharmacol Ther. 2012 May 16. doi: 10.1038/clpt.2011.368. [Epub ahead of print]

(320) Afzal S, Jensen SA, Sørensen JB, Henriksen T, Weimann A, Poulsen HE Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin. Cancer Chemother Pharmacol. 2012 Feb;69(2):301-7. Epub 2011 Jun 28.PMID: 21710244 

(321) Espen Jimenez-Solem, Jon Traerup Andersen, Morten Petersen, Kasper Broedbaek, Jonas Krogh Jensen, Shoaib Afzal, Gunnar H Gislason, Christian Torp-Pedersen, Henrik Enghusen Poulsen Exposure to selective serotonin reuptake inhibitors and the risk of congenital malformations: a nationwide cohort studyPharmacology and therapeutics BMJ Open 2012;2:e001148 doi:10.1136/bmjopen-2012-001148Free via Creative Commons: OPEN ACCESS

(322) Petersen M, Andersen JT, Jimenez-Solem E, Broedbaek K, Hjelvang BR, Henriksen T, Frandsen E, Forman JL, Torp-Pedersen C, Køber L, Poulsen HE. The Effect of the Arg389Gly Beta-1 Adrenoceptor Polymorphism on Plasma Renin Activity and Heart Rate and the Genotype-Dependent Response to Metoprolol Treatment. Clin Exp Pharmacol Physiol. 2012 Jun 16. doi: 10.1111/j.1440-1681.2012.05736.x. [Epub ahead of print]

(323) Meidahl PK, Jimenez-Solem E, Andersen JT, Petersen M, Brodbaek K, Kober L, et al. beta-Blocker treatment during pregnancy and adverse pregnancy outcomes: a nationwide population-based cohort study. BMJ Open 2012;2(4).

(324) Petersen M, Andersen JT, Jimenez-Solem E, Broedbaek K, Afzal S, Nyegaard M, Børglum AD, Stender S, Torp-Pedersen C, Køber L, Poulsen HE.Effect of specific ADRB1/ADRB2/AGT genotype combinations on the association between survival and carvedilol treatment in chronic heart failure: a substudy of the ECHOS trial.Pharmacogenet Genomics. 2012 Jul 2. [Epub ahead of print]

(325)  A. Torp-PedersenE. Jimenez-Solem,J. T. AndersenK. BroedbaekC. Torp-Pedersen, and H. E. Poulsen "Exposure to Mebendazole and Pyrvinium during Pregnancy: A Danish Nationwide Cohort Study," Infectious Diseases in Obstetrics and Gynecology, vol. 2012, Article ID 769851, 6 pages, 2012. doi:10.1155/2012/769851.

(326) Torp-Pedersen A, Jimenez-Solem E, Andersen JT, Broedbaek K, Torp-Pedersen C, Poulsen HE. Exposure to Mebendazole and Pyrvinium during Pregnancy: A Danish Nationwide Cohort Study. Infect Dis Obstet Gynecol 2012;2012:769851..

(327) Egefjord L, Gejl M, Moller A, Braendgaard H, Gottrup H, Antropova O, et al. Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer s disease - protocol for a controlled, randomized double-blinded trial. Dan Med J 2012 Oct;59(10):A4519.

Henrik Enghusen Poulsen: Klinisk farmakologi og farmakoterapi. In: Basisbog i Diagnostiske Fag. Eds. Thomsen HS et al. Munksgaard Forlag. Kapitel 7 (2012) 251-268

 

2013

 

(328)  Mullner E, Brath H, Pleifer S, Schiermayr C, Baierl A, Wallner M, et al. Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes. Mol. Nutr. Food Res. 2013, 57, 328–338 

 

(329) Broedbaek K, Siersma V, Henriksen T, Weimann A, Petersen M, Andersen JT, et al. Association between urinary markers of nucleic acid oxidation and mortality in type 2 diabetes: a population-based cohort study. Diabetes Care 2013 Mar;36(3):669-76.]PMID:23150279 

 

(330) Barregard L, Moller P, Henriksen T, Mistry V, Koppen G, Rossner P, Jr., et al. Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2'-deoxyguanosine. Antioxid Redox Signal 2013 Jan 31.

