Henrik Enghusen Poulsen
Professor and Chief

         Professor of Clinical Pharmacology, Head of Department of Clinical Pharmacology Q, Rigshospitalet, University Hospital, DK-2200 Copenhagen N, Denmark,  Telephone (+45) 3545 7671 Fax: (+45) 3545 2745 E-mail: hepo"AT" ("AT" is @ for spam confusion)
Citizenship Date of Birth
        Danish March 29, 1948 in Aalborg, Denmark
Private address
        4 Birkevænget, PO Box 71, DK-3050 Humlebæk. Telephone (+45) 49 19 39 11
Education and University degrees

Medical Doctor. Faculty of Health Sciences, University of Copenhagen, January 1976. Licence to independent medical practice 1979. Dr. Sci. (Dr. med.) University of Copenhagen, 1986. License to practise as specialist in Clinical Pharmacology May, 1997.

Region H:S Leadership Development Course, Modules I and II. Copenhagen, 2004-5.

Leadership for Physicians, OLAU 2, Rigshospitalet, Copenhagen, 1998-1999


February 1976 - August 1977, Basic training as hospital physician

September 1977 - January 1978, University of Copenhagen, Research position and postgraduate course in scientific methods

February 1978 - February 1982, Research Fellow, Department of Medicine A, Rigshospitalet, Copenhagen, Denmark

Marts 1982 - September 1985, Clinical Research Fellow, Department of Medicine A, Rigshospitalet, Copenhagen, Denmark

October 1985 - Marts 1986, Physician, Department of Medicine A, Rigshospitalet, Copenhagen, Denmark

April 1986 - October 1994, Associate professor, Department of Pharmacology, Faculty of Health Sciences, University of Copenhagen, Denmark.

May 1994, Appointed Professor of Pharmacology and Toxicology, Royal Danish School of Pharmacy, position not filled.

November 1994 - July 1996, Professor of Medical Toxicology, Department of Pharmacology, Faculty of Health Sciences, University of Copenhagen, Denmark.

August 1996 - present. Professor, Chair in Clinical Pharmacology, Rigshospitalet, Copenhagen. 

Other appointments

Medical Assessor, Danish National Drug Registration Board, Ministry of Health, Denmark, November 1984 to April 1992

Editorial Board:

Pharmacogenetic, 1993 - 2000.

Pharmacology & Toxicology, 1995 - present (including member execlusive committe and editorial handling of manuscripts).

Free Radical Research, 1999-present (including editorial handling of manuscript).

Mechanisms of Ageing and Development, 1999 - present.

Food and Chemical Toxicology, 2000 - present

Ageing Research Reviews, 2004 - present

Free Radical Biology and Medicine,  2004 - present

Administrative experience

        Academic administrative experience. Since 1981 member of various boards at Rigshospitalet and University of Copenhagen. Positions include: Chairman of the MD. PhD programme (about 450 PhD students), member of the executive faculty committee and the steering Board of the Faculty of Health Sciences. Member of the steering committee for the research priority area Environment, University of Copenhagen, Chairman of the Committee for Environmental Medicine in an Institute of Public Health at the University of Copenhagen and member of the Co-ordinating Committee for establishing an Institute of Public Health, University of Copenhagen. Representative for Rigshospitalet in the Central Drug Committee of Copenhagen and chairman of The Drug Committee of Rigshospitalet. Chariman of the board of Danish Society of Clinical Pharmacology (1997-2001).


Other tasks

The advisory research committee, National Institute of Occupational Health, 1990-1998

The advisory research committee, Ministry of Health Environmental Medicine Research Centre, 1991-1998

Chairman of the Committee for the initiation of The Strategic Environmental Research Program (appointed by The Danish Research Advisory Council)

Vice Chairman, Danish Toxicology Centre, 1991-1999

Member of the Danish Nutritional Council, 1995-1996

Member of Danish Scientific Ethics Committee, 2009-2014

President SFRR-Europe, 2009-2011 ( )

Research Supervision

Since 1980 supervision of 20 students and PhD students. Three doctoral theses and 6 PhD theses have been given, 1 PhD thesis is being evaluated and four are in the writing process. Five master theses have been approved.

Evaluation of applicants for positions: Eight positions as senior researchers have been evaluated 1992 - 1995

Evaluation of five doctoral theses and nine PhD theses have been performed

Reviewing on regular basis
Journal of Hepatology
European Journal of Clinical Investigation
Pharmacology and Toxicology
Scandinavian Journal of Clinical and Laboratory Investigation
European Journal of Clinical Pharmacology
Ugeskrift for Læger
Cardiovascular Research
Free Radical Research
Journal articles, Monographs, Proceedings, Chapters


Journal articles:



Gidén K, Andersen JT, Torp-Pedersen AL, Enghusen Poulsen H, Torp-Pedersen C, Jimenez-Solem E. Use of thyroid hormones in relation to pregnancy: a Danish nationwide cohort study. Acta Obstet Gynecol Scand. 2015 Mar 3. doi: 10.1111/aogs.12621. [Epub ahead of print]

Gjesing A, Gislason GH, Christensen SB, Jørgensen ME, Mérie C, Norgaard ML, Poulsen HE, Gustafsson F, Køber L, Torp-Pedersen C, Andersson C. Use of quinine and mortality-risk in patients with heart failure-a Danish nationwide observational study.Pharmacoepidemiol Drug Saf. 2015 Feb 4. doi: 10.1002/pds.3746. [Epub ahead of print] PMID: 25656791 [

Broedbaek K, Siersma V, Henriksen T, Weimann A, Petersen M, Andersen JT, Jimenez-Solem E, Hansen LJ, Henriksen JE, Bonnema SJ, de Fine Olivarius N, Friis S, Poulsen HE.Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes. Redox Biol. 2015;4:34-9. doi: 10.1016/j.redox.2014.11.010. Epub 2014 Dec 2. PMID: 25498965

Skov M, Pressler T, Lykkesfeldt J, Poulsen HE, Jensen PØ, Johansen HK, Qvist T, Kræmer D, Høiby N, Ciofu O.The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection - A pilot study.J Cyst Fibros. 2015 Mar;14(2):211-8. doi: 10.1016/j.jcf.2014.09.015. Epub 2014 Oct 23. PMID: 25458464 [PubMed - in process] Related citations

Steen J. Bonnema Elisabeth S. Stovgaard Søren Fast Kasper Broedbaek Jon T. Andersen  Allan Weimann  Peter Grupe  Laszlo Hegedüs Henrik E. Poulsen Systemic Oxidative Stress to Nucleic Acids Is Unaltered Following Radioiodine Therapy of Patients with Benign Nodular Goiter Eur Thyroid J DOI: 10.1159/000371883

Nielsen TK, Højgaard M, Andersen JT, Poulsen HE, Lykkesfeldt J, Mikines KJ. Elimination of ascorbic Acid after high-dose infusion in prostate cancer patients: a pharmacokinetic evaluation. Basic Clin Pharmacol Toxicol. 2015 Apr;116(4):343-8. doi: 10.1111/bcpt.12323. Epub 2014 Oct 7.PMID: 25220574


Broedbaek, K., Siersma, V., Henriksen, T., Weimann, A., Petersen, M., Andersen, J. T., Jimenez-Solem, E., Hansen, L. J., Henriksen, J. E., Bonnema, S. J., de Fine, Olivarius N., Friis, S., Poulsen, H. E. Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes. Redox Biol 2014 Dec 2;4C:34-9 .

Skov, M., Pressler, T., Lykkesfeldt, J., Poulsen, H. E., Jensen, P. O., Johansen, H. K., Qvist, T., Kraemer, D., Hoiby, N., Ciofu, O. The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection - A pilot study. J Cyst Fibros 2014 Oct 23

Andersen JT, Andersen NL, Horwitz H, Poulsen HE, Jimenez-Solem E. Exposure to selective serotonin reuptake inhibitors in early pregnancy and the risk of miscarriage. Obstet Gynecol 2014 Oct;124(4):655-61.

Bolling R, Scheller NM, Kober L, Poulsen HE, Gislason GH, Torp-Pedersen C. Comparison of the clinical outcome of different beta-blockers in heart failure patients: a retrospective nationwide cohort study. Eur J Heart Fail 2014 Jun;16(6):678-84.

Cejvanovic V, Jimenez-Solem E, Poulsen H, Andersen J. NSAID use during pregnancy: maternal characteristics and prescription patterns. A nationwide cohort study. Scand J Rheumatol 2014;43(5):424-6.

Grew IS, Cejvanovic V, Broedbaek K, Henriksen T, Petersen M, Andersen JT, et al. Diurnal variation of urinary markers of nucleic acid oxidation. Scand J Clin Lab Invest 2014 Jun;74(4):336-43.

Munkholm K, Poulsen HE, Kessing LV, Vinberg M. Elevated levels of urinary markers of oxidatively generated DNA and RNA damage in bipolar disorder. Bipolar Disord 2014 Aug 13.

Nielsen TK, Hojgaard M, Andersen JT, Poulsen HE, Lykkesfeldt J, Mikines KJ. Elimination of Ascorbic Acid After High-Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation. Basic Clin Pharmacol Toxicol 2014 Sep 12.

Poulsen HE, Nadal LL, Broedbaek K, Nielsen PE, Weimann A. Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid. Biochim Biophys Acta 2014 Feb;1840(2):801-8.

Weeke P., Jensen A., Folke F., Gislason G. H., Olesen J. B., Fosbol E. L., Wissenberg M., Lippert F. K., Christensen E. F., Nielsen S. L., Holm E., Kanters J. K., Poulsen H. E., Kober L., Torp-Pedersen C. Antipsychotics and associated risk of out-of-hospital cardiac arrest. Clin Pharmacol Ther 2014 Oct;96(4):490-7..

 Bjarke Askaa, Espen Jimenez-Solem, Henrik Enghusen Poulsen, Jon Traerup Andersen, Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during Pregnancy Obstetrics and Gynecology International, vol. 2014, Article ID 945621, 5 pages, 2014. doi:10.1155/2014/945621.



Andersen J. T., Petersen M., Jimenez-Solem E., Rasmussen J. N., Andersen N. L., Afzal S., Broedbaek K., Hjelvang B. R., Kober L., Torp-Pedersen C., Poulsen H. E. Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study. Obstet Gynecol Int 2013;2013:364526.

