Henrik Enghusen Poulsen
Professor and Chief

         Professor of Clinical Pharmacology, Head of Department of Clinical Pharmacology Q, Rigshospitalet, University Hospital, DK-2200 Copenhagen N, Denmark,  Telephone (+45) 3545 7671 Fax: (+45) 3545 2745 E-mail: hepo"AT" ("AT" is @ for spam confusion)
Citizenship Date of Birth
        Danish March 29, 1948 in Aalborg, Denmark
Private address
        4 Birkevænget, PO Box 71, DK-3050 Humlebæk. Telephone (+45) 49 19 39 11
Education and University degrees

Medical Doctor. Faculty of Health Sciences, University of Copenhagen, January 1976. Licence to independent medical practice 1979. Dr. Sci. (Dr. med.) University of Copenhagen, 1986. License to practise as specialist in Clinical Pharmacology May, 1997.

Region H:S Leadership Development Course, Modules I and II. Copenhagen, 2004-5.

Leadership for Physicians, OLAU 2, Rigshospitalet, Copenhagen, 1998-1999


February 1976 - August 1977, Basic training as hospital physician

September 1977 - January 1978, University of Copenhagen, Research position and postgraduate course in scientific methods

February 1978 - February 1982, Research Fellow, Department of Medicine A, Rigshospitalet, Copenhagen, Denmark

Marts 1982 - September 1985, Clinical Research Fellow, Department of Medicine A, Rigshospitalet, Copenhagen, Denmark

October 1985 - Marts 1986, Physician, Department of Medicine A, Rigshospitalet, Copenhagen, Denmark

April 1986 - October 1994, Associate professor, Department of Pharmacology, Faculty of Health Sciences, University of Copenhagen, Denmark.

May 1994, Appointed Professor of Pharmacology and Toxicology, Royal Danish School of Pharmacy, position not filled.

November 1994 - July 1996, Professor of Medical Toxicology, Department of Pharmacology, Faculty of Health Sciences, University of Copenhagen, Denmark.

August 1996 - present. Professor, Chair in Clinical Pharmacology, Rigshospitalet, Copenhagen. 

Other appointments

Medical Assessor, Danish National Drug Registration Board, Ministry of Health, Denmark, November 1984 to April 1992

Editorial Board:

Pharmacogenetic, 1993 - 2000.

Pharmacology & Toxicology, 1995 - present (including member execlusive committe and editorial handling of manuscripts).

Free Radical Research, 1999-present (including editorial handling of manuscript).

Mechanisms of Ageing and Development, 1999 - present.

Food and Chemical Toxicology, 2000 - present

Ageing Research Reviews, 2004 - present

Free Radical Biology and Medicine,  2004 - present

Administrative experience

        Academic administrative experience. Since 1981 member of various boards at Rigshospitalet and University of Copenhagen. Positions include: Chairman of the MD. PhD programme (about 450 PhD students), member of the executive faculty committee and the steering Board of the Faculty of Health Sciences. Member of the steering committee for the research priority area Environment, University of Copenhagen, Chairman of the Committee for Environmental Medicine in an Institute of Public Health at the University of Copenhagen and member of the Co-ordinating Committee for establishing an Institute of Public Health, University of Copenhagen. Representative for Rigshospitalet in the Central Drug Committee of Copenhagen and chairman of The Drug Committee of Rigshospitalet. Chariman of the board of Danish Society of Clinical Pharmacology (1997-2001).


Other tasks

The advisory research committee, National Institute of Occupational Health, 1990-1998

The advisory research committee, Ministry of Health Environmental Medicine Research Centre, 1991-1998

Chairman of the Committee for the initiation of The Strategic Environmental Research Program (appointed by The Danish Research Advisory Council)

Vice Chairman, Danish Toxicology Centre, 1991-1999

Member of the Danish Nutritional Council, 1995-1996

Member of Danish Scientific Ethics Committee, 2009-2014

President SFRR-Europe, 2009-2011 ( )

Deputy Member of Board of Studienævnet For Medicin in Copenhagen

Member of the Institutrådet for Diagnostisk Institut

Expert for the Danish Legal Council / Retlægerådet (Alcohol and Drug Cases)

Research Supervision

Since 1980 supervision of 20 students and PhD students. Three doctoral theses and 6 PhD theses have been given, 1 PhD thesis is being evaluated and four are in the writing process. Five master theses have been approved.

Evaluation of applicants for positions: Eight positions as senior researchers have been evaluated 1992 - 1995

Evaluation of six doctoral theses and ten PhD theses have been performed

Reviewing on regular basis
Journal of Hepatology
European Journal of Clinical Investigation
Pharmacology and Toxicology
Scandinavian Journal of Clinical and Laboratory Investigation
European Journal of Clinical Pharmacology
Ugeskrift for Læger
Cardiovascular Research
Free Radical Research
Scientific publications


(1) Poulsen HE, Ranek L. Ulcus duodeni som årsag til miltvenetrombose og eosophagusvaricer. Ugeskr Laeger 1976; 138:1712-1713.


(2) Poulsen HE, Bengmark S, Borgeson S, Flodgren P, Kallum B. Staging laparotomy with splenectomy in Hodkin's disease. Acta Chir Scand 1977; 143:347-357.


(3) Milandri M, Poulsen HE, Ranek L, Andreasen PB. Effect of long-term disulfiram administration on rat liver. Pharmacology 1980; 21(1):76-80.


(4) Poulsen HE, Ranek L, Andreasen PB. The hepatic glutathione content in liver diseases. Scand J Clin Lab Invest 1981; 41(6):573-576.

(5) Poulsen HE, Petersen P, Vilstrup H. Quantitative liver function and morphology after paracetamol administration to rats. European Journal of Clinical Investigation 1981; 11(3):161-164.

(6) Sonne J, Poulsen HE, Dossing M, Larsen NE, Andreasen PB. Cimetidine clearance and bioavailability in hepatic cirrhosis. Clin Pharmacol Ther 1981; 29(2):191-197.

(7) Yildirim SI, Poulsen HE. Quantitative liver functions after 70% hepatectomy. European Journal of Clinical Investigation 1981; 11(6):469-472.


(8) Dossing M, Poulsen HE, Andreasen PB, Tygstrup N. A simple method for determination of antipyrine clearance. Clin Pharmacol Ther 1982; 32(3):392-396.


(9) Dossing M, Volund A, Poulsen HE. Optimal sampling times for minimum variance of clearance determination. Br J Clin Pharmacol 1983; 15(2):231-235.

(10) Dossing M, Pilsgaard H, Rasmussen B, Poulsen HE. Time course of phenobarbital and cimetidine mediated changes in hepatic drug metabolism. European Journal of Clinical Pharmacology 1983; 25(2):215-222.

(11) Poulsen HE. A pocket calculator program to sort data. Comput Biol Med 1983; 13(4):299-301.


(12) Pilsgaard H, Poulsen HE. A one-sample method for antipyrine clearance determination in rats. Pharmacology 1984; 29(2):110-116.

(13) Poulsen HE, Vilstrup H, Keiding S. Galactose elimination kinetics in perfused rat liver after two thirds hepatectomy. Scand J Clin Lab Invest 1984; 44(2):155-158.

(14) Poulsen HE, Ranek L. Paracetamolforgiftning. Ugeskr Laeger 1984; 146:4030-4033.

(15) Poulsen HE, Korsholm B. Quantitative liver functions after administration of allyl alcohol to rats. Acta Pharmacol Toxicol 1984; 54(2):120-123.

(16) Tvedegaard E, Poulsen HE, Vilstrup H, Thomsen HK. Liver function during chronic renal failure in rabbits. Experientia 1984; 40(11):1255-1256.


(17) Adelhøj B, Petring OU, Ibsen M, Brynnum J, Poulsen HE. Buprenorphine delays drug absorption and gastric emptying in man. Acta Anaesth Scand 1985; 29(6):599-601.

(18) Adelhøj B, Petring OU, Brynnum J, Ibsen M, Poulsen HE. Effect of diazepam on drug absorption and gastric emptying in man. Br J Anaesth 1985; 57(11):1107-1109.

(19) Adelhøj B, Petring OU, Ibsen M, Brynnum J, Poulsen HE. Tardiv respirationsdepression efter intravenøs buprenorfin. Ugeskr Laeger 1985; 147:1343.

(20) Petring OU, Adelhøj B, Ibsen M, Brynnum J, Poulsen HE. Abstaining from cigarette smoking has no major effect on gastric emptying in habitual smokers. Br J Anaesth 1985; 57(11):1104-1106.

(21) Poulsen HE, Lerche A, Skovgaard LT. Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose. Biochem Pharmacol 1985; 34(20):3729-3733.

(22) Poulsen HE, Pilsgaard H. Antipyrine metabolism during hepatic regeneration in the rat. Liver 1985; 5(4):196-199.

(23) Poulsen HE. One sample antipyrine clearance after 90% partial hepatectomy in the rat. Liver 1985; 5(4):200-204.

(24) Poulsen HE, Gaub J, Iversen J. Changes in quantitative measures of hepatic function after 90% hepatectomy in rats. European Journal of Clinical Investigation 1985; 15(5):285-289.

(25) Poulsen HE, Lerche A, Pedersen NT. Potentiated hepatotoxicity from concurrent administration of acetaminophen and allyl alcohol to rats. Biochem Pharmacol 1985; 34(6):727-731.

(26) Poulsen HE, Lerche A, Pedersen NT. Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. Pharmacology 1985; 30(2):100-108.

(27) Tvedegaard E, Poulsen HE, Vilstrup H, Thomsen HK. Functional status of the liver during chronic renal failure: an experimental study in the rabbit. Liver 1985; 5(4):183-188.


(28) Hansen BA, Poulsen HE. Changes in the hepatic capacity of urea-N synthesis, galactose elimination and antipyrine clearance following 70% hepatectomy in the rat. Scand J Clin Lab Invest 1986; 46:233-237.

(29) Hansen BA, Poulsen HE. The capacity of urea-N synthesis as a quantitative measure of the liver mass in rats. J Hepatol 1986; 2(3):468-474.

(30) Hansen BA, Poulsen HE. Starvation induced changes in quantitative measures of liver function in the rat. Clin Nutrit 1986; 5:213-216.

(31) Loft S, Dossing M, Poulsen HE, Sonne J, Olesen KL, Simonsen K et al. Influence of dose and route of administration on disposition of metronidazole and its major metabolites. European Journal of Clinical Pharmacology 1986; 30(4):467-473.

