(1(1) Poulsen HE, Ranek L.
Ulcus duodeni som årsag til miltvenetrombose og eosophagusvaricer.
Ugeskr Laeger 1976;
138:1712-1713.
(2) Poulsen HE, Bengmark
S, Borgeson S, Flodgren P, Kallum B. Staging laparotomy with splenectomy in Hodkin's disease.
Acta Chir Scand 1977; 143:347-357.
(3) Milandri M, Poulsen HE, Ranek L,
Andreasen PB. Effect of long-term disulfiram administration on rat liver. Pharmacology
1980; 21(1):76-80.
(5) Poulsen HE, Petersen P, Vilstrup
H. Quantitative liver function and morphology after paracetamol
administration to rats. European Journal of Clinical Investigation 1981; 11(3):161-164.
(6) Sonne J, Poulsen HE, Dossing M,
Larsen NE, Andreasen PB. Cimetidine clearance and bioavailability in
hepatic cirrhosis.
Clin Pharmacol Ther 1981; 29(2):191-197.
(7) Yildirim SI, Poulsen HE.
Quantitative liver functions after 70% hepatectomy. European Journal of Clinical Investigation
1981; 11(6):469-472.
(8) Dossing M, Poulsen HE, Andreasen
PB, Tygstrup N. A simple method for determination of antipyrine clearance. Clin
Pharmacol Ther 1982; 32(3):392-396.
(9) Dossing M, Volund A, Poulsen HE.
Optimal sampling times for minimum variance of clearance determination. Br J Clin
Pharmacol 1983; 15(2):231-235.
(10) Dossing M, Pilsgaard H, Rasmussen
B, Poulsen HE. Time course of phenobarbital and cimetidine mediated
changes in hepatic drug metabolism. European Journal of Clinical Pharmacology
1983; 25(2):215-222.
(11) Poulsen HE. A pocket calculator program to sort data. Comput Biol Med 1983; 13(4):299-301.
(12) Pilsgaard H, Poulsen HE. A
one-sample method for antipyrine clearance determination in rats. Pharmacology
1984; 29(2):110-116.
(13) Poulsen HE, Vilstrup H, Keiding
S. Galactose elimination kinetics in perfused rat liver after two thirds
hepatectomy. Scand J Clin Lab Invest 1984; 44(2):155-158.
(14) Poulsen HE, Korsholm B.
Quantitative liver functions after administration of allyl alcohol to rats. Acta Pharmacol
Toxicol 1984; 54(2):120-123.
(15) Poulsen HE, Ranek L. Paracetamolforgiftning. Ugeskr Laeger 1984; 146:4030-4033.
(16) Tvedegaard E, Poulsen HE,
Vilstrup H, Thomsen HK. Liver function during chronic renal failure in rabbits.
Experientia 1984; 40(11):1255-1256.
(17)
Adelhøj B, Petring OU, Brynnum J, Ibsen M, Poulsen HE. Effect of
diazepam on drug absorption and gastric emptying in man. Br J Anaesth 1985; 57(11):1107-1109.
(18) Adelhøj B, Petring OU, Ibsen M,
Brynnum J, Poulsen HE. Buprenorphine delays drug absorption and gastric emptying in
man. Acta Anaesth Scand 1985; 29(6):599-601.
(19) Adelhøj B, Petring OU, Ibsen M,
Brynnum J, Poulsen HE. Tardiv respirationsdepression efter
intravenøs buprenorfin.
Ugeskr Laeger 1985; 147:1343.
(20) Petring OU, Adelhøj B, Ibsen M,
Brynnum J, Poulsen HE. Abstaining from cigarette smoking has no
major effect on gastric emptying in habitual smokers. Br J Anaesth
1985; 57(11):1104-1106
(21) Poulsen HE. One sample antipyrine
clearance after 90% partial hepatectomy in the rat. Liver 1985;
5(4):200-204.
(22) Poulsen HE, Lerche A, Skovgaard
LT. Acetaminophen metabolism by the perfused rat liver twelve hours
after acetaminophen overdose. Biochem Pharmacol 1985;34(20):3729-3733.
(23) Poulsen HE, Pilsgaard H.
Antipyrine metabolism during hepatic regeneration in the rat. Liver
1985; 5(4):196-199.
(24) Poulsen HE, Lerche A, Pedersen
NT. Phenobarbital induction does not potentiate hepatotoxicity but
accelerates liver cell necrosis from acetaminophen overdose in the rat. Pharmacology 1985;
30(2):100-108.
(25) Poulsen HE, Gaub J, Iversen J.
Changes in quantitative measures of hepatic function after 90%
hepatectomy in rats. European Journal of Clinical Investigation1985; 15(5):285-289.
(26) Poulsen HE, Lerche A, Pedersen
NT. Potentiated hepatotoxicity from concurrent administration of
acetaminophen and allyl alcohol to rats. Biochem Pharmacol 1985;34(6):727-731.
(27) Tvedegaard E, Poulsen HE,
Vilstrup H, Thomsen HK. Functional status of the liver during
chronic renal failure: an experimental study in the rabbit. Liver
1985; 5(4):183-188.
(28) Hansen BA, Poulsen HE. The
capacity of urea-N synthesis as a quantitative measure of the liver mass in rats. J
Hepatol 1986; 2(3):468-474.
(29) Hansen BA, Poulsen HE. Changes in
the hepatic capacity of urea-N synthesis, galactose elimination and
antipyrine clearance following 70% hepatectomy in the rat. Scand J Clin
Lab Invest 1986; 46:233-237.
(30) Hansen BA, Poulsen HE. Starvation
induced changes in quantitative measures of liver function in the rat. Clin
Nutrit 1986; 5:213-216.
(31) Loft S, Dossing M, Poulsen HE,
Sonne J, Olesen KL, Simonsen K et al. Influence of dose and route of
administration on disposition of metronidazole and its major
metabolites. European Journal of Clinical Pharmacology 1986;
30(4):467-473.
(32) Loft S, Sonne J, Pilsgaard H,
Dossing M, Poulsen HE, Ciraulo DA et al. Inhibition of antipyrine
elimination by disulfiram and cimetidine: the effect of concomitant
administration Pharmacokinetic interaction of disulfiram and antidepressants. British Journal of Clinical
Pharmacology 1986; 21:75-77.
(33) Petring OU, Adelhøj B, Ibsen M,
Poulsen HE. The relationship between gastric emptying of semisolids and paracetamol
absorption. Br J Clin Pharmacol 1986; 22(6):659-662.
(34) Poulsen HE. Kvantitering af leverfunktionen ved eksperimentel akut toksisk leverskade sammenlignet med forholdene efter partiel og subtotal hepatectomi. Disputats. Copenhagen: University of Copenhagen, 1986.
(35) Sonne J, Poulsen HE, Andreasen PB.
Single dose oxazepam has no effect on acetaminophen clearance or
metabolism. European Journal of Clinical Pharmacology 1986 ;
30(1):127-129.
(37) Dalhoff K, Poulsen HE, Garred P,
Placchi M, Gammans RE, Mayol RF et al. Buspirone pharmacokinetics in
patients with
cirrhosis. Br J Clin Pharmacol 1987; 24(4):547-550.
(38) Loft S, Sonne J, Poulsen HE,
Petersen KT, Jorgensen BG, Dossing M. Inhibition and induction of
metronidazole and antipyrine metabolism. European Journal of Clinical Pharmacology 1987; 32(1):35-41.
(39) Petersen KF, Hansen BA, Poulsen
HE. Hepatic regeneration following glucagon treatment. Horm Metab
Res 1987; 19(6):239-241.
(40) Petring OU, Adelhøj B, Ibsen M,
Poulsen HE. Effect of chlorpromazine on drug absorption and gastric emptying in man.
Can J Anaesth 1987; 34(6):563-565.
(41) Poulsen HE, Loft S. Quantitation
of liver function: Antipyrine, an update. In: Okolicsanyi L, editor.
Assessment and management of hepatobiliary disease. Berlin
Heidelberg: Springer-Verlag, 1987: 189-195.
(42) Poulsen HE, Jorgensen L, Thomsen
P. Prevention of acetaminophen hepatotoxicity by disulfiram. Pharmacol Ther
1987; 33(1):83.
(43) Sonne J, Dossing M, Poulsen HE,
Pilsgaard H, Rasmussen B, Loft S. Effect of concomitant
administration of cimetidine and phenobarbital on antipyrine
elimination and metabolite formation. Int J Clin Pharmacol Ther Toxicol 1987; 25(4):194-196.
(44) Tygstrup N, Poulsen HE.
Post-marketing surveillance of hepatotoxicity. Milan, Italy: Wichtig Editore, 1987.
(47) Knudsen GM, Poulsen HE. Unchanged
blood-brain barrier permability to GABA in experimental hepatic
encephalopathy. In: Soeter PB, Wilson JHP, Maijer AJ, Holm E,
editors. Advances in ammonia metabolism and hepatic encephalopathy. Elsevier Science Publishers B.V., 1988: 309-313.
(48) Loft S, Poulsen HE, Sonne J,
Dossing M. Metronidazole clearance: a one-sample method and influencing factors. Clin
Pharmacol Ther 1988; 43(4):420-428.
(49) Loft S, Dossing M, Sonne J,
Dalhof K, Bjerrum K, Poulsen HE. Lack of effect of cimetidine on the
pharmacokinetics and metabolism of a single oral dose of
metronidazole. European Journal of Clinical Pharmacology 1988; ;
35(1):65-68.
(50) Loft S, Dossing M, Poulsen HE.
Influence of age and consumption of tobacco, alcohol and caffeine on on antipyrine
clearance. Hum Toxicol 1988; 7(3):277-280.
(51) Poulsen HE, Thomsen P. Long-term
administration of toxic doses of paracetamol (acetaminophen) to
rats. Liver 1988; 8(3):151-156.
(52) Poulsen HE, Loft S. Antipyrine as
a model drug to study hepatic drug-metabolizing capacity. J Hepatol 1988; 6(3):374-382.
(53) Sonne J, Poulsen HE, Loft S,
Dossing M, Vollmer-Larsen A, Simonsen K et al. Therapeutic doses of
codeine have no effect on acetaminophen clearance or metabolism. European Journal of Clinical Pharmacology
1988; 35(1):109-111.
(54) Vilstrup H, Hansen BA, Almdal T,
PetersenKF, Siggaard I, Poulsen HE. The capacity of urea synthesis
in rats: regulation and physiological importance. In: Soeters PB,
editor. Advances in ammonia metabolism and hepatic encephalopathy.
Elsevier Science Publisheres B.V., 1988: 79-85
(55) Fischer-Nielsen A, Poulsen HE,
Hansen BA, Tygstrup N, Keiding S. Age dependence of rat liver function measurements. J
Hepatol 1989; 9(2):190-197.
(56) Loft S, Poulsen HE. Metabolism of
metronidazole and antipyrine in isolated rat hepatocytes. Influence
of sex and enzyme induction and inhibition. Biochem Pharmacol 1989;
38(7):1125-1136.
(57) Perrild H, Kayser L, Poulsen HE,
Skovsted L, Jorgensen B, Hansen JM. Differential effect of
continuous administration of beta-adrenoceptor antagonists on
antipyrine and phenytoin clearance. Br J Clin Pharmacol 1989;28(5):551-554.
(58) Poulsen HE, Hansen BA, Egeberg
JC. Neutral red changes arginine-induced glucagon and insulin response in the rat.
Pharmacology and Toxicology 1989; 65(1):65-68.
(59) Tvede KG, Loft S, Poulsen HE,
Schou JS. Methyl parathion toxicity in rats is changed by
pretreatment with the pesticides chlordecone, mirex and linuron.Arch Toxicol Suppl 1989; 13:446-447.