Andersen J. T., Petersen M., Jimenez-Solem E., Broedbaek K., Andersen N. L., Torp-Pedersen C., Keiding N., Poulsen H. E. Clarithromycin in early pregnancy and the risk of miscarriage and malformation: a register based nationwide cohort study. PLoS One 2013;8(1):e53327.

Andersen J. T., Petersen M., Jimenez-Solem E., Broedbaek K., Andersen E. W., Andersen N. L., Afzal S., Torp-Pedersen C., Keiding N., Poulsen H. E. Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study. Epidemiol Infect 2013 Aug;141(8):1749-55.

Barregard L., Moller P., Henriksen T., Mistry V., Koppen G., Rossner P., Jr., Sram R. J., Weimann A., Poulsen H. E., Nataf R., Andreoli R., Manini P., Marczylo T., Lam P., Evans M. D., Kasai H., Kawai K., Li Y. S., Sakai K., Singh R., Teichert F., Farmer P. B., Rozalski R., Gackowski D., Siomek A., Saez G. T., Cerda C., Broberg K., Lindh C., Hossain M. B., Haghdoost S., Hu C. W., Chao M. R., Wu K. Y., Orhan H., Senduran N., Smith R. J., Santella R. M., Su Y., Cortez C., Yeh S., Olinski R., Loft S., Cooke M. S. Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine. Antioxid Redox Signal 2013 Jun 20;18(18):2377-91.

Broedbaek K., Siersma V., Henriksen T., Weimann A., Petersen M., Andersen J. T., Jimenez-Solem E., Hansen L. J., Henriksen J. E., Bonnema S. J., de Fine Olivarius N., Poulsen H. E. Association between urinary markers of nucleic acid oxidation and mortality in type 2 diabetes: a population-based cohort study. Diabetes Care 2013 Mar;36(3):669-76.

Jimenez-Solem E., Andersen J. T., Petersen M., Broedbaek K., Lander A. R., Afzal S., Torp-Pedersen C., Poulsen H. E. SSRI use during pregnancy and risk of stillbirth and neonatal mortality. Am J Psychiatry 2013 Mar;170(3):299-304.

Jimenez-Solem E., Andersen J. T., Petersen M., Broedbaek K., Andersen N. L., Torp-Pedersen C., Poulsen H. E. Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study. PLoS One 2013;8(4):e63034.

Jorgensen A., Broedbaek K., Fink-Jensen A., Knorr U., Greisen Soendergaard M., Henriksen T., Weimann A., Jepsen P., Lykkesfeldt J., Poulsen H. E., Balslev Jorgensen M. Increased systemic oxidatively generated DNA and RNA damage in schizophrenia. Psychiatry Res 2013 Oct 30;209(3):417-23.

Jorgensen A., Maigaard K., Wortwein G., Hageman I., Henriksen T., Weimann A., Moller P., Loft S., Hau J., Poulsen H. E., Jorgensen M. B. Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage. Prog Neuropsychopharmacol Biol Psychiatry 2013 Jan 10;40:30-7.

Jorgensen A., Krogh J., Miskowiak K., Bolwig T. G., Kessing L. V., Fink-Jensen A., Nordentoft M., Henriksen T., Weimann A., Poulsen H. E., Jorgensen M. B. Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy. J Affect Disord 2013 Jul;149(1-3):355-62.

Kalliokoski O., Jacobsen K. R., Darusman H. S., Henriksen T., Weimann A., Poulsen H. E., Hau J., Abelson K. S. Mice do not habituate to metabolism cage housing--a three week study of male BALB/c mice. PLoS One 2013;8(3):e58460.

Klarskov P., Andersen J. T., Jimenez-Solem E., Torp-Pedersen C., Poulsen H. E. Short-acting sulfonamides near term and neonatal jaundice. Obstet Gynecol 2013 Jul;122(1):105-10.

Loft S., Olsen A., Moller P., Poulsen H. E., Tjonneland A. Association between 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and risk of postmenopausal breast cancer: nested case-control study. Cancer Epidemiol Biomarkers Prev 2013 Jul;22(7):1289-96.

Mullner E., Brath H., Pleifer S., Schiermayr C., Baierl A., Wallner M., Fastian T., Millner Y., Paller K., Henriksen T., Poulsen H. E., Forster E., Wagner K. H. Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes. Mol Nutr Food Res 2013 Feb;57(2):328-38.

Wallner M., Antl N., Rittmannsberger B., Schreidl S., Najafi K., Mullner E., Molzer C., Ferk F., Knasmuller S., Marculescu R., Doberer D., Poulsen H. E., Vitek L., Bulmer A. C., Wagner K. H. Anti-genotoxic potential of bilirubin in vivo: damage to DNA in hyperbilirubinemic human and animal models. Cancer Prev Res (Phila) 2013 Oct;6(10):1056-63.


Afzal S., Jensen S. A., Sorensen J. B., Henriksen T., Weimann A., Poulsen H. E. Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin. Cancer Chemother Pharmacol 2012 Feb;69(2):301-7.

Egefjord L., Gejl M., Moller A., Braendgaard H., Gottrup H., Antropova O., Moller N., Poulsen H. E., Gjedde A., Brock B., Rungby J. Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer s disease - protocol for a controlled, randomized double-blinded trial. Dan Med J 2012 Oct;59(10):A4519.

Jimenez-Solem E., Andersen J. T., Petersen M., Broedbaek K., Jensen J. K., Afzal S., Gislason G. H., Torp-Pedersen C., Poulsen H. E. Exposure to selective serotonin reuptake inhibitors and the risk of congenital malformations: a nationwide cohort study. BMJ Open 2012;2(3).

Jorgensen A., Jorgensen M. B., Poulsen H. E. [Stress and aging]. Ugeskr Laeger 2012 Jan 23;174(4):201-4.

Meidahl Petersen K., Jimenez-Solem E., Andersen J. T., Petersen M., Brodbaek K., Kober L., Torp-Pedersen C., Poulsen H. E. beta-Blocker treatment during pregnancy and adverse pregnancy outcomes: a nationwide population-based cohort study. BMJ Open 2012;2(4).

Petersen M., Andersen J. T., Jimenez-Solem E., Broedbaek K., Hjelvang B. R., Henriksen T., Frandsen E., Forman J. L., Torp-Pedersen C., Kober L., Poulsen H. E. Effect of the Arg389Gly beta(1)-adrenoceptor polymorphism on plasma renin activity and heart rate, and the genotype-dependent response to metoprolol treatment. Clin Exp Pharmacol Physiol 2012 Sep;39(9):779-85.

Petersen M., Andersen J. T., Jimenez-Solem E., Broedbaek K., Afzal S., Nyegaard M., Borglum A. D., Stender S., Torp-Pedersen C., Kober L., Poulsen H. E. Effect of specific ADRB1/ADRB2/AGT genotype combinations on the association between survival and carvedilol treatment in chronic heart failure: a substudy of the ECHOS trial. Pharmacogenet Genomics 2012 Oct;22(10):709-15.

Poulsen H. E., Specht E., Broedbaek K., Henriksen T., Ellervik C., Mandrup-Poulsen T., Tonnesen M., Nielsen P. E., Andersen H. U., Weimann A. RNA modifications by oxidation: a novel disease mechanism? Free Radic Biol Med 2012 Apr 15;52(8):1353-61.

Sarac S. B., Rasmussen C. H., Afzal S., Thirstrup S., Jensen S. A., Colding-Jorgensen M., Poulsen H. E., Mosekilde E. Data-driven assessment of the association of polymorphisms in 5-Fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer. Basic Clin Pharmacol Toxicol 2012 Sep;111(3):189-97.

Torp-Pedersen A., Jimenez-Solem E., Andersen J. T., Broedbaek K., Torp-Pedersen C., Poulsen H. E. Exposure to mebendazole and pyrvinium during pregnancy: a Danish nationwide cohort study. Infect Dis Obstet Gynecol 2012;2012:769851.

Tveden-Nyborg P., Hasselholt S., Miyashita N., Moos T., Poulsen H. E., Lykkesfeldt J. Chronic vitamin C deficiency does not accelerate oxidative stress in ageing brains of guinea pigs. Basic Clin Pharmacol Toxicol 2012 Jun;110(6):524-9.

Weeke P., Folke F., Gislason G. H., Lippert F. K., Olesen J. B., Andersson C., Wissenberg M., Poulsen H. E., Nielsen S. L., Kober L., Torp-Pedersen C. Hospital admissions and pharmacotherapy before out-of-hospital cardiac arrest according to age. Resuscitation 2012 May;83(5):584-90.

Weeke P., Jensen A., Folke F., Gislason G. H., Olesen J. B., Andersson C., Fosbol E. L., Larsen J. K., Lippert F. K., Nielsen S. L., Gerds T., Andersen P. K., Kanters J. K., Poulsen H. E., Pehrson S., Kober L., Torp-Pedersen C. Antidepressant use and risk of out-of-hospital cardiac arrest: a nationwide case-time-control study. Clin Pharmacol Ther 2012 Jul;92(1):72-9.

Weimann A., Broedbaek K., Henriksen T., Stovgaard E. S., Poulsen H. E. Assays for urinary biomarkers of oxidatively damaged nucleic acids. Free Radic Res 2012 Apr;46(4):531-40.


Afzal S, Gusella M, Jensen SA, Vainer B, Vogel U, Andersen JT, et al. The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer. Pharmacogenomics 2011 Sep;12(9):1257-67.

Afzal S, Gusella M, Vainer B, Vogel UB, Andersen JT, Broedbaek K, et al. Combinations of polymorphisms in genes involved in the 5-Fluorouracil metabolism pathway are associated with gastrointestinal toxicity in chemotherapy-treated colorectal cancer patients. Clin Cancer Res 2011 Jun 1;17(11):3822-9.

Broedbaek K, Siersma V, Henriksen T, Weimann A, Petersen M, Andersen JT, et al. Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients. Diabetes Care 2011 Dec;34(12):2594-6.

Broedbaek K, Ribel-Madsen R, Henriksen T, Weimann A, Petersen M, Andersen JT, et al. Genetic and environmental influences on oxidative damage assessed in elderly Danish twins. Free Radic Biol Med 2011 Jun 1;50(11):1488-91.