(32) Loft S, Sonne J, Pilsgaard H, Dossing M, Poulsen HE, Ciraulo DA et al. Inhibition of antipyrine elimination by disulfiram and cimetidine: the effect of concomitant administration
Pharmacokinetic interaction of disulfiram and antidepressants. British Journal of Clinical Pharmacology 1986; 21:75-77.

(33) Petring OU, Adelhøj B, Ibsen M, Poulsen HE. The relationship between gastric emptying of semisolids and paracetamol absorption. Br J Clin Pharmacol 1986; 22(6):659-662.

(34) Poulsen HE. Kvantitering af leverfunktionen ved eksperimentel akut toksisk leverskade sammenlignet med forholdene efter partiel og subtotal hepatectomi. Disputats. Copenhagen: University of Copenhagen, 1986.

(35) Sonne J, Poulsen HE, Andreasen PB. Single dose oxazepam has no effect on acetaminophen clearance or metabolism. European Journal of Clinical Pharmacology 1986; 30(1):127-129.


(36) Adelhøj B, Petring OU, Frosig F, Jensen BN, Ibsen M, Poulsen HE. The effect of spinal analgesia and surgery on peroperative drug absorption and gastric emptying in man. Acta Anaesth Scand 1987; 31(2):165-167.

(37) Dalhoff K, Poulsen HE, Garred P, Placchi M, Gammans RE, Mayol RF et al. Buspirone pharmacokinetics in patients with cirrhosis. Br J Clin Pharmacol 1987; 24(4):547-550.

(38) Loft S, Sonne J, Poulsen HE, Petersen KT, Jorgensen BG, Dossing M. Inhibition and induction of metronidazole and antipyrine metabolism. European Journal of Clinical Pharmacology 1987; 32(1):35-41.

(39) Petersen KF, Hansen BA, Poulsen HE. Hepatic regeneration following glucagon treatment. Horm Metab Res 1987; 19(6):239-241.

(40) Petring OU, Adelhøj B, Ibsen M, Poulsen HE. Effect of chlorpromazine on drug absorption and gastric emptying in man. Can J Anaesth 1987; 34(6):563-565.

(41) Poulsen HE, Loft S. Quantitation of liver function: Antipyrine, an update. In: Okolicsanyi L, editor. Assessment and management of hepatobiliary disease. Berlin Heidelberg: Springer-Verlag, 1987: 189-195.

(42) Poulsen HE, Jorgensen L, Thomsen P. Prevention of acetaminophen hepatotoxicity by disulfiram. Pharmacol Ther 1987; 33(1):83.

(43) Sonne J, Dossing M, Poulsen HE, Pilsgaard H, Rasmussen B, Loft S. Effect of concomitant administration of cimetidine and phenobarbital on antipyrine elimination and metabolite formation. Int J Clin Pharmacol Ther Toxicol 1987; 25(4):194-196.

(44) Tygstrup N, Poulsen HE. Post-marketing surveillance of hepatotoxicity. Milan, Italy: Wichtig Editore, 1987.


(45) Jorgensen L, Thomsen P, Poulsen HE. Disulfiram prevents acetaminophen hepatotoxicity in rats. Pharmacology and Toxicology 1988; 62(5):267-271.

(46) Knudsen GM, Poulsen HE. Unchanged blood-brain barrier permability to GABA in experimental hepatic encephalopathy. In: Soeter PB, Wilson JHP, Maijer AJ, Holm E, editors. Advances in ammonia metabolism and hepatic encephalopathy. Elsevier Science Publishers B.V., 1988: 309-313.

(47) Knudsen GM, Poulsen HE, Paulson OB. Blood-brain barrier permeability in galactosamine-induced hepatic encephalopathy. No evidence for increased GABA-transport. J Hepatol 1988; 6(2):187-192.

(48) Loft S, Dossing M, Poulsen HE. Influence of age and consumption of tobacco, alcohol and caffeine on antipyrine clearance. Hum Toxicol 1988; 7(3):277-280.

(49) Loft S, Dossing M, Sonne J, Dalhof K, Bjerrum K, Poulsen HE. Lack of effect of cimetidine on the pharmacokinetics and metabolism of a single oral dose of metronidazole. European Journal of Clinical Pharmacology 1988; 35(1):65-68.

(50) Loft S, Poulsen HE, Sonne J, Dossing M. Metronidazole clearance: a one-sample method and influencing factors. Clin Pharmacol Ther 1988; 43(4):420-428.

(51) Poulsen HE, Loft S. Antipyrine as a model drug to study hepatic drug-metabolizing capacity. [Review] [62 refs]. J Hepatol 1988; 6(3):374-382.

(52) Poulsen HE, Thomsen P. Long-term administration of toxic doses of paracetamol (acetaminophen) to rats. Liver 1988; 8(3):151-156.

(53) Sonne J, Poulsen HE, Loft S, Dossing M, Vollmer-Larsen A, Simonsen K et al. Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism. European Journal of Clinical Pharmacology 1988; 35(1):109-111.

(54) Vilstrup H, Hansen BA, Almdal T, PetersenKF, Siggaard I, Poulsen HE. The capacity of urea synthesis in rats: regulation and physiological importance. In: Soeters PB, editor. Advances in ammonia metabolism and hepatic encephalopathy. Elsevier Science Publisheres B.V., 1988: 79-85.


(55) Fischer-Nielsen A, Poulsen HE, Hansen BA, Tygstrup N, Keiding S. Age dependence of rat liver function measurements. J Hepatol 1989; 9(2):190-197.

(56) Loft S, Poulsen HE. Metabolism of metronidazole and antipyrine in isolated rat hepatocytes. Influence of sex and enzyme induction and inhibition. Biochem Pharmacol 1989; 38(7):1125-1136.

(57) Perrild H, Kayser L, Poulsen HE, Skovsted L, Jorgensen B, Hansen JM. Differential effect of continuous administration of beta-adrenoceptor antagonists on antipyrine and phenytoin clearance. Br J Clin Pharmacol 1989; 28(5):551-554.

(58) Poulsen HE, Hansen BA, Egeberg JC. Neutral red changes arginine-induced glucagon and insulin response in the rat. Pharmacology and Toxicology 1989; 65(1):65-68.

(59) Tvede KG, Loft S, Poulsen HE, Schou JS. Methyl parathion toxicity in rats is changed by pretreatment with the pesticides chlordecone, mirex and linuron. Arch Toxicol Suppl 1989; 13:446-447.


(60) Hinson JA, Roberts DW, Benson RW, Dalhoff K, Loft S, Poulsen HE. Mechanism of paracetamol toxicity [letter]. Lancet 1990; 335(8691):732.

(61) Loft S, Poulsen HE. Metabolism of metronidazole and antipyrine in hepatocytes isolated from mouse and rat. Xenobiotica 1990; 20(2):185-191.

(62) Loft S, Egsmose C, Sonne J, Poulsen HE, Dossing M, Andreasen PB. Metronidazole elimination is preserved in the elderly. Hum Exp Toxicol 1990; 9(3):155-159.

(63) Loft S, Poulsen HE. Prediction of xenobiotic metabolism by non-invasive methods. [Review] [104 refs]. Pharmacology and Toxicology 1990; 67(2):101-108.

(64) Ott P, Hansen PB, Dalhoff KP, Loft SH, Poulsen HE. [Consumption of, overdose and fatal poisoning with analgesics in Denmark 1979-1986]. Ugeskr Laeger 1990; 152(4):250-252.

(65) Ott P, Dalhoff KP, Poulsen HE. [Analgesic-induced mortality (letter)]. Ugeskr Laeger 1990; 152(39):2867-2868.

(66) Ott P, Dalhoff K, Hansen PB, Loft S, Poulsen HE. Consumption, overdose and death from analgesics during a period of over-the-counter availability of paracetamol in Denmark. J Intern Med 1990; 227(6):423-428.

(67) Sonne J, Boesgaard S, Poulsen HE, Loft S, Hansen JM, Dossing M et al. Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism. Br J Clin Pharmacol 1990; 30(5):737-742.


(68) Andersson R, Poulsen HE, Ahren B. Effect of bile on liver function tests in experimental E. coli peritonitis in the rat. Hepatogastroenterology 1991; 38(5):388-390.

(69) Boesgaard S, Petersen JS, Aldershvile J, Poulsen HE, Flachs H. Nitrate tolerance: effect of thiol supplementation during prolonged nitroglycerin infusion in an in vivo rat model. J Pharmacol Exp Ther 1991; 258(3):851-856.

(70) Dalhoff K, Hansen PB, Ott P, Loft S, Poulsen HE. Acute ethanol administration reduces the antidote effect of N-acetylcysteine after acetaminophen overdose in mice. Hum Exp Toxicol 1991; 10(6):431-433.

(71) Fischer-Nielsen A, Poulsen HE, Hansen BA, Hage E, Keiding S. CCl4 cirrhosis in rats: irreversible histological changes and differentiated functional impairment. J Hepatol 1991; 12(1):110-117.

(72) Loft S, Otton SV, Lennard MS, Tucker GT, Poulsen HE. Characterization of metronidazole metabolism by human liver microsomes. Biochem Pharmacol 1991; 41(8):1127-1134.

(73) Loft S, Nielsen AJ, Borg BE, Poulsen HE. Metronidazole and antipyrine metabolism in the rat: clearance determination from one saliva sample. Xenobiotica 1991; 21(1):33-46.

(74) Poulsen HE, Ranek L, Jorgensen L. The influence of disulfiram on acetaminophen metabolism in man. Xenobiotica 1991; 21(2):243-249.

(75) Roberts DW, Benson RW, Pumford, NR, Potter DW, Poulsen HE et al. Sensitive immunochemical assays for monitoring acetaminophen toxicity in humans. In: Vanderlaan M, editor. Immunoassays for trace chemical analysis. Washington DC: American Chemical Society, 1991: 314-326.

(76) Sjovall S, Ahren B, Hansson P, Loft S, Poulsen HE, Bengmark S. Metabolic responses to intermittent hepatic dearterialization in the rat. J Hepatol 1991; 13(1):33-37.

(77) Vistisen K, Loft S, Poulsen HE. Cytochrome P450 IA2 activity in man measured by caffeine metabolism: effect of smoking, broccoli and exercise. Adv Exp Med Biol 1991; 283:407-411.


(78) Boesgaard S, Aldershvile J, Poulsen HE. Preventive administration of intravenous N-acetylcysteine and development of tolerance to isosorbide dinitrate in patients with angina pectoris. Circulation 1992; 85(1):143-149.

(79) Dalhoff K, Poulsen HE. Effects of cysteine and acetaminophen on the syntheses of glutathione and adenosine 3'-phosphate 5'-phosphosulfate in isolated rat hepatocytes. Biochem Pharmacol 1992; 44(3):447-454.