(60) Hinson JA, Roberts DW, Benson RW,
Dalhoff K, Loft S, Poulsen HE. Mechanism of paracetamol toxicity.
Lancet 1990; 335(8691):732.
(61) Loft S, Poulsen HE. Prediction of
xenobiotic metabolism by non-invasive methods. [Review] [104 refs]. Pharmacology and Toxicology 1990; 67(2):101-108.
(62) Loft S, Poulsen HE. Metabolism of
metronidazole and antipyrine in hepatocytes isolated from mouse and
rat. Xenobiotica 1990; 20(2):185-191.
(63) Loft S, Egsmose C, Sonne J,
Poulsen HE, Dossing M, Andreasen PB. Metronidazole elimination is preserved in the
elderly. Hum Exp Toxicol 1990; 9(3):155-159.
(64) Ott P, Hansen PB, Dalhoff KP,
Loft SH, Poulsen HE. [Consumption of, overdose and fatal poisoning
with analgesics in Denmark 1979-1986]. Ugeskr Laeger 1990;
152(4):250-252.
(65) Ott P, Dalhoff KP, Poulsen HE. [Analgesic-induced.mortality (letter)]. Ugeskr Laeger
1990;152(39):2867-2868.
(66) Ott P, Dalhoff K, Hansen PB, Loft
S, Poulsen HE. Consumption, overdose and death from analgesics
during a period of over-the-counter availability of paracetamol in
in Denmark. J Intern Med 1990; 227(6):423-428
(67) Sonne J, Boesgaard S, Poulsen HE,
Loft S, Hansen JM, Dossing M et al. Pharmacokinetics and
pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism. Br J Clin Pharmacol
1990; 30(5):737-742.
(68) Andersson R, Poulsen HE, Ahren B.
Effect of bile on liver function tests in experimental E. coli
peritonitis in the rat. Hepatogastroenterology 1991; 38(5):388-390.
(69) Boesgaard S, Petersen JS,
Aldershvile J, Poulsen HE, Flachs H. Nitrate tolerance: effect of
thiol supplementation during prolonged nitroglycerin infusion in an
an in vivo rat model. J Pharmacol Exp Ther 1991; 258(3):851-856.
(70) Dalhoff K, Hansen PB, Ott P, Loft
S, Poulsen HE. Acute ethanol administration reduces the antidote
effect of N-acetylcysteine after acetaminophen overdose in mice. Hum Exp Toxicol 1991;
10(6):431-433.
(71) Fischer-Nielsen A, Poulsen HE,
Hansen BA, Hage E, Keiding S. CCl4 cirrhosis in rats: irreversible
histological changes and differentiated functional impairment. J Hepatol 1991; 12(1):110-117.
(72) Loft S, Nielsen AJ, Borg BE,
Poulsen HE. Metronidazole and antipyrine metabolism in the rat:
clearance determination from one saliva sample. Xenobiotica 1991;
21(1):33-46.
(73) Loft S, Otton SV, Lennard MS,
Tucker GT, Poulsen HE. Characterization of metronidazole metabolism by human liver
microsomes. Biochem Pharmacol 1991; 41(8):1127-1134.
(74) Poulsen HE, Ranek L, Jorgensen L.
The influence of disulfiram on acetaminophen metabolism in man. Xenobiotica
1991; 21(2):243-249.
(75) Roberts DW, Benson RW, Pumford,
NR, Potter DW, Poulsen HE et al. Sensitive immunochemical assays for
monitoring acetaminophen toxicity in humans. In: Vanderlaan M,
editor. Immunoassays for trace chemical analysis. Washington DC:
(76) Sjovall S, Ahren B, Hansson P,
Loft S, Poulsen HE, Bengmark S. Metabolic responses to intermittent hepatic
dearterialization in the rat. J Hepatol 1991; 13(1):33-37.
(77) Vistisen K, Loft S, Poulsen HE.
Cytochrome P450 IA2 activity in man measured by caffeine metabolism:
effect of smoking, broccoli and exercise. Adv Exp Med Biol 1991;
283:407-411.
1992
(78) Boesgaard S, Aldershvile J,
Poulsen HE. Preventive administration of intravenous
N-acetylcysteine and development of tolerance to isosorbide
dinitrate in patients with angina pectoris. Circulation 1992;
85(1):143-149.
(79) Dalhoff K, Ranek L, Mantoni M,
Poulsen HE. Glutathione treatment of hepatocellular carcinoma. Liver
1992; 12(5):341-343.
(80) Dalhoff K, Poulsen HE. Effects of
cysteine and acetaminophen on the syntheses of glutathione and
adenosine 3'-phosphate 5'-phosphosulfate in isolated rat hepatocytes. Biochem Pharmacol 1992;
44(3):447-454.
(81) Fischer-Nielsen A, Poulsen HE,
Loft S. 8-Hydroxydeoxyguanosine in vitro: effects of glutathione,
ascorbate, and 5-aminosalicylic acid. Free Rad Biol Med 1992;
13(2):121-126.
(82) Loft S, Vistisen K, Ewertz M,
Tjonneland A, Overvad K, Poulsen HE. Oxidative DNA damage estimated
by 8-hydroxydeoxyguanosine excretion in humans: influence of
smoking, gender and body mass index. Carcinogenesis 1992;13(12):2241-2247.
(83) Loft S, Otte J, Poulsen HE,
Sorensen H. Influence of intact and myrosinase-treated indolyl
glucosinolates on the metabolism in vivo of metronidazole and antipyrine in the rat. Food Chem Toxicol 1992;
30(11):927-935.
(84) Poulsen HE, Loft S, Andersen M,
Andersen JR. Disulfiram therapy - adverse drug reactions and
interactions. Acta Scand
Psych 1992; 86:59-66.
(85) Sherson D, Sigsgaard T, Overgaard
E, Loft S, Poulsen HE, Jongeneelen FJ. Interaction of smoking,
uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers.
Br J Ind Med 1992; 49(3):197-202.
(86) Vistisen K, Poulsen HE, Loft S.
Foreign compound metabolism capacity in man measured from
metabolites of dietary caffeine. Carcinogenesis 1992; 13(9):1561-1568.
(87) Boesgaard S, Poulsen HE,
Aldershvile J, Loft S, Anderson ME, Meister A. Acute effects of
nitroglycerin depend on both plasma and intracellular sulfhydryl
compound levels in vivo. Effect of agents with different sulfhydryl-modulating properties. Circulation 1993; 87(2):547-553.
(88) Boesgaard S, Aldershvile J,
Poulsen HE, Christensen S, Dige-Petersen H, Giese J.
N-acetylcysteine inhibits angiotensin converting enzyme in vivo. J Pharmacol Exp Ther
1993; 265(3):1239-1244.
(89) Brosen K, Skjelbo E, Rasmussen
BB, Poulsen HE, Loft S. Fluvoxamine is a potent inhibitor of cytochrome P4501A2.
Biochem Pharmacol 1993; 45(6):1211-1214.
(90) Dalhoff K, Poulsen HE. Inhibition
of acetaminophen oxidation by cimetidine and the effects on
glutathione and activated sulphate synthesis rates. Pharmacology and
Toxicolgy.1993, 73, 215-8
(91) Dalhoff K, Poulsen HE.
Simultaneous measurements of glutathione and activated sulphate
(PAPS) synthesis rates and the effects of selective inhibition of
glutathione conjugation or sulphation of acetaminophen. Biochem Pharmacol
1993; 46(3):383-388.
(92) Dalhoff K, Poulsen HE. Synthesis
rates of glutathione and activated sulphate (PAPS) and response to
cysteine and acetaminophen administration in glutathione-depleted rat hepatocytes. Biochem Pharmacol
1993; 46(7):1295-1297.
(93) Ding JW, Andersson R, Soltesz V,
Willen R, Loft S, Poulsen HE et al. The effect of biliary
decompression on bacterial translocation in jaundiced rats. Hpb Surg
1993; 7(2):99-110.
(94) Jeding IB, Loft S, Poulsen HE.
Non-induction of extrahepatic antipyrine and metronidazole
metabolism evaluated from partially hepatectomized rats. Xenobiotica
1993; 23(4):411-418.
(95) Jensen KG, Onfelt A, Poulsen HE,
Doehmer J, Loft S. Effects of benzo[a]pyrene and
(+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene on mitosis in
Chinese hamster V79 cells with stable expression of rat cytochrome
P4501A1 or 1A2. Carcinogenesis 1993; 14(10):2115-2118.
(96) Jensen KG, Loft S, Doehmer J,
Poulsen HE. Metabolism of phenacetin in V79 Chinese hamster cell
cultures expressing rat liver cytochrome P4501A2 compared to isolated rat hepatocytes. Biochem Pharmacol 1993;
45(5):1171-1173.
(97) Kjoller-Hansen L, Boesgaard S,
Laursen JB, Aldershvile J, Poulsen HE. [Importance of thiols (SH
group) in the cardiovascular system]. [Review] [37 refs] [Danish].
Ugeskr Laeger 1993; 155(45):3642-3645.
(98) Loft S, Fischer-Nielsen A, Jeding
IB, Vistisen K, Poulsen HE. 8-Hydroxydeoxyguanosine as a urinary
biomarker of oxidative DNA damage. J Toxicol Environ Health 1993;
40(2-3):391-404.
(99) Poulsen HE, Vilstrup H, Almdal T,
Dalhoff K. No net splanchnic release of glutathione in man during
N-acetylcysteine infusion. Scand J Gastroenterol 1993;
28(5):408-412.
(100) Poulsen HE, Roberts DW, Hinson
JA. Covalent binding of acetaminophen estimated from protein adducts.
In: Jeffery EH, editor. Human Drug Metabolism. From molecular
biology to man. Boca Raton, Ann Arbor, London, Tokyo: CRC Press,
(101) Poulsen HE, Loft S, Wassermann
K. Cancer risk related to genetic polymorphisms in carcinogen
metabolism and DNA repair. [Review] [93 refs]. Pharmacology and
Toxicology 1993; 72:Suppl-103.
(102) Ranek L, Dalhoff K, Poulsen HE,
Brøsen K, Flacks H, Loft S. Drug metabolism in subjects with
previous halothane hepatitis. Scand J Gastroenterol 1993;
28:677-680.
(103) Ranek L, Dalhoff K, Poulsen HE,
Brosen K, Flachs H, Loft S et al. Drug metabolism and genetic
polymorphism in subjects with previous halothane hepatitis. Scand J Gastroenterol 1993; 28(8):677-680.
(104) Sherson DL, Sigsgaard TI,
Overgaard E, Loft SH, Poulsen HE, Jongeneelen FC. [Risk of lung
cancer among foundry workers]. [Danish]. Ugeskr Laeger 1993;
155(9):620-623.
(105) Boesgaard S, Iversen HK,
Wroblewski H, Poulsen HE, Frandsen H, Kastrup J et al. Altered
peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine. J Am Coll Cardiol
1994; 23(1):163-169.
(106) Boesgaard S, Aldershvile J,
Poulsen HE, Loft S, Anderson ME, Meister A. Nitrate tolerance in
vivo is not associated with depletion of arterial or venous thiol
levels. Circ Res 1994; 74(1):115-120.
(107) Kjoller-Hansen L, Boesgaard S,
Laursen JB, Poulsen HE, Aldershvile J. [Nitroglycerin preparations.
Effect and tolerance]. [Review] [38 refs] [Danish]. Ugeskr Laeger
1994; 156(24):3621-3625.