 

(331)  Andersen JT, Petersen M, Jimenez-Solem E, Broedbaek K, Andersen NL, Torp-Pedersen C, Keiding N, Poulsen HE.Clarithromycin in early pregnancy and the risk of miscarriage and malformation: a register based nationwide cohort study.PLoS One. 2013;8(1):e53327. doi: 10.1371/journal.pone.0053327. Epub 2013 Jan 2.

 

(332)  Jorgensen A, Maigaard K, Wortwein G, Hageman I, Henriksen T, Weimann A, et al. Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage. Prog Neuropsychopharmacol Biol Psychiatry 2013 Jan 10;40:30-7.

 

(333) Jimenez-Solem E, Andersen JT, Petersen M, Broedbaek K, Lander AR, Afzal S, et al. SSRI use during pregnancy and risk of stillbirth and neonatal mortality. Am J Psychiatry 2013 Mar 1;170(3):299-304.PMID: 23361562

 

(334)  Jimenez-Solem E, Andersen JT, Petersen M, Broedbaek K, Andersen NL, Torp-Pedersen C, Poulsen HE. Prevalence of Antidepressant Use during Pregnancy in Denmark, a Nation-Wide Cohort Study. PLoS One. 2013 Apr 25;8(4):e63034. doi: 10.1371/journal.pone.0063034. Print 2013. PMID:23638179[PubMed

 

(335)  Kalliokoski O, Jacobsen KR, Darusman HS, Henriksen T, Weimann A, Poulsen HE, Hau J, Abelson KS. Mice do not habituate to metabolism cage housing--a three week study of male BALB/c mice. PLoS One. 2013;8(3):e58460. doi: 10.1371/journal.pone.0058460. Epub 2013 Mar 7. PMID:23505511[PubMed - in process]

 

(336) Jorgensen A, Krogh J, Miskowiak K, Bolwig TG, Kessing LV, Fink-Jensen A, Nordentoft M, Henriksen T, Weimann A, Poulsen HE, Jorgensen MB. Systemic oxidatively generated DNA/RNA damage in clinical depression: Associations to symptom severity and response to electroconvulsive therapy. J Affect Disord 2013 Jul;149(1-3):355-62. PMID:23497793

 

(337) Andersen JT, Petersen M, Jimenez-Solem E, Rasmussen JN, Andersen NL, Afzal S, Broedbaek K, Hjelvang BR, Køber L, Torp-Pedersen C, Poulsen HE.
Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study. Obstet Gynecol Int. 2013;2013:364526. doi: 10.1155/2013/364526. Epub 2013 Feb 14. PMID:23476656[PubMed] Free PMC Article

 

(338)  Loft S, Olsen A, Moller P, Poulsen HE, Tjonneland A. Association between 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and risk of postmenopausal breast cancer: nested case-control study.  Cancer Epidemiol Biomarkers Prev. 2013 May 8. [Epub ahead of print]

 

(339) Klarskov P, Andersen JT, Jimenez-Solem E, Torp-Pedersen C, Poulsen HE. Short-acting sulfonamides near term and neonatal jaundice. Obstet Gynecol 2013 Jul;122(1):105-10.

 

(340) Andersen JT, Petersen M, Jimenez-Solem E, Broedbaek K, Andersen EW, Andersen NL, et al. Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study. Epidemiol Infect 2013 Aug;141(8):1749-55.