(80) Dalhoff K, Ranek L, Mantoni M, Poulsen HE. Glutathione treatment of hepatocellular carcinoma. Liver 1992; 12(5):341-343.

(81) Fischer-Nielsen A, Poulsen HE, Loft S. 8-Hydroxydeoxyguanosine in vitro: effects of glutathione, ascorbate, and 5-aminosalicylic acid. Free Rad Biol Med 1992; 13(2):121-126.

(82) Loft S, Vistisen K, Ewertz M, Tjonneland A, Overvad K, Poulsen HE. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis 1992; 13(12):2241-2247.

(83) Loft S, Otte J, Poulsen HE, Sorensen H. Influence of intact and myrosinase-treated indolyl glucosinolates on the metabolism in vivo of metronidazole and antipyrine in the rat. Food Chem Toxicol 1992; 30(11):927-935.

(84) Poulsen HE, Loft S, Andersen M, Andersen JR. Disulfiram therapy - adverse drug reactions and interactions. Acta Scand Psych 1992; 86:59-66.

(85) Sherson D, Sigsgaard T, Overgaard E, Loft S, Poulsen HE, Jongeneelen FJ. Interaction of smoking, uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers. Br J Ind Med 1992; 49(3):197-202.

(86) Vistisen K, Poulsen HE, Loft S. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis 1992; 13(9):1561-1568.


(87) Boesgaard S, Poulsen HE, Aldershvile J, Loft S, Anderson ME, Meister A. Acute effects of nitroglycerin depend on both plasma and intracellular sulfhydryl compound levels in vivo. Effect of agents with different sulfhydryl-modulating properties. Circulation 1993; 87(2):547-553.

(88) Boesgaard S, Aldershvile J, Poulsen HE, Christensen S, Dige-Petersen H, Giese J. N-acetylcysteine inhibits angiotensin converting enzyme in vivo. J Pharmacol Exp Ther 1993; 265(3):1239-1244.

(89) Brosen K, Skjelbo E, Rasmussen BB, Poulsen HE, Loft S. Fluvoxamine is a potent inhibitor of cytochrome P4501A2. Biochem Pharmacol 1993; 45(6):1211-1214.

(90) Dalhoff K, Poulsen HE. Simultaneous measurements of glutathione and activated sulphate (PAPS) synthesis rates and the effects of selective inhibition of glutathione conjugation or sulphation of acetaminophen. Biochem Pharmacol 1993; 46(3):383-388.

(91) Dalhoff K, Poulsen HE. Inhibition of acetaminophen oxidation by cimetidine and the effects on glutathione and activated sulphate synthesis rates. Pharmacology and Toxicology 1993; 73(4):215-218.

(92) Dalhoff K, Poulsen HE. Synthesis rates of glutathione and activated sulphate (PAPS) and response to cysteine and acetaminophen administration in glutathione-depleted rat hepatocytes. Biochem Pharmacol 1993; 46(7):1295-1297.

(93) Ding JW, Andersson R, Soltesz V, Willen R, Loft S, Poulsen HE et al. The effect of biliary decompression on bacterial translocation in jaundiced rats. Hpb Surg 1993; 7(2):99-110.

(94) Jeding IB, Loft S, Poulsen HE. Non-induction of extrahepatic antipyrine and metronidazole metabolism evaluated from partially hepatectomized rats. Xenobiotica 1993; 23(4):411-418.

(95) Jensen KG, Loft S, Doehmer J, Poulsen HE. Metabolism of phenacetin in V79 Chinese hamster cell cultures expressing rat liver cytochrome P4501A2 compared to isolated rat hepatocytes. Biochem Pharmacol 1993; 45(5):1171-1173.

(96) Jensen KG, Onfelt A, Poulsen HE, Doehmer J, Loft S. Effects of benzo[a]pyrene and (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene on mitosis in Chinese hamster V79 cells with stable expression of rat cytochrome P4501A1 or 1A2. Carcinogenesis 1993; 14(10):2115-2118.

(97) Kjoller-Hansen L, Boesgaard S, Laursen JB, Aldershvile J, Poulsen HE. [Importance of thiols (SH group) in the cardiovascular system]. [Review] [37 refs] [Danish]. Ugeskr Laeger 1993; 155(45):3642-3645.

(98) Loft S, Fischer-Nielsen A, Jeding IB, Vistisen K, Poulsen HE. 8-Hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage. J Toxicol Environ Health 1993; 40(2-3):391-404.

(99) Poulsen HE, Vilstrup H, Almdal T, Dalhoff K. No net splanchnic release of glutathione in man during N-acetylcysteine infusion. Scand J Gastroenterol 1993; 28(5):408-412.

(100) Poulsen HE, Roberts DW, Hinson JA. Covalent binding of acetaminophen estimated from protein adducts. In: Jeffery EH, editor. Human Drug Metabolism. From molecular biology to man. Boca Raton, Ann Arbor, London, Tokyo: CRC Press, 1993: 43-52.

(101) Poulsen HE, Loft S, Wassermann K. Cancer risk related to genetic polymorphisms in carcinogen metabolism and DNA repair. [Review] [93 refs]. Pharmacology and Toxicology 1993; 72:Suppl-103.

(102) Ranek L, Dalhoff K, Poulsen HE, Brøsen K, Flacks H, Loft S. Drug metabolism in subjects with previous halothane hepatitis. Scand J Gastroenterol 1993; 28:677-680.

(103) Ranek L, Dalhoff K, Poulsen HE, Brosen K, Flachs H, Loft S et al. Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis. Scand J Gastroenterol 1993; 28(8):677-680.

(104) Sherson DL, Sigsgaard TI, Overgaard E, Loft SH, Poulsen HE, Jongeneelen FC. [Risk of lung cancer among foundry workers]. [Danish]. Ugeskr Laeger 1993; 155(9):620-623.


(105) Boesgaard S, Aldershvile J, Poulsen HE, Loft S, Anderson ME, Meister A. Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels. Circ Res 1994; 74(1):115-120.

(106) Boesgaard S, Iversen HK, Wroblewski H, Poulsen HE, Frandsen H, Kastrup J et al. Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine. J Am Coll Cardiol 1994; 23(1):163-169.

(107) Kjoller-Hansen L, Boesgaard S, Laursen JB, Poulsen HE, Aldershvile J. [Nitroglycerin preparations. Effect and tolerance]. [Review] [38 refs] [Danish]. Ugeskr Laeger 1994; 156(24):3621-3625.

(108) Laursen JB, Boesgaard S, Poulsen HE, Aldershvile J. Endotelderiveret relakserende faktor/nitrogenoxid. Ugeskr Laeger 1994; 156:5661-5666.

(109) Loft S, Astrup A, Buemann B, Poulsen HE. Oxidative DNA damage correlates with oxygen consumption in humans. Faseb J 1994; 8(8):534-537.

(110) Lykkesfeldt J, Loft S, Poulsen HE. Simultaneous determination of urinary free cortisol and 6 beta-hydroxycortisol by high-performance liquid chromatography to measure human CYP3A activity. J Chromatogr B Biomed Appl 1994; 660(1):23-29.

(111) Poulsen HE, Loft S. The impact of genetic polymorphisms in risk assessment of drugs. [Review] [73 refs]. Arch Toxicol Suppl 1994; 16:211-222.

(112) Sandstrøm B, Astrup A, Dyerberg J, Hølmer G, Poulsen HE, Stender S et al. Den sundhedsmæssige betydning af antioxidanter i levnedsmidler og som kosttilskud. Ugeskr Laeger 1994; 156:7675-7679.


(113) Fischer-Nielsen A, Corcoran GB, Poulsen HE, Kamendulis LM, Loft S. Menadione-induced DNA fragmentation without 8-oxo-2'-deoxyguanosine formation in isolated rat hepatocytes. Biochem Pharmacol 1995; 49(10):1469-1474.

(114) Jensen KG, Poulsen HE, Doehmer J, Loft S. Kinetics and inhibition by fluvoxamine of phenacetin O-deethylation in V79 cells expressing human CYP1A2. Pharmacology and Toxicology 1995; 76(4):286-288.

(115) Loft S, Larsen PN, Rasmussen A, Fischer-Nielsen A, Bondesen S, Kirkegaard P et al. Oxidative DNA damage after transplantation of the liver and small intestine in pigs. Transplantation 1995; 59:16-20.

(116) Loft S, Velthuis-te WE, Van den Berg H, Poulsen HE. Energy restriction and oxidative DNA damage in humans. Cancer Epidemiol Biomarkers Prev 1995; 4(5):515-519.

(117) Lykkesfeldt J, Loft S, Poulsen HE. Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection--are they reliable biomarkers of oxidative stress? Anal Biochem 1995; 229(2):329-335.

(118) Lykkesfeldt J, Loft S, Poulsen HE. Individuel kræftrisiko - biomarkører kan måske give os svaret. Naturens Verden 1995; 78:32-40.

(119) Nielsen HB, Hanel B, Loft S, Poulsen HE, Pedersen BK, Diamant M et al. Restricted pulmonary diffusion capacity after exercise is not an ARDS-like injury. J Sports Sci 1995; 13(2):109-113.

(120) Poulsen HE, Loft S. Early biochemical markers of effects: enzyme induction, oncogene activation and markers of oxidative damage. Toxicology 1995; 101(1-2):55-64.

(121) Rasmussen BB, Maenpaa J, Pelkonen O, Loft S, Poulsen HE, Lykkesfeldt J et al. Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine. Br J Clin Pharmacol 1995; 39(2):151-159.

(122) Thomsen MS, Loft S, Roberts DW, Poulsen HE. Cytochrome P4502E1 inhibition by propylene glycol prevents acetaminophen (paracetamol) hepatotoxicity in mice without cytochrome P4501A2 inhibition. Pharmacology and Toxicology 1995; 76(6):395-399.

(123) van Poppel G, Poulsen HE, Loft S, Verhagen H. No influence of beta carotene on oxidative DNA damage in male smokers. J Nat Can Inst 1995; 87:310-311.

(124) Velthuis-te WE, van Leeuwen RE, Hendriks HF, Verhagen H, Loft S, Poulsen HE et al. Short-term moderate energy restriction does not affect indicators of oxidative stress and genotoxicity in humans. Journal of Nutrition 1995; 125(10):2631-2639.

(125) Verhagen H, Poulsen HE, Loft S, van Poppel G, Willems MI, van Bladeren PJ. Reduction of oxidative DNA-damage in humans by brussels sprouts. Carcinogenesis 1995; 16(4):969-970.