(108) Laursen JB, Boesgaard S, Poulsen
HE, Aldershvile J. Endotelderiveret relakserende
faktor/nitrogenoxid. Ugeskr Laeger 1994; 156:5661-5666.
(109) Loft S, Astrup A, Buemann B,
Poulsen HE. Oxidative DNA damage correlates with oxygen consumption
in humans. Faseb J 1994; 8(8):534-537.
(110) Lykkesfeldt J, Loft S, Poulsen
HE. Simultaneous determination of urinary free cortisol and 6
beta-hydroxycortisol by high-performance liquid chromatography to
measure human CYP3A activity. J Chromatogr B Biomed Appl 1994;
660(1):23-29.
(111) Poulsen HE, Loft S. The impact
of genetic polymorphisms in risk assessment of drugs. [Review] [73
refs]. Arch Toxicol Suppl 1994; 16:211-222.
(112) Sandstrøm B, Astrup A, Dyerberg
J, Hølmer G, Poulsen HE, Stender S et al. Den sundhedsmæssige
betydning af antioxidanter i levnedsmidler og som kosttilskud.
Ugeskr Laeger 1994; 156:7675-7679.
(113) Fischer-Nielsen A, Corcoran GB,
Poulsen HE, Kamendulis LM, Loft S. Menadione-induced DNA
fragmentation without 8-oxo-2'-deoxyguanosine formation in isolated
(114) Jensen KG, Poulsen HE, Doehmer
J, Loft S. Kinetics and inhibition by fluvoxamine of phenacetin
O-deethylation in V79 cells expressing human CYP1A2. Pharmacology
and Toxicology 1995; 76(4):286-288.
(115) Loft S, Velthuis-te WE, Van den
Berg H, Poulsen HE. Energy restriction and oxidative DNA damage in humans. Cancer
Epidemiol Biomarkers Prev 1995; 4(5):515-519.
(116) Loft S, Larsen PN, Rasmussen A,
Fischer-Nielsen A, Bondesen S, Kirkegaard P et al. Oxidative DNA
damage after transplantation of the liver and small intestine in
pigs. Transplantation 1995; 59:16-20.
(117) Lykkesfeldt J, Loft S, Poulsen
HE. Determination of ascorbic acid and dehydroascorbic acid in
plasma by high-performance liquid chromatography with coulometric
detection--are they reliable biomarkers of oxidative stress? Anal
Biochem 1995; 229(2):329-335.
(118) Lykkesfeldt J, Loft S, Poulsen
HE. Individuel kræftrisiko - biomarkører kan måske give os svaret.
Naturens Verden 1995; 78:32-40.
(119) Nielsen HB, Hanel B, Loft S,
Poulsen HE, Pedersen BK, Diamant M et al. Restricted pulmonary
diffusion capacity after exercise is not an ARDS-like injury. J
Sports Sci 1995; 13(2):109-113.
(120) Poulsen HE, Loft S. Early
biochemical markers of effects: enzyme induction, oncogene
activation and markers of oxidative damage. Toxicology 1995;
101(1-2):55-64.
(121) Rasmussen BB, Maenpaa J, Pelkonen O, Loft S, Poulsen HE, Lykkesfeldt J et al. Selective
serotonin reuptake inhibitors and theophylline metabolism in human
liver microsomes: potent inhibition by fluvoxamine. Br J Clin
Pharmacol 1995; 39(2):151-159.
(122) Thomsen MS, Loft S, Roberts DW,
Poulsen HE. Cytochrome P4502E1 inhibition by propylene glycol
prevents acetaminophen (paracetamol) hepatotoxicity in mice without
cytochrome P4501A2 inhibition. Pharmacology and Toxicology 1995;
76(6):395-399.
(123) van Poppel G, Poulsen HE, Loft
S, Verhagen H. No influence of beta carotene on oxidative DNA damage
in male smokers. J Nat Can Inst 1995; 87:310-311.
(124) Velthuis-te WE, van Leeuwen RE,
Hendriks HF, Verhagen H, Loft S, Poulsen HE et al. Short-term
moderate energy restriction does not affect indicators of oxidative
stress and genotoxicity in humans. Journal of Nutrition 1995;
125(10):2631-2639.
(125) Verhagen H, Poulsen HE, Loft S,
van Poppel G, Willems MI, van Bladeren PJ. Reduction of oxidative
DNA-damage in humans by brussels sprouts. Carcinogenesis 1995;
16(4):969-970.
(126) Clemmensen JO, Ott P, Dalhoff
KP, Astrup LB, Tage-Jensen U, Poulsen HE. Rekommandation for
behandling af paracetamolforgiftning. Ugeskr Laeger 1996;
158:6892-6895.
(127) Jensen KG, Poulsen HE, Doehmer
J, Loft S. Paracetamol-induced spindle disturbances in V79 cells
with and without expression of human CYP1A2. Pharmacology and
Toxicology 1996; 78(4):224-228.
(128) Jeppesen U, Loft S, Poulsen HE,
Brosen K. A fluvoxamine-caffeine interaction study. Pharmacogenetics
1996; 6(3):213-222.
(129) Jeppesen U, Gram LF, Vistisen K,
Loft S, Poulsen HE, Brosen K. Dose-dependent inhibition of CYP1A2,
CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and
paroxetine. European Journal of Clinical Pharmacology 1996;
51(1):73-78.
(130) Laursen JB, Boesgaard S, Poulsen
HE, Aldershvile J. Nitrate tolerance impairs nitric oxide-mediated
vasodilation in vivo. Cardiovasc Res 1996; 31(5):814-819.
(131) Loft S, Poulsen HE. Cancer risk
and oxidative DNA damage in man. J Mol Med 1996; 74(6):297-312.
(132) Loft S, Jensen KG, Ringby L,
Poulsen HE, Doehmer J. Kinetic studies in engineered V79 cells in
comparison with primary hepatocytes and human liver microsomes.
Experimental and Toxicologic Pathology 1996; 48:249-256.
(133) Lykkesfeldt J, Prieme H, Loft S,
Poulsen HE. Effect of smoking cessation on plasma ascorbic acid
concentration. British Medical Journal 1996; 313(7049):91.
(134) Poulsen HE, Loft S, Vistisen K.
Extreme exercise and oxidative DNA modification. J Sports Sci 1996;
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(135) Poulsen HE. [Markers of vitamin deficiencies (editorial)]. [Danish]. Ugeskr Laeger 1996; 158(27):3906.
(136) Prieme H, Loft S, Cutler RG,
Poulsen HE. Measurement of oxidative DNA injury in humans:
evaluation of a commercially available ELISA assay. In: Kumpulainen
JT, editor. Natural antioxidants and food quality in atherosclerosis
and cancer prevention. The royal society of chemistry 1996, 1996:
78-82.
(137) Tuo J, Loft S, Thomsen MS,
Poulsen HE. Ex vivo time-dependent cell DNA-degradation shown by
single cell gel electrophoresis. Pharmacology and Toxicology 1996;
78(1):55-57.
(138) Tuo J, Loft S, Thomsen MS,
Poulsen HE. Benzene-induced genotoxicity in mice in vivo detected by
the alkaline comet assay: reduction by CYP2E1 inhibition. Mutat Res
1996; 368(3-4):213-219.
(139) Cadenas S, Barja G, Poulsen HE,
Loft S. Oxidative DNA damage estimated by oxo8dG in the liver of
guinea-pigs supplemented with graded dietary doses of ascorbic acid
and alpha-tocopherol. Carcinogenesis 1997; 18(12):2373-2377.
(140) Deng XS, Tuo J, Poulsen HE, Loft
S. 2-Nitropropane-induced DNA damage in rat bone marrow. Mutat Res
1997; 391(3):165-169.
(141) Kaikkonen J, Nyyssonen K,
Porkkala SE, Poulsen HE, Metsa KT, Hayn M et al. Effect of oral
coenzyme Q10 supplementation on the oxidation resistance of human
VLDL+LDL fraction: absorption and antioxidative properties of oil
and granule-based preparations. Free Rad Biol Med 1997;
22(7):1195-1202.
(142) Kaikkonen J, Nyyssonen K,
Porkkala-Sarataho E, Poulsen HE, Metsa-Ketela T, Hayn M et al.
Effect of oral coenzyme Q10 supplementation on the oxidation
resistance of human VLDL+LDL fraction: absorption and antioxidative
properties of oil and granule-based preparations. Free Rad Biol Med
1997; 22(7):1195-1202.
(143) Klarlund M, Prieme H, Loft S,
Poulsen HE. Smoking cessation does not change urinary albumin
excretion in normal subjects. Scand J Clin Lab Invest 1997;
(144) Lykkesfeldt J, Loft S, Nielsen
JB, Poulsen HE. Ascorbic acid and dehydroascorbic acid as biomarkers
of oxidative stress caused by smoking. Am J Clin Nutr 1997;
(145) Nyyssonen K, Poulsen HE, Hayn M,
Agerbo P, Porkkala-Sarataho E, Kaikkonen J et al. Effect of
supplementation of smoking men with plain or slow release ascorbic
acid on lipoprotein oxidation. European Journal of Clinical
(146) Poulsen HE. [Adverse effects of drugs--25 years later (editorial)]. Ugeskr Laeger 1997; 159(33):4964.
(147) Poulsen HE, Loft S, Prieme H,
Salonen JT. Antioxidants. In: Haunsø S, editor. Coronary
microcirculation during ischaemia and reperfusion. Copenhagen:
Munksgaard, 1997: 455-461.
(148) Prieme H, Loft S, Nyyssonen K,
Salonen JT, Poulsen HE. No effect of supplementation with vitamin E,
ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by
8-oxo-7,8-dihydro-2'-deoxyguanosine excretion in smokers. Am J Clin
(149) Vistisen K, Prieme H, Okkels H,
Vallentin S, Loft S, Olsen JH et al. Genotype and phenotype of
glutathione S-transferase mu in testicular cancer patients.
(150) Deng XS, Tuo J, Poulsen HE, Loft
S. Prevention of oxidative DNA damage in rats by brussels sprouts.
Free Rad Res 1998; 28(3):323-333.
(151) Haderslev KV, Sonne J, Poulsen
HE, Loft S. Paracetamol metabolism in patients with ulcerative
colitis. British Journal of Clinical Pharmacology 1998; 46:513-516.
(152) Loft S, Poulsen HE. Markers of oxidative damage to DNA:
Antioxidants and molecular damage. Methods
Enzymol 1998; 300:166-184.
(154) Loft S, Deng XS, Tuo J, Wellejus
A, Sorensen M, Poulsen HE. Experimental study of oxidative DNA
damage. Free Rad Res 1998; 29:525-539.
(155) Loft S, Thorling EB, Poulsen HE.
High fat diet induced oxidative DNA damage estimated by
8-oxo-7,8-dehydro-2'-deoxyguanosine excretion in rats. Free Rad Res
1998; 29:595-600.
(156) Loft S, Poulsen HE. Estimation
of oxidative DNA damage in man from urinary excretion of repair
products. Acta Biochim Pol 1998; 45:133-144.
(157) Porkkala SE, Nyyssonen MK,
Kaikkonen JE, Poulsen HE, Hayn EM, Salonen RM et al. A randomized,
single-blind, placebo-controlled trial of the effects of 200 mg
alpha -tocopherol on the oxidation resistance of atherogenic
lipoproteins. Am J Clin Nutr 1998; 68/5(1034-1041):-1041.
(158) Poulsen HE, Loft S.
Interpretation of oxidative DNA modification: Relation between
tissue levels, excretion of urinary repair products and sigle cell
gel electrophoresis (comet assay). In: Aruoma OI, Halliwell B,
editors. DNA & free radicals: Techniques, mechanisms and
applications. London: OICA International, 1998: 261-270.