 

(341) Wallner M, Antl N, Rittmannsberger B, Schreidl S, Najafi K, Müllner E, Mölzer C, Ferk F, Knasmüller S, Marculescu R, Doberer D, Poulsen HE, Vitek L, Bulmer AC, Wagner KH. Anti-genotoxic potential of bilirubin in-vivo: Damage to DNA in hyperbilirubinemic human and animal models.  Cancer Prev Res 6 (10) October 2013 PMID: 23983086

 

(342) Jorgensen A, Broedbaek K, Fink-Jensen A, Knorr U, Greisen Soendergaard M, Henriksen T, Weimann A, Jepsen P, Lykkesfeldt J, Poulsen HE, Balslev Jorgensen M. Increased systemic oxidatively generated DNA and RNA damage in schizophrenia. Psychiatry Res. 2013 Oct 30;209(3):417-23. doi: 10.1016/j.psychres.2013.01.033.

 

(343)  Broedbaek, Kasper; Andersen, Jon T.; Jimenez-Solem, Espen; Petersen, Morten; Lajer, Maria; Henriksen, Trine; Weimann, Allan; Parving, Hans-Henrik; Rossing, Peter; Poulsen, Henrik. RNA oxidation and albuminuria in type 1 diabetes patients. Cardiovascular  Endocrinology: December 2013 - Volume 2 - Issue 4 - p 103-105

 

2014

 

(344) Poulsen HE, Nadal LL, Broedbaek K, Nielsen PE, Weimann A. Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid.
Biochim Biophys Acta. 2014 Feb;1840(2):801-8. doi: 10.1016/j.bbagen.2013.06.009. Epub 2013 Jun 19.

 

(345) Grew IS, Cejvanovic V, Broedbaek K, Henriksen T, Petersen M, Andersen JT, Jimenez-Solem E, Weimann A, Poulsen HE. Diurnal variation of urinary markers of nucleic acid oxidation. Scand J Clin Lab Invest. 2014 Mar 16. [Epub ahead of print] PMID: 24628455

 

(346) Bølling R, Scheller NM, Køber L, Poulsen HE, Gislason GH, Torp-Pedersen C. Comparison of the clinical outcome of different beta-blockers in heart failure patients: a retrospective nationwide cohort study. Eur J Heart Fail. 2014 Apr 4. doi: 10.1002/ejhf.81. [Epub ahead of print] PMID: 24706485 [PubMed - as supplied by publisher]

 

(347) Bjarke Askaa, Espen Jimenez-Solem, Henrik Enghusen Poulsen, Jon Traerup Andersen, Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during Pregnancy Obstetrics and Gynecology International, vol. 2014, Article ID 945621, 5 pages, 2014. doi:10.1155/2014/945621.

 

(348) Cejvanovic V, Jimenez-Solem E, Poulsen H, Andersen J. NSAID use during pregnancy: maternal characteristics and prescription patterns. A nationwide cohort study. Scand J Rheumatol 2014 Apr 22.

 

(349) Weeke P, Jensen A, Folke F, Gislason GH, Olesen JB, Fosbøl EL, Wissenberg M, Lippert FK, Christensen EF, Nielsen SL, Holm E, Kanters JK, Poulsen HE, Køber L, Torp-Pedersen C.  Antipsychotics and associated risk of out-of-hospital cardiac arrest. Clin Pharmacol Ther. 2014 Jun 24. doi: 10.1038/clpt.2014.139. [Epub ahead of print]

 

(350) Munkholm K, Poulsen HE, Kessing LV, Vinberg M. Elevated levels of urinary markers of oxidatively generated DNA and RNA damage in bipolar disorder.  Bipolar Disord. 2014 Aug 13. doi: 10.1111/bdi.12245. [Epub ahead of print]  PMID: 25118140 [PubMed - as supplied by publisher]

 

(350) Jon Trærup Andersen, MD, PhD, Nadia Lyhne Andersen, MD, PhD, Henrik Horwitz, MD, Henrik Enghusen Poulsen, MD, DMSc, and Espen Jimenez-Solem, MD, PhDExposure to Selective Serotonin Reuptake Inhibitors in Early Pregnancy and the Risk of Miscarriage  OBSTETRICS & GYNECOLOGY