(126) Clemmensen JO, Ott P, Dalhoff KP, Astrup LB, Tage-Jensen U, Poulsen HE. Rekommandation for behandling af paracetamolforgiftning. Ugeskr Laeger 1996; 158:6892-6895.

(127) Jensen KG, Poulsen HE, Doehmer J, Loft S. Paracetamol-induced spindle disturbances in V79 cells with and without expression of human CYP1A2. Pharmacology and Toxicology 1996; 78(4):224-228.

(128) Jeppesen U, Gram LF, Vistisen K, Loft S, Poulsen HE, Brosen K. Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. European Journal of Clinical Pharmacology 1996; 51(1):73-78.

(129) Jeppesen U, Loft S, Poulsen HE, Brsen K. A fluvoxamine-caffeine interaction study. Pharmacogenetics 1996; 6(3):213-222.

(130) Laursen JB, Boesgaard S, Poulsen HE, Aldershvile J. Nitrate tolerance impairs nitric oxide-mediated vasodilation in vivo. Cardiovasc Res 1996; 31(5):814-819.

(131) Loft S, Jensen KG, Ringby L, Poulsen HE, Doehmer J. Kinetic studies in engineered V79 cells in comparison with primary hepatocytes and human liver microsomes. Experimental and Toxicologic Pathology 1996; 48:249-256.

(132) Loft S, Poulsen HE. Cancer risk and oxidative DNA damage in man. J Mol Med 1996; 74:297-312.

(133) Lykkesfeldt J, Prieme H, Loft S, Poulsen HE. Effect of smoking cessation on plasma ascorbic acid concentration. British Medical Journal 1996; 313(7049):91.

(134) Poulsen HE. [Markers of vitamin deficiencies (editorial)]. [Danish]. Ugeskr Laeger 1996; 158(27):3906.

(135) Poulsen HE, Loft S, Vistisen K. Extreme exercise and oxidative DNA modification. J Sports Sci 1996; 14(4):343-346.

(136) Prieme H, Loft S, Cutler RG, Poulsen HE. Measurement of oxidative DNA injury in humans: evaluation of a commercially available ELISA assay. In: Kumpulainen JT, editor. Natural antioxidants and food quality in atherosclerosis and cancer prevention. The royal society of chemistry 1996, 1996: 78-82.

(137) Tuo J, Loft S, Thomsen MS, Poulsen HE. Ex vivo time-dependent cell DNA-degradation shown by single cell gel electrophoresis. Pharmacology and Toxicology 1996; 78(1):55-57.

(138) Tuo J, Loft S, Thomsen MS, Poulsen HE. Benzene-induced genotoxicity in mice in vivo detected by the alkaline comet assay: reduction by CYP2E1 inhibition. Mutat Res 1996; 368(3-4):213-219.


(139) Cadenas S, Barja G, Poulsen HE, Loft S. Oxidative DNA damage estimated by oxo8dG in the liver of guinea-pigs supplemented with graded dietary doses of ascorbic acid and alpha-tocopherol. Carcinogenesis 1997; 18(12):2373-2377.

(140) Deng XS, Tuo J, Poulsen HE, Loft S. 2-Nitropropane-induced DNA damage in rat bone marrow. Mutat Res 1997; 391(3):165-169.

(141) Kaikkonen J, Nyyssonen K, Porkkala SE, Poulsen HE, Metsa KT, Hayn M et al. Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Rad Biol Med 1997; 22(7):1195-1202.

(142) Kaikkonen J, Nyyssonen K, Porkkala-Sarataho E, Poulsen HE, Metsa-Ketela T, Hayn M et al. Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Rad Biol Med 1997; 22(7):1195-1202.

(143) Klarlund M, Prieme H, Loft S, Poulsen HE. Smoking cessation does not change urinary albumin excretion in normal subjects. Scand J Clin Lab Invest 1997; 57:513-520.

(144) Lykkesfeldt J, Loft S, Nielsen JB, Poulsen HE. Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking. Am J Clin Nutr 1997; 65(4):959-963.

(145) Nyyssonen K, Poulsen HE, Hayn M, Agerbo P, Porkkala-Sarataho E, Kaikkonen J et al. Effect of supplementation of smoking men with plain or slow release ascorbic acid on lipoprotein oxidation. European Journal of Clinical Nutrition 1997; 51(3):154-163.

(146) Poulsen HE. [Adverse effects of drugs--25 years later (editorial)]. Ugeskr Laeger 1997; 159(33):4964.

(147) Poulsen HE, Loft S, Prieme H, Salonen JT. Antioxidants. In: Haunsø S, editor. Coronary microcirculation during ischaemia and reperfusion. Copenhagen: Munksgaard, 1997: 455-461.

(148) Prieme H, Loft S, Nyyssonen K, Salonen JT, Poulsen HE. No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion in smokers. Am J Clin Nutr 1997; 65(2):503-507.


(149) Vistisen K, Prieme H, Okkels H, Vallentin S, Loft S, Olsen JH et al. Genotype and phenotype of glutathione S-transferase mu in testicular cancer patients. Pharmacogenetics 1997; 7(1):21-25.

(150) Deng XS, Tuo J, Poulsen HE, Loft S. Prevention of oxidative DNA damage in rats by brussels sprouts. Free Rad Res 1998; 28(3):323-333.

(151) Haderslev KV, Sonne J, Poulsen HE, Loft S. Paracetamol metabolism in patients with ulcerative colitis. British Journal of Clinical Pharmacology 1998; 46:513-516.

(152) Loft S, Poulsen HE. Markers of oxidative damage to DNA: Antioxidants and molecular damage. Methods Enzymol 1998; 300:166-184.

(153) Loft S, Deng XS, Tuo J, Wellejus A, Sorensen M, Poulsen HE. Experimental study of oxidative DNA damage. Free Rad Res 1998; 29:525-539.

(154) Loft S, Poulsen HE. Estimation of oxidative DNA damage in man from urinary excretion of repair products. Acta Biochim Pol 1998; 45:133-144.

(155) Loft S, Poulsen HE. Measurement of oxidative damage to DNA: interpretation of nuclear levels and urinary excretion of repair products in DNA damage and Repair: Oxygen Radical effects, cellular protection and biological consequeences. In: Karakaya A, Dizdaroglu M, editors. Oxygen Radical Effects, Cellular Protection and Biological Consequences. New York: Plenum Press, 1998: 267-281.

(156) Loft S, Thorling EB, Poulsen HE. High fat diet induced oxidative DNA damage estimated by 8-oxo-7,8-dehydro-2'-deoxyguanosine excretion in rats. Free Rad Res 1998; 29:595-600.

(157) Porkkala SE, Nyyssonen MK, Kaikkonen JE, Poulsen HE, Hayn EM, Salonen RM et al. A randomized, single-blind, placebo-controlled trial of the effects of 200 mg alpha -tocopherol on the oxidation resistance of atherogenic lipoproteins. Am J Clin Nutr 1998; 68/5(1034-1041):-1041.

(158) Poulsen HE, Weimann A, Salonen JT, Nyyssonen K, Loft S, Cadet J et al. Does vitamin C have a pro-oxidant effect? [letter]. Nature 1998; 395(6699):231-232.

(159) Poulsen HE, Loft S. Interpretation of oxidative DNA modification: Relation between tissue levels, excretion of urinary repair products and sigle cell gel electrophoresis (comet assay). In: Aruoma OI, Halliwell B, editors. DNA & free radicals: Techniques, mechanisms and applications. London: OICA International, 1998: 261-270.

(160) Poulsen HE. [Medication errors--the top of an iceberg? (editorial)]. Ugeskr Laeger 1998; 160(27):4041.

(161) Poulsen HE, Prieme H, Loft S. Role of oxidative DNA damage in cancer initiation and promotion. European Journal of Cancer Prevention 1998; 7(1):9-16.

(162) Poulsen HE, Loft S, Prieme H, Vistisen K, Lykkesfeldt J, Nyyssonen K et al. Oxidative DNA damage in Vivo: Relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion. Free Rad Res 1998; 29:565-571.

(163) Prieme H, Nyyssonen K, Gronbaek K, Klarlund M, Loft S, Tonnesen P et al. Randomized controlled smoking cessation study: transient increase in plasma high density lipoprotein but no change in lipoprotein oxidation resistance. Scand J Clin Lab Invest 1998; 58(1):11-18.

(164) Prieme H, Loft S, Klarlund M, Gronbaek K, Tonnesen P, Poulsen HE. Effect of smoking cessation on oxidative DNA modification estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion. Carcinogenesis 1998; 19(2):347-351.

(165) Tuo J, Wolff SP, Loft S, Poulsen HE. Formation of nitrated and hydroxylated aromatic compounds from benzene and peroxynitrite, a possible mechanism of benzene genotoxicity. Free Rad Res 1998; 28(4):369-375.


(166) Jensen SA, Jensen BR, Weimann A, Liu L, Poulsen HE. Oxidativ stress og aldring. Ugeskr Laeger 1999; 162(17):2431-2435.

(167) Loft S, Poulsen HE, Vistisen K, Knudsen LE. Increased urinary excretion of 8-oxo-2'-deoxyguanosine, a biomaker of oxidative DNA damage, in urban bus drivers. Mutat Res 1999; 441:11-19.

(168) Loft S, Poulsen HE. Measurement of oxidative damage to DNA nucleobases in vivo. In: Dizdaroglu M, Karakaya A, editors. Advances in DNA Damage and Repair. New York: Kluwer Academic/Plenum Publishers, 1999: 267-279.

(169) Loft S, Poulsen HE. Markers of oxidative damage to DNA: antioxidants and molecular damage. Methods Enzymol 1999; 300:166-184.

(170) Poulsen HE, Loft S. Motion og velvære. Miljømedicin. 1999: 364-367.

(171) Poulsen HE, Loft S, Strandgaard S, Vilstrup H. Rationel farmakoterapi. In: Lorenzen I, Bendixen G, Hansen NE, editors. Medicinsk Kompendium. Copenhagen: Nyt Nordisk forlag Arnold Busck A/S, 1999: 2942-2954.

(172) Poulsen HE, Weimann A, Loft S. Methods to detect DNA damage by free radicals: relation to exercise. Proceedings of the Nutritional Society 1999; 58:1007-1014.

(173) Salonen J, Nyyssonen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E et al. The Effect of Vitamin E and Vitamin C on Carotid Atherosclerotic Progression: The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study. Circulation 1999; Suppl. 100:I-238.

(174) Tuo J, Loft S, Poulsen HE. Enhanced benzene-induced DNA damage in PMA-stimulated cells in vitro and in LPS-treated animals. Free Rad Biol Med 1999; 26:801-808.