Broedbaek K, Henriksen T, Weimann A, Petersen M, Andersen JT, Afzal S, et al. Long-term effects of Irbesartan treatment and smoking on nucleic acid oxidation in patients with type 2 diabetes and microalbuminuria: an Irbesartan in patients with type 2 diabetes and Microalbuminuria (IRMA 2) substudy. Diabetes Care 2011 May;34(5):1192-8.

Broedbaek K, Weimann A, Stovgaard ES, Poulsen HE. Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker in type 2 diabetes. Free Radic Biol Med 2011 Oct 15;51(8):1473-9.

Broedbaek K, Siersma V, Andersen JT, Petersen M, Afzal S, Hjelvang B, et al. The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly. Free Radic Res 2011 Apr;45(4):409-16.

Castaner O, Fito M, Lopez-Sabater MC, Poulsen HE, Nyyssonen K, Schroder H, et al. The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial. Clin Nutr 2011 Aug;30(4):490-3.

Gorovic N, Afzal S, Tjonneland A, Overvad K, Vogel U, Albrechtsen C, et al. Genetic variation in the hTAS2R38 taste receptor and brassica vegetable intake. Scand J Clin Lab Invest 2011 Jul;71(4):274-9.

Joergensen A, Broedbaek K, Weimann A, Semba RD, Ferrucci L, Joergensen MB, et al. Association between urinary excretion of cortisol and markers of oxidatively damaged DNA and RNA in humans. PLoS One 2011;6(6):e20795.

Petersen M, Andersen JT, Hjelvang BR, Broedbaek K, Afzal S, Nyegaard M, et al. Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients. Br J Clin Pharmacol 2011 Apr;71(4):556-65.

Berendt L, Hakansson C, Bach KF, Andreasen PB, Petersen LG, Andersen E, et al. Methodological characteristics of academic clinical drug trials--a retrospective cohort study of applications to the Danish Medicines Agency 1993-2005. Br J Clin Pharmacol 2010 Nov;70(5):729-35.


Dominguez H, Schramm TK, Gislason GH, Norgaard ML, Raunso J, Abildstrom SZ, et al. National Background is Associated with Disparities in Initiation and Persistence to Statin Treatment in Subjects with Diabetes in Denmark. Front Pharmacol 2010;1:142.

Evans MD, Olinski R, Loft S, Cooke MS. Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress. FASEB J 2010 Apr;24(4):1249-60.

Fosbol EL, Folke F, Jacobsen S, Rasmussen JN, Sorensen R, Schramm TK, et al. Cause-specific cardiovascular risk associated with nonsteroidal antiinflammatory drugs among healthy individuals. Circ Cardiovasc Qual Outcomes 2010 Jul;3(4):395-405.

Glintborg B, Andersen SK, Poulsen HE. Prescription data improve the medication history in primary care. Qual Saf Health Care 2010 Jun;19(3):164-8.

Hansen ML, Sorensen R, Clausen MT, Fog-Petersen ML, Raunso J, Gadsboll N, et al. Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. Arch Intern Med 2010 Sep 13;170(16):1433-41.

Lopez-Miranda J, Perez-Jimenez F, Ros E, De CR, Badimon L, Covas MI, et al. Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008. Nutr Metab Cardiovasc Dis 2010 May;20(4):284-94.

Lykkesfeldt J, Poulsen HE. Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials. Br J Nutr 2010 May;103(9):1251-9.

Nurmi T, Mursu J, Penalvo JL, Poulsen HE, Voutilainen S. Dietary intake and urinary excretion of lignans in Finnish men. Br J Nutr 2010 Mar;103(5):677-85.

Olesen JB, Hansen PR, Erdal J, Abildstrom SZ, Weeke P, Fosbol EL, et al. Antiepileptic drugs and risk of suicide: a nationwide study. Pharmacoepidemiol Drug Saf 2010 May;19(5):518-24.

Sorensen R, Abildstrom SZ, Weeke P, Fosbol EL, Folke F, Hansen ML, et al. Duration of clopidogrel treatment and risk of mortality and recurrent myocardial infarction among 11 680 patients with myocardial infarction treated with percutaneous coronary intervention: a cohort study. BMC Cardiovasc Disord 2010;10:6.

Torre-Carbot K, Chavez-Servin JL, Jauregui O, Castellote AI, Lamuela-Raventos RM, Nurmi T, et al. Elevated circulating LDL phenol levels in men who consumed virgin rather than refined olive oil are associated with less oxidation of plasma LDL. J Nutr 2010 Mar;140(3):501-8.

Weeke P, Folke F, Gislason GH, Lippert FK, Olesen JB, Andersson C, et al. Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest: a nationwide study. Resuscitation 2010 Dec;81(12):1657-63.


Afzal S, Jensen SA, Vainer B, Vogel U, Matsen JP, Sorensen JB, et al. MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer. Ann Oncol 2009 Oct;20(10):1660-6.

Broedbaek K, Poulsen HE, Weimann A, Kom GD, Schwedhelm E, Nielsen P, et al. Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis. Free Radic Biol Med 2009 Oct 15;47(8):1230-3.

Davanipour Z, Poulsen HE, Weimann A, Sobel E. Endogenous melatonin and oxidatively damaged guanine in DNA. BMC Endocr Disord 2009;9:22.

Dominguez H, Schramm TK, Norgaard ML, Abildstrom SZ, Kober L, Jorgensen C, et al. Initiation and persistence to statin treatment in patients with diabetes receiving glucose-lowering medications. Open Cardiovasc Med J 2009;3:152-9.

Fosbol EL, Gislason GH, Poulsen HE, Hansen ML, Folke F, Schramm TK, et al. Prognosis in heart failure and the value of {beta}-blockers are altered by the use of antidepressants and depend on the type of antidepressants used. Circ Heart Fail 2009 Nov;2(6):582-90.

Fosbol EL, Gislason GH, Jacobsen S, Folke F, Hansen ML, Schramm TK, et al. Risk of myocardial infarction and death associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) among healthy individuals: a nationwide cohort study. Clin Pharmacol Ther 2009 Feb;85(2):190-7.

Gislason GH, Rasmussen JN, Abildstrom SZ, Schramm TK, Hansen ML, Fosbol EL, et al. Increased mortality and cardiovascular morbidity associated with use of nonsteroidal anti-inflammatory drugs in chronic heart failure. Arch Intern Med 2009 Jan 26;169(2):141-9.

Hansen ML, Gadsboll N, Rasmussen S, Gislason GH, Folke F, Andersen SS, et al. Clinical consequences of hospital variation in use of oral anticoagulant therapy after first-time admission for atrial fibrillation. J Intern Med 2009 Mar;265(3):335-44.

Henriksen T, Hillestrom PR, Poulsen HE, Weimann A. Automated method for the direct analysis of 8-oxo-guanosine and 8-oxo-2'-deoxyguanosine in human urine using ultraperformance liquid chromatography and tandem mass spectrometry. Free Radic Biol Med 2009 Sep 1;47(5):629-35.

Mandsberg LF, Ciofu O, Kirkby N, Christiansen LE, Poulsen HE, Hoiby N. Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system. Antimicrob Agents Chemother 2009 Jun;53(6):2483-91.

Poulsen HE, Andersen JT, Keiding N, Schramm TK, Sorensen R, Gislasson G, et al. Why epidemiological and clinical intervention studies often give different or diverging results? IUBMB Life 2009 Apr;61(4):391-3.


Berendt L, Hakansson C, Bach KF, Dalhoff K, Andreasen PB, Petersen LG, et al. [Effect of the GCP Directive on academic drug trials]. Ugeskr Laeger 2008 Aug 11;170(33):2437-9.

Berendt L, Hakansson C, Bach KF, Dalhoff K, Andreasen PB, Petersen LG, et al. Effect of European Clinical Trials Directive on academic drug trials in Denmark: retrospective study of applications to the Danish Medicines Agency 1993-2006. BMJ 2008 Jan 5;336(7634):33-5.

Cicero AF, Nascetti S, Lopez-Sabater MC, Elosua R, Salonen JT, Nyyssonen K, et al. Changes in LDL fatty acid composition as a response to olive oil treatment are inversely related to lipid oxidative damage: The EUROLIVE study. J Am Coll Nutr 2008 Apr;27(2):314-20.

Glintborg B, Poulsen HE, Dalhoff KP. The use of nationwide on-line prescription records improves the drug history in hospitalized patients. Br J Clin Pharmacol 2008 Feb;65(2):265-9.

Guarnieri S, Loft S, Riso P, Porrini M, Risom L, Poulsen HE, et al. DNA repair phenotype and dietary antioxidant supplementation. Br J Nutr 2008 May;99(5):1018-24.

Hansen M, Baunsgaard D, Autrup H, Vogel UB, Moller P, Lindecrona R, et al. Sucrose, glucose and fructose have similar genotoxicity in the rat colon and affect the metabolome. Food Chem Toxicol 2008 Feb;46(2):752-60.

Hansen ML, Gadsboll N, Gislason GH, Abildstrom SZ, Schramm TK, Folke F, et al. Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers. Europace 2008 Apr;10(4):395-402.

Bader N, Bosy-Westphal A, Koch A, Rimbach G, Weimann A, Poulsen HE, et al. Effect of hyperbaric oxygen and vitamin C and E supplementation on biomarkers of oxidative stress in healthy men. Br J Nutr 2007 Oct;98(4):826-33.

Bondia-Pons I, Schroder H, Covas MI, Castellote AI, Kaikkonen J, Poulsen HE, et al. Moderate consumption of olive oil by healthy European men reduces systolic blood pressure in non-Mediterranean participants. J Nutr 2007 Jan;137(1):84-7.

Glintborg B, Hillestrom PR, Olsen LH, Dalhoff KP, Poulsen HE. Are patients reliable when self-reporting medication use? Validation of structured drug interviews and home visits by drug analysis and prescription data in acutely hospitalized patients. J Clin Pharmacol 2007 Nov;47(11):1440-9.

Gravholt CH, Poulsen HE, Ott P, Christiansen JS, Vilstrup H. Quantitative liver functions in Turner syndrome with and without hormone replacement therapy. Eur J Endocrinol 2007 Jun;156(6):679-86.

Lykkesfeldt J, Trueba GP, Poulsen HE, Christen S. Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain. Br J Nutr 2007 Dec;98(6):1116-9.