(159) Poulsen HE. [Medication
errors--the top of an iceberg? (editorial)]. Ugeskr Laeger 1998;
160(27):4041.
(160) Poulsen HE, Weimann A, Salonen
JT, Nyyssonen K, Loft S, Cadet J et al. Does vitamin C have a
pro-oxidant effect? [letter]. Nature 1998; 395(6699):231-232.
(161) Poulsen HE, Loft S, Prieme H,
Vistisen K, Lykkesfeldt J, Nyyssonen K et al. Oxidative DNA damage
in Vivo: Relationship to age, plasma antioxidants, drug metabolism,
glutathione-S-transferase activity and urinary creatinine excretion.
Free Rad Res 1998; 29:565-571.
(162) Poulsen HE, Prieme H, Loft S.
Role of oxidative DNA damage in cancer initiation and promotion.
European Journal of Cancer Prevention 1998; 7(1):9-16.
(163) Prieme H, Nyyssonen K, Gronbaek
K, Klarlund M, Loft S, Tonnesen P et al. Randomized controlled
smoking cessation study: transient increase in plasma high density
lipoprotein but no change in lipoprotein oxidation resistance. Scand
J Clin Lab Invest 1998; 58(1):11-18.
(164) Prieme H, Loft S, Klarlund M,
Gronbaek K, Tonnesen P, Poulsen HE. Effect of smoking cessation on
oxidative DNA modification estimated by
8-oxo-7,8-dihydro-2'-deoxyguanosine excretion. Carcinogenesis 1998;
19(2):347-351.
(165) Tuo J, Wolff SP, Loft S, Poulsen
HE. Formation of nitrated and hydroxylated aromatic compounds from
benzene and peroxynitrite, a possible mechanism of benzene
genotoxicity. Free Rad Res 1998; 28(4):369-375.
1999
(166) Jensen SA, Jensen BR, Weiman A, Li L, Poulsen HE. [Oxidative stress and
aging]. Ugeskr Laeger 1999; 162(17):2431-2435.
(167) Loft S, Poulsen HE, Vistisen K,
Knudsen LE. Increased urinary excretion of 8-oxo-2'-deoxyguanosine,
a biomaker of oxidative DNA damage, in urban bus drivers. Mutat Res
1999; 441:11-19.
(168) Loft S, Poulsen HE. Measurement
of oxidative damage to DNA: interpretation of nuclear levels and
urinary excretion of repair products in DNA damage and Repair:
Oxygen Radical effects, cellular protection and biological
consequeences. In: Karakaya A, Dizdaroglu M, editors. Oxygen Radical
Effects, Cellular Protection and Biological Consequences. New York:
Plenum Press, 1999: 267-281.
(169) Loft S, Poulsen HE. Markers of
oxidative damage to DNA: antioxidants and molecular damage. Methods
Enzymol 1999; 300:166-184.
(170) Poulsen HE, Loft S. Motion og velvære. Miljømedicin. 1999: 364-367.
(171) Poulsen HE, Loft S, Strandgaard S, Vilstrup H. Rationel farmakoterapi. In: Lorenzen I, Bendixen G, Hansen NE, editors. Medicinsk Kompendium. Copenhagen: Nyt Nordisk forlag Arnold Busck A/S, 1999: 2942-2954.
(172) Poulsen HE, Weimann A, Loft S.
Methods to detect DNA damage by free radicals: relation to exercise.
Proceeding of the Nutritional Society 1999; 58.
(173) Salonen J, Nyyssonen K, Salonen
R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E et al. The Effect of
Vitamin E and Vitamin C on Carotid Atherosclerotic Progression: The
Antioxidant Supplementation in Atherosclerosis Prevention (ASAP)
study. Circulation 1999; Suppl. 100:I-238.
(174) Tuo J, Loft S, Poulsen HE.
Enhanced benzene-induced DNA damage in PMA-stimulated cells in vitro
and in LPS-treated animals. Free Rad Biol Med 1999; 26:801-808.
(175) Tuo J, Deng X, Loft S, Poulsen
HE. Dexamethasone ameliorates oxidative DNA damage induced by
benzene and LPS in mouse bone marrow. Free Rad Res 1999; 30:29-36.
(176) ESCODD (European Standards
Committee on Oxidative DNA Damage) Comparison of different Methods
of Measuring 8-oxoguanine as a Marker of Oxidative DNA Damage.Free
Rad. Res 2000; 32:333-341
(177) Loft S, Poulsen HE. Antioxidant
Intervention Studies Related to DNA Damage, DNA Repair and Gene
Expression. Free Rad Res 2000; 33:S67-83
(178) Dalhoff KP, Poulsen HE. Talidomid
fiasko eller succes. Ugeskr Laeger 2000; 162(1):52-53.
(179) Porkkala-Sarataho E, Salonen JT,
Nyyssonen K, Kaikkonen J, Salonen R, Ristonmaa U et al. Long-term
effects of vitamin E, vitamin C, and combined supplementation on
urinary 7-hydro-8-oxo-2'-deoxyguanosine, serum cholesterol oxidation
products, and oxidation resistance of lipids in nondepleted men.
Arterioscler Thromb Vasc Biol 2000; 20(9):2087-2093.
(180) Poulsen HE, Jensen BR, Weimann A,
Jensen SA, Sørensen M, Loft S. Antioxidants, DNA damage and gene
expression. Free Rad Res 2000; 33:S33-39
(181) Salonen JT, Nyyssonen K, Salonen
R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E et al. Antioxidant
Supplementation in Atherosclerosis Prevention (ASAP) study: a
randomized trial of the effect of vitamins E and C on 3-year
progression of carotid atherosclerosis. J Intern Med 2000;
248(5):377-386.
(182) Jingsheng Tuo, Li Liu, Henrik E.
Poulsen, Allan Weimann, Ove Svendsen and Steffen Loft. Importance of
guanine nitration and hydroxylation in DNA in vitro and in vivo.
Free Radical Biology & Medicine 2000;29:147-155
(183) Voutilainen
S, Lakka TA, Hamelahti P, Lehtimaki T, Poulsen HE, Salonen JT.
Plasma total homocysteine concentration and the risk of acute
coronary events: the Kuopio Ischaemic Heart Disease Risk Factor
Studytpdel. J Intern Med 2000; 248(3):217-222.
(184) Wellejus A, Poulsen HE, Loft S.
Iron-induced oxidative DNA damage in rat sperm cells in vivo and in
vitro. Free Radic Res 2000; 32(1):75-83.
(185) Wellejus A, Poulsen HE, Loft S.
Iron-induced oxidative DNA damage in rat sperm cells in vivo and in
vitro. Free Radic Res 2000; 32(1):75-83.
(186) Zhu C, Poulsen HE, Loft S.
Inhibition of oxidative DNA damage in vitro by extracts of brussels
sprouts [In Process Citation]. Free Radic Res 2000; 33(2):187-196.
(187) Poulsen HE, Loft S, Weimann A.
Urinary measurement of 8-oxodG (8-oxo-2'-deoxyguanosine). In: Lunec
J, Griffiths HR, editors. Measuring in vivo Oxidative Damage: A
practical Approach. London: John Wiley and Sons (Ltd.), 2000: 69-80
(188) Dalhoff K, Laursen H, Bangert K, Poulsen HE, Anderson ME, Grunnet N
et al. Autoprotection in acetaminophen intoxication in rats: the
role of liver regeneration. Pharmacol Toxicol 2001; 88(3):135-141.
(189) Weimann A, Belling D, Poulsen HE. Measurement of
8-oxo-2-deoxyguanosine and 8-oxo-2-deoxyadenosine in DNA and Human
Urine by High Performance Liquid Chromatography-Electrospray Tandem
Mass Spectrometry. Free Rad Biol Med 2001; 30:757-764.
(190) Schmidt LE, Rasmussen A, Norrelykke MR, Poulsen HE, Hansen BA.
The effect of selective bowel decontamination on the
pharmacokinetics of mycophenolate mofetil in liver transplant
recipients. Liver Transpl 2001; 7(8):739-742.
(191) Sorensen M, Jensen BR, Poulsen HE, Deng X, Tygstrup N, Dalhoff
K et al. Effects of a Brussels sprouts extract on oxidative DNA
damage and metabolising enzymes in rat liver. Food Chem Toxicol
2001; 39(6):533-540.
(192) Nielsen HB, Kharazmi A, Bolbjerg ML, Poulsen HE, Pedersen BK,
Secher NH. N-acetylcysteine attenuates oxidative burst by
neutrophils in response to ergometer rowing with no effect on
pulmonary gas exchange. Int J Sports Med 2001; 22 (4):256-260.
(193) Laursen JB, Boesgaard S, Trautner S, Rubin I, Poulsen HE,
Aldershvile J. Endothelium-dependent vasorelaxation is
inhibited by in vivo depletion of vascular thiol levels:role of
endothelial nitric oxide synthase. Free Rad Res 2001; 35:387-394.
(194) P, Poulsen HE, Parving HH, Pedersen O. Double-blind, randomised
study of the effect of combined treatment with vitamin C and E on
albuminuria in Type 2 diabetic patients. Diabetic Medicine 2001; 18
:756-760.
(195) Hoberg, AM, Poulsen HE. Analysis of a promutagenic exocyclic DNA
adduct in human urine by HPLC APCI tandem mass spectrometry.
Advances in Mass Spectrometry, 2001; 15:597-598.
(196) Weimann, A, Belling D, Poulsen HE. Quantification of
8-oxoGuanine and Guanine as the Nucleobase, Nucleoside and
Deoxynucleoside forms in Human Urine by High Preformance Liquid
Chromatography - Electrospray Tandem Mass Spectrometry. Nucleic
Acids Research 2002; 30 no.2 e 7
(197) Kaikkonen, J, Porkkala-Sarataho, E, Morrow JD, Jackson Roberts II,
L, Nyyssönen, K, Salonen, R, Tuomainen, TP, Ristonmaa, U, Poulsen,
HE, Salonen JT. Supplementation with Vitamin E but not with Vitamin
C Lowers Lipid Peroxidation In Vivo in Mildly
Hypercholesterolemic Men. Free Radical Researchs, 2002; 35:967-978
(198) Schmidt,L.E., Dalhoff,K. Poulsen,H.E. Acute versus chronic alcohol
consumption in acetaminophen-induced hepatotoxicity, Hepatology,
2002, 35:876-882
(199) ESCODD. Inter-laboratory Validation of Procedures for Measuring
8-oxo7,8-dihydrogunanine/8-oxo-7,8-dihydro-2´-deoxyguanosine in DNA.
Free Radical Research, 2002; 36 (3):239-245
(200) Riis, Bente and ESCODD. Comparison of Results from Different
Laboratories in Measuring 8-oxo-2´-deoxyguanosine in Synthetic
Oligonucleotides. Free Radical Research, 2002; 36 (3): 649-659.
(201) B, Risom L, Loft S, Poulsen H.E. Increased rOGG1 expression in
regenerating rat liver tissue without a corresponding increase in
incision activity. DNA Repair, 2002; (1): 419-424
(202) Møller P, Wallin H, Vogel U, Autrup H,Risom l, Hald M.T., Daneshvar
B, Dragsted L.O., Poulsen H.E., Loft S. Mutagenicity of
2-amino-3methylimidazo [4,5f] quinoline in colon and liver of
Big Blue rats: role of DNA adducts, strand breaks, DNA repair and
oxidative stress. Carcinogenesis, 2002; 23(8): 1379-1385.
(203) Dragsted L.O., Daneshvar B, Vogel U, Autrup H.N., Wallin H, Risom L,
Møller P, Mølck A.M., Hansen M, Poulsen H.E., Loft s. A sucrose-rich
Diet Induces Mutation in the Rat Colon. Cancer Research, 2002; 62:
4339-4345.