(175) Tuo J, Deng X, Loft S, Poulsen HE. Dexamethasone ameliorates oxidative DNA damage induced by benzene and LPS in mouse bone marrow. Free Rad Res 1999; 30:29-36.


  (176) ESCODD (European Standards Committee on Oxidative DNA Damage) Comparison of different Methods of Measuring 8-oxoguanine as a Marker of Oxidative DNA Damage.Free Rad. Res 2000; 32:333-341

   (177) Loft S, Poulsen HE. Antioxidant Intervention Studies Related to DNA Damage, DNA Repair and Gene Expression. Free Rad Res 2000; 33:S67-83

(178) Dalhoff KP, Poulsen HE. [Thalidomide--failure or success? A controversial drug during the last fifty years--the pendulum swings--a renaissance for thalidomide?]. Ugeskr Laeger 2000; 162(1):52-53.

(179) Jensen SA, Jensen BR, Weiman A, Li L, Poulsen HE. [Oxidative stress and aging]. Ugeskr Laeger 2000; 162(17):2431-2435.

(180) Porkkala-Sarataho E, Salonen JT, Nyyssonen K, Kaikkonen J, Salonen R, Ristonmaa U et al. Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2'-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men. Arterioscler Thromb Vasc Biol 2000; 20(9):2087-2093.

(181) Poulsen HE, Jensen BR, Weimann A, Jensen SA, Sørensen M, Loft S. Antioxidants, DNA damage and gene expression. Free Rad Res 2000; 33:S33-39.

(182) Salonen J, Nyyssonen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E et al. Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. Journal of Internal Medicine 248[November], 377-386. 2000.

(183) Tuo J, Liu L, Poulsen HE, Weimann A, Svendsen O, Loft S. Importance of guanine nitration and hydroxylation in DNA in vitro and in vivo. Free Radic Biol Med 2000; 29(2):147-155.

(184) Voutilainen S, Lakka TA, Hamelahti P, Lehtimaki T, Poulsen HE, Salonen JT. Plasma total homocysteine concentration and the risk of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Studytpdel. J Intern Med 2000; 248(3):217-222.

(185) Wellejus A, Poulsen HE, Loft S. Iron-induced oxidative DNA damage in rat sperm cells in vivo and in vitro. Free Radic Res 2000; 32(1):75-83.

(186) Zhu C, Poulsen HE, Loft S. Inhibition of oxidative DNA damage in vitro by extracts of brussels sprouts [In Process Citation]. Free Radic Res 2000; 33(2):187-196

(187) Poulsen HE, Loft S, Weimann A. Urinary measurement of 8-oxodG (8-oxo-2'-deoxyguanosine). In: Lunec J, Griffiths HR, editors. Measuring in vivo Oxidative Damage: A practical Approach. London: John Wiley and Sons (Ltd.), 2000: 69-80


(188) Dalhoff K, Laursen H, Bangert K, Poulsen HE, Anderson ME, Grunnet N et al. Autoprotection in acetaminophen intoxication in rats: the role of liver regeneration. Pharmacol Toxicol 2001; 88(3):135-141.

(189) Weimann A, Belling D, Poulsen HE. Measurement of 8-oxo-2-deoxyguanosine and 8-oxo-2-deoxyadenosine in DNA and Human Urine by High Performance Liquid Chromatography-Electrospray Tandem Mass Spectrometry. Free Rad Biol Med 2001; 30:757-764.

(190)Schmidt LE, Rasmussen A, Norrelykke MR, Poulsen HE, Hansen BA. The effect of selective bowel decontamination on the pharmacokinetics of mycophenolate mofetil in liver transplant recipients. Liver Transpl 2001; 7(8):739-742.

(191)Sorensen M, Jensen BR, Poulsen HE, Deng X, Tygstrup N, Dalhoff K et al. Effects of a Brussels sprouts extract on oxidative DNA damage and metabolising enzymes in rat liver. Food Chem Toxicol 2001; 39(6):533-540.

(192)Nielsen HB, Kharazmi A, Bolbjerg ML, Poulsen HE, Pedersen BK, Secher NH. N-acetylcysteine attenuates oxidative burst by neutrophils in response to ergometer rowing with no effect on pulmonary gas exchange. Int J Sports Med 2001; 22 (4):256-260.

(193) Laursen JB, Boesgaard S, Trautner S, Rubin I, Poulsen HE, Aldershvile J.       Endothelium-dependent vasorelaxation is inhibited by in vivo depletion of vascular  thiol levels:role of endothelial nitric oxide synthase. Free Rad Res 2001; 35:387-394.

(194) Gæde P, Poulsen HE, Parving HH, Pedersen O. Double-blind, randomised study of the effect of combined treatment with vitamin C and E on albuminuria in Type 2 diabetic patients. Diabetic Medicine 2001; 18 :756-760.

(195) Hoberg, AM, Poulsen HE. Analysis of a promutagenic exocyclic DNA adduct in human urine by HPLC APCI tandem mass spectrometry. Advances in Mass Spectrometry, 2001; 15:597-598.


(196) Weimann, A, Belling D, Poulsen HE. Quantification of 8-oxoGuanine and Guanine as the Nucleobase, Nucleoside and Deoxynucleoside forms in Human Urine by High Preformance Liquid Chromatography - Electrospray Tandem Mass Spectrometry. Nucleic Acids Research 2002; 30 no.2 e7

(197) Kaikkonen, J, Porkkala-Sarataho, E, Morrow JD, Jackson Roberts II, L, Nyyssönen, K, Salonen, R, Tuomainen, TP, Ristonmaa, U, Poulsen, HE, Salonen JT. Supplementation with Vitamin E but not with Vitamin C Lowers Lipid Peroxidation In Vivo in Mildly Hypercholesterolemic Men. Free Radical Research, 2002; 35:967-978

(198) Schmidt,L.E., Dalhoff,K. Poulsen,H.E. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity, Hepatology,2002, 35:876-882

(199) ESCODD. Inter-laboratory Validation of Procedures for Measuring 8-oxo7,8-dihydrogunanine/8-oxo-7,8-dihydro-2´-deoxyguanosine in DNA. Free Radical Research, 2002; 36 (3):239-245

(200) Riis, B. and ESCODD. Comparison of Results from Different Laboratories in Measuring 8-oxo-2´-deoxyguanosine in Synthetic Oligonucleotides. Free Radical Research, 2002; 36 (3): 649-659.

(201) Riis B, Risom L, Loft S, Poulsen H.E. Increased rOGG1 expression in regenerating rat liver tissue without a corresponding increase in incision activity. DNA Repair, 2002; (1): 419-424

(202) Møller P, Wallin H, Vogel U, Autrup H,Risom l, Hald M.T., Daneshvar B, Dragsted L.O., Poulsen H.E., Loft S. Mutagenicity of 2-amino-3methylimidazo [4,5f] quinoline in colon and liver of Big Blue rats: role of DNA adducts, strand breaks, DNA repair and oxidative stress. Carcinogenesis, 2002; 23(8): 1379-1385.

(203) Dragsted L.O., Daneshvar B, Vogel U, Autrup H.N., Wallin H, Risom L, Møller P, Mølck A.M., Hansen M, Poulsen H.E., Loft s. A sucrose-rich Diet Induces Mutation in the Rat Colon. Cancer Research, 2002; 62: 4339-4345.

(204) Griffiths HR, Møller L, Bartosz G, Bast A, Bertoni-Freddari C, Collins A, Cooke M, Coolen S,  
Haenen  G, Hoberg AM, Loft S, Lunec J, Olinski R, Parry J, Pompella A, Poulsen HE, Verhagen H, Astley SB. Chap 3; Biomarkers. In Molecular Aspects of Medicine 23 2002; 101-208.

(205)Escodd (European Standards Comittee on Oxidative DNA Damage). Comparative analysis of baseline 8-oxo-7,8-dihydroguanine in mammalian cell DNA, by  different methods in different laboratories: an approach to consensus. Carcinogenesis, 2002;23(12): 2129-2133.

(206)Riis B, Risom L, Loft S, Poulsen HE. OGG1 m RNA expression and incision activity in rats are higher in foetal tissue than in adult liver tissue while 8-oxo-2'-deoxyguanosine levels are unchanged. DNA Repair 2002;1:709-17.

(207)Clinical pharmacology 2001--important events. The Danish Society of Clinical Pharmacology]
Ugeskr Laeger. 2002 18;164:1652.


(208)Salonen RM, Nyyssonen K, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Rissanen TH et al. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression - The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study. Circulation 2003; 107(7):947-953.

(209)Collins A, Gedik C, Vaughan N, Wood S, White A, Dubois J et al. Measurement of DNA oxidation in human cells by chromatographic and enzymic methods. Free Radical Biology and Medicine 2003; 34(8):1089-1099. 

(210)Bruunsgaard H, Poulsen HE, Pedersen BK, Nyyssonen K, Kaikkonen J, Salonen JT. Long-term combined supplementations with alpha-tocopherol and vitamin C have no detectable anti-inflammatory effects in healthy men.Journal of Nutrition 2003;133:1170-1173

(211) Lykkesfeldt J, Bolbjerg ML, Poulsen HE. Effect of smoking on erythorbic acid pharmacokinetics. British Journal of Nutrition 2003; 89:667-671

(212)Osterberg O, Kiehr B, Erichsen L, Poulsen HE, Ingwersen SH. Pharmocokinetics and allometric scaling of levormeloxifene, a selective oestrogen receptor modulator. Biopharm Drug Dispos. 2003;24:121-129.

(213)Verhagen H, Aruoma OI, van Delft JH, Dragsted LO, Ferguson LR, Knasmuller S, Pool-Zobel BL, Poulsen HE, Williamson G, Yannai S.The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo. Food Chem Toxicol 2003;41(5):603-10

(214)Vogel U, Danesvar B, Autrup H, Risom L, Weimann A, Poulsen HE, Moller P, Loft S, Wallin H, Dragsted LO. Effect of increased intake of dietary animal fat and fat energy on oxidative damage, mutation frequency, DNA adduct level and DNA repair in rat colon and liver. Free Radic Res. 2003;37(9):947-56.