Machowetz A, Poulsen HE, Gruendel S, Weimann A, Fito M, Marrugat J, et al. Effect of olive oils on biomarkers of oxidative DNA stress in Northern and Southern Europeans. FASEB J 2007 Jan;21(1):45-52.

Tuomainen TP, Loft S, Nyyssonen K, Punnonen K, Salonen JT, Poulsen HE. Body iron is a contributor to oxidative damage of DNA. Free Radic Res 2007 Mar;41(3):324-8.


Covas MI, Nyyssonen K, Poulsen HE, Kaikkonen J, Zunft HJ, Kiesewetter H, et al. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med 2006 Sep 5;145(5):333-41.

Glintborg B, Weimann A, Kensler TW, Poulsen HE. Oltipraz chemoprevention trial in Qidong, People's Republic of China: unaltered oxidative biomarkers. Free Radic Biol Med 2006 Sep 15;41(6):1010-4.

Hillestrom PR, Covas MI, Poulsen HE. Effect of dietary virgin olive oil on urinary excretion of etheno-DNA adducts. Free Radic Biol Med 2006 Oct 1;41(7):1133-8.

Hillestrom PR, Weimann A, Jensen CB, Storgaard H, Vaag AA, Poulsen HE. Consequences of low birthweight on urinary excretion of DNA markers of oxidative stress in young men. Scand J Clin Lab Invest 2006;66(5):363-70.

Hillestrom PR, Weimann A, Poulsen HE. Quantification of urinary etheno-DNA adducts by column-switching LC/APCI-MS/MS. J Am Soc Mass Spectrom 2006 Apr;17(4):605-10.


Ciofu O, Riis B, Pressler T, Poulsen HE, Hoiby N. Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation. Antimicrob Agents Chemother 2005 Jun;49(6):2276-82.

Dalhoff KP, Poulsen HE. [Toxicology and pharmacogenetics]. Ugeskr Laeger 2005 May 16;167(20):2170-2.

Gronbaek K, Sonne J, Ring-Larsen H, Poulsen HE, Friis H, Bygum KH. Viral load is a negative predictor of antioxidant levels in hepatitis C patients. Scand J Infect Dis 2005;37(9):686-9.

Hillestrom PR, Nyssonen K, Tuomainen TP, Pukkala E, Salonen JT, Poulsen HE. Urinary excretion of epsilondA is not predictive of cancer development: a prospective nested case-control study. Free Radic Res 2005 Jan;39(1):51-3.

Laska MJ, Nexo BA, Vistisen K, Poulsen HE, Loft S, Vogel U. Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer. Cancer Lett 2005 Jul 28;225(2):245-51.

Poulsen HE. Oxidative DNA modifications. Exp Toxicol Pathol 2005 Jul;57 Suppl 1:161-9.

Weimann A, Sabroe M, Poulsen HE. Measurement of caffeine and five of the major metabolites in urine by high-performance liquid chromatography/tandem mass spectrometry. J Mass Spectrom 2005 Mar;40(3):307-16.


Collins AR, Cadet J, Moller L, Poulsen HE, Vina J. Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells? Arch Biochem Biophys 2004 Mar 1;423(1):57-65.

de WH, de WJ, Andressoo JO, van Oostrom CT, Riis B, Weimann A, et al. Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage. Mol Cell Biol 2004 Sep;24(18):7941-8.

Hansen M, Hald MT, Autrup H, Vogel U, Bornholdt J, Moller P, et al. Sucrose and IQ induced mutations in rat colon by independent mechanism. Mutat Res 2004 Oct 4;554(1-2):279-86.

Hillestrom PR, Hoberg AM, Weimann A, Poulsen HE. Quantification of 1,N6-etheno-2'-deoxyadenosine in human urine by column-switching LC/APCI-MS/MS. Free Radic Biol Med 2004 Jun 1;36(11):1383-92.

Hoberg AM, Otteneder M, Marnett LJ, Poulsen HE. Measurement of the malondialdehyde-2'-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. J Mass Spectrom 2004 Jan;39(1):38-42.

Lykkesfeldt J, Viscovich M, Poulsen HE. Plasma malondialdehyde is induced by smoking: a study with balanced antioxidant profiles. Br J Nutr 2004 Aug;92(2):203-6.

Moller P, Viscovich M, Lykkesfeldt J, Loft S, Jensen A, Poulsen HE. Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers. Eur J Nutr 2004 Oct;43(5):267-74.

Poulsen HE. [Alcohol elimination in alcopops]. Ugeskr Laeger 2004 Nov 29;166(49):4449.

Poulsen HE, Dalhoff KP. [Insufficient registration of drug poisonings and adverse effects in Denmark]. Ugeskr Laeger 2004 Nov 29;166(49):4451.

Viscovich M, Lykkesfeldt J, Poulsen HE. Vitamin C pharmacokinetics of plain and slow release formulations in smokers. Clin Nutr 2004 Oct;23(5):1043-50.

Vistisen K, Loft S, Olsen JH, Vallentin S, Ottesen S, Hirsch FR, et al. Low CYP1A2 activity associated with testicular cancer. Carcinogenesis 2004 Jun;25(6):923-9.

Weimann A, Riis B, Poulsen HE. Oligonucleotides in human urine do not contain 8-oxo-7,8-dihydrodeoxyguanosine. Free Radic Biol Med 2004 Jun 1;36(11):1378-82.


Bruunsgaard H, Poulsen HE, Pedersen BK, Nyyssonen K, Kaikkonen J, Salonen JT. Long-term combined supplementations with alpha-tocopherol and vitamin C have no detectable anti-inflammatory effects in healthy men. J Nutr 2003 Apr;133(4):1170-3.

Dybdahl M, Risom L, Moller P, Autrup H, Wallin H, Vogel U, et al. DNA adduct formation and oxidative stress in colon and liver of Big Blue rats after dietary exposure to diesel particles. Carcinogenesis 2003 Nov;24(11):1759-66.

Kramer I, Dalhoff K, Clemmesen JO, Loft S, Poulsen HE. Comparison of chlorzoxazone one-sample methods to estimate CYP2E1 activity in humans. Eur J Clin Pharmacol 2003 Dec;59(10):775-8.

Loft S, Kold-Jensen T, Hjollund NH, Giwercman A, Gyllemborg J, Ernst E, et al. Oxidative DNA damage in human sperm influences time to pregnancy. Hum Reprod 2003 Jun;18(6):1265-72.

Lykkesfeldt J, Viscovich M, Poulsen HE. Ascorbic acid recycling in human erythrocytes is induced by smoking in vivo. Free Radic Biol Med 2003 Dec 1;35(11):1439-47.

Lykkesfeldt J, Bolbjerg ML, Poulsen HE. Effect of smoking on erythorbic acid pharmacokinetics. Br J Nutr 2003 May;89(5):667-71.

Moller P, Hansen M, Autrup H, Bornholt J, Vogel U, Molck AM, et al. Dietary low-dose sucrose modulation of IQ-induced genotoxicity in the colon and liver of Big Blue rats. Mutat Res 2003 Jun 19;527(1-2):91-7.

Moller P, Daneshvar B, Loft S, Wallin H, Poulsen HE, Autrup H, et al. Oxidative DNA damage in vitamin C-supplemented guinea pigs after intratracheal instillation of diesel exhaust particles. Toxicol Appl Pharmacol 2003 May 15;189(1):39-44.

Osterberg O, Erichsen L, Ingwersen SH, Plum A, Poulsen HE, Vicini P. Pharmacokinetic and pharmacodynamic properties of insulin aspart and human insulin. J Pharmacokinet Pharmacodyn 2003 Jun;30(3):221-35.

Osterberg O, Kiehr B, Erichsen L, Poulsen HE, Ingwersen SH. Pharmacokinetics and allometric scaling of levormeloxifene, a selective oestrogen receptor modulator. Biopharm Drug Dispos 2003 Apr;24(3):121-9.

Poulsen HE, Gronlykke TB. [Does the public sector have an independent research role in the development of drugs?]. Ugeskr Laeger 2003 Apr 14;165(16):1674-6.

Risom L, Moller P, Hansen M, Autrup H, Bornholdt J, Vogel U, et al. Dietary elevated sucrose modulation of diesel-induced genotoxicity in the colon and liver of Big Blue rats. Arch Toxicol 2003 Nov;77(11):651-6.

Salonen RM, Nyyssonen K, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Rissanen TH, et al. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation 2003 Feb 25;107(7):947-53.

Verhagen H, Aruoma OI, van Delft JH, Dragsted LO, Ferguson LR, Knasmuller S, et al. The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo. Food Chem Toxicol 2003 May;41(5):603-10.

Vogel U, Danesvar B, Autrup H, Risom L, Weimann A, Poulsen HE, et al. Effect of increased intake of dietary animal fat and fat energy on oxidative damage, mutation frequency, DNA adduct level and DNA repair in rat colon and liver. Free Radic Res 2003 Sep;37(9):947-56.


Dragsted LO, Daneshvar B, Vogel U, Autrup HN, Wallin H, Risom L, et al. A sucrose-rich diet induces mutations in the rat colon. Cancer Res 2002 Aug 1;62(15):4339-45.

Moller P, Wallin H, Vogel U, Autrup H, Risom L, Hald MT, et al. Mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in colon and liver of Big Blue rats: role of DNA adducts, strand breaks, DNA repair and oxidative stress. Carcinogenesis 2002 Aug;23(8):1379-85.

Poulsen HE, Schmitz OE, Brosen K. [Clinical pharmacology 2001--important events. The Danish Society of Clinical Pharmacology]. Ugeskr Laeger 2002 Mar 18;164(12):1652.

Riis B, Risom L, Loft S, Poulsen HE. OGG1 mRNA expression and incision activity in rats are higher in foetal tissue than in adult liver tissue while 8-oxo-2'-deoxyguanosine levels are unchanged. DNA Repair (Amst) 2002 Sep 4;1(9):709-17.

Riis B, Risom L, Loft S, Poulsen HE. Increased rOGG1 expression in regenerating rat liver tissue without a corresponding increase in incision activity. DNA Repair (Amst) 2002 May 30;1(5):419-24.

Schmidt LE, Dalhoff K, Poulsen HE. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology 2002 Apr;35(4):876-82.