 

(351) Nielsen TK1, Højgaard M, Andersen JT, Poulsen HE, Lykkesfeldt J, Mikines KJ. Elimination of Ascorbic Acid following High-Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation. Basic Clin Pharmacol Toxicol. 2014 Sep 12. doi: 10.1111/bcpt.12323. [Epub ahead of print]

 

 

Andre publikationer

1990

(1) Poulsen HE, Juul P. Note on the statistical evaluation of a randomized, cross-over bioavailability study. Danish National Board of Health, 1990  PDF (289K) 

1992

Boesgaard S, Aldershvile J, Poulsen HE. Preventive administration of intravenous N-acetylcysteine and development of tolerance to isosorbide dinitrate in patients with angina pectoris. Circulation 1992 Jan;85(1):143-9.

Dalhoff K, Ranek L, Mantoni M, Poulsen HE. Glutathione treatment of hepatocellular carcinoma. Liver 1992 Oct;12(5):341-3.

Dalhoff K, Poulsen HE. Effects of cysteine and acetaminophen on the syntheses of glutathione and adenosine 3'-phosphate 5'-phosphosulfate in isolated rat hepatocytes. Biochem Pharmacol 1992 Aug 4;44(3):447-54.

Fischer-Nielsen A, Poulsen HE, Loft S. 8-Hydroxydeoxyguanosine in vitro: effects of glutathione, ascorbate, and 5-aminosalicylic acid. Free Radic Biol Med 1992;13(2):121-6.

Loft S, Vistisen K, Ewertz M, Tjonneland A, Overvad K, Poulsen HE. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis 1992 Dec;13(12):2241-7.

Loft S, Otte J, Poulsen HE, Sorensen H. Influence of intact and myrosinase-treated indolyl glucosinolates on the metabolism in vivo of metronidazole and antipyrine in the rat. Food Chem Toxicol 1992 Nov;30(11):927-35.

Sherson D, Sigsgaard T, Overgaard E, Loft S, Poulsen HE, Jongeneelen FJ. Interaction of smoking, uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers. Br J Ind Med 1992 Mar;49(3):197-202.

Vistisen K, Poulsen HE, Loft S. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis 1992 Sep;13(9):1561-8.

1991

Andersson R, Poulsen HE, Ahren B. Effect of bile on liver function tests in experimental E. coli peritonitis in the rat. Hepatogastroenterology 1991 Oct;38(5):388-90.

Boesgaard S, Petersen JS, Aldershvile J, Poulsen HE, Flachs H. Nitrate tolerance: effect of thiol supplementation during prolonged nitroglycerin infusion in an in vivo rat model. J Pharmacol Exp Ther 1991 Sep;258(3):851-6.

Dalhoff K, Hansen PB, Ott P, Loft S, Poulsen HE. Acute ethanol administration reduces the antidote effect of N-acetylcysteine after acetaminophen overdose in mice. Hum Exp Toxicol 1991 Nov;10(6):431-3.

Fischer-Nielsen A, Poulsen HE, Hansen BA, Hage E, Keiding S. CCl4 cirrhosis in rats: irreversible histological changes and differentiated functional impairment. J Hepatol 1991 Jan;12(1):110-7.

Loft S, Otton SV, Lennard MS, Tucker GT, Poulsen HE. Characterization of metronidazole metabolism by human liver microsomes. Biochem Pharmacol 1991 Apr 15;41(8):1127-34.

Loft S, Nielsen AJ, Borg BE, Poulsen HE. Metronidazole and antipyrine metabolism in the rat: clearance determination from one saliva sample. Xenobiotica 1991 Jan;21(1):33-46.

Poulsen HE, Ranek L, Jorgensen L. The influence of disulfiram on acetaminophen metabolism in man. Xenobiotica 1991 Feb;21(2):243-9.