(215) Møller P, Daneshvar B, Loft S, Wallin H, Poulsen HE, Autrup H, Ravn-Haren G, Dragsted LO. Oxidative DNA damage in vitamin C-supplemented guinea pigs after intrtracheal instillation of diesel exhaust particles. Toxicology and Applied Pharmacology 2003;189:39-44

(216) Møller P, Hansen M, Autrup H, Bornholt J, Vogel  U, Mølck A-M, Wallin H , Dragsted LO, Risom L,  Poulsen HE, Loft S. Dietary low-dose sucrose modulation of IQ-induced genotoxicity in the colon and liver of Big Blue™ rats Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2003; 527:91-97

(217) Dybdahl M, Risom L, Moller P, Autrup H, Wallin H, Vogel U, Bornholdt J, Daneshvar B, Dragsted L, Weimann A, Poulsen HE, Loft S. DNA adduct formation and oxidative stress in colon and liver of Big Blue(R) rats after dietary exposure to diesel particles. Carcinogenesis. 2003 Nov;24(11):1759-66

(218) Loft S, Kold-Jensen T, Hjollund NH, Giwercman A, Gyllemborg J, Ernst E, Olsen J, Scheike T, Poulsen HE, Bonde JP. Oxidative DNA damage in human sperm influences time to pregnancy. Hum Reprod. 2003;18(6):1265-72.

(219) Poulsen HE, Gronlykke TB[Does the public sector have an independent research role in the development of drugs?]
Ugeskr Laeger. 2003 Apr 14;165(16):1674-6. Danish.

(220) Risom L, Moller P, Hansen M, Autrup H, Bornholdt J, Vogel U, Wallin H, Poulsen HE, Dragsted LO, Loft S.Dietary elevated sucrose modulation of diesel-induced genotoxicity in the colon and liver of Big Blue rats. Arch Toxicol 2003;77:651-6

(221) Lykkesfeldt J, Viscovich M, Poulsen H. Ascorbic acid recycling in human erythrocytes is induced by smoking in vivo. FRBM 2003;35:1439-47.

(222) Kramer I, Dalhoff K, Clemmensen JO, Loft S, Poulsen HE. Comparison of chlorzoxazone one-sample methods to estimate CYP2E1 activity in humans. Eur J Clin Pharm 2003; 59:775-8

(223) Osterberg O, Erichsen L, Ingwersen SH, Plum A, Poulsen HE, Vicini P.Pharmacokinetic and pharmacodynamic properties of insulin aspart and human insulin. J Pharmacokinet Pharmacodyn. 2003 Jun;30(3):221-35.

(224) Loft, S., Møller, P., Vogel, U., Risom. L., Sørensen, M., Riis, B., Poulsen, H.E., Dybdahl, M., and Wallin, H. (2003) Oxidative Stress by Environmental Agents, Journal of University of Occupational and Environmental Health 2003;25(suppl.1):47-59

(225) Poulsen HE, Loft S, Jensen BR, Sørensen, M, Hoberg A-M, Weimann A. HPLC-ECD, LC-MS/MS (Urinary Biomarkers): In: Oxidative Stress and Aging. Advances in Basic Science, Diagnostics, and Intervention, eds. Cutler RG, Rodriguez H. Singapore: World Scientific Publishing Co. Pte. Ltd; 2003:233-56

(226) Poulsen HE. Proper design of human intervention studies, power calculations. In: Free radicals, nitric oxide, and inflammation: Molecular, biochemical, and clinical aspects, eds. Tomasi A et al. Ohmsha: IOS Press; 2003:252-3.

(227) Poulsen HE.Estimation of oxidative and lipids peroxidation DNA adduct in urine and DNA. Free radicals, nitric oxide, and inflammation: Methodological aspects and application in Molecular epidemiology.In: Molecular, biochemical, and clinical aspects, eds. Tomasi A, et al. Ohmsha: IOS Press; 2003:34-8.


(228) Hoberg AM, Otteneder M, Marnett LJ, Poulsen HE. Measurement of the malondialdehyde-2'-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.J Mass Spectrom. (2004); 39(1):38-42.

(229) Collins AR, Cadet J, Möller L, Poulsen HE, Vina J. Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells? Archives of Biochemistry and Biophysics 423 (2004) 57-65

(230) Poulsen HE, Moller P, Lykkesfeldt J, Weimann A, Loft S. Vitamin C and oxidative damage to DNA. In: Vitamin C, edited by Han Asard, James M. May and Nicholas Smirnoff, BIOS Scientific Publishers Ltd, Oxford 2004:189-202

(231) Vistisen K, Loft S, Olsen JH, Vallentin S, Ottesen S, Hirsch FR, Poulsen HE. Low CYP1A2 activity associated with testicular cancer. Carcinogenesis. 2004 Jun;25(6):923-929

(232) Hillestrom PR, Hoberg AM, Weimann A, Poulsen HE. Quantification of 1,N6-etheno-2'-deoxyadenosine in human urine by column-switching LC/APCI-MS/MS. Free Radic Biol Med. 2004 Jun 1;36(11):1383-92.

(233) Weimann A, Riis B, Poulsen HE. Oligonucleotides in human urine do not contain 8-oxo-7,8-dihydrodeoxyguanosine. Free Radic Biol Med. (2004) 1;36(11):1378-82

(234) de Waard H, de Wit J, Andresson J-O, van Oostrom CTM, Riis B, Weimann A, Poulsen HE, van Steeg H, Hoeijmakers JHJ, van der Horst GTJ. Different Effects of CSA and CSB Deficiency on Sensitivity to Oxidative DNA Damage Molecular and Cellular Biology, (2004);24:7941-8

(235)  Møller, P, Viscovich M, Lykkesfeldt J, Loft S,  Jensen A, Poulsen HE. Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers. European Journal of Nutrition 2004 Jan;:1-8

(236) Lykkesfeldt J, Viscovich M, Poulsen HE. Plasma malondialdehyde is induced by smoking: a study with balanced antioxidant profiles. Br J Nutr. 2004;92(2):203-6.

(237) Viscovich M, Lykkesfeldt L, Poulsen HE. Vitamin C pharmacokinetics of plain and slow release formulations in smokers Clinical Nutrition (2004) 23,1043-50

(238) Hansen M, Hald MT, Autrup H, Vogel U, Bornholdt J, Moller P, Molck AM, Lindecrona R, Poulsen HE, Wallin H, Loft S, Dragsted LO. Sucrose and IQ induced mutations in rat colon by independent mechanism. Mutat Res. 2004 Oct 4;554(1-2):279-86

(239) ESCODD (European Standards Committee on Oxidative DNA Damage). Establishing the background level of base oxidation in
human lymphocyte DNA: results of an interlaboratory validation study. The FASEB Journal express article10.1096/fj.04-1767fje. Published online November 8, 2004.

(240) Poulsen HE. Alkoholelimination i alkopops. Ugeskr Laeger. 2004;166:4449

(241) Poulsen HE, Dalhoff KP. Mangelfuld registrering af lægemiddelforgiftninger og – bivirkninger i Danmark. Ugeskr Laeger. 2004;166:4451


(242) Riis B, Poulsen HE, Repair and Removal Systems DNA Repair: Mechanisms and Measurements In:The Handbook of Environmental Chemistry Vol. 2, Part O. eds. Springer-Verlag Berlin Heidelberg 2005: 151–75  

(243) Weimann A, Sabroe M, Poulsen HE Measurement of caffeine and five of the major metabolites in urine by high-performance liquid chromatography/tandem mass spectrometry. J Mass Spectrom. 2005;40:307-16

(244) Hillestrøm PR, Nyssönen K, Tuomainen T-P, Pukkala E, Salonen JT, Poulsen HE Urinary excretion of edA is not predictive of cancer development: A prospective nested case control study Free Rad Research, 2005;39:51-3

(245) Ciofu O, Riis B, Pressler T, Poulsen HE, Hoiby N Occurrence of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Patients Is Associated with the Oxidative Stress Caused by Chronic Lung Inflammation Antimicrob. Agents Chemother. 2005;49:2276-2282

(246) Laska MJ, Nexo BA, Vistisen K, Poulsen HE, Loft S, Vogel U Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer.
Cancer Lett. 2005;225:245-51

(247) Dalhoff KP, Poulsen HE.[Toxicology and pharmacogenetics] Ugeskr Laeger. 2005;167:2170-2. Danish

(248) Poulsen HE. Oxidative DNA modifications.Exp Toxicol Pathol. 2005 Jul;57 Suppl 1:161-9.

(249) Gronbaek K, Sonne J, Ring-Larsen H, Poulsen HE, Friis H, Bygum Krarup H.Viral load is a negative predictor of antioxidant levels in hepatitis C patients.Scand J Infect Dis. 2005;37:686-9

(250) Dalhoff K, Buus JK, Poulsen HE. Cancer and molecular biomarkers of phase 2. In: John Abelson, USA, ed. Methods Enzymol. 400 ed. New York: Elsevier; 2005:618-27


(251) Hillestrom PR, Weimann A, Poulsen HE.Quantification of Urinary Etheno-DNA Adducts by Column-Switching LC/APCI-MS/MS. J Am Soc Mass Spectrom 2006:605–10

(252) Hillestrom PR, Weimann A, Jensen, CB, Storgaard H, Vaag AA, Poulsen HE.  Consequences of low birthweight on urinary excretion of DNA markers of oxidative stress in young men. Scand J Clin Lab Invest 2006; 66: 363–70

(253) Hillestrom PR, Covas MI, Poulsen HE. Effect of dietary virgin olive oil on urinary excretion of etheno-DNA adducts. Free Radic Biol Med. 2006 Oct 1;41(7):1133-8.

(254) Covas MI, Nyyssonen K, Poulsen HE, Kaikkonen J, Zunft HJ, Kiesewetter H, Gaddi A, de la Torre R, Mursu J, Baumler H, Nascetti S, Salonen JT, Fito M, Virtanen J, Marrugat J, EUROLIVE Study Group. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med. 2006 Sep 5;145(5):333-41.

(255) Glintborg B, Weimann A, Kensler TW, Poulsen HE. Oltipraz chemoprevention trial in Qidong, People's Republic of China: Unaltered oxidative biomarkers.
Free Radic Biol Med. 2006 Sep 15;41(6):1010-4.

(256) Henrik E. Poulsen, Allan Weimann and Berry B. Halliwell: Cigarette Smoke and Oxidative DNA Modification in “Cigarette Smoke and Oxidative Stress”. Ed. Berry B. Halliwell and Henrik E. Poulsen. Springer-Verlag Berlin Heidelberg Chapter 16 (2006) 387-402.


(257) Anja Machowetz, Henrik E. Poulsen, Sindy Gruendel, Allan Weimann, Montserrat Fito, Jaume Marrugat, Rafael de la Torre, Jukka T. Salonen, Kristiina Nyyssonen, Jaakko Mursu, Simona Nascetti, Antonio Gaddi, Holger Kiesewetter, Hans Bäumler, Hany Selmi, Jari Kaikkonen, Hans-Joachim F. Zunft, Maria-Isabel Covas, Corinna Koebnick  Effect of olive oils on biomarkers of oxidative DNA stress in Northern and Southern Europeans The FASEB Journal • Research Communication, The FASEB Journal. 2007;21:45-52.