Weimann A, Belling D, Poulsen HE. Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography-electrospray tandem mass spectrometry. Nucleic Acids Res 2002 Jan 15;30(2):E7


Dalhoff K, Laursen H, Bangert K, Poulsen HE, Anderson ME, Grunnet N, et al. Autoprotection in acetaminophen intoxication in rats: the role of liver regeneration. Pharmacol Toxicol 2001 Mar;88(3):135-41.

Gaede P, Poulsen HE, Parving HH, Pedersen O. Double-blind, randomised study of the effect of combined treatment with vitamin C and E on albuminuria in Type 2 diabetic patients. Diabet Med 2001 Sep;18(9):756-60.

Kaikkonen J, Porkkala-Sarataho E, Morrow JD, Roberts LJ, Nyyssonen K, Salonen R, et al. Supplementation with vitamin E but not with vitamin C lowers lipid peroxidation in vivo in mildly hypercholesterolemic men. Free Radic Res 2001 Dec;35(6):967-78.

Laursen JB, Boesgaard S, Trautner S, Rubin I, Poulsen HE, Aldershvile J. Endothelium-dependent vasorelaxation in inhibited by in vivo depletion of vascular thiol levels: role of endothelial nitric oxide synthase. Free Radic Res 2001 Oct;35(4):387-94.

Nielsen HB, Kharazmi A, Bolbjerg ML, Poulsen HE, Pedersen BK, Secher NH. N-acetylcysteine attenuates oxidative burst by neutrophils in response to ergometer rowing with no effect on pulmonary gas exchange. Int J Sports Med 2001 May;22(4):256-60.

Schmidt LE, Rasmussen A, Norrelykke MR, Poulsen HE, Hansen BA. The effect of selective bowel decontamination on the pharmacokinetics of mycophenolate mofetil in liver transplant recipients. Liver Transpl 2001 Aug;7(8):739-42.

Sorensen M, Jensen BR, Poulsen HE, Deng X, Tygstrup N, Dalhoff K, et al. Effects of a Brussels sprouts extract on oxidative DNA damage and metabolising enzymes in rat liver. Food Chem Toxicol 2001 Jun;39(6):533-40.

Weimann A, Belling D, Poulsen HE. Measurement of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in DNA and human urine by high performance liquid chromatography-electrospray tandem mass spectrometry. Free Radic Biol Med 2001 Apr 1;30(7):757-64.


Dalhoff KP, Poulsen HE. [Thalidomide--failure or success? A controversial drug during the last fifty years--the pendulum swings--a renaissance for thalidomide?]. Ugeskr Laeger 2000 Jan 3;162(1):52-3.

Jensen SA, Jensen BR, Weiman A, Li L, Poulsen HE. [Oxidative stress and aging]. Ugeskr Laeger 2000 Apr 24;162(17):2431-5.

Loft S, Poulsen HE. Antioxidant intervention studies related to DNA damage, DNA repair and gene expression. Free Radic Res 2000 Nov;33 Suppl:S67-S83.

Porkkala-Sarataho E, Salonen JT, Nyyssonen K, Kaikkonen J, Salonen R, Ristonmaa U, et al. Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2'-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men. Arterioscler Thromb Vasc Biol 2000 Sep;20(9):2087-93.

Poulsen HE, Jensen BR, Weimann A, Jensen SA, Sorensen M, Loft S. Antioxidants, DNA damage and gene expression. Free Radic Res 2000 Nov;33 Suppl:S33-S39.

Salonen JT, Nyyssonen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E, et al. Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Intern Med 2000 Nov;248(5):377-86.

Tuo J, Liu L, Poulsen HE, Weimann A, Svendsen O, Loft S. Importance of guanine nitration and hydroxylation in DNA in vitro and in vivo. Free Radic Biol Med 2000 Jul 15;29(2):147-55.

Voutilainen S, Lakka TA, Hamelahti P, Lehtimaki T, Poulsen HE, Salonen JT. Plasma total homocysteine concentration and the risk of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. J Intern Med 2000 Sep;248(3):217-22.

Wellejus A, Poulsen HE, Loft S. Iron-induced oxidative DNA damage in rat sperm cells in vivo and in vitro. Free Radic Res 2000 Jan;32(1):75-83.

Zhu C, Poulsen HE, Loft S. Inhibition of oxidative DNA damage in vitro by extracts of brussels sprouts. Free Radic Res 2000 Aug;33(2):187-96.


Loft S, Poulsen HE, Vistisen K, Knudsen LE. Increased urinary excretion of 8-oxo-2'-deoxyguanosine, a biomarker of oxidative DNA damage, in urban bus drivers. Mutat Res 1999 Apr 26;441(1):11-9.

Loft S, Poulsen HE. Markers of oxidative damage to DNA: antioxidants and molecular damage. Methods Enzymol 1999;300:166-84.

Tuo J, Loft S, Poulsen HE. Enhanced benzene-induced DNA damage in PMA-stimulated cells in vitro and in LPS-treated animals. Free Radic Biol Med 1999 Apr;26(7-8):801-8.

Tuo J, Deng X, Loft S, Poulsen HE. Dexamethasone ameliorates oxidative DNA damage induced by benzene and LPS in mouse bone marrow. Free Radic Res 1999 Jan;30(1):29-36.


Deng XS, Tuo J, Poulsen HE, Loft S. Prevention of oxidative DNA damage in rats by brussels sprouts. Free Radic Res 1998 Mar;28(3):323-33.

Haderslev KV, Sonne J, Poulsen HE, Loft S. Paracetamol metabolism in patients with ulcerative colitis. Br J Clin Pharmacol 1998 Nov;46(5):513-6.

Loft S, Thorling EB, Poulsen HE. High fat diet induced oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2-deoxyguanosine excretion in rats. Free Radic Res 1998 Dec;29(6):595-600.

Loft S, Deng XS, Tuo J, Wellejus A, Sorensen M, Poulsen HE. Experimental study of oxidative DNA damage. Free Radic Res 1998 Dec;29(6):525-39.

Loft S, Poulsen HE. Estimation of oxidative DNA damage in man from urinary excretion of repair products. Acta Biochim Pol 1998;45(1):133-44.

Porkkala-Sarataho EK, Nyyssonen MK, Kaikkonen JE, Poulsen HE, Hayn EM, Salonen RM, et al. A randomized, single-blind, placebo-controlled trial of the effects of 200 mg alpha-tocopherol on the oxidation resistance of atherogenic lipoproteins. Am J Clin Nutr 1998 Nov;68(5):1034-41.

Poulsen HE, Weimann A, Salonen JT, Nyyssonen K, Loft S, Cadet J, et al. Does vitamin C have a pro-oxidant effect? Nature 1998 Sep 17;395(6699):231-2.

Poulsen HE, Prieme H, Loft S. Role of oxidative DNA damage in cancer initiation and promotion. Eur J Cancer Prev 1998 Feb;7(1):9-16.

Poulsen HE. [Medication errors--the top of an iceberg?]. Ugeskr Laeger 1998 Jun 29;160(27):4041.

Poulsen HE, Loft S, Prieme H, Vistisen K, Lykkesfeldt J, Nyyssonen K, et al. Oxidative DNA damage in vivo: relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion. Free Radic Res 1998 Dec;29(6):565-71.

Prieme H, Nyyssonen K, Gronbaek K, Klarlund M, Loft S, Tonnesen P, et al. Randomized controlled smoking cessation study: transient increase in plasma high density lipoprotein but no change in lipoprotein oxidation resistance. Scand J Clin Lab Invest 1998 Feb;58(1):11-8.

Prieme H, Loft S, Klarlund M, Gronbaek K, Tonnesen P, Poulsen HE. Effect of smoking cessation on oxidative DNA modification estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion. Carcinogenesis 1998 Feb;19(2):347-51.

Tuo J, Wolff SP, Loft S, Poulsen HE. Formation of nitrated and hydroxylated aromatic compounds from benzene and peroxynitrite, a possible mechanism of benzene genotoxicity. Free Radic Res 1998 Apr;28(4):369-75.


Cadenas S, Barja G, Poulsen HE, Loft S. Oxidative DNA damage estimated by oxo8dG in the liver of guinea-pigs supplemented with graded dietary doses of ascorbic acid and alpha-tocopherol. Carcinogenesis 1997 Dec;18(12):2373-7.

Deng XS, Tuo J, Poulsen HE, Loft S. 2-Nitropropane-induced DNA damage in rat bone marrow. Mutat Res 1997 Jul 14;391(3):165-9.

Kaikkonen J, Nyyssonen K, Porkkala-Sarataho E, Poulsen HE, Metsa-Ketela T, Hayn M, et al. Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Radic Biol Med 1997;22(7):1195-202.

Lykkesfeldt J, Loft S, Nielsen JB, Poulsen HE. Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking. Am J Clin Nutr 1997 Apr;65(4):959-63.

Nyyssonen K, Poulsen HE, Hayn M, Agerbo P, Porkkala-Sarataho E, Kaikkonen J, et al. Effect of supplementation of smoking men with plain or slow release ascorbic acid on lipoprotein oxidation. Eur J Clin Nutr 1997 Mar;51(3):154-63.

Poulsen HE. [Adverse effects of drugs--25 years later]. Ugeskr Laeger 1997 Aug 11;159(33):4964.

Prieme H, Loft S, Nyyssonen K, Salonen JT, Poulsen HE. No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion in smokers. Am J Clin Nutr 1997 Feb;65(2):503-7.

Vistisen K, Prieme H, Okkels H, Vallentin S, Loft S, Olsen JH, et al. Genotype and phenotype of glutathione S-transferase mu in testicular cancer patients. Pharmacogenetics 1997 Feb;7(1):21-5.


Clemmesen JO, Ott P, Dalhoff KP, Astrup LB, Tage-Jensen U, Poulsen HE. [Recommendations for treatment of paracetamol poisoning. Danish Medical Society, Study of the Liver]. Ugeskr Laeger 1996 Nov 25;158(48):6892-5.

Jensen KG, Poulsen HE, Doehmer J, Loft S. Paracetamol-induced spindle disturbances in V79 cells with and without expression of human CYP1A2. Pharmacol Toxicol 1996 Apr;78(4):224-8.

Jeppesen U, Loft S, Poulsen HE, Brsen K. A fluvoxamine-caffeine interaction study. Pharmacogenetics 1996 Jun;6(3):213-22.