(204) Griffiths HR, Møller L, Bartosz G, Bast A, Bertoni-Freddari C,
Collins A, Cooke M, Coolen S,
Haenen G, Hpberg AM, Loft S, Lunec J, Olinski R, Parry J, Pompella
A, Poulsen HE, Verhagen H,
Astley SB. Chap 3; Biomarkers. In Molecular Aspects of Medicine 23
2002; 101-208.
(205) Escodd (European Standards Comittee on
Oxidative DNA Damage). Comparative analysis of baseline
8-oxo-7,8-dihydroguanine in mammalian cell DNA, by different
methods in different laboratories: an approach to consensus.
Carcinogenesis, 2002;23(12): 2129-2133.
(206) Riis B, Risom L, Loft S, Poulsen HE. OGG1 m RNA
expression and incision activity in rats are higher in foetal tissue
than in adult liver tissue while 8-oxo-2'-deoxyguanosine levels are
unchanged. DNA Repair 2002;1:709-17.
(207) Clinical pharmacology
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(208) Salonen RM, Nyyssonen K, Kaikkonen J,
Porkkala-Sarataho E, Voutilainen S, Rissanen TH et al. Six-year
effect of combined vitamin C and E supplementation on
atherosclerotic progression - The Antioxidant Supplementation in
Atherosclerosis Prevention (ASAP) study. Circulation 2003;
107(7):947-953.
(209) Collins A, Gedik C, Vaughan N, Wood S, White A,
Dubois J et al. Measurement of DNA oxidation in human cells by
chromatographic and enzymic methods. Free Radical Biology and
Medicine 2003; 34(8):1089-1099.
(210) Bruunsgaard H, Poulsen HE, Pedersen BK,
Nyyssonen K, Kaikkonen J, Salonen JT. Long-term combined
supplementations with alpha-tocopherol and vitamin C have no
detectable anti-inflammatory effects in healthy men.Journal of
Nutrition 2003;133:1170-1173
(211) Lykkesfeldt J, Bolbjerg ML, Poulsen HE. Effect of smoking on
erythorbic acid pharmacokinetics. British Journal of Nutrition 2003;
89:667-671
(212) Osterberg O, Kiehr B, Erichsen L, Poulsen HE, Ingwersen SH.
Pharmocokinetics and allometric scaling of levormeloxifene, a
selective oestrogen receptor modulator. Biopharm Drug Dispos.
2003;24:121-129.
(213) Verhagen H, Aruoma OI, van Delft JH, Dragsted LO, Ferguson LR,
Knasmuller S, Pool-Zobel BL, Poulsen HE, Williamson G, Yannai S. The
10 basic requirements for a scientific paper reporting antioxidant,
antimutagenic or anticarcinogenic potential of test substances in in
vitro experiments and animal studies in vivo. Food Chem Toxicol
2003;41(5):603-10
(214) Vogel U, Danesvar B, Autrup H, Risom L, Weimann A, Poulsen HE,
Moller P, Loft S, Wallin H, Dragsted LO.
Effect of increased intake of
dietary animal fat and fat energy on oxidative damage, mutation
frequency, DNA adduct level and DNA repair in rat colon and liver. Free Radic Res. 2003;37(9):947-56.
(215) Møller P, Daneshvar B, Loft S, Wallin H, Poulsen HE, Autrup H,
Ravn-Haren G, Dragsted LO. Oxidative DNA damage in vitamin
C-supplemented guinea pigs after intrtracheal instillation of diesel
exhaust particles. Toxicology and Applied Pharmacology
2003;189:39-44.
(216) Møller P, Hansen M, Autrup H, Bornholt J, Vogel U, Mølck A-M,
Wallin H , Dragsted LO, Risom L, Poulsen HE, Loft S. Dietary
low-dose sucrose modulation of IQ-induced genotoxicity in the colon
and liver of Big Blue™ rats
Mutation Research/Fundamental and Molecular Mechanisms of
Mutagenesis
2003; 527:91-97
(217) Dybdahl M, Risom L, Moller P, Autrup H, Wallin H, Vogel U, Bornholdt
J, Daneshvar B, Dragsted L, Weimann A, Poulsen HE, Loft S. DNA
adduct formation and oxidative stress in colon and liver of Big
Blue(R) rats after dietary exposure to diesel
particles.Carcinogenesis. 2003 Nov;24(11):1759-66
(218) Loft S, Kold-Jensen T, Hjollund NH, Giwercman A, Gyllemborg J, Ernst
E, Olsen J, Scheike T, Poulsen HE, Bonde JP. Oxidative DNA
damage in human sperm influences time to pregnancy.Hum Reprod.
2003;18(6):1265-72.
(219) Poulsen HE, Gronlykke TB [Does the public sector have an independent
research role in the development of drugs?]
Ugeskr Laeger. 2003 Apr 14;165(16):1674-6. Danish.
(220) Risom L, Moller P, Hansen M, Autrup H, Bornholdt J, Vogel U, Wallin
H, Poulsen HE, Dragsted LO, Loft S. Dietary
elevated sucrose modulation of diesel-induced genotoxicity in the
colon and liver of Big Blue rats.
Arch Toxicol 2003;77:651-6
(221) Lykkesfeldt J, Viscovich M, Poulsen H. Ascorbic acid recycling in
human erythrocytes is induced by smoking in vivo. FRBM
2003;35:1439-47.
(222) Kramer I, Dalhoff K, Clemmensen JO, Loft S, Poulsen HE,
Comparison of chlorzoxazone one-sample methods
to estimate CYP2E1 activity in humans. Eur J Clin Pharm 2003;
59:775-8
(223) Osterberg O, Erichsen L, Ingwersen SH, Plum A, Poulsen HE, Vicini P.Pharmacokinetic
and pharmacodynamic properties of insulin aspart and human insulin.
J Pharmacokinet Pharmacodyn. 2003 Jun;30(3):221-35.
(224) Loft, S., Møller,
P., Vogel, U., Risom. L., Sørensen, M., Riis, B., Poulsen, H.E.,
Dybdahl, M., and Wallin, H. (2003) Oxidative Stress by Environmental
Agents, Journal of University of Occupational and Environmental
Health 2003;25(suppl.1):47-59
(225) Poulsen HE, Loft S, Jensen BR, Sørensen, M, Hoberg A-M, Weimann A.
HPLC-ECD, LC-MS/MS (Urinary Biomarkers): In: Oxidative Stress and
Aging. Advances in Basic Science,
Diagnostics, and Intervention, eds. Cutler RG, Rodriguez H.
Singapore: World Scientific Publishing Co. Pte. Ltd; 2003:233-56
(226) Poulsen HE. Proper design of human
intervention studies, power calculations. In:Free radicals, nitric
oxide, and inflammation: Molecular, biochemical, and clinical
aspects, eds. Tomasi A et al. Ohmsha: IOS Press; 2003:252-3.
(227) Poulsen HE.Estimation of oxidative
and lipids peroxidation DNA adduct in urine and DNA. Free radicals,
nitric oxide, and inflammation: Methodological aspects and
application in Molecular epidemiology.In: Molecular, biochemical,
and clinical aspects, eds. Tomasi A, et al. Ohmsha: IOS Press;
(228) Hoberg AM, Otteneder M, Marnett LJ, Poulsen HE.
Measurement of the malondialdehyde-2'-deoxyguanosine adduct
in human urine by immuno-extraction and liquid
chromatography/atmospheric pressure chemical ionization tandem mass
spectrometry.J Mass Spectrom. (2004);
39(1):38-42.
(229) Collins AR, Cadet J, Möller L, Poulsen HE, Vina J. Are we
sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from
human cells? Archives of Biochemistry and Biophysics 423 (2004)
57-65
(230) Poulsen HE, Moller P, Lykkesfeldt J, Weimann A, Loft S.
Vitamin C and oxidative damage to DNA. In:
Vitamin C, edited by Han Asard, James M. May and Nicholas Smirnoff,
BIOS Scientific Publishers Ltd, Oxford 2004:189-202
(231) Vistisen K, Loft S, Olsen JH, Vallentin S, Ottesen S, Hirsch FR,
Poulsen HE. Low CYP1A2 activity
associated with testicular cancer.
Carcinogenesis. 2004 Jun;25(6):923-929
(232) Hillestrom PR, Hoberg AM, Weimann A, Poulsen HE.
Quantification of 1,N6-etheno-2'-deoxyadenosine in human urine by
column-switching LC/APCI-MS/MS. Free Radic Biol
Med. 2004 Jun 1;36(11):1383-92
(233) Weimann A, Riis B, Poulsen HE. Oligonucleotides in
human urine do not contain 8-oxo-7,8-dihydrodeoxyguanosine.
Free Radic Biol Med. 2004 1;36(11):1378-82
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de Waard H
de Wit J, Andresson
J-O, van Oostrom CTM,
Riis B, Weimann A,
Poulsen HE, van Steeg H,
Hoeijmakers JHJ, van der Horst
GTJ. Different Effects of CSA and CSB Deficiency on
Sensitivity to Oxidative DNA Damage Molecular and Cellular Biology, (2004);24:7941-8
(235) Møller, P,Viscovich
M, Lykkesfeldt
J, Loft S, Jensen A,
Poulsen HE. Vitamin C supplementation
decreases oxidative DNA damage in mononuclear blood cells of smokers. European Journal of Nutrition
2004 Jan;1-8
(236) Lykkesfeldt J, Viscovich M, Poulsen HE.
Plasma malondialdehyde is induced by smoking: a study with
balanced antioxidant profiles. Br J Nutr.
2004;92(2):203-6.
(237) Viscovich M, Lykkesfeldt L, Poulsen HE.
Vitamin C pharmacokinetics of plain and slow release formulations in
smokers Clinical Nutrition (2004) 23,1043-50
(238)
Hansen M, Hald MT, Autrup H, Vogel U,
Bornholdt J, Moller P, Molck AM, Lindecrona R, Poulsen HE, Wallin H,
Loft S, Dragsted LO. Sucrose and
IQ induced mutations in rat colon by independent mechanism.Mutat Res. 2004 Oct 4;554(1-2):279-86
(239) ESCODD (European Standards Committee on
Oxidative DNA Damage). Establishing the
background level of base oxidation in
human lymphocyte DNA: results of an interlaboratory
validation study. The FASEB Journal
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(240) Poulsen HE. Alkoholelimination i alkopops. Ugeskr Laeger.
2004;166:4449.
(241) Poulsen HE, Dalhoff KP.
Mangelfuld registrering af lægemiddelforgiftninger og –
bivirkninger i Danmark. Ugeskr Laeger.
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Riis B, Poulsen HE, Repair and Removal Systems DNA Repair:
Mechanisms and Measurements In:The Handbook of Environmental
Chemistry Vol. 2, Part O. eds.
Springer-Verlag Berlin Heidelberg 2005: 151–75
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Weimann A, Sabroe M, Poulsen HE
Measurement of caffeine and five of the major metabolites in
urine by high-performance liquid chromatography/tandem mass Spectrom. 2005;40:307-16
(244)
Hillestrøm PR, Nyssönen
K, Tuomainen T-P, Pukkala E, Salonen JT, Poulsen HE Urinary
excretion of of
edA is not predictive of
cancer development: A prospective nested case
control study. Free Rad Research, 2005;39:51-3
(245)
Ciofu O, Riis B,
Pressler T, Poulsen HE, Hoiby N Occurrence of Hypermutable
Pseudomonas aeruginosa in Cystic Fibrosis Patients Is Associated
with the Oxidative Stress Caused by Chronic Lung Inflammation.