(258) Bondia-Pons I, Schroder H, Covas MI, Castellote AI, Kaikkonen J, Poulsen HE, Gaddi AV, Machowetz A, Kiesewetter H, Lopez-Sabater MC. Moderate Consumption of Olive Oil by Healthy European Men Reduces Systolic Blood Pressure in Non-Mediterranean Participants. J Nutr. 2007 Jan;137(1):84-87.

(259) Tuomainen TP, Loft S, Nyyssonen K, Punnonen K, Salonen JT, Poulsen HE. Body iron is a contributor to oxidative damage of DNA.  Free Radic. Res. 2007 Mar;41(3):324-8

(260) Bader N, Bosy-Westphal A, Koch A, Rimbach G, Weimann A, Poulsen HE, Muller MJ Effect of hyperbaric oxygen and vitamin C and E supplementation on biomarkers of oxidative stress in healthy men. Br J Nutr.  2007 Oct;98(4):826-33

(261) Gravholt CH, Poulsen HE, Ott P, Christiansen JS, Vilstrup H. Quantitative liver functions in Turner syndrome with and without hormone replacement therapy. Eur J Endocrinol. 2007 Jun;156(6):679-86

(262) Glintborg B, Hillestrom PR, Olsen LH, Dalhoff KP, Poulsen HE. Are patients reliable when self-reporting medication use? Validation of structured drug interviews and home visits by drug analysis and prescription data in acutely hospitalized patients.PMID: 17962430 J Clin Pharmacol. 2007 Nov;47(11):1440-9.

(263) Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain. Lykkesfeldt J, Trueba GP, Poulsen HE, Christen S. Br J Nutr. 2007 Dec;98(6):1116-9.


(264) Glintborg B, Poulsen HE, Dalhoff KP.The use of nationwide on-line prescription records improves the drug history in hospitalized patients. Br J Clin Pharmacol. 2008 Feb;65(2):265-9;

(265) Hansen M, Baunsgaard D, Autrup H, Vogel UB, Møller P, Lindecrona R, Wallin H, Poulsen HE, Loft S, Dragsted LO.Sucrose, glucose and fructose have similar genotoxicity in the rat colon and affect the metabolome.Food Chem Toxicol.Volume 46,  2008;46:752-60

(266) Berendt L, Håkansson C, Bach KF, Dalhoff K, Andreasen PB, Petersen LG, Andersen E, Poulsen HE. Effect of European Clinical Trials Directive on academic drug trials in Denmark: retrospective study of applications to the Danish Medicines Agency 1993-2006. BMJ 2008;336;33-35

(267) Morten Lock Hansen, Niels Gadsbøll, Gunnar H. Gislason, Steen Z. Abildstrom, Tina K. Schramm, Fredrik Folke, Jens Friberg, Rikke Sørensen, Søren Rasmussen, Henrik E. Poulsen, Lars Køber, Mette Madsen, and Christian Torp-Pedersen. Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers. Europace.  2008 Apr;10(4):395-402

(268) Serena Guarnieri, Steffen Loft, Patrizia Riso, Marisa Porrini, Lotte Risom, Henrik E. Poulsen, Lars O. Dragsted and Peter Møller. DNA repair phenotype and dietary antioxidant supplementation British Journal of Nutrition (2008), 99, 1018–1024

(269) Marcus S. Cooke, Ryszard Olinski, and Steffen Loft members of the European Standards Committee on Urinary (DNA) Lesion Analysis (ESCULA) ESCULA members include Mark D. Evans, Rajinder Singh, Vilas Mistry, Peter B. Farmer (University of Leicester, United Kingdom); Rafal Rozalski, Daniel Gackowski, Marek Foksinski, Agnieszka Siomek (Nicolaus Copernicus University, Poland); Peter Møller, Pernille Danielsen, Elvira Vaklavik, Lykke Forchhammer (University of Copenhagen, Denmark); Jean Cadet, Jean-luc Ravanat (CEA/Grenoble, France); Jagadeesan Nair, Urmila Nair (DKFZ, Germany); Henrik E. Poulsen, Allan Weimann, Peter R. Hillestrom (Rigshospitalet, Denmark). Measurement and Meaning of Oxidatively Modified DNA Lesions in Urine. Cancer Epidemiol Biomarkers Prev 2008;17(1)(274)

(270) Cand.pharm Louise Berendt, cand.pharm. Cecilia Håkansson, cand.pharm. Karin Friis Bach, overlæge Kim Dalhoff, overlæge Per Buch Andreasen, cand.pharm. Lene Grejs Petersen, kontorchef Elin Andersen & professor Henrik Enghusen Poulsen. Effekten af GCP- direktivet på forskerinitierede kliniske lægemiddelforsøg – sekundærpublikation. Ugeskr Laeger. 2008;170:2437

(271) Glintborg B, Olsen L, Poulsen H, Linnet K, Dalhoff K.Clin Toxicol (Phila). Reliability of self-reported use of amphetamine, barbiturates, benzodiazepines, cannabinoids, cocaine, methadone, and opiates among acutely hospitalized elderly medical patients. 2008 Mar;46(3):239-42

(272) Arrigo F.G. Cicero, MD, PhD, Simona Nascetti, MD, PhD, Maria C. López-Sabater, MD, Roberto Elosua, MD, Jukka T. Salonen, MD, PhD, Kristiina Nyyssönen, MD, Henrik E. Poulsen, MD, PhD, Hans-Joachim F. Zunft, MD, PhD, Holger Kiesewetter, MD, Karina de la Torre, MD, Marıa-Isabel Covas, BD, PhD, Jari Kaikkonen, Jaakko Mursu, Corina Koenbick, MD, Hans Bäumler, MD, PhD, and Antonio V. Gaddi, MD, PhD, for the EUROLIVE Study Group. Changes in LDL fatty acid composition as a response to olive oil treatment are inversely related to lipid oxidative damage: The EUROLIVE Study. Journal of the American College of Nutrition, 2008;27:314–20

(273) Gottipati KR, Poulsen H, Starcher B. Passive cigarette smoke exposure inhibits ultraviolet light B-induced skin tumors in SKH-1 hairless mice by blocking the nuclear factor kappa B signalling pathway. Exp Dermatol. 2008 Sep;17(9):780-7.



(274) Poulsen HE, Andersen JT, Keiding N, Schramm TK, Sørensen R, Gislasson G, Fosbøl EL, Torp-Pedersen C. Why epidemiological and clinical intervention studies often give different or diverging results? IUBMB Life, 61(4): 391–393, April 2009

 (275) Fosbøl E, Gislason G, Jacobsen S, Folke F, Hansen M, Schramm T, Sørensen R, Rasmussen J, Andersen S, Abildstrom S, Trærup J, Poulsen H, Rasmussen S, Køber L, Torp-Pedersen C. Risk of Myocardial Infarction and Death Associated With the Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Among Healthy Individuals: A Nationwide Cohort Study. Clin Pharmacol Ther. (2009); 85, 2, 190–197

(276) Christine Dalgård , Flemming Nielsen, Jason D. Morrow, Henrik Enghusen-Poulsen, Torbjörn Jonung, Mogens Hørder and Moniek P. M. de Maat. Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease.  Br J Nutr. 2009 Feb;101(2):263-9.

(277) Gunnar H. Gislason, MD, PhD; Jeppe N. Rasmussen, MD, PhD; Steen Z. Abildstrom, MD, PhD; Tina K. Schramm, MD; Morten L. Hansen, MD; Emil L. Fosbøl, MB; Rikke Sørensen, MD; Fredrik Folke, MD; Pernille Buch, MD, PhD; Niels Gadsbøll, MD, DMSc; Søren Rasmussen, MSc, PhD; Henrik E. Poulsen, MD, DMSc; Lars Køber, MD, DMSc; Mette Madsen, MSc; Christian Torp-Pedersen, MD, DMSc Increased Mortality and Cardiovascular Morbidity Associated With Use of Nonsteroidal Anti-inflammatory Drugs in Chronic Heart Failure. Arch Intern Med. 2009 Jan 26;169(2):141-9.

(278) Hansen ML, Gadsbøll N, Rasmussen S, Gislason GH, Folke F, Andersen SS, Schramm TK, Sørensen R, Fosbøl EL, Abildstrøm SZ, Madsen M, Poulsen HE, Køber L, Torp-Pedersen C.Clinical consequences of hospital variation in use of oral anticoagulant therapy after first-time admission for atrial fibrillation. J Intern Med. 2009 Jan 9.

(279) L. F. Mandsberg, O. Ciofu, N. Kirkby, L. E. Christiansen, H. E. Poulsen and N. Høiby Antibiotic Resistance in Pseudomonas aeruginosa Strains with Increased Mutation Frequency Due to Inactivation of the DNA Oxidative Repair System Antimicrobial Agents and Chemotherapy, June 2009, 2483–91

(280) Afzal S, Jensen SA, Vainer B, Vogel U, Matsen JP, Sørensen JB, Andersen PK and Poulsen HE. HMTHFR polymorphisms and 5-FU based adjuvant chemotherapy in colorectal cancer. Annals of Oncology.Advance Access published May 22, 2009

(281) Trine Henriksen, Peter R. Hillestrøm, Henrik E. Poulsen, Allan Weimann. Automated method for the direct analysis of 8-oxo-guanosine and 8-oxo-2′-deoxyguanosine in human urine using ultraperformance liquid chromatography and tandem mass spectrometry. Free Radical Biology & Medicine 2009 Sep 1;47(5):629-35.

(282) Kasper Broedbaek, Henrik E. Poulsen, Allan Weimann, Ghainsom D Kom, Edzard Schwedhelm, Peter Nielsen, Rainer H. Böger Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis Free Radic. Biol. Med. 2009 Aug 14. [Epub ahead of print]

(283)  Davanipour Z, Poulsen HE, Weimann A, Sobel E. Endogenous melatonin and oxidatively damaged guanine in DNA .BMC Endocr Disord. 2009 Oct 18;9(1):22. [Epub ahead of print]

(284) Poulsen HE.Report from the President of SFRR-Europe.Free Radical Research, December 2009; 43(12): 1254–1255

(285) Fosbøl EL, Gislason GH, Poulsen HE, Hansen ML, Folke F, Schramm TK, Olesen JB, Bretler DM, Abildstrøm SZ, Sørensen R, Hvelplund A, Køber L, Torp-Pedersen C. Prognosis in Heart Failure and the Value of {beta}-Blockers Are Altered by the Use of Antidepressants and Depend on the Type of Antidepressants Used. Circ Heart Fail. 2009 Nov 1;2(6):582-590. Epub 2009 Sep 22

(286) Dominguez H, Schramm TK, Norgaard ML, Abildstrøm SZ, Kober L, Jørgensen C, Guterbaum TJ, Poulsen HE, Torp-Pedersen C, Gislason GH.Initiation and persistence to statin treatment in patients with diabetes receiving glucose-lowering medications 1997- 2006. Open Cardiovasc Med J. 2009 Nov 12;3:152-9.
PMID: 20016749 [PubMed - in process]


(287) Nurmi T, Mursu J, Penalvo JL, Poulsen HE, Voutilainen S. Dietary intake and urinary excretion of lignans in Finnish men. Br J Nutr 2010 Mar;103(5):677-85.