Jeppesen U, Gram LF, Vistisen K, Loft S, Poulsen HE, Brosen K. Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. Eur J Clin Pharmacol 1996;51(1):73-8.

Laursen JB, Boesgaard S, Poulsen HE, Aldershvile J. Nitrate tolerance impairs nitric oxide-mediated vasodilation in vivo. Cardiovasc Res 1996 May;31(5):814-9.

Loft S, Poulsen HE. Cancer risk and oxidative DNA damage in man. J Mol Med (Berl) 1996 Jun;74(6):297-312.

Lykkesfeldt J, Prieme H, Loft S, Poulsen HE. Effect of smoking cessation on plasma ascorbic acid concentration. BMJ 1996 Jul 13;313(7049):91.

Poulsen HE. [Markers of vitamin deficiencies]. Ugeskr Laeger 1996 Jul 1;158(27):3906.

Poulsen HE, Loft S, Vistisen K. Extreme exercise and oxidative DNA modification. J Sports Sci 1996 Aug;14(4):343-6.

Tuo J, Loft S, Thomsen MS, Poulsen HE. Ex vivo time-dependent cell DNA-degradation shown by single cell gel electrophoresis. Pharmacol Toxicol 1996 Jan;78(1):55-7.

Tuo J, Loft S, Thomsen MS, Poulsen HE. Benzene-induced genotoxicity in mice in vivo detected by the alkaline comet assay: reduction by CYP2E1 inhibition. Mutat Res 1996 Jul 5;368(3-4):213-9.


Fischer-Nielsen A, Corcoran GB, Poulsen HE, Kamendulis LM, Loft S. Menadione-induced DNA fragmentation without 8-oxo-2'-deoxyguanosine formation in isolated rat hepatocytes. Biochem Pharmacol 1995 May 17;49(10):1469-74.

Jensen KG, Poulsen HE, Doehmer J, Loft S. Kinetics and inhibition by fluvoxamine of phenacetin O-deethylation in V79 cells expressing human CYP1A2. Pharmacol Toxicol 1995 Apr;76(4):286-8.

Loft S, Velthuis-te Wierik EJ, Van den Berg H, Poulsen HE. Energy restriction and oxidative DNA damage in humans. Cancer Epidemiol Biomarkers Prev 1995 Jul;4(5):515-9.

Lykkesfeldt J, Loft S, Poulsen HE. Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection--are they reliable biomarkers of oxidative stress? Anal Biochem 1995 Aug 10;229(2):329-35.

Nielsen HB, Hanel B, Loft S, Poulsen HE, Pedersen BK, Diamant M, et al. Restricted pulmonary diffusion capacity after exercise is not an ARDS-like injury. J Sports Sci 1995 Apr;13(2):109-13.

Poulsen HE, Loft S. Early biochemical markers of effects: enzyme induction, oncogene activation and markers of oxidative damage. Toxicology 1995 Jul 26;101(1-2):55-64.

Rasmussen BB, Maenpaa J, Pelkonen O, Loft S, Poulsen HE, Lykkesfeldt J, et al. Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine. Br J Clin Pharmacol 1995 Feb;39(2):151-9.

Thomsen MS, Loft S, Roberts DW, Poulsen HE. Cytochrome P4502E1 inhibition by propylene glycol prevents acetaminophen (paracetamol) hepatotoxicity in mice without cytochrome P4501A2 inhibition. Pharmacol Toxicol 1995 Jun;76(6):395-9.

Velthuis-te Wierik EJ, van Leeuwen RE, Hendriks HF, Verhagen H, Loft S, Poulsen HE, et al. Short-term moderate energy restriction does not affect indicators of oxidative stress and genotoxicity in humans. J Nutr 1995 Oct;125(10):2631-9.

Verhagen H, Poulsen HE, Loft S, van PG, Willems MI, van Bladeren PJ. Reduction of oxidative DNA-damage in humans by brussels sprouts. Carcinogenesis 1995 Apr;16(4):969-70.


Boesgaard S, Aldershvile J, Poulsen HE, Loft S, Anderson ME, Meister A. Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels. Circ Res 1994 Jan;74(1):115-20.

Boesgaard S, Iversen HK, Wroblewski H, Poulsen HE, Frandsen H, Kastrup J, et al. Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine. J Am Coll Cardiol 1994 Jan;23(1):163-9.

Kjoller-Hansen L, Boesgaard S, Laursen JB, Poulsen HE, Aldershvile J. [Nitroglycerin preparations. Effect and tolerance]. Ugeskr Laeger 1994 Jun 13;156(24):3621-5.

Laursen JB, Boesgaard S, Poulsen HE, Aldershvile J. [Endothelium-derived relaxing factor/nitrogen oxide. Pharmacological and clinical cardiovascular aspects]. Ugeskr Laeger 1994 Sep 26;156(39):5661-6.

Loft S, Astrup A, Buemann B, Poulsen HE. Oxidative DNA damage correlates with oxygen consumption in humans. FASEB J 1994 May;8(8):534-7.

Lykkesfeldt J, Loft S, Poulsen HE. Simultaneous determination of urinary free cortisol and 6 beta-hydroxycortisol by high-performance liquid chromatography to measure human CYP3A activity. J Chromatogr B Biomed Appl 1994 Oct 3;660(1):23-9.

Poulsen HE, Loft S. The impact of genetic polymorphisms in risk assessment of drugs. Arch Toxicol Suppl 1994;16:211-22.

Sandstrom B, Astrup AV, Dyerberg J, Holmer G, Poulsen HE, Stender S, et al. [The effect on health of dietary antioxidants and antioxidant supplements]. Ugeskr Laeger 1994 Dec 19;156(51):7675-9.


Boesgaard S, Poulsen HE, Aldershvile J, Loft S, Anderson ME, Meister A. Acute effects of nitroglycerin depend on both plasma and intracellular sulfhydryl compound levels in vivo. Effect of agents with different sulfhydryl-modulating properties. Circulation 1993 Feb;87(2):547-53.

Boesgaard S, Aldershvile J, Poulsen HE, Christensen S, Dige-Petersen H, Giese J. N-acetylcysteine inhibits angiotensin converting enzyme in vivo. J Pharmacol Exp Ther 1993 Jun;265(3):1239-44.

Brosen K, Skjelbo E, Rasmussen BB, Poulsen HE, Loft S. Fluvoxamine is a potent inhibitor of cytochrome P4501A2. Biochem Pharmacol 1993 Mar 24;45(6):1211-4.

Dalhoff K, Poulsen HE. Synthesis rates of glutathione and activated sulphate (PAPS) and response to cysteine and acetaminophen administration in glutathione-depleted rat hepatocytes. Biochem Pharmacol 1993 Oct 5;46(7):1295-7.

Dalhoff K, Poulsen HE. Simultaneous measurements of glutathione and activated sulphate (PAPS) synthesis rates and the effects of selective inhibition of glutathione conjugation or sulphation of acetaminophen. Biochem Pharmacol 1993 Aug 3;46(3):383-8.

Dalhoff K, Poulsen HE. Inhibition of acetaminophen oxidation by cimetidine and the effects on glutathione and activated sulphate synthesis rates. Pharmacol Toxicol 1993 Oct;73(4):215-8.

Ding JW, Andersson R, Soltesz V, Willen R, Loft S, Poulsen HE, et al. The effect of biliary decompression on bacterial translocation in jaundiced rats. HPB Surg 1993;7(2):99-110.

Jeding IB, Loft S, Poulsen HE. Non-induction of extrahepatic antipyrine and metronidazole metabolism evaluated from partially hepatectomized rats. Xenobiotica 1993 Apr;23(4):411-8.

Jensen KG, Onfelt A, Poulsen HE, Doehmer J, Loft S. Effects of benzo[a]pyrene and (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene on mitosis in Chinese hamster V79 cells with stable expression of rat cytochrome P4501A1 or 1A2. Carcinogenesis 1993 Oct;14(10):2115-8.

Jensen KG, Loft S, Doehmer J, Poulsen HE. Metabolism of phenacetin in V79 Chinese hamster cell cultures expressing rat liver cytochrome P4501A2 compared to isolated rat hepatocytes. Biochem Pharmacol 1993 Mar 9;45(5):1171-3.

Kjoller-Hansen L, Boesgaard S, Laursen JB, Aldershvile J, Poulsen HE. [Importance of thiols (SH group) in the cardiovascular system]. Ugeskr Laeger 1993 Nov 8;155(45):3642-5.

Loft S, Fischer-Nielsen A, Jeding IB, Vistisen K, Poulsen HE. 8-Hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage. J Toxicol Environ Health 1993 Oct;40(2-3):391-404.

Lykkesfeldt J, Poulsen HE. [Nitrosamine formation via non-prescription drugs?]. Ugeskr Laeger 1993 Dec 13;155(50):4106-7.

Poulsen HE, Vilstrup H, Almdal T, Dalhoff K. No net splanchnic release of glutathione in man during N-acetylcysteine infusion. Scand J Gastroenterol 1993 May;28(5):408-12.

Poulsen HE, Loft S, Wassermann K. Cancer risk related to genetic polymorphisms in carcinogen metabolism and DNA repair. Pharmacol Toxicol 1993;72 Suppl 1:93-103.

Ranek L, Dalhoff K, Poulsen HE, Brosen K, Flachs H, Loft S, et al. Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis. Scand J Gastroenterol 1993 Aug;28(8):677-80.

Sherson DL, Sigsgaard TI, Overgaard E, Loft SH, Poulsen HE, Jongeneelen FC. [Risk of lung cancer among foundry workers]. Ugeskr Laeger 1993 Mar 1;155(9):620-3.


Boesgaard S, Aldershvile J, Poulsen HE. Preventive administration of intravenous N-acetylcysteine and development of tolerance to isosorbide dinitrate in patients with angina pectoris. Circulation 1992 Jan;85(1):143-9.

Dalhoff K, Ranek L, Mantoni M, Poulsen HE. Glutathione treatment of hepatocellular carcinoma. Liver 1992 Oct;12(5):341-3.

Dalhoff K, Poulsen HE. Effects of cysteine and acetaminophen on the syntheses of glutathione and adenosine 3'-phosphate 5'-phosphosulfate in isolated rat hepatocytes. Biochem Pharmacol 1992 Aug 4;44(3):447-54.