Sjovall S, Ahren B, Hansson P, Loft S, Poulsen HE, Bengmark S. Metabolic responses to intermittent hepatic dearterialization in the rat. J Hepatol 1991 Jul;13(1):33-7.

Vistisen K, Loft S, Poulsen HE. Cytochrome P450 IA2 activity in man measured by caffeine metabolism: effect of smoking, broccoli and exercise. Adv Exp Med Biol 1991;283:407-11.

1990

Hinson JA, Roberts DW, Benson RW, Dalhoff K, Loft S, Poulsen HE. Mechanism of paracetamol toxicity. Lancet 1990 Mar 24;335(8691):732.

Loft S, Poulsen HE. Metabolism of metronidazole and antipyrine in hepatocytes isolated from mouse and rat. Xenobiotica 1990 Feb;20(2):185-91.

Loft S, Poulsen HE. Prediction of xenobiotic metabolism by non-invasive methods. Pharmacol Toxicol 1990 Aug;67(2):101-8.

Loft S, Egsmose C, Sonne J, Poulsen HE, Dossing M, Andreasen PB. Metronidazole elimination is preserved in the elderly. Hum Exp Toxicol 1990 May;9(3):155-9.

Ott P, Dalhoff K, Hansen PB, Loft S, Poulsen HE. Consumption, overdose and death from analgesics during a period of over-the-counter availability of paracetamol in Denmark. J Intern Med 1990 Jun;227(6):423-8.

Ott P, Hansen PB, Dalhoff KP, Loft SH, Poulsen HE. [Consumption of, overdose and fatal poisoning with analgesics in Denmark 1979-1986]. Ugeskr Laeger 1990 Jan 22;152(4):250-2.

Ott P, Dalhoff KP, Poulsen HE. [Analgesic-induced mortality]. Ugeskr Laeger 1990 Sep 24;152(39):2867-8.

Sonne J, Boesgaard S, Poulsen HE, Loft S, Hansen JM, Dossing M, et al. Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism. Br J Clin Pharmacol 1990 Nov;30(5):737-42.

1989

Fischer-Nielsen A, Poulsen HE, Hansen BA, Tygstrup N, Keiding S. Age dependence of rat liver function measurements. J Hepatol 1989 Sep;9(2):190-7.

Loft S, Poulsen HE. Metabolism of metronidazole and antipyrine in isolated rat hepatocytes. Influence of sex and enzyme induction and inhibition. Biochem Pharmacol 1989 Apr 1;38(7):1125-36.

Perrild H, Kayser L, Poulsen HE, Skovsted L, Jorgensen B, Hansen JM. Differential effect of continuous administration of beta-adrenoceptor antagonists on antipyrine and phenytoin clearance. Br J Clin Pharmacol 1989 Nov;28(5):551-4.

Poulsen HE, Hansen BA, Egeberg JC. Neutral red changes arginine-induced glucagon and insulin response in the rat. Pharmacol Toxicol 1989 Jul;65(1):65-8.

Tvede KG, Loft S, Poulsen HE, Schou JS. Methyl parathion toxicity in rats is changed by pretreatment with the pesticides chlordecone, mirex and linuron. Arch Toxicol Suppl 1989;13:446-7.

1988

Jorgensen L, Thomsen P, Poulsen HE. Disulfiram prevents acetaminophen hepatotoxicity in rats. Pharmacol Toxicol 1988 May;62(5):267-71.

Knudsen GM, Poulsen HE, Paulson OB. Blood-brain barrier permeability in galactosamine-induced hepatic encephalopathy. No evidence for increased GABA-transport. J Hepatol 1988 Apr;6(2):187-92.

Loft S, Poulsen HE, Sonne J, Dossing M. Metronidazole clearance: a one-sample method and influencing factors. Clin Pharmacol Ther 1988 Apr;43(4):420-8.

Loft S, Dossing M, Poulsen HE. Influence of age and consumption of tobacco, alcohol and caffeine on antipyrine clearance. Hum Toxicol 1988 May;7(3):277-80.