(288) Lykkesfeldt J, Poulsen HE.Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials.Br J Nutr. 2010 May;103(9):1251-9. Epub 2009 Dec 15. Review.

(289) Lopez-Miranda J, Perez-Jimenez F, Ros E, De CR, Badimon L, Covas MI, et al. Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008. Nutr Metab Cardiovasc Dis 2010 Mar 19.

(290) Olesen JB, Hansen PR, Erdal J, Abildstrom SZ, Weeke P, Fosbol EL, et al. Antiepileptic drugs and risk of suicide: a nationwide study. Pharmacoepidemiol Drug Saf 2010 Mar 16.

(291) Glintborg B, Andersen SK, Poulsen HE. Prescription data improve the medication history in primary care. Qual Saf Health Care 2010 Mar 1.

(292)  Sorensen R, Abildstrom SZ, Weeke P, Fosbol EL, Folke F, Hansen ML, et al. Duration of clopidogrel treatment and risk of mortality and recurrent myocardial infarction among 11 680 patients with myocardial infarction treated with percutaneous coronary intervention: a cohort study. BMC Cardiovasc Disord 2010;10:6.

 (293) de lT-C, Chavez-Servin JL, Jauregui O, Castellote AI, Lamuela-Raventos RM, Nurmi T, et al. Elevated circulating LDL phenol levels in men who consumed virgin rather than refined olive oil are associated with less oxidation of plasma LDL. J Nutr 2010 Mar;140(3):501-8.

(294) Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress.
European Standards Committee on Urinary (DNA) Lesion Analysis, Evans MD, Olinski R, Loft S, Cooke MS. Collaborators (40) Rossner P Jr, Sram R, Henriksen T, Poulsen HE, Weimann A, Barbieri A, Sabatini L, Violante F, Kino S, Ochi T, Tairin K, Takeuchi M, Kasai H, Meerman JH, Gackowski D, Rozalski R, Siomek A, Halliwell B, Jenner AM, Wang H, Cerda C, Saez G, Haghdoost S, Svoboda P, Hu CW, Chao MR, Peng KY, Shih WC, Wu KY, Orhan H, Istanbullu NS, Mistry V, Farmer PB, Sandhu J, Singh R, Cortez C, Su Y, Santella RM, Lambert P, Smith R

(295) Cadet J, Poulsen H. Measurement of oxidatively generated base damage in cellular DNA and urine.  Free Radic Biol Med. 2010 Jun 1;48(11):1457-9. Epub 2010 Mar 12.

(296) Fosbøl EL, Folke F, Jacobsen S, Rasmussen JN, Sørensen R, Schramm TK, Andersen SS, Rasmussen S, Poulsen HE, Køber L, Torp-Pedersen C, Gislason GH. Cause-Specific Cardiovascular Risk Associated With Nonsteroidal Antiinflammatory Drugs Among Healthy Individuals. Circ Cardiovasc Qual Outcomes. 2010 Jun 8. [Epub ahead of print]

(297) Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest: A nationwide study. Weeke P, Folke F, Gislason GH, Lippert FK, Olesen JB, Andersson C, Fosbøl EL, Charlot MG, Kanters JK, Poulsen HE, Nielsen SL, Køber L, Torp-Pedersen C.Resuscitation. 2010 Aug 18. [Epub ahead of print]

(298) Morten L. Hansen, MD, PhD; Rikke Sørensen, MD; Mette T. Clausen, MSc Pharm; Marie Louise Fog-Petersen, MSc Pharm; Jakob Raunsø, MD; Niels Gadsbøll, MD, DMSc; Gunnar H. Gislason, MD, PhD; Fredrik Folke, MD; Søren S. Andersen, MD; Tina K. Schramm, MD; Steen Z. Abildstrøm, MD, PhD; Henrik E. Poulsen, MD, DMSc; Lars Køber, MD, DMSc; Christian Torp-Pedersen, MD, DMSc. Risk of Bleeding With Single, Dual, or Triple Therapy With Warfarin, Aspirin, and Clopidogrel in Patients With Atrial Fibrillation ARCH INTERN MED/VOL 170 (NO. 16), SEP 13, 2010

(299) Lykkesfeldt J, Poulsen HE.Reply to Hemilä by Lykkesfeldt and Poulsen. [PMID: 20854702 [PubMed - as supplied by publisher]Br J Nutr. 2010 Sep 21:1.

(300) Berendt L, Håkansson C, Bach KF, Andreasen PB, Petersen LG, Andersen E, Poulsen HE, Dalhoff K. Methodological characteristics of academic clinical drug trials--a retrospective cohort study of applications to the Danish Medicines Agency 1993-2005.Br J Clin Pharmacol. 2010 Nov;70(5):729-35

(307) Shoaib Afzal, Milena Gusella, Ben Vainer, Ulla B. Vogel, Jon T. Andersen, Kasper Broedbaek, Morten Petersen, Espen Jimenez-Solem, Laura Bertolaso, Carmen Barile, Roberto Padrini, Felice Pasini, Søren A. Jensen, and Henrik E. Poulsen. Combinations of Polymorphisms in Genes Involved in the 5-Fluorouracil Metabolism Pathway Are Associated with Gastrointestinal Toxicity in Chemotherapy-Treated Colorectal Cancer Patients. Clin Cancer Res; 17(11) June 1, 2011 -   Published OnlineFirst on April 6, 2011; DOI:10.1158/1078-0432.CCR-11-0304


(301) Broedbaek K, Siersma V, Andersen JT, Petersen M, Afzal S, Hjelvang B, Weimann A, Semba RD, Ferrucci L, Poulsen HE.The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly.Free Radic Res. 2011 Jan 28. [Epub ahead of print]

vegetable intakeBr J Clin Pharmacol. 2010 Nov;70(5):729-35

(303) Castañer O, Fitó M, López-Sabater MC, Poulsen HE, Nyyssönen K, Schröder H, Salonen JT, De la Torre-Carbot K, Zunft HF, De la Torre R, Bäumler H, Gaddi AV, Saez GT, Tomás M, Covas MI; for the EUROLIVE Study Group. The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial.Clin Nutr. 2011 Mar 2. [Epub ahead of print] PMID:21376434

(304)  Broedbaek K, Ribel-Madsen R, Henriksen T, Weimann A, Petersen M, Andersen JT, et al. Genetic and environmental influences on oxidative damage assessed in elderly Danish twins. Free Radic Biol Med 2011 Feb 24. [Epub ahead of print] PMID: 21354303

(305) Petersen M, Andersen JT, Hjelvang BR, Broedbaek K, Afzal S, Nyegaard M, Børglum AD, Stender S, Køber L, Torp-Pedersen C, Poulsen HE. Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients.Br J Clin Pharmacol. 2011 Apr;71(4):556-565.

(306) Broedbaek K, Henriksen T, Weimann A, Petersen M, Andersen JT, Afzal S, et al. Long-Term Effects of Irbesartan Treatment and Smoking on Nucleic Acid Oxidation in Patients With Type 2 Diabetes and Microalbuminuria: An Irbesartan Microalbuminuria Type 2 Diabetes in Hypertensive Patients (IRMA) 2 substudy. Diabetes Care 2011 Mar 31.

(307) Shoaib Afzal, Milena Gusella, Ben Vainer, Ulla B. Vogel, Jon T. Andersen, Kasper Broedbaek, Morten Petersen, Espen Jimenez-Solem, Laura Bertolaso, Carmen Barile, Roberto Padrini, Felice Pasini, Søren A. Jensen, and Henrik E. Poulsen. Combinations of Polymorphisms in Genes Involved in the 5-Fluorouracil Metabolism Pathway Are Associated with Gastrointestinal Toxicity in Chemotherapy-Treated Colorectal Cancer Patients. Clin Cancer Res; 17(11) June 1, 2011 -   Published OnlineFirst on April 6, 2011; DOI:10.1158/1078-0432.CCR-11-0304

(308) Shoaib Afzal, Milena Gusella, Ben Vainer, Ulla B. Vogel, Jon T. Andersen, Kasper Broedbaek, Morten Petersen, Espen Jimenez-Solem, Laura Bertolaso, Carmen Barile, Roberto Padrini, Felice Pasini, Søren A. Jensen, and Henrik E. Poulsen. Combinations of Polymorphisms in Genes Involved in the 5-Fluorouracil Metabolism Pathway Are Associated with Gastrointestinal Toxicity in Chemotherapy-Treated Colorectal Cancer Patients. Clin Cancer Res; 17(11) June 1, 2011 -   Published Online First on April 6, 2011; DOI:10.1158/1078-0432.CCR-11-0304 

(309) Joergensen A, Broedbaek K, Weimann A, Semba RD, Ferrucci L, Joergensen MB, Poulsen HE. Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans. PLoS One. 2011;6(6):e20795. Epub 2011 Jun 7

(310) Afzal S, Jensen SA, Sørensen JB, Henriksen T, Weimann A, Poulsen HE Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin Cancer Chemother Pharmacol DOI 10.1007/s00280-011-1700-2

(311) Broedbaek K, Weimann A, Specht E, Poulsen HE. Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker in type 2 diabetes. Free Radic Biol Med. 2011 Jul 19. [Epub ahead of print] PMID:21820047

(312) Afzal S, Gusella M, Jensen SA, Vainer B, Vogel U, Andersen JT, Brødbæk K, Petersen M, Jimenez-Solem E, Adleff V, Budai B, Hitre E, Láng I, Orosz E, Bertolaso L, Barile C, Padrini R, Kralovánszky J, Pasini F, Poulsen HE. The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer.Pharmacogenomics. 2011 Sep;12(9):1257-1267. PMID: 21919605


Other Publications


(1) Poulsen HE, Juul P. Note on the statistical evaluation of a randomized, cross-over bioavailability study. Danish National Board of Health, 1990 PDF (289K)