Fischer-Nielsen A, Poulsen HE, Loft S. 8-Hydroxydeoxyguanosine in vitro: effects of glutathione, ascorbate, and 5-aminosalicylic acid. Free Radic Biol Med 1992;13(2):121-6.

Loft S, Vistisen K, Ewertz M, Tjonneland A, Overvad K, Poulsen HE. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis 1992 Dec;13(12):2241-7.

Loft S, Otte J, Poulsen HE, Sorensen H. Influence of intact and myrosinase-treated indolyl glucosinolates on the metabolism in vivo of metronidazole and antipyrine in the rat. Food Chem Toxicol 1992 Nov;30(11):927-35.

Sherson D, Sigsgaard T, Overgaard E, Loft S, Poulsen HE, Jongeneelen FJ. Interaction of smoking, uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers. Br J Ind Med 1992 Mar;49(3):197-202.

Vistisen K, Poulsen HE, Loft S. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis 1992 Sep;13(9):1561-8.


Andersson R, Poulsen HE, Ahren B. Effect of bile on liver function tests in experimental E. coli peritonitis in the rat. Hepatogastroenterology 1991 Oct;38(5):388-90.

Boesgaard S, Petersen JS, Aldershvile J, Poulsen HE, Flachs H. Nitrate tolerance: effect of thiol supplementation during prolonged nitroglycerin infusion in an in vivo rat model. J Pharmacol Exp Ther 1991 Sep;258(3):851-6.

Dalhoff K, Hansen PB, Ott P, Loft S, Poulsen HE. Acute ethanol administration reduces the antidote effect of N-acetylcysteine after acetaminophen overdose in mice. Hum Exp Toxicol 1991 Nov;10(6):431-3.

Fischer-Nielsen A, Poulsen HE, Hansen BA, Hage E, Keiding S. CCl4 cirrhosis in rats: irreversible histological changes and differentiated functional impairment. J Hepatol 1991 Jan;12(1):110-7.

Loft S, Otton SV, Lennard MS, Tucker GT, Poulsen HE. Characterization of metronidazole metabolism by human liver microsomes. Biochem Pharmacol 1991 Apr 15;41(8):1127-34.

Loft S, Nielsen AJ, Borg BE, Poulsen HE. Metronidazole and antipyrine metabolism in the rat: clearance determination from one saliva sample. Xenobiotica 1991 Jan;21(1):33-46.

Poulsen HE, Ranek L, Jorgensen L. The influence of disulfiram on acetaminophen metabolism in man. Xenobiotica 1991 Feb;21(2):243-9.

Sjovall S, Ahren B, Hansson P, Loft S, Poulsen HE, Bengmark S. Metabolic responses to intermittent hepatic dearterialization in the rat. J Hepatol 1991 Jul;13(1):33-7.

Vistisen K, Loft S, Poulsen HE. Cytochrome P450 IA2 activity in man measured by caffeine metabolism: effect of smoking, broccoli and exercise. Adv Exp Med Biol 1991;283:407-11.


Hinson JA, Roberts DW, Benson RW, Dalhoff K, Loft S, Poulsen HE. Mechanism of paracetamol toxicity. Lancet 1990 Mar 24;335(8691):732.

Loft S, Poulsen HE. Metabolism of metronidazole and antipyrine in hepatocytes isolated from mouse and rat. Xenobiotica 1990 Feb;20(2):185-91.

Loft S, Poulsen HE. Prediction of xenobiotic metabolism by non-invasive methods. Pharmacol Toxicol 1990 Aug;67(2):101-8.

Loft S, Egsmose C, Sonne J, Poulsen HE, Dossing M, Andreasen PB. Metronidazole elimination is preserved in the elderly. Hum Exp Toxicol 1990 May;9(3):155-9.

Ott P, Dalhoff K, Hansen PB, Loft S, Poulsen HE. Consumption, overdose and death from analgesics during a period of over-the-counter availability of paracetamol in Denmark. J Intern Med 1990 Jun;227(6):423-8.

Ott P, Hansen PB, Dalhoff KP, Loft SH, Poulsen HE. [Consumption of, overdose and fatal poisoning with analgesics in Denmark 1979-1986]. Ugeskr Laeger 1990 Jan 22;152(4):250-2.

Ott P, Dalhoff KP, Poulsen HE. [Analgesic-induced mortality]. Ugeskr Laeger 1990 Sep 24;152(39):2867-8.

Sonne J, Boesgaard S, Poulsen HE, Loft S, Hansen JM, Dossing M, et al. Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism. Br J Clin Pharmacol 1990 Nov;30(5):737-42.


Fischer-Nielsen A, Poulsen HE, Hansen BA, Tygstrup N, Keiding S. Age dependence of rat liver function measurements. J Hepatol 1989 Sep;9(2):190-7.

Loft S, Poulsen HE. Metabolism of metronidazole and antipyrine in isolated rat hepatocytes. Influence of sex and enzyme induction and inhibition. Biochem Pharmacol 1989 Apr 1;38(7):1125-36.

Perrild H, Kayser L, Poulsen HE, Skovsted L, Jorgensen B, Hansen JM. Differential effect of continuous administration of beta-adrenoceptor antagonists on antipyrine and phenytoin clearance. Br J Clin Pharmacol 1989 Nov;28(5):551-4.

Poulsen HE, Hansen BA, Egeberg JC. Neutral red changes arginine-induced glucagon and insulin response in the rat. Pharmacol Toxicol 1989 Jul;65(1):65-8.

Tvede KG, Loft S, Poulsen HE, Schou JS. Methyl parathion toxicity in rats is changed by pretreatment with the pesticides chlordecone, mirex and linuron. Arch Toxicol Suppl 1989;13:446-7.


Jorgensen L, Thomsen P, Poulsen HE. Disulfiram prevents acetaminophen hepatotoxicity in rats. Pharmacol Toxicol 1988 May;62(5):267-71.

Knudsen GM, Poulsen HE, Paulson OB. Blood-brain barrier permeability in galactosamine-induced hepatic encephalopathy. No evidence for increased GABA-transport. J Hepatol 1988 Apr;6(2):187-92.

Loft S, Poulsen HE, Sonne J, Dossing M. Metronidazole clearance: a one-sample method and influencing factors. Clin Pharmacol Ther 1988 Apr;43(4):420-8.

Loft S, Dossing M, Poulsen HE. Influence of age and consumption of tobacco, alcohol and caffeine on antipyrine clearance. Hum Toxicol 1988 May;7(3):277-80.

Loft S, Dossing M, Sonne J, Dalhof K, Bjerrum K, Poulsen HE. Lack of effect of cimetidine on the pharmacokinetics and metabolism of a single oral dose of metronidazole. Eur J Clin Pharmacol 1988;35(1):65-8.

Poulsen HE, Thomsen P. Long-term administration of toxic doses of paracetamol (acetaminophen) to rats. Liver 1988 Jun;8(3):151-6.

Poulsen HE, Loft S. Antipyrine as a model drug to study hepatic drug-metabolizing capacity. J Hepatol 1988 Jun;6(3):374-82.

Sonne J, Poulsen HE, Loft S, Dossing M, Vollmer-Larsen A, Simonsen K, et al. Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism. Eur J Clin Pharmacol 1988;35(1):109-11.


Adelhoj B, Petring OU, Frosig F, Jensen BN, Ibsen M, Poulsen HE. The effect of spinal analgesia and surgery on peroperative drug absorption and gastric emptying in man. Acta Anaesthesiol Scand 1987 Feb;31(2):165-7.

Dalhoff K, Poulsen HE, Garred P, Placchi M, Gammans RE, Mayol RF, et al. Buspirone pharmacokinetics in patients with cirrhosis. Br J Clin Pharmacol 1987 Oct;24(4):547-50.

Loft S, Sonne J, Poulsen HE, Petersen KT, Jorgensen BG, Dossing M. Inhibition and induction of metronidazole and antipyrine metabolism. Eur J Clin Pharmacol 1987;32(1):35-41.

Petersen KF, Hansen BA, Poulsen HE. Hepatic regeneration following glucagon treatment. Horm Metab Res 1987 Jun;19(6):239-41.

Petring OU, Adelhoj B, Ibsen M, Poulsen HE. Effect of chlorpromazine on drug absorption and gastric emptying in man. Can J Anaesth 1987 Nov;34(6):563-5.

Poulsen HE, Jorgensen L, Thomsen P. Prevention of acetaminophen hepatotoxicity by disulfiram. Pharmacol Ther 1987;33(1):83.

Sonne J, Dossing M, Poulsen HE, Pilsgaard H, Rasmussen B, Loft S. Effect of concomitant administration of cimetidine and phenobarbital on antipyrine elimination and metabolite formation. Int J Clin Pharmacol Ther Toxicol 1987 Apr;25(4):194-6.


Hansen BA, Poulsen HE. The capacity of urea-N synthesis as a quantitative measure of the liver mass in rats. J Hepatol 1986;2(3):468-74.

Hansen BA, Poulsen HE. Starvation induced changes in quantitative measures of liver function in the rat. Clin Nutr 1986 Nov;5(4):213-6.

Loft S, Dossing M, Poulsen HE, Sonne J, Olesen KL, Simonsen K, et al. Influence of dose and route of administration on disposition of metronidazole and its major metabolites. Eur J Clin Pharmacol 1986;30(4):467-73.

Petring OU, Adelhoj B, Ibsen M, Poulsen HE. The relationship between gastric emptying of semisolids and paracetamol absorption. Br J Clin Pharmacol 1986 Dec;22(6):659-62.

Sonne J, Poulsen HE, Andreasen PB. Single dose oxazepam has no effect on acetaminophen clearance or metabolism. Eur J Clin Pharmacol 1986;30(1):127-9.


Adelhoj B, Petring OU, Ibsen M, Brynnum J, Poulsen HE. Buprenorphine delays drug absorption and gastric emptying in man. Acta Anaesthesiol Scand 1985 Aug;29(6):599-601.

Adelhoj B, Petring OU, Ibsen M, Brynnum J, Poulsen HE. [Tardive respiratory depression in a young healthy man after intravenous buprenorphine]. Ugeskr Laeger 1985 Apr 15;147(16):1343.