Loft S, Dossing M, Sonne J, Dalhof K, Bjerrum K, Poulsen HE. Lack of effect of cimetidine on the pharmacokinetics and metabolism of a single oral dose of metronidazole. Eur J Clin Pharmacol 1988;35(1):65-8.

Poulsen HE, Thomsen P. Long-term administration of toxic doses of paracetamol (acetaminophen) to rats. Liver 1988 Jun;8(3):151-6.

Poulsen HE, Loft S. Antipyrine as a model drug to study hepatic drug-metabolizing capacity. J Hepatol 1988 Jun;6(3):374-82.

Sonne J, Poulsen HE, Loft S, Dossing M, Vollmer-Larsen A, Simonsen K, et al. Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism. Eur J Clin Pharmacol 1988;35(1):109-11.

1987

Adelhoj B, Petring OU, Frosig F, Jensen BN, Ibsen M, Poulsen HE. The effect of spinal analgesia and surgery on peroperative drug absorption and gastric emptying in man. Acta Anaesthesiol Scand 1987 Feb;31(2):165-7.

Dalhoff K, Poulsen HE, Garred P, Placchi M, Gammans RE, Mayol RF, et al. Buspirone pharmacokinetics in patients with cirrhosis. Br J Clin Pharmacol 1987 Oct;24(4):547-50.

Loft S, Sonne J, Poulsen HE, Petersen KT, Jorgensen BG, Dossing M. Inhibition and induction of metronidazole and antipyrine metabolism. Eur J Clin Pharmacol 1987;32(1):35-41.

Petersen KF, Hansen BA, Poulsen HE. Hepatic regeneration following glucagon treatment. Horm Metab Res 1987 Jun;19(6):239-41.

Petring OU, Adelhoj B, Ibsen M, Poulsen HE. Effect of chlorpromazine on drug absorption and gastric emptying in man. Can J Anaesth 1987 Nov;34(6):563-5.

Poulsen HE, Jorgensen L, Thomsen P. Prevention of acetaminophen hepatotoxicity by disulfiram. Pharmacol Ther 1987;33(1):83.

Sonne J, Dossing M, Poulsen HE, Pilsgaard H, Rasmussen B, Loft S. Effect of concomitant administration of cimetidine and phenobarbital on antipyrine elimination and metabolite formation. Int J Clin Pharmacol Ther Toxicol 1987 Apr;25(4):194-6.

1986

Hansen BA, Poulsen HE. The capacity of urea-N synthesis as a quantitative measure of the liver mass in rats. J Hepatol 1986;2(3):468-74.

Hansen BA, Poulsen HE. Starvation induced changes in quantitative measures of liver function in the rat. Clin Nutr 1986 Nov;5(4):213-6.

Loft S, Dossing M, Poulsen HE, Sonne J, Olesen KL, Simonsen K, et al. Influence of dose and route of administration on disposition of metronidazole and its major metabolites. Eur J Clin Pharmacol 1986;30(4):467-73.

Petring OU, Adelhoj B, Ibsen M, Poulsen HE. The relationship between gastric emptying of semisolids and paracetamol absorption. Br J Clin Pharmacol 1986 Dec;22(6):659-62.

Sonne J, Poulsen HE, Andreasen PB. Single dose oxazepam has no effect on acetaminophen clearance or metabolism. Eur J Clin Pharmacol 1986;30(1):127-9.

 

1985

(17) Adelhøj B, Petring OU, Brynnum J, Ibsen M, Poulsen HE. Effect of diazepam on drug absorption and gastric emptying in man. Br J Anaesth 1985; 57(11):1107-1109.

(18) Adelhøj B, Petring OU, Ibsen M, Brynnum J, Poulsen HE. Buprenorphine delays drug absorption and gastric emptying in man. Acta Anaesth Scand 1985; 29(6):599-601.