Antimicrob. Agents Chemother.
2005;49:2276-2282
(246)
Laska MJ, Nexo BA, Vistisen K, Poulsen HE, Loft S, Vogel U
Polymorphisms in RAI and in genes of nucleotide and base
excision repair are not associated with risk of testicular cancer.
Cancer Lett. 2005;225:245-51
(247)
Dalhoff KP, Poulsen HE.[Toxicology and pharmacogenetics]
Ugeskr Laeger. 2005;167:2170-2.
Danish.
(248)
Poulsen HE. Oxidative DNA modifications. Exp
Toxicol Pathol. 2005 Jul;57 Suppl 1:161-9. Review.
(249)
Gronbaek K, Sonne J, Ring-Larsen H, Poulsen HE, Friis H, Bygum
Krarup H. Viral load is a negative predictor of antioxidant
levels in hepatitis C patients .Scand J Infect Dis. 2005;37:686-9
(250)
Dalhoff K, Jensen
KB, Poulsen HE. Cancer and molecular
biomarkers of phase 2. In: John Abelson, USA, ed. Methods Enzymol.
400 ed. New York: Elsevier; 2005:618-27
(251) Hillestrom PR,
Weimann A,
Poulsen HE.Quantification of Urinary Etheno-DNA Adducts by
Column-Switching LC/APCI-MS/MS. J Am Soc Mass
(252)
Hillestrom PR, Weimann
A, Jensen, CB, Storgaard H, Vaag AA, Poulsen HE. Consequences
of low birthweight on urinary excretion of
DNA markers of oxidative stress in young men. Scand J
Clin Lab Invest 2006; 66: 363–70.
(253) Hillestrom PR, Covas MI, Poulsen HE.
Effect of dietary virgin olive oil on urinary excretion of
etheno-DNA adducts. Free Radic Biol Med. 2006
Oct 1;41(7):1133-8. Epub 2006 Jul 4.
(254)
Covas MI,
Nyyssonen K, Poulsen HE, Kaikkonen J, Zunft HJ, Kiesewetter H, Gaddi
A, de la Torre R, Mursu J, Baumler H, Nascetti S, Salonen JT, Fito
M, Virtanen J, Marrugat J, EUROLIVE Study Group. The effect of
polyphenols in olive oil on heart disease risk factors: a randomized
trial. Ann Intern Med. 2006 Sep 5;145(5):333-41.
(255) Glintborg B, Weimann A, Kensler TW,
Poulsen HE. Oltipraz chemoprevention trial in Qidong, People's
Republic of China: Unaltered oxidative biomarkers.
Free Radic Biol Med. 2006 Sep 15;41(6):1010-4.
(256) Henrik E. Poulsen, Allan Weimann and
Berry B. Halliwell: Cigarette Smoke and Oxidative DNA Modification
in Cigarette Smoke and Oxidative Stress. Ed. Berry B. Halliwell
and Henrik E. Poulsen. Springer-Verlag Berlin Heidelberg Chapter 16
(2006) 387-402.
(257) Machowetz A, Poulsen HE, Gruendel S, Weimann A, Fito M, Marrugat J,
de la Torre R, Salonen JT, Nyyssonen K, Mursu J, Nascetti S, Gaddi
A, Kiesewetter H, Baumler H, Selmi H, Kaikkonen J, Zunft HJ, Covas
MI, Koebnick C. Effect of olive oils on biomarkers of oxidative DNA
stress in Northern and Southern Europeans
The FASEB Journal • Research Communication.
The FASEB Journal. 2007;21:45-52.
(258)
Bondia-Pons I, Schroder H, Covas MI, Castellote AI, Kaikkonen J,
Poulsen HE, Gaddi AV, Machowetz A, Kiesewetter H, Lopez-Sabater MC.Moderate
Consumption of Olive Oil by Healthy European Men Reduces Systolic
Blood Pressure in Non-Mediterranean Participants.
J Nutr. 2007 Jan;137(1):84-87.
(259) Tuomainen TP, Loft S, Nyyssonen K,
Punnonen K, Salonen JT, Poulsen HE. Body iron is a
contributor to oxidative damage of DNA. Free Radic. Res. 2007
Mar;41(3):324-8.
(260)
Bader N, Bosy-Westphal A, Koch A, Rimbach G, Weimann A, Poulsen HE,
Muller MJ Effect of hyperbaric oxygen and
vitamin C and E supplementation on biomarkers of oxidative stress in
healthy men. Br J Nutr. 2007 Oct;98(4):826-33
(261)
Gravholt CH,
Poulsen HE,
Ott P,
Christiansen JS,
Vilstrup H. Quantitative liver functions in Turner syndrome with
and without hormone replacement therapy. Eur J
Endocrinol. 2007 Jun;156(6):679-86.
(262)
Glintborg B, Hillestrom PR, Olsen LH, Dalhoff KP, Poulsen HE.
Are patients reliable when self-reporting medication use? Validation
of structured drug interviews and home visits by drug analysis and
prescription data in acutely hospitalized patients.
J Clin Pharmacol. 2007 Nov;47(11):1440-9.
(263)
Vitamin C deficiency in weanling guinea pigs: differential expression of
oxidative stress and DNA repair in liver and brain. Lykkesfeldt J, Trueba GP,
Poulsen HE, Christen S. Br J Nutr. 2007 Dec;98(6):1116-9.
2008
(264)
Glintborg B, Poulsen HE, Dalhoff KP.The use of nationwide
on-line prescription records improves the drug history in
hospitalized patients. Br J Clin Pharmacol.
2008 Feb;65(2):265-9;
(265)
Hansen M,
Baunsgaard D,
Autrup H,
Vogel UB,
Møller P,
Lindecrona R,
Wallin H,
Poulsen HE,
Loft S,
Dragsted LO.Sucrose, glucose and fructose have similar
genotoxicity in the rat colon and affect the metabolome.Food
Chem Toxicol.Volume
46, 2008;46:752-60
(266) Berendt L, Håkansson C, Bach KF, Dalhoff K, Andreasen PB,
Petersen LG, Andersen E, Poulsen HE. Effect of European Clinical
Trials Directive on academic drug trials in
Denmark: retrospective study of applications
to the Danish Medicines Agency 1993-2006.
BMJ 2008;336;33-35
(267) Morten Lock Hansen, Niels Gadsbøll, Gunnar H.
Gislason, Steen Z. Abildstrom, Tina K. Schramm, Fredrik Folke, Jens
Friberg, Rikke Sørensen, Søren Rasmussen, Henrik E. Poulsen, Lars
Køber, Mette Madsen, and Christian Torp-Pedersen. Atrial
fibrillation pharmacotherapy after hospital discharge between 1995
and 2004: a shift towards beta-blockers.Europace.
2008 Apr;10(4):395-402
(268) Serena Guarnieri, Steffen Loft, Patrizia Riso, Marisa Porrini, Lotte
Risom, Henrik E. Poulsen, Lars O. Dragsted and Peter
Møller. DNA repair phenotype and dietary antioxidant
supplementation British Journal of Nutrition (2008), 99,
1018–1024
(269) Marcus S. Cooke, Ryszard
Olinski, and Steffen Loft members of the European
Standards Committee on Urinary (DNA) Lesion Analysis (ESCULA)
ESCULA members include Mark D. Evans, Rajinder Singh, Vilas Mistry,
Peter B. Farmer (University of Leicester, United Kingdom); Rafal Rozalski,
Daniel Gackowski, Marek Foksinski, Agnieszka Siomek (Nicolaus
Copernicus University, Poland); Peter Møller, Pernille
Danielsen, Elvira Vaklavik, Lykke Forchhammer (University
of Copenhagen, Denmark); Jean Cadet, Jean-luc Ravanat (CEA/Grenoble,
France); Jagadeesan Nair, Urmila Nair (DKFZ, Germany); Henrik E. Poulsen,
Allan Weimann, Peter R. Hillestrom (Rigshospitalet, Denmark).
Measurement and Meaning of Oxidatively Modified
DNA Lesions in Urine. Cancer Epidemiol Biomarkers Prev
2008;17(1).
(272) Arrigo F.G. Cicero, MD, PhD, Simona Nascetti, MD, PhD,
Maria C. López-Sabater, MD, Roberto Elosua, MD, Jukka T. Salonen, MD, PhD,
Kristiina Nyyssönen, MD, Henrik E. Poulsen, MD, PhD, Hans-Joachim F. Zunft, MD,
PhD, Holger Kiesewetter, MD, Karina de la Torre, MD, Marıa-Isabel Covas, BD, PhD,
Jari Kaikkonen, Jaakko Mursu, Corina Koenbick, MD, Hans Bäumler, MD, PhD, and
Antonio V. Gaddi, MD, PhD, for the EUROLIVE Study Group. Changes in LDL fatty
acid composition as a response to olive oil treatment are inversely related to
lipid oxidative damage: The EUROLIVE Study. Journal of the American College of
Nutrition, 2008;27:314–20
(273)
Gottipati KR,
Poulsen H,
Starcher B. Passive cigarette smoke exposure inhibits
ultraviolet light B-induced skin tumors in SKH-1 hairless mice by blocking the
nuclear factor kappa B signalling pathway.Exp
Dermatol. 2008 Sep;17(9):780-7.
2009
(274)
Poulsen HE,
Andersen JT,
Keiding N,
Schramm TK,
Sørensen R,
Gislasson G,
Fosbøl EL,
Torp-Pedersen C. Why
epidemiological and clinical
intervention studies often give different or diverging results?
IUBMB Life, 61(4): 391–393, April 2009
(275) Fosbøl E, Gislason G, Jacobsen S, Folke F,
Hansen M, Schramm T, Sørensen R, Rasmussen J, Andersen S, Abildstrom S, Trærup
J, Poulsen H, Rasmussen S, Køber L, Torp-Pedersen C.
Risk of Myocardial Infarction and Death
Associated With the Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Among
Healthy Individuals: A Nationwide Cohort Study. Clin Pharmacol Ther.
(2009); 85, 2, 190–197
(276) Christine Dalgård , Flemming Nielsen, Jason D.
Morrow, Henrik Enghusen-Poulsen, Torbjörn Jonung, Mogens Hørder and Moniek P. M.
de Maat. Supplementation with orange and blackcurrant juice, but not vitamin E,
improves inflammatory markers in patients with peripheral arterial disease
Br J Nutr.
2009 Feb;101(2):263-9.
(277) Gunnar H. Gislason, MD, PhD; Jeppe N. Rasmussen, MD,
PhD; Steen Z. Abildstrom, MD, PhD; Tina K. Schramm, MD;Morten L. Hansen, MD; Emil L. Fosbøl, MB; Rikke Sørensen, MD; Fredrik Folke, MD;
Pernille Buch, MD, PhD;
Niels Gadsbøll, MD, DMSc; Søren Rasmussen, MSc, PhD; Henrik E. Poulsen, MD, DMSc;
Lars Køber, MD, DMSc;
Mette Madsen, MSc; Christian Torp-Pedersen, MD, DMSc. Increased Mortality
and Cardiovascular Morbidity Associated With Use of
Nonsteroidal Anti-inflammatory Drugs in Chronic Heart
Failure.
Arch Intern Med.
2009 Jan 26;169(2):141-9.
(278) Hansen ML, Gadsbøll N, Rasmussen
S, Gislason GH, Folke F, Andersen SS, Schramm TK, Sørensen R, Fosbøl EL,
Abildstrøm SZ, Madsen M, Poulsen HE, Køber L, Torp-Pedersen C.Clinical
consequences of hospital variation in use of oral anticoagulant therapy after
first-time admission for atrial fibrillation. Journal
of Internal Medicine 265; 335–344
(279) L. F. Mandsberg, O. Ciofu, N. Kirkby, L. E.