Adelhoj B, Petring OU, Brynnum J, Ibsen M, Poulsen HE. Effect of diazepam on drug absorption and gastric emptying in man. Br J Anaesth 1985 Nov;57(11):1107-9.

Petring OU, Adelhoj B, Ibsen M, Brynnum J, Poulsen HE. Abstaining from cigarette smoking has no major effect on gastric emptying in habitual smokers. Br J Anaesth 1985 Nov;57(11):1104-6.

Poulsen HE. One sample antipyrine clearance after 90% partial hepatectomy in the rat. Liver 1985 Aug;5(4):200-4.

Poulsen HE, Gaub J, Iversen J. Changes in quantitative measures of hepatic function after 90% hepatectomy in rats. Eur J Clin Invest 1985 Oct;15(5):285-9.

Poulsen HE, Lerche A, Pedersen NT. Potentiated hepatotoxicity from concurrent administration of acetaminophen and allyl alcohol to rats. Biochem Pharmacol 1985 Mar 15;34(6):727-31.

Poulsen HE, Lerche A, Skovgaard LT. Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose. Biochem Pharmacol 1985 Oct 15;34(20):3729-33.

Poulsen HE, Pilsgaard H. Antipyrine metabolism during hepatic regeneration in the rat. Liver 1985 Aug;5(4):196-9.

Poulsen HE, Lerche A, Pedersen NT. Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. Pharmacology 1985;30(2):100-8.

Tvedegaard E, Poulsen HE, Vilstrup H, Thomsen HK. Functional status of the liver during chronic renal failure: an experimental study in the rabbit. Liver 1985 Aug;5(4):183-8.


Pilsgaard H, Poulsen HE. A one-sample method for antipyrine clearance determination in rats. Pharmacology 1984;29(2):110-6.

Poulsen HE, Ranek L. [Paracetamol poisoning]. Ugeskr Laeger 1984 Dec 17;146(51):4030-3.

Poulsen HE, Vilstrup H, Keiding S. Galactose elimination kinetics in perfused rat liver after two thirds hepatectomy. Scand J Clin Lab Invest 1984 Apr;44(2):155-8.

Poulsen HE, Korsholm B. Quantitative liver functions after administration of allyl alcohol to rats. Acta Pharmacol Toxicol (Copenh) 1984 Feb;54(2):120-3.

Tvedegaard E, Poulsen HE, Vilstrup H, Thomsen HK. Liver function during chronic renal failure in rabbits. Experientia 1984 Nov 15;40(11):1255-6.


Dossing M, Volund A, Poulsen HE. Optimal sampling times for minimum variance of clearance determination. Br J Clin Pharmacol 1983 Feb;15(2):231-5.

Dossing M, Pilsgaard H, Rasmussen B, Poulsen HE. Time course of phenobarbital and cimetidine mediated changes in hepatic drug metabolism. Eur J Clin Pharmacol 1983;25(2):215-22.

Poulsen HE. A pocket calculator program to sort data. Comput Biol Med 1983;13(4):299-301.


Dossing M, Poulsen HE, Andreasen PB, Tygstrup N. A simple method for determination of antipyrine clearance. Clin Pharmacol Ther 1982 Sep;32(3):392-6.


Poulsen HE, Ranek L, Andreasen PB. The hepatic glutathione content in liver diseases. Scand J Clin Lab Invest 1981 Oct;41(6):573-6.

Poulsen HE, Petersen P, Vilstrup H. Quantitative liver function and morphology after paracetamol administration to rats. Eur J Clin Invest 1981 Jun;11(3):161-4.

Sonne J, Poulsen HE, Dossing M, Larsen NE, Andreasen PB. Cimetidine clearance and bioavailability in hepatic cirrhosis. Clin Pharmacol Ther 1981 Feb;29(2):191-7.

Yildirim SI, Poulsen HE. Quantitative liver functions after 70% hepatectomy. Eur J Clin Invest 1981 Dec;11(6):469-72.


Milandri M, Poulsen HE, Ranek L, Andreasen PB. Effect of long-term disulfiram administration on rat liver. Pharmacology 1980;21(1):76-80.


Poulsen HE, Ranek L. [Duodenal ulcer as a cause of splenic vein thrombosis and esophageal varices]. Ugeskr Laeger 1976 Jul 5;138(28):1712-3.






Poulsen HE. Kvantitering af leverfunktionen ved eksperimentel akut toksisk leverskade sammenlignet med forholdene efter partiel og subtotal hepatectomi. Disputats. Copenhagen: University of Copenhagen, 1986




 Lykkesfeldt J, Loft S, Poulsen HE. Individuel kræftrisiko - biomarkører kan måske give os svaret. Naturens Verden 1995; 78:32-40.

Poulsen HE, Weimann A, Loft S. Methods to detect DNA damage by free radicals: relation to exercise. Proc Nutr Soc 1999 Nov;58(4):1007-14.



Book Chapters



Poulsen HE: Klinisk farmakologi og farmakoterapi. In: Basisbog i Diagnostiske Fag. Eds. Thomsen HS et al. Munksgaard Forlag. Kapitel 7 (2012) 251-268


Poulsen HE, Weimann A and Halliwell HB: Cigarette Smoke and Oxidative DNA Modification in Cigarette Smoke and Oxidative Stress. Ed. Berry B. Halliwell and Henrik E. Poulsen. Springer-Verlag Berlin Heidelberg Chapter 16 (2006) 387-402.


Dalhoff K, Jensen KB, Poulsen HE. Cancer and molecular biomarkers of phase 2. In: John Abelson, USA, ed. Methods Enzymol. 400 ed. New York: Elsevier; 2005:618-27


Poulsen HE, Loft S, Jensen BR, Sørensen, M, Hoberg A-M, Weimann A. HPLC-ECD, LC-MS/MS (Urinary Biomarkers):  In: Oxidative Stress and Aging. Advances in Basic Science, Diagnostics, and Intervention, eds. Cutler RG, Rodriguez H. Singapore: World Scientific Publishing Co. Pte. Ltd; 2003:233-56

Poulsen HE. Proper design of human intervention studies, power calculations. In:Free radicals, nitric oxide, and inflammation: Molecular, biochemical, and clinical aspects, eds. Tomasi A et al. Ohmsha: IOS Press; 2003:252-3.

Poulsen HE. Estimation of oxidative and lipids peroxidation DNA adduct in urine and DNA. Free radicals, nitric oxide, and inflammation: Methodological aspects and application in Molecular epidemiology.In: Molecular, biochemical, and clinical aspects, eds. Tomasi A, et al. Ohmsha: IOS Press; 2003:34-38


Griffiths HR, Møller L, Bartosz G, Bast A, Bertoni-Freddari C, Collins A, Cooke M, Coolen S,  Haenen  G, Hpberg AM, Loft S, Lunec J, Olinski R, Parry J, Pompella A, Poulsen HE, Verhagen H, Astley SB. Chap 3; Biomarkers. In Molecular Aspects of Medicine 23 2002; 101-208.


Poulsen HE, Loft S, Weimann A. Urinary measurement of 8-oxodG (8-oxo-2'-deoxyguanosine). In: Lunec J, Griffiths HR, editors. Measuring in vivo Oxidative Damage: A practical Approach. London: John Wiley and Sons (Ltd.), 2000: 69-80


Loft S, Poulsen HE. Measurement of oxidative damage to DNA: interpretation of nuclear levels and urinary excretion of repair products in DNA damage and Repair: Oxygen Radical effects, cellular protection and biological consequeences. In: Karakaya A, Dizdaroglu M, editors. Oxygen Radical Effects, Cellular Protection and Biological Consequences. New York: Plenum Press, 1999: 267-281.

Poulsen HE, Loft S. Motion og velvære. Miljømedicin. 1999: 364-367.

Poulsen HE, Loft S, Strandgaard S, Vilstrup H. Rationel farmakoterapi. In: Lorenzen I, Bendixen G, Hansen NE, editors. Medicinsk Kompendium. Copenhagen: Nyt Nordisk forlag Arnold Busck A/S, 1999: 2942-2954.


Poulsen HE, Loft S. Interpretation of oxidative DNA modification: Relation between tissue levels, excretion of urinary repair products and sigle cell gel electrophoresis (comet assay). In: Aruoma OI, Halliwell B, editors. DNA & free radicals: Techniques, mechanisms and applications. London: OICA International, 1998: 261-270. 


Poulsen HE, Loft S, Prieme H, Salonen JT. Antioxidants. In: Haunsø S, editor. Coronary microcirculation during ischaemia and reperfusion. Copenhagen: Munksgaard, 1997: 455-461


Prieme H, Loft S, Cutler RG, Poulsen HE. Measurement of oxidative DNA injury in humans: evaluation of a commercially available ELISA assay. In: Kumpulainen JT, editor. Natural antioxidants and food quality in atherosclerosis and cancer prevention. The royal society of chemistry 1996, 1996: 78-82.


Roberts DW, Benson RW, Pumford, NR, Potter DW, Poulsen HE et al. Sensitive immunochemical assays for monitoring acetaminophen toxicity in humans. In: Vanderlaan M, editor. Immunoassays for trace chemical analysis. Washington DC:  1989:44-50


Knudsen GM, Poulsen HE. Unchanged blood-brain barrier permability to GABA in experimental hepatic encephalopathy. In: Soeter PB, Wilson JHP, Maijer AJ, Holm E, editors. Advances in ammonia metabolism and hepatic encephalopathy. Elsevier Science Publishers B.V., 1988: 309-313

Vilstrup H, Hansen BA, Almdal T, PetersenKF, Siggaard I, Poulsen HE. The capacity of urea synthesis in rats: regulation and physiological importance. In: Soeters PB, editor. Advances in ammonia metabolism and hepatic encephalopathy. Elsevier Science Publisheres B.V., 1988: 79-85


Poulsen HE, Loft S. Quantitation of liver function: Antipyrine, an update. In: Okolicsanyi L, editor. Assessment and management of hepatobiliary disease. Berlin Heidelberg: Springer-Verlag, 1987: 189-195. 

Tygstrup N, Poulsen HE. Post-marketing surveillance of hepatotoxicity. Milan, Italy: Wichtig Editore, 1987.


Other Publications


Poulsen HE, Juul P. Note on the statistical evaluation of a randomized, cross-over bioavailability study. Danish National Board of Health, 1990 PDF (289K)