(19) Adelhøj B, Petring OU, Ibsen M, Brynnum J, Poulsen HE. Tardiv respirationsdepression efter intravenøs buprenorfin. Ugeskr Laeger 1985; 147:1343.

(20) Petring OU, Adelhøj B, Ibsen M, Brynnum J, Poulsen HE. Abstaining from cigarette smoking has no major effect on gastric emptying in habitual smokers. Br J Anaesth 1985; 57(11):1104-1106

(21) Poulsen HE. One sample antipyrine clearance after 90% partial hepatectomy in the rat. Liver 1985; 5(4):200-204.

(22) Poulsen HE, Lerche A, Skovgaard LT. Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose. Biochem Pharmacol 1985;34(20):3729-3733.

(23) Poulsen HE, Pilsgaard H. Antipyrine metabolism during hepatic regeneration in the rat. Liver 1985; 5(4):196-199.

(24) Poulsen HE, Lerche A, Pedersen NT. Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. Pharmacology 1985; 30(2):100-108.

(25) Poulsen HE, Gaub J, Iversen J. Changes in quantitative measures of hepatic function after 90% hepatectomy in rats. European Journal of Clinical Investigation1985; 15(5):285-289.

(26) Poulsen HE, Lerche A, Pedersen NT. Potentiated hepatotoxicity from concurrent administration of acetaminophen and allyl alcohol to rats. Biochem Pharmacol 1985;34(6):727-731.

(27) Tvedegaard E, Poulsen HE, Vilstrup H, Thomsen HK. Functional status of the liver during chronic renal failure: an experimental study in the rabbit. Liver 1985; 5(4):183-188.

1984

Pilsgaard H, Poulsen HE. A one-sample method for antipyrine clearance determination in rats. Pharmacology 1984;29(2):110-6.

Poulsen HE, Ranek L. [Paracetamol poisoning]. Ugeskr Laeger 1984 Dec 17;146(51):4030-3.

Poulsen HE, Vilstrup H, Keiding S. Galactose elimination kinetics in perfused rat liver after two thirds hepatectomy. Scand J Clin Lab Invest 1984 Apr;44(2):155-8.

Poulsen HE, Korsholm B. Quantitative liver functions after administration of allyl alcohol to rats. Acta Pharmacol Toxicol (Copenh) 1984 Feb;54(2):120-3.

Tvedegaard E, Poulsen HE, Vilstrup H, Thomsen HK. Liver function during chronic renal failure in rabbits. Experientia 1984 Nov 15;40(11):1255-6.

1983

Dossing M, Volund A, Poulsen HE. Optimal sampling times for minimum variance of clearance determination. Br J Clin Pharmacol 1983 Feb;15(2):231-5.

Dossing M, Pilsgaard H, Rasmussen B, Poulsen HE. Time course of phenobarbital and cimetidine mediated changes in hepatic drug metabolism. Eur J Clin Pharmacol 1983;25(2):215-22.

Poulsen HE. A pocket calculator program to sort data. Comput Biol Med 1983;13(4):299-301.

1982

Dossing M, Poulsen HE, Andreasen PB, Tygstrup N. A simple method for determination of antipyrine clearance. Clin Pharmacol Ther 1982 Sep;32(3):392-6.

1981

Poulsen HE, Ranek L, Andreasen PB. The hepatic glutathione content in liver diseases. Scand J Clin Lab Invest 1981 Oct;41(6):573-6.

Poulsen HE, Petersen P, Vilstrup H. Quantitative liver function and morphology after paracetamol administration to rats. Eur J Clin Invest 1981 Jun;11(3):161-4.

Sonne J, Poulsen HE, Dossing M, Larsen NE, Andreasen PB. Cimetidine clearance and bioavailability in hepatic cirrhosis. Clin Pharmacol Ther 1981 Feb;29(2):191-7.

Yildirim SI, Poulsen HE. Quantitative liver functions after 70% hepatectomy. Eur J Clin Invest 1981 Dec;11(6):469-72.