Christiansen, H. E. Poulsen and N. Høiby.
Antibiotic Resistance in Pseudomonas aeruginosa Strains with
Increased Mutation Frequency due to Inactivation of the
DNA Oxidative Repair System.
Antimicrobial Agents and Chemotherapy, June 2009, 2483–91
(280)
Afzal S, Jensen SA, Vainer
B, Vogel U, Matsen JP, Sorensen JB, et al. MTHFR polymorphisms and 5-FU-based
adjuvant chemotherapy in colorectal cancer. Ann Oncol 2009 Oct;20(10):1660-6
(281) Trine Henriksen, Peter R. Hillestrøm, Henrik E. Poulsen,
Allan Weimann. Automated method for the direct analysis of 8-oxo-guanosine and
8-oxo-2′-deoxyguanosine in human urine using ultraperformance liquid
chromatography and tandem mass spectrometry. Free Radical Biology &
Medicine 47 (2009) 629–635
(282)
Broedbaek K, Poulsen HE,
Weimann A, Kom GD, Schwedhelm E, Nielsen P, et al. Urinary excretion of
biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis.
Free Radic Biol Med 2009 Oct 15;47(8):1230-3.
(283)
Davanipour Z, Poulsen HE,
Weimann A, Sobel E. Endogenous melatonin and oxidatively damaged guanine in DNA.
BMC Endocr Disord 2009;9:22(
(284)
Poulsen HE. Report from the President of SFRR-Europe.
Free Radical Research, December 2009; 43(12): 1254–1255
(285)
Fosbol EL, Gislason GH,
Poulsen HE, Hansen ML, Folke F, Schramm TK, et al. Prognosis in heart failure
and the value of {beta}-blockers are altered by the use of antidepressants and
depend on the type of antidepressants used. Circ Heart Fail 2009
Nov;2(6):582-90.
(286)
Dominguez H, Schramm TK,
Norgaard ML, Abildstrom SZ, Kober L, Jorgensen C, et al. Initiation and
persistence to statin treatment in patients with diabetes receiving
glucose-lowering medications. Open Cardiovasc Med J 2009;3:152-9
2010
(287) Nurmi T,
Mursu J, Penalvo JL, Poulsen HE, Voutilainen S. Dietary intake and urinary
excretion of lignans in Finnish men. Br J Nutr 2010
Mar;103(5):677-85.
(288)
Lykkesfeldt J, Poulsen HE. Is vitamin C supplementation beneficial?
Lessons learned from randomised controlled trials.
Br J Nutr.
2010 May;103(9):1251-9. Epub 2009 Dec 15. Review..
(289) Lopez-Miranda J, Perez-Jimenez F, Ros E, De CR,
Badimon L, Covas MI, et al. Olive oil and health: Summary of the II
international conference on olive oil and health consensus report, Jaen and
Cordoba (Spain) 2008. Nutr Metab Cardiovasc Dis 2010 Mar 19.
(290) Olesen JB, Hansen PR, Erdal J, Abildstrom SZ,
Weeke P, Fosbol EL, et al. Antiepileptic drugs and risk of suicide: a nationwide
study. Pharmacoepidemiol Drug Saf 2010 Mar 16.
(291) Glintborg B, Andersen SK, Poulsen HE.
Prescription data improve the medication history in primary care. Qual Saf
Health Care 2010 Mar 1.
(292) Sorensen R, Abildstrom SZ, Weeke P, Fosbol EL,
Folke F, Hansen ML, et al. Duration of clopidogrel treatment and risk of
mortality and recurrent myocardial infarction among 11 680 patients with
myocardial infarction treated with percutaneous coronary intervention: a cohort
study. BMC Cardiovasc Disord 2010;10:6.
(294) Toward consensus in the analysis of urinary
8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative
stress.
European Standards Committee on Urinary (DNA) Lesion Analysis, Evans MD, Olinski
R, Loft S, Cooke MS.
Collaborators (40)
Rossner P Jr,
Sram
R,
Henriksen T,
Poulsen HE,
Weimann A,
Barbieri A,
Sabatini L,
Violante F,
Kino
S,
Ochi
T,
Tairin K,
Takeuchi M,
Kasai H,
Meerman JH,
Gackowski D,
Rozalski R,
Siomek A,
Halliwell B,
Jenner AM,
Wang
H,
Cerda C,
Saez
G,
Haghdoost S,
Svoboda P,
Hu CW,
Chao MR,
Peng KY,
Shih WC,
Wu KY,
Orhan H,
Istanbullu NS,
Mistry V,
Farmer PB,
Sandhu J,
Singh R,
Cortez C,
Su Y,
Santella RM,
Lambert P,
Smith R.
(295)
Cadet J,
Poulsen H.
Measurement of oxidatively generated base damage in cellular
DNA and urine.
Free Radic Biol Med. 2010 Jun 1;48(11):1457-9. Epub 2010 Mar 12.
(296)
Fosbøl EL,
Folke F,
Jacobsen S,
Rasmussen JN,
Sørensen R,
Schramm TK,
Andersen SS,
Rasmussen S,
Poulsen HE,
Køber L,
Torp-Pedersen C,
Gislason GH. Cause-Specific Cardiovascular Risk
Associated With Nonsteroidal Antiinflammatory Drugs Among Healthy Individuals.
Circ Cardiovasc Qual Outcomes. 2010 Jun 8. [Epub ahead of print]
(297) Weeke P, Folke F, Gislason GH, Lippert FK, Olesen JB, Andersson C, et
al. Pharmacotherapy and hospital admissions before out-of-hospital cardiac
arrest: a nationwide study. Resuscitation 2010 Dec;81(12):1657-63
(298) Morten L. Hansen, MD, PhD; Rikke Sørensen, MD;
Mette T. Clausen, MSc Pharm; Marie Louise Fog-Petersen,
MSc Pharm; Jakob Raunsø, MD; Niels Gadsbøll, MD, DMSc; Gunnar H. Gislason, MD,
PhD; Fredrik Folke, MD; Søren S. Andersen, MD; Tina K.
Schramm, MD; Steen Z. Abildstrøm, MD, PhD; Henrik E.
Poulsen, MD, DMSc; Lars Køber, MD, DMSc; Christian Torp-Pedersen, MD, DMSc.
Risk of Bleeding With Single, Dual, or Triple
Therapy With Warfarin, Aspirin, and Clopidogrel in
Patients With Atrial Fibrillation ARCH INTERN MED/VOL 170
(NO. 16), SEP 13, 2010
(299)
Lykkesfeldt J,
Poulsen HE.Reply to Hemilä by Lykkesfeldt and Poulsen. PMID: 20854702 [PubMed
- as supplied by publisher]Br
J Nutr. 2010 Sep 21:1.
(300)
Berendt L,
Håkansson C,
Bach KF,
Andreasen PB,
Petersen LG,
Andersen E,
Poulsen HE,
Dalhoff K. Methodological characteristics of academic
clinical drug trials--a retrospective cohort study of applications to the Danish
Medicines Agency 1993-2005.Br
J Clin Pharmacol. 2010 Nov;70(5):729-35
(301)
Helena Dominguez1*, Tina Kenn Schramm2, Gunnar Hilmar Gislason3, Mette Lykke
Norgaard3, Jakob Raunsø3, Steen Zabell Abildstrøm4,5, Lars Kober2, Henrik
Enghusen Poulsen5,6,7 and Christian Tobias Torp-Pedersen3,7 National background
is associated with disparities in initiation and persistence to statin treatment
in subjects with diabetes in Denmark. Frontiers in Pharmacology, Pharmacotherapy
of Cardiovascular Disorders December 2010 | Volume 1 | Article 142 doi:
10.3389/fphar.2010.00142
2011
(302) Broedbaek K, Siersma V, Andersen JT, Petersen M,
Afzal S, Hjelvang B, Weimann A, Semba RD, Ferrucci L, Poulsen HE.
The
association between low-grade inflammation, iron status and nucleic acid
oxidation in the elderly.Free
Radic Res. 2011 Jan 28. [Epub ahead of print]
(303) NELA GOROVIC SHOAIB AFZAL , ANNE TJØNNELAND KIM OVERVAD ULLA
VOGEL CHRISTINA ALBRECHTSEN HENRIK E. POULSEN Genetic variation in the hTAS2R38
taste receptor and brassica vegetable intake
Scandinavian Journal of Clinical & Laboratory Investigation, 2011; 71:
(4):274-9. Epub 2011 Feb 21.
(304) Castañer O, Fitó M, López-Sabater MC, Poulsen HE,
Nyyssönen K, Schröder H, Salonen JT, De la Torre-Carbot K, Zunft HF, De la Torre
R, Bäumler H, Gaddi AV, Saez GT, Tomás M, Covas MI; for the EUROLIVE Study
Group.
The effect of olive oil polyphenols on antibodies against oxidized LDL. A
randomized clinical trial.Clin Nutr. 2011 Mar 2. [Epub ahead of print]
PMID:21376434
(305) Broedbaek K, Ribel-Madsen R, Henriksen T,
Weimann A, Petersen M, Andersen JT, Afzal S, Hjelvang B, Roberts LJ 2nd, Vaag A,
Poulsen P, Poulsen HE.
Genetic and environmental influences on oxidative damage assessed in elderly
Danish twins. Free Radic Biol Med. 2011 Feb 23. [Epub
ahead of print]
PMID: 21354303
(306)
Petersen M,
Andersen JT,
Hjelvang BR,
Broedbaek K,
Afzal S,
Nyegaard M,
Børglum AD,
Stender S,
Køber L,
Torp-Pedersen C,
Poulsen HE. Association of beta-adrenergic receptor
polymorphisms and mortality in carvedilol-treated chronic heart-failure
patients.Br
J Clin Pharmacol. 2011 Apr;71(4):556-565. doi:
10.1111/j.1365-2125.2010.03868.
(307) Broedbaek K, Henriksen T, Weimann A, Petersen M, Andersen JT, Afzal S,
et al. Long-Term Effects of Irbesartan Treatment and Smoking on Nucleic Acid
Oxidation in Patients With Type 2 Diabetes and Microalbuminuria: An Irbesartan
Microalbuminuria Type 2 Diabetes in Hypertensive Patients (IRMA) 2 substudy.
Diabetes Care 2011 Mar 31.
(308) Shoaib Afzal, Milena Gusella, Ben Vainer, Ulla B.
Vogel, Jon T. Andersen, Kasper Broedbaek, Morten Petersen, Espen Jimenez-Solem,
Laura Bertolaso, Carmen Barile, Roberto Padrini, Felice Pasini, Søren A. Jensen,
and Henrik E. Poulsen. Combinations of Polymorphisms in Genes Involved in the
5-Fluorouracil Metabolism Pathway Are Associated with Gastrointestinal Toxicity
in Chemotherapy-Treated Colorectal Cancer Patients. Clin Cancer Res; 17(11) June
1, 2011 - Published Online First on April 6, 2011;
DOI:10.1158/1078-0432.CCR-11-0304
(309) Joergensen A, Broedbaek K, Weimann A, Semba RD,
Ferrucci L, Joergensen MB, Poulsen HE.
Association between Urinary Excretion of Cortisol and Markers of Oxidatively
Damaged DNA and RNA in Humans. PLoS One. 2011;6(6):e20795. Epub 2011 Jun 7
(310) Afzal S, Gusella M, Jensen SA, Vainer B, Vogel
U, Andersen JT, Brødbæk K, Petersen M, Jimenez-Solem E, Adleff V, Budai B, Hitre
E, Láng I, Orosz E, Bertolaso L, Barile C, Padrini R, Kralovánszky J, Pasini F,
Poulsen HE. The association of polymorphisms in 5-fluorouracil
metabolism genes with outcome in adjuvant treatment of colorectal
cancer.Pharmacogenomics. 2011 Sep;12(9):1257-1267. PMID: 21919605
(311) Broedbaek K, Weimann A, Specht E, Poulsen HE.
Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker in type 2 diabetes.
Free Radic
Biol Med. 2011 Jul 19. [Epub ahead of print] PMID:21820047
(312) KASPER BROEDBAEK, MD,
VOLKERT SIERSMA, PHD, TRINE HENRIKSEN, PHD, ALLAN WEIMANN, PHD,
MORTEN PETERSEN, MD, JON T. ANDERSEN, MD, ESPEN JIMENEZ-SOLEM, MD,
ELISABETH S. STOVGAARD, MD, LARS J. HANSEN, PHD, JAN ERIK HENRIKSEN,
PHD, STEEN J. BONNEMA, PHD NIELS DE FINE OLIVARIUS, MD, HENRIK E.
POULSEN, DMSC, Urinary Markers of Nucleic Acid
Oxidation and Long-Term Mortality of Newly Diagnosed Type 2
Diabetic
Patients. Diabetes Care 34:2594–2596, 2011
2012
(313) Pernille Tveden-Nyborg, Stine Hasselholt, Namiyo
Miyashita, Torben Moos, Henrik E. Poulsen, Jens Lykkesfeldt.
Chronic Vitamin C Deficiency does not Accelerate Oxidative Stress in Ageing
Brains of Guinea Pigs Basic Clin Pharmacol Toxicol. 2012 Jun;110(6):524-9. doi:
10.1111/j.1742-7843.2011.00852.x. Epub 2012 Jan 20.PMID: 22212866
(314) Weimann A, Broedbaek K, Henriksen T, Stovgaard
ES, Poulsen HE. Assays for urinary biomarkers of oxidatively damaged nucleic
acids. Free Radic Res 2012 Apr;46(4):531-40.
(315) Jørgensen A, Jørgensen MB,
Poulsen HE.[Stress
and aging.]
Ugeskr Laeger. 2012 Jan
23;174(4):201-204. Danish. PMID: 22277362
(316) Henrik E. Poulsen, Elisabeth
Specht, Kasper Broedbaek,Trine Henriksen, Christina Ellervik, Thomas
Mandrup-Poulsen, Morten Tonnesen, Peter E. Nielsen, Henrik U. Andersen, Allan
Weimann, RNA modifications by oxidation: A novel disease mechanism?, Free
Radical Biology and Medicine (2012), doi:10.1016/j.freeradbiomed.2012.01.009
(317) Sarac SB, Rasmussen CH, Afzal S,
Thirstrup S, Jensen SA, Colding-Jørgensen M, Poulsen HE, Mosekilde E.Data-Driven
Assessment of the Association of Polymorphisms in 5-Fluorouracil Metabolism
Genes with Outcome in Adjuvant Treatment of Colorectal Cancer.
Basic Clin Pharmacol Toxicol. 2012 Mar 26. doi:
10.1111/j.1742-7843.2012.00885.x. [Epub ahead of print]
(318) Weeke P, Folke F, Gislason GH,
Lippert FK, Olesen JB, Andersson C, Wissenberg M, Poulsen HE, Nielsen SL,
Køber L, Torp-Pedersen C.Hospital
admissions and pharmacotherapy before out-of-hospital cardiac arrest according
to age. Resuscitation. 2012 May;83(5):584-90. Epub 2011 Nov 6.]
(319) Weeke P, Jensen A, Folke F,
Gislason GH, Olesen JB, Andersson C, Fosbøl EL, Larsen JK, Lippert FK, Nielsen
SL, Gerds T, Andersen PK, Kanters JK, Poulsen HE, Pehrson S, Køber L,
Torp-Pedersen C.
Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide
Case-Time-Control Study. Clin Pharmacol Ther. 2012 May 16. doi:
10.1038/clpt.2011.368. [Epub ahead of print]
(320) Afzal S, Jensen SA, Sørensen JB, Henriksen T, Weimann A, Poulsen HE
Oxidative damage to guanine nucleosides following combination chemotherapy with
5-fluorouracil and oxaliplatin.
Cancer Chemother Pharmacol. 2012 Feb;69(2):301-7. Epub 2011 Jun 28.PMID: 21710244
(321)
Espen Jimenez-Solem,
Jon Traerup Andersen,
Morten Petersen,
Kasper Broedbaek,
Jonas Krogh Jensen,
Shoaib Afzal,
Gunnar H Gislason,
Christian Torp-Pedersen,
Henrik Enghusen Poulsen Exposure
to selective serotonin reuptake inhibitors and the risk of congenital
malformations: a nationwide cohort studyPharmacology and therapeutics
BMJ Open 2012;2:e001148 doi:10.1136/bmjopen-2012-001148
OPEN
ACCESS
(322) Petersen M, Andersen JT,
Jimenez-Solem E, Broedbaek K, Hjelvang BR, Henriksen T, Frandsen E, Forman JL,
Torp-Pedersen C, Køber L, Poulsen HE.
The
Effect of the Arg389Gly Beta-1 Adrenoceptor Polymorphism on Plasma Renin
Activity and Heart Rate and the Genotype-Dependent Response to Metoprolol
Treatment. Clin Exp Pharmacol Physiol. 2012 Jun 16.
doi: 10.1111/j.1440-1681.2012.05736.x. [Epub ahead of print]
(323) Meidahl PK, Jimenez-Solem E,
Andersen JT, Petersen M, Brodbaek K, Kober L, et al. beta-Blocker treatment
during pregnancy and adverse pregnancy outcomes: a nationwide population-based
cohort study. BMJ Open 2012;2(4).
(324) Petersen M, Andersen JT,
Jimenez-Solem E, Broedbaek K, Afzal S, Nyegaard M, Børglum AD, Stender S,
Torp-Pedersen C, Køber L, Poulsen HE.Effect
of specific ADRB1/ADRB2/AGT genotype combinations on the association between
survival and carvedilol treatment in chronic heart failure: a substudy of the
ECHOS trial.Pharmacogenet Genomics. 2012 Jul 2. [Epub ahead of print]
(325) A. Torp-Pedersen, E.
Jimenez-Solem,J. T. Andersen, K.
Broedbaek, C. Torp-Pedersen, and H.
E. Poulsen "Exposure to Mebendazole and Pyrvinium during Pregnancy: A Danish
Nationwide Cohort Study," Infectious Diseases in Obstetrics and Gynecology, vol.
2012, Article ID 769851, 6 pages, 2012. doi:10.1155/2012/769851.
(326) Andersen JT, Petersen M, Jimenez-Solem E, Broedbaek K,
Andersen EW, Andersen NL, et al. Trimethoprim use in early pregnancy and the
risk of miscarriage: a register-based nationwide cohort study. Epidemiol Infect
2012 Sep 25;1-7.
(327) Torp-Pedersen A, Jimenez-Solem E, Andersen JT, Broedbaek K, Torp-Pedersen
C, Poulsen HE. Exposure to Mebendazole and Pyrvinium during Pregnancy: A Danish
Nationwide Cohort Study. Infect Dis Obstet Gynecol 2012;2012:769851..
(328) Egefjord L, Gejl M, Moller A, Braendgaard H,
Gottrup H, Antropova O, et al. Effects of liraglutide on neurodegeneration,
blood flow and cognition in Alzheimer s disease - protocol for a controlled,
randomized double-blinded trial. Dan Med J 2012 Oct;59(10):A4519.
2013
(329) Mullner E, Brath H, Pleifer S, Schiermayr C, Baierl A, Wallner M, et al.
Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with
type 2 diabetes. Mol. Nutr. Food Res. 2013, 57, 328–338
(330) Broedbaek K, Siersma V, Henriksen T, Weimann A,
Petersen M, Andersen JT, et al. Association between urinary markers of nucleic
acid oxidation and mortality in type 2 diabetes: a population-based cohort
study. Diabetes Care 2013 Mar;36(3):669-76.]PMID:23150279
(331) Barregard L, Moller P, Henriksen T, Mistry V,
Koppen G, Rossner P, Jr., et al. Human and Methodological Sources of Variability
in the Measurement of Urinary 8-Oxo-7,8-dihydro-2'-deoxyguanosine. Antioxid
Redox Signal 2013 Jan 31.
(332) Andersen JT, Petersen M, Jimenez-Solem E, Broedbaek
K, Andersen NL, Torp-Pedersen C, Keiding N, Poulsen HE.Clarithromycin in early
pregnancy and the risk of miscarriage and malformation: a register based
nationwide cohort study.PLoS One. 2013;8(1):e53327. doi:
10.1371/journal.pone.0053327. Epub 2013 Jan 2.
(333) Jorgensen A, Maigaard K, Wortwein G, Hageman
I, Henriksen T, Weimann A, et al. Chronic restraint stress in rats causes
sustained increase in urinary corticosterone excretion without affecting
cerebral or systemic oxidatively generated DNA/RNA damage. Prog
Neuropsychopharmacol Biol Psychiatry 2013 Jan 10;40:30-7.
(334) Jimenez-Solem E, Andersen JT, Petersen M, Broedbaek
K, Lander AR, Afzal S, et al. SSRI use during pregnancy and risk of stillbirth
and neonatal mortality. Am J Psychiatry 2013 Mar 1;170(3):299-304.PMID: 23361562
(335) Jimenez-Solem E, Andersen JT, Petersen M, Broedbaek
K, Andersen NL, Torp-Pedersen C, Poulsen HE. Prevalence
of Antidepressant Use during Pregnancy in Denmark, a Nation-Wide Cohort Study.
PLoS One. 2013 Apr 25;8(4):e63034. doi: 10.1371/journal.pone.0063034.
Print 2013. PMID:23638179[PubMed
(336) Kalliokoski O, Jacobsen KR, Darusman HS, Henriksen
T, Weimann A, Poulsen HE, Hau J, Abelson KS. Mice do not
habituate to metabolism cage housing--a three week study of male BALB/c mice.
PLoS One. 2013;8(3):e58460. doi: 10.1371/journal.pone.0058460. Epub 2013
Mar 7. PMID:23505511[PubMed - in process]
(337) Jorgensen A, Krogh J, Miskowiak K, Bolwig TG, Kessing LV, Fink-Jensen A,
Nordentoft M, Henriksen T, Weimann A, Poulsen HE, Jorgensen MB. Systemic
oxidatively generated DNA/RNA damage in clinical depression: Associations to
symptom severity and response to electroconvulsive therapy. J Affect Disord 2013
Jul;149(1-3):355-62.
PMID:23497793
(338) Andersen JT, Petersen M, Jimenez-Solem E, Rasmussen
JN, Andersen NL, Afzal S, Broedbaek K, Hjelvang BR, Køber L, Torp-Pedersen C,
Poulsen HE.
Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A
Register-Based Nationwide Cohort Study. Obstet Gynecol
Int. 2013;2013:364526. doi: 10.1155/2013/364526. Epub 2013 Feb 14.
PMID:23476656[PubMed] Free PMC Article
(339) Loft S, Olsen A, Moller P, Poulsen HE, Tjonneland
A. Association between
8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and risk of postmenopausal breast
cancer: nested case-control study. Cancer Epidemiol
Biomarkers Prev. 2013 May 8. [Epub ahead of print]
Andre publikationer
(1) Poulsen HE, Juul P. Note on the statistical evaluation of a
randomized, cross-over bioavailability study. Danish National Board
of Health, 1